Linshang Chemical
PRODUCTS
Benzenemethanol, 3-Chloro-5-Fluoro-
Linshang Chemical
|
HS Code |
326007 |
| Chemical Formula | C7H6ClFO |
| Molar Mass | 160.573 g/mol |
As an accredited Benzenemethanol, 3-Chloro-5-Fluoro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 5 - fluorobenzenemethanol in a sealed, chemical - resistant bottle. |
| Storage | Store “3 - chloro - 5 - fluoro - benzenemethanol” in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to air and moisture, which could potentially lead to degradation. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions. |
| Shipping | For the chemical 3 - chloro - 5 - fluorobenzenemethanol, shipping is carefully regulated. It must be packaged in compliant containers to prevent leakage. Shipments follow hazardous chemical transport guidelines, ensuring safety during transit. |
Competitive Benzenemethanol, 3-Chloro-5-Fluoro- prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 3-chloro-5-fluorobenzyl alcohol?
3-Cyanogen-5-hydroxyacetophenone is one of the organic compounds. It has unique characteristics and is widely used in various chemical fields.
In this compound, the cyano group (-CN) coexists with the hydroxyl group (-OH) and acetophenone structures, which makes its chemical properties interesting. The presence of cyanyl groups gives molecules a certain reactivity. Cyanyl groups can participate in a variety of reactions, such as hydrolysis reactions. After hydrolysis under specific conditions, they can be converted into carboxyl groups (-COOH), and new compounds containing carboxyl groups can be derived, which is particularly important for the preparation of carboxylic acid derivatives in organic synthesis.
The properties of hydroxyl groups cannot be underestimated. The hydroxy group is hydrophilic, which makes 3-cyano- 5-hydroxyacetophenone soluble in water to a certain extent, and the hydroxy group can participate in the formation of hydrogen bonds, which has a great influence on the physical properties of the compound, such as melting point and boiling point. At the same time, the hydroxy group can undergo esterification reaction, and under appropriate catalysts and conditions, the corresponding ester compounds are formed with acids. This reaction is widely used in flavors, drug synthesis, etc.
Furthermore, the structure of acetophenone provides the compound with aromaticity and certain stability. The conjugate system of the benzene ring reduces the molecular energy and enhances the stability. The substituents (cyano and hydroxyl) on the benzene ring will affect the electron cloud distribution of the benzene ring, thereby changing the reactivity of the benzene ring. In the electrophilic substitution reaction, the cyano group is the electron-withdrawing group and the hydroxyl group is the donator group. The two work together to determine the location and difficulty of the substitution reaction on the benzene ring.
In addition, the carbonyl group of 3-cyano-5-hydroxyacetophenone (C = O) is also reactive and can be added to nucleophiles, such as with alcohols under acid catalysis to generate acetals or acetals. It is often used in organic synthesis to protect carbonyl groups, and then deprotected at an appropriate time to achieve specific synthesis goals.
In this compound, the cyano group (-CN) coexists with the hydroxyl group (-OH) and acetophenone structures, which makes its chemical properties interesting. The presence of cyanyl groups gives molecules a certain reactivity. Cyanyl groups can participate in a variety of reactions, such as hydrolysis reactions. After hydrolysis under specific conditions, they can be converted into carboxyl groups (-COOH), and new compounds containing carboxyl groups can be derived, which is particularly important for the preparation of carboxylic acid derivatives in organic synthesis.
The properties of hydroxyl groups cannot be underestimated. The hydroxy group is hydrophilic, which makes 3-cyano- 5-hydroxyacetophenone soluble in water to a certain extent, and the hydroxy group can participate in the formation of hydrogen bonds, which has a great influence on the physical properties of the compound, such as melting point and boiling point. At the same time, the hydroxy group can undergo esterification reaction, and under appropriate catalysts and conditions, the corresponding ester compounds are formed with acids. This reaction is widely used in flavors, drug synthesis, etc.
Furthermore, the structure of acetophenone provides the compound with aromaticity and certain stability. The conjugate system of the benzene ring reduces the molecular energy and enhances the stability. The substituents (cyano and hydroxyl) on the benzene ring will affect the electron cloud distribution of the benzene ring, thereby changing the reactivity of the benzene ring. In the electrophilic substitution reaction, the cyano group is the electron-withdrawing group and the hydroxyl group is the donator group. The two work together to determine the location and difficulty of the substitution reaction on the benzene ring.
In addition, the carbonyl group of 3-cyano-5-hydroxyacetophenone (C = O) is also reactive and can be added to nucleophiles, such as with alcohols under acid catalysis to generate acetals or acetals. It is often used in organic synthesis to protect carbonyl groups, and then deprotected at an appropriate time to achieve specific synthesis goals.
What are the physical properties of 3-chloro-5-fluorobenzyl alcohol?
3-Bromo-5-chlorotoluonitrile is a kind of organic compound. Its physical properties are as follows:
Looking at its color state, under room temperature, it often takes a white to light yellow crystalline powder shape. This morphology is quite common in many organic compounds, and it is also easy to store and use.
When it comes to the melting point, its melting point is within a specific range, about [X] ° C. The characteristics of this melting point can be used as an important reference in the identification and separation of organic compounds. In terms of boiling point, it boils at about [X] ° C in an atmospheric pressure environment. Such boiling point characteristics are of great significance in experimental operations such as separation and purification such as distillation.
In terms of solubility, 3-bromo-5-chlorotoluenitrile exhibits different solubility in organic solvents. In common organic solvents such as dichloromethane and chloroform, its solubility is quite good, and it can be well dissolved to form a uniform solution. This characteristic makes it possible to participate in various chemical reactions as a reactant or product in a suitable solvent system during the reaction of organic synthesis. However, its solubility in water is extremely low and almost insoluble. This is due to the strong hydrophobicity of the molecular structure of the compound. The existence of hydrocarbon skeleton, halogen atom and cyanyl group in the molecule makes it difficult to form an effective interaction with water molecules, so it is difficult to dissolve in water.
In addition, the density of 3-bromo-5-chlorotoluenitrile is also one of its important physical properties. At a specific temperature, its density is about [X] g/cm ³. This density data has certain guiding value in the material accounting of chemical production and the quantitative analysis of related experimental operations.
Looking at its color state, under room temperature, it often takes a white to light yellow crystalline powder shape. This morphology is quite common in many organic compounds, and it is also easy to store and use.
When it comes to the melting point, its melting point is within a specific range, about [X] ° C. The characteristics of this melting point can be used as an important reference in the identification and separation of organic compounds. In terms of boiling point, it boils at about [X] ° C in an atmospheric pressure environment. Such boiling point characteristics are of great significance in experimental operations such as separation and purification such as distillation.
In terms of solubility, 3-bromo-5-chlorotoluenitrile exhibits different solubility in organic solvents. In common organic solvents such as dichloromethane and chloroform, its solubility is quite good, and it can be well dissolved to form a uniform solution. This characteristic makes it possible to participate in various chemical reactions as a reactant or product in a suitable solvent system during the reaction of organic synthesis. However, its solubility in water is extremely low and almost insoluble. This is due to the strong hydrophobicity of the molecular structure of the compound. The existence of hydrocarbon skeleton, halogen atom and cyanyl group in the molecule makes it difficult to form an effective interaction with water molecules, so it is difficult to dissolve in water.
In addition, the density of 3-bromo-5-chlorotoluenitrile is also one of its important physical properties. At a specific temperature, its density is about [X] g/cm ³. This density data has certain guiding value in the material accounting of chemical production and the quantitative analysis of related experimental operations.
What are the main uses of 3-chloro-5-fluorobenzyl alcohol?
3-Chloro-5-bromotoluenonitrile is an important intermediate in organic synthesis and has critical uses in many fields.
In the field of medicinal chemistry, it has a wide range of uses. For example, in the development of new antibacterial drugs, 3-chloro-5-bromotoluenonitrile can act as a key structural fragment, which can be integrated into the molecular structure of the drug through a series of chemical reactions to give the drug specific antibacterial activity. Because of its chlorine, bromine atoms and nitrile groups, it can interact with specific targets in bacteria, interfere with bacterial cell wall synthesis, or hinder bacterial protein transcription, thereby inhibiting bacterial growth and reproduction. For example, in the research and development of anti-tumor drugs, this compound can be used as a starting material, modified and modified to prepare drugs with high selective inhibitory effect on tumor cells. Its special chemical structure can help drug molecules target tumor cells more accurately, improve drug efficacy, and reduce toxic and side effects on normal cells.
In the field of pesticide chemistry, 3-chloro-5-bromotoluenonitrile also plays an important role. It can be used to synthesize high-efficiency insecticides. Its structural characteristics make the synthesized insecticides highly toxic to specific pests. For example, for some chewing mouth pests, the insecticide can enter the body through pests, interfering with the normal function of the pest's nervous system or digestive system, causing its death. At the same time, it is also indispensable in the synthesis of herbicides. After rational design of the reaction, the herbicide based on 3-chloro-5-bromotoluenitrile has a high selective killing effect on specific weeds, and the residual period in the environment is suitable, which not only ensures the herbicide effect, but also reduces the negative impact on the environment.
In the field of materials science, 3-chloro-5-bromotoluenitrile can be used to prepare functional materials. For example, when synthesizing high-performance polymer materials, introducing them into the polymer backbone as comonomers can change the physical and chemical properties of the polymer. Due to the high electronegativity of chlorine and bromine atoms, it can enhance the interaction between polymer molecules and improve the thermal stability and mechanical properties of the material. In addition, in the preparation of optoelectronic materials, this compound can have unique optoelectronic properties after specific modifications, and is expected to be applied to fields such as organic Light Emitting Diodes (OLEDs) or solar cells, providing new options for the development of materials science.
In the field of medicinal chemistry, it has a wide range of uses. For example, in the development of new antibacterial drugs, 3-chloro-5-bromotoluenonitrile can act as a key structural fragment, which can be integrated into the molecular structure of the drug through a series of chemical reactions to give the drug specific antibacterial activity. Because of its chlorine, bromine atoms and nitrile groups, it can interact with specific targets in bacteria, interfere with bacterial cell wall synthesis, or hinder bacterial protein transcription, thereby inhibiting bacterial growth and reproduction. For example, in the research and development of anti-tumor drugs, this compound can be used as a starting material, modified and modified to prepare drugs with high selective inhibitory effect on tumor cells. Its special chemical structure can help drug molecules target tumor cells more accurately, improve drug efficacy, and reduce toxic and side effects on normal cells.
In the field of pesticide chemistry, 3-chloro-5-bromotoluenonitrile also plays an important role. It can be used to synthesize high-efficiency insecticides. Its structural characteristics make the synthesized insecticides highly toxic to specific pests. For example, for some chewing mouth pests, the insecticide can enter the body through pests, interfering with the normal function of the pest's nervous system or digestive system, causing its death. At the same time, it is also indispensable in the synthesis of herbicides. After rational design of the reaction, the herbicide based on 3-chloro-5-bromotoluenitrile has a high selective killing effect on specific weeds, and the residual period in the environment is suitable, which not only ensures the herbicide effect, but also reduces the negative impact on the environment.
In the field of materials science, 3-chloro-5-bromotoluenitrile can be used to prepare functional materials. For example, when synthesizing high-performance polymer materials, introducing them into the polymer backbone as comonomers can change the physical and chemical properties of the polymer. Due to the high electronegativity of chlorine and bromine atoms, it can enhance the interaction between polymer molecules and improve the thermal stability and mechanical properties of the material. In addition, in the preparation of optoelectronic materials, this compound can have unique optoelectronic properties after specific modifications, and is expected to be applied to fields such as organic Light Emitting Diodes (OLEDs) or solar cells, providing new options for the development of materials science.
What is the synthesis method of 3-chloro-5-fluorobenzyl alcohol?
To prepare 3-bromo-5-fluorotoluene, the following ancient method can be used.
First take toluene as the group, and use the method of sulfonation to make the sulfonyl group enter the para-position of toluene. The methyl group of captoluene is the o-para-position locator, and the para-position substitution product is easy to separate. The reaction needs to use concentrated sulfuric acid as the sulfonating agent, and heat it to an appropriate temperature to promote the electrophilic substitution of toluene and sulfuric acid to obtain p-toluenesulfonic acid.
Treat p-toluenesulfonic acid with fluoroboric acid for the first time, so that the sulfonic acid group is replaced by a fluorine atom to obtain p-fluorotoluene. This step requires strict temperature
Then bromine atoms are introduced into the 3-position of p-fluorotoluene by bromination method. Because the fluorine atom is an ortho-para-position group and the para-position is occupied, the brominating reagent can be selected from the catalytic system of bromine and ferric tribromide, reacted in an appropriate solvent, and electrophilic substitution to obtain 3-bromo-5-fluorotoluene.
During operation, all reaction conditions need to be precisely controlled, such as temperature, reagent ratio, reaction time, etc., and the products in each step must be properly separated and purified to prevent the accumulation of impurities and hinder the purity and yield of the final product. Although this synthesis method follows the ancient method, the principle is clear and the steps are orderly, which can lead to the preparation of 3-bromo-5-fluorotoluene.
First take toluene as the group, and use the method of sulfonation to make the sulfonyl group enter the para-position of toluene. The methyl group of captoluene is the o-para-position locator, and the para-position substitution product is easy to separate. The reaction needs to use concentrated sulfuric acid as the sulfonating agent, and heat it to an appropriate temperature to promote the electrophilic substitution of toluene and sulfuric acid to obtain p-toluenesulfonic acid.
Treat p-toluenesulfonic acid with fluoroboric acid for the first time, so that the sulfonic acid group is replaced by a fluorine atom to obtain p-fluorotoluene. This step requires strict temperature
Then bromine atoms are introduced into the 3-position of p-fluorotoluene by bromination method. Because the fluorine atom is an ortho-para-position group and the para-position is occupied, the brominating reagent can be selected from the catalytic system of bromine and ferric tribromide, reacted in an appropriate solvent, and electrophilic substitution to obtain 3-bromo-5-fluorotoluene.
During operation, all reaction conditions need to be precisely controlled, such as temperature, reagent ratio, reaction time, etc., and the products in each step must be properly separated and purified to prevent the accumulation of impurities and hinder the purity and yield of the final product. Although this synthesis method follows the ancient method, the principle is clear and the steps are orderly, which can lead to the preparation of 3-bromo-5-fluorotoluene.
What are the precautions for storing and transporting 3-chloro-5-fluorobenzyl alcohol?
3-Chloro-5-bromoacetophenone has a number of things to pay attention to during storage and transportation, and needs to be paid attention to in detail.
The first thing to pay attention to is its chemical properties. This substance contains chlorine, bromine and other halogen elements, which are active in nature. When exposed to heat, open flame or oxidant, it is easy to cause violent reactions, and even the risk of combustion and explosion. Therefore, when storing, it must be placed in a cool and ventilated place, away from fire and heat sources, and it must be stored separately from oxidants, acids, bases, etc., and must not be mixed in storage and transportation to prevent unexpected interactions.
Times and packaging. Packaging must be tight to prevent leakage. The packaging materials used must be resistant to corrosion of this substance and have good sealing properties. If special metal or plastic drums are used with sealing caps, the barrel body should be clearly marked with the name of the substance, characteristics, hazard warnings and other information, so that the situation can be clarified during transportation and storage.
Further transportation. During transportation, transportation enterprises and vehicles with professional qualifications should be selected. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies. During driving, drivers and escorts must be careful to avoid violent vibration and impact of vehicles to prevent packaging damage.
Store in the warehouse, warehouse management personnel should regularly inspect to check whether the packaging is damaged or leaked, monitor the temperature and humidity of the warehouse, and ensure that the environmental conditions are suitable. If any abnormalities are found, immediate and effective measures should be taken to prevent the harm from expanding.
In summary, the storage and transportation of 3-chloro-5-bromoacetophenone is a matter of safety, and all links must strictly follow relevant regulations and operating procedures. Do not be negligent in order to ensure safety.
The first thing to pay attention to is its chemical properties. This substance contains chlorine, bromine and other halogen elements, which are active in nature. When exposed to heat, open flame or oxidant, it is easy to cause violent reactions, and even the risk of combustion and explosion. Therefore, when storing, it must be placed in a cool and ventilated place, away from fire and heat sources, and it must be stored separately from oxidants, acids, bases, etc., and must not be mixed in storage and transportation to prevent unexpected interactions.
Times and packaging. Packaging must be tight to prevent leakage. The packaging materials used must be resistant to corrosion of this substance and have good sealing properties. If special metal or plastic drums are used with sealing caps, the barrel body should be clearly marked with the name of the substance, characteristics, hazard warnings and other information, so that the situation can be clarified during transportation and storage.
Further transportation. During transportation, transportation enterprises and vehicles with professional qualifications should be selected. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies. During driving, drivers and escorts must be careful to avoid violent vibration and impact of vehicles to prevent packaging damage.
Store in the warehouse, warehouse management personnel should regularly inspect to check whether the packaging is damaged or leaked, monitor the temperature and humidity of the warehouse, and ensure that the environmental conditions are suitable. If any abnormalities are found, immediate and effective measures should be taken to prevent the harm from expanding.
In summary, the storage and transportation of 3-chloro-5-bromoacetophenone is a matter of safety, and all links must strictly follow relevant regulations and operating procedures. Do not be negligent in order to ensure safety.
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