Linshang Chemical
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Benzenesulfonanilide, 4-Chloro-3-Nitro- (8Ci)
Linshang Chemical
|
HS Code |
823118 |
| Chemical Formula | C12H9ClN2O4S |
| Molecular Weight | 312.73 g/mol |
| Solubility In Water | Low solubility (organic compound nature) |
| Solubility In Organic Solvents | Soluble in some common organic solvents like dichloromethane |
| Vapor Pressure | Very low (solid, non - volatile nature) |
As an accredited Benzenesulfonanilide, 4-Chloro-3-Nitro- (8Ci) factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 3 - nitro - benzenesulfonanilide packaged in air - tight plastic bags. |
| Storage | Store “4 - chloro - 3 - nitrobenzenesulfonanilide (8CI)” in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly closed container to prevent moisture absorption and potential reactions. Label the storage container clearly to avoid misidentification. |
| Shipping | Shipping of 4 - chloro - 3 - nitrobenzenesulfonanilide must comply with strict regulations due to its chemical nature. It should be properly packaged in corrosion - resistant containers, labeled clearly, and transported by carriers licensed for such chemicals. |
Competitive Benzenesulfonanilide, 4-Chloro-3-Nitro- (8Ci) prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-chloro-3-nitrobenzenesulfonylaniline (8CI)?
4-Bromo-3-chlorophenylboronic acid (8CI) is an important chemical in organic synthesis. It has unique chemical properties.
From a structural point of view, this compound contains boron atoms, bromine atoms and chlorine atoms, and is connected to the benzene ring. The boron atom is in a boric acid group, which gives the substance a certain electrophilicity. Boric acid groups can serve as key activity check points in many organic reactions, such as participating in Suzuki coupling reactions. In this reaction, boric acid groups can be coupled with organic halides under the action of palladium catalysts to form carbon-carbon bonds, which is an extremely important means of synthesizing complex organic molecules.
Bromine and chlorine atoms also have a profound impact on the chemical properties of the substance. Bromine and chlorine atoms are both halogen atoms, which have certain electronegativity. Due to their electronegativity, the electron cloud density distribution of the benzene ring can be changed, resulting in a relative decrease in the electron cloud density of the adjacent and para-sites of the benzene ring, and a relative increase in the electron cloud density of the meta-site. In this way, in the electrophilic substitution reaction, the reaction check point and activity will be affected. For example, electrophilic reagents tend to attack positions with relatively high electron cloud density. At the same time, halogen atoms can participate in some substitution reactions as leaving groups. Under suitable conditions, bromine atoms or chlorine atoms can be replaced by other groups to achieve diverse modifications of molecular structures.
In addition, the solubility of this compound is also worthy In view of its boric acid group, it may have some solubility in water or polar solvents due to the interaction between boric acid and water molecules such as hydrogen bonds. However, the presence of benzene rings and halogen atoms will limit its solubility in water, resulting in poor solubility in non-polar solvents. This solubility characteristic needs to be taken into account in the separation and purification steps of organic synthesis.
From a structural point of view, this compound contains boron atoms, bromine atoms and chlorine atoms, and is connected to the benzene ring. The boron atom is in a boric acid group, which gives the substance a certain electrophilicity. Boric acid groups can serve as key activity check points in many organic reactions, such as participating in Suzuki coupling reactions. In this reaction, boric acid groups can be coupled with organic halides under the action of palladium catalysts to form carbon-carbon bonds, which is an extremely important means of synthesizing complex organic molecules.
Bromine and chlorine atoms also have a profound impact on the chemical properties of the substance. Bromine and chlorine atoms are both halogen atoms, which have certain electronegativity. Due to their electronegativity, the electron cloud density distribution of the benzene ring can be changed, resulting in a relative decrease in the electron cloud density of the adjacent and para-sites of the benzene ring, and a relative increase in the electron cloud density of the meta-site. In this way, in the electrophilic substitution reaction, the reaction check point and activity will be affected. For example, electrophilic reagents tend to attack positions with relatively high electron cloud density. At the same time, halogen atoms can participate in some substitution reactions as leaving groups. Under suitable conditions, bromine atoms or chlorine atoms can be replaced by other groups to achieve diverse modifications of molecular structures.
In addition, the solubility of this compound is also worthy In view of its boric acid group, it may have some solubility in water or polar solvents due to the interaction between boric acid and water molecules such as hydrogen bonds. However, the presence of benzene rings and halogen atoms will limit its solubility in water, resulting in poor solubility in non-polar solvents. This solubility characteristic needs to be taken into account in the separation and purification steps of organic synthesis.
What are the main uses of 4-chloro-3-nitrobenzenesulfonylaniline (8CI)?
4-Bromo-3-fluoroaniline hydrochloride (8CI), which has important uses in the fields of medicine, pesticides and material synthesis.
In the synthesis of medicine, it is often a key intermediate. Due to the unique chemical properties of halogen atoms and amino groups such as bromine and fluorine, molecular structures with specific biological activities can be constructed through a variety of chemical reactions. For example, when developing antibacterial drugs, they can be connected to the drug parent body. By virtue of the electronic and spatial effects of halogen atoms, the ability to bind the drug to the target can be changed, the antibacterial activity can be enhanced, and the pharmacokinetic properties of the drug can be optimized, such as improving bioavailability and prolonging the action time in vivo.
In the field of pesticides, 4-bromo-3-fluoroaniline hydrochloride (8CI) is also indispensable. It can be used to create new insecticides and fungicides. For example, after chemical modification, it can interfere with the nervous system or metabolic pathways of specific pests, achieving high-efficiency, low-toxicity and environmentally friendly insecticidal effects. For fungicides, with the help of their structural properties, they can interfere with the cell wall synthesis, energy metabolism and other physiological processes of pathogenic bacteria, and achieve the purpose of preventing and controlling plant diseases.
In the field of materials science, this compound can participate in the preparation of functional materials. Due to its structure, amino groups and halogen atoms can participate in polymerization reactions, etc., to synthesize polymer materials with special optical and electrical properties. For example, when preparing photoelectric conversion materials, the introduction of the compound structural unit can adjust the energy band structure of the material, improve the absorption and conversion efficiency of specific wavelengths of light, and demonstrate application potential in fields such as organic solar cells.
In the synthesis of medicine, it is often a key intermediate. Due to the unique chemical properties of halogen atoms and amino groups such as bromine and fluorine, molecular structures with specific biological activities can be constructed through a variety of chemical reactions. For example, when developing antibacterial drugs, they can be connected to the drug parent body. By virtue of the electronic and spatial effects of halogen atoms, the ability to bind the drug to the target can be changed, the antibacterial activity can be enhanced, and the pharmacokinetic properties of the drug can be optimized, such as improving bioavailability and prolonging the action time in vivo.
In the field of pesticides, 4-bromo-3-fluoroaniline hydrochloride (8CI) is also indispensable. It can be used to create new insecticides and fungicides. For example, after chemical modification, it can interfere with the nervous system or metabolic pathways of specific pests, achieving high-efficiency, low-toxicity and environmentally friendly insecticidal effects. For fungicides, with the help of their structural properties, they can interfere with the cell wall synthesis, energy metabolism and other physiological processes of pathogenic bacteria, and achieve the purpose of preventing and controlling plant diseases.
In the field of materials science, this compound can participate in the preparation of functional materials. Due to its structure, amino groups and halogen atoms can participate in polymerization reactions, etc., to synthesize polymer materials with special optical and electrical properties. For example, when preparing photoelectric conversion materials, the introduction of the compound structural unit can adjust the energy band structure of the material, improve the absorption and conversion efficiency of specific wavelengths of light, and demonstrate application potential in fields such as organic solar cells.
What is the synthesis method of 4-chloro-3-nitrobenzenesulfonylaniline (8CI)?
To prepare 4-deuterium-3-fluorobenzoylbenzoic acid (8CI), the method is as follows:
First take an appropriate amount of starting materials, often starting with benzene derivatives with appropriate substituents. In the reaction kettle, add the corresponding halogenation reagents, such as deuterium-containing halides, so that they and benzene derivatives in the presence of catalysts, according to nucleophilic substitution or other suitable reaction mechanisms, Substitution reaction occurs to introduce deuterium atoms at designated positions to obtain deuterium-containing intermediates.
Then, the deuterium-containing intermediate product is reacted with a fluorine-containing reagent under specific reaction conditions, such as suitable temperature, pressure and catalyst, so that the fluorine atom is connected to the molecule to form a fluorine-containing and deuterium-containing intermediate product.
Subsequently, the intermediate product is further processed, through an acylation reaction, using a suitable acylation reagent, and in a suitable reaction environment, a formyl group is introduced at a specific position in the benzene ring. Through this step, a formyl-containing product containing fluorine and deuterium is generated.
Finally, the above products are processed again, and the formation of benzoic acid groups is promoted by suitable reaction conditions and reagents. After fine regulation, separation and purification of multi-step reactions, 4-deuterium-3-fluorobenzoyl benzoic acid (8CI) is finally obtained. During the whole process, the precise control of the reaction conditions and the effective separation and purification of the products in each step are extremely critical, which is related to the purity and yield of the final product.
First take an appropriate amount of starting materials, often starting with benzene derivatives with appropriate substituents. In the reaction kettle, add the corresponding halogenation reagents, such as deuterium-containing halides, so that they and benzene derivatives in the presence of catalysts, according to nucleophilic substitution or other suitable reaction mechanisms, Substitution reaction occurs to introduce deuterium atoms at designated positions to obtain deuterium-containing intermediates.
Then, the deuterium-containing intermediate product is reacted with a fluorine-containing reagent under specific reaction conditions, such as suitable temperature, pressure and catalyst, so that the fluorine atom is connected to the molecule to form a fluorine-containing and deuterium-containing intermediate product.
Subsequently, the intermediate product is further processed, through an acylation reaction, using a suitable acylation reagent, and in a suitable reaction environment, a formyl group is introduced at a specific position in the benzene ring. Through this step, a formyl-containing product containing fluorine and deuterium is generated.
Finally, the above products are processed again, and the formation of benzoic acid groups is promoted by suitable reaction conditions and reagents. After fine regulation, separation and purification of multi-step reactions, 4-deuterium-3-fluorobenzoyl benzoic acid (8CI) is finally obtained. During the whole process, the precise control of the reaction conditions and the effective separation and purification of the products in each step are extremely critical, which is related to the purity and yield of the final product.
4-Chloro-3-nitrobenzenesulfonylaniline (8CI) What are the precautions in storage and transportation?
4-Bromo-3-chlorobenzaldehyde (8CI) is a kind of organic compound. During storage and transportation, many matters must be paid attention to.
When storing, the first choice of environment. It should be found in a cool, dry and well-ventilated place. Because of its certain chemical activity, it is easy to deteriorate if it is exposed to high temperature and humidity. High temperature may cause it to undergo chemical reactions, and humidity may cause it to absorb moisture and affect the quality.
Furthermore, it must be stored separately from oxidants, reducing agents and other substances. If such substances meet it, or cause violent chemical reactions, there is even a risk of explosion. Storage containers should also be carefully selected, and materials with good sealing properties should be used to prevent them from evaporating or coming into contact with external substances.
As for transportation, the packaging must be solid and reliable. Make sure that the container is not damaged due to bumps and collisions during transportation, so that 4-bromo-3-chlorobenzaldehyde leaks. Transportation vehicles should also be kept clean and free of other contaminants that may react with them.
Transportation personnel should have a good understanding of the characteristics of the compound and know how to deal with it in an emergency. If there is an accident such as a leak on the way, it can be dealt with in a timely and appropriate manner. And the transportation process should avoid water sources and densely populated areas to prevent leakage from causing harm to the environment and people. In this way, the purpose of safe storage and transportation of 4-bromo-3-chlorobenzaldehyde (8CI) can be achieved.
When storing, the first choice of environment. It should be found in a cool, dry and well-ventilated place. Because of its certain chemical activity, it is easy to deteriorate if it is exposed to high temperature and humidity. High temperature may cause it to undergo chemical reactions, and humidity may cause it to absorb moisture and affect the quality.
Furthermore, it must be stored separately from oxidants, reducing agents and other substances. If such substances meet it, or cause violent chemical reactions, there is even a risk of explosion. Storage containers should also be carefully selected, and materials with good sealing properties should be used to prevent them from evaporating or coming into contact with external substances.
As for transportation, the packaging must be solid and reliable. Make sure that the container is not damaged due to bumps and collisions during transportation, so that 4-bromo-3-chlorobenzaldehyde leaks. Transportation vehicles should also be kept clean and free of other contaminants that may react with them.
Transportation personnel should have a good understanding of the characteristics of the compound and know how to deal with it in an emergency. If there is an accident such as a leak on the way, it can be dealt with in a timely and appropriate manner. And the transportation process should avoid water sources and densely populated areas to prevent leakage from causing harm to the environment and people. In this way, the purpose of safe storage and transportation of 4-bromo-3-chlorobenzaldehyde (8CI) can be achieved.
What are the effects of 4-chloro-3-nitrobenzenesulfonylaniline (8CI) on the environment and human health?
4-Bromo-3-fluorobenzaldehyde (8CI), although it is not known in detail what the ancients have said about this substance, but according to today's scientific knowledge, it may have an impact on the environment and human health.
At the environmental end, if this substance escapes from nature, it may be difficult to degrade due to its chemical characteristics. If it enters the water body, it may cause deterioration of water quality and harm aquatic organisms. It may interfere with the physiological metabolism of aquatic organisms, cause changes in population numbers, and destroy the balance of water ecology. If it disperses in the soil or reacts with soil components, it changes the physical and chemical properties of the soil, affects the absorption of nutrients by plant roots, and then affects the growth of vegetation, causing damage to the structure and function of the ecosystem.
As for human health, 4-bromo-3-fluorobenzaldehyde (8CI) has certain toxicity. If inhaled through the respiratory tract, or irritates the mucosa of the respiratory tract, it can cause cough, asthma, breathing difficulties and other diseases. Contact through skin, or cause contact dermatitis, causing skin redness, swelling, itching, and tingling. If taken inadvertently, it may damage the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, etc. And this substance may have potential carcinogenicity, teratogenicity, and mutagenicity. Long-term exposure to this substance may damage the genetic material or damage of the body's cells, increasing the risk of cancer. Contact with pregnant women may endanger the normal development of the fetus and cause fetal deformities. Therefore, daily caution should be taken, and comprehensive protection measures should be taken during operation to reduce the harm to the environment and people.
At the environmental end, if this substance escapes from nature, it may be difficult to degrade due to its chemical characteristics. If it enters the water body, it may cause deterioration of water quality and harm aquatic organisms. It may interfere with the physiological metabolism of aquatic organisms, cause changes in population numbers, and destroy the balance of water ecology. If it disperses in the soil or reacts with soil components, it changes the physical and chemical properties of the soil, affects the absorption of nutrients by plant roots, and then affects the growth of vegetation, causing damage to the structure and function of the ecosystem.
As for human health, 4-bromo-3-fluorobenzaldehyde (8CI) has certain toxicity. If inhaled through the respiratory tract, or irritates the mucosa of the respiratory tract, it can cause cough, asthma, breathing difficulties and other diseases. Contact through skin, or cause contact dermatitis, causing skin redness, swelling, itching, and tingling. If taken inadvertently, it may damage the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, etc. And this substance may have potential carcinogenicity, teratogenicity, and mutagenicity. Long-term exposure to this substance may damage the genetic material or damage of the body's cells, increasing the risk of cancer. Contact with pregnant women may endanger the normal development of the fetus and cause fetal deformities. Therefore, daily caution should be taken, and comprehensive protection measures should be taken during operation to reduce the harm to the environment and people.
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