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Chloro-3-Methylbenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
981124 |
| Chemical Formula | C7H6Cl2O2S |
| Molecular Weight | 225.09 |
| Appearance | Typically a colorless to pale yellow liquid |
| Odor | Pungent, irritating odor |
| Boiling Point | Around 270 - 280 °C |
| Density | Approx. 1.4 - 1.5 g/cm³ |
| Solubility | Insoluble in water, soluble in organic solvents like dichloromethane, toluene |
| Reactivity | Highly reactive, reacts with nucleophiles such as amines, alcohols |
| Hazard Class | Corrosive, can cause severe skin and eye burns |
As an accredited Chloro-3-Methylbenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of Chloro - 3 - methylbenzenesulfonyl Chloride packaged in a sealed glass bottle. |
| Storage | Chloro - 3 - methylbenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It must be stored in a tightly - sealed container, preferably made of corrosion - resistant materials due to its reactive and corrosive nature. Keep it separate from incompatible substances like bases, amines, and water to prevent dangerous reactions. |
| Shipping | Chloro - 3 - methylbenzenesulfonyl chloride is a hazardous chemical. Shipping requires compliance with strict regulations. It must be properly packaged in approved containers to prevent leakage, and shipped via methods suitable for its dangerous nature. |
Competitive Chloro-3-Methylbenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of Chloro-3-methylbenzenesulfonyl Chloride?
Chloro-3-methylbenzenesulfonyl chloride has a wide range of uses and is often a key reagent in the field of organic synthesis.
First, it can be used as an important intermediate in the process of drug synthesis. In terms of creating a drug molecule with a specific structure, it can introduce a sulfonyl chloride group, which can react with many nitrogenous, oxygen-containing and other nucleophiles to build a complex drug skeleton. For example, when synthesizing a certain type of antibacterial drug, chloro-3-methylbenzenesulfonyl chloride reacts with a specific amine compound. After carefully regulating the reaction conditions, key drug precursors can be obtained, which can be subsequently transformed into antibacterial drugs.
Second, in the field of materials science, it also has important functions. It can be used to prepare special polymer materials. Reacting it with polymer monomers containing active hydrogen, such as some polymers containing hydroxyl groups, can make sulfonyl chloride groups react with hydroxyl groups and react with hydroxyl groups, and then modify the polymer. The modified polymer may have significant improvement in heat resistance, mechanical properties, etc., and can be used in aerospace, automobile manufacturing and other fields that require strict material properties.
Third, it also has a place in the field of dye synthesis. It can be used to react with specific aromatic amines and other compounds to construct chromophore groups to synthesize dyes with specific colors and properties. By ingeniously designing the reaction route, dyes with bright colors and good light fastness can be prepared, which can be used in textile printing and dyeing and other industries to impart brilliant colors to fabrics.
All of these demonstrate the important uses of chlorine-3-methylbenzenesulfonyl chloride in many fields of organic synthesis, and are indeed indispensable compounds in the field of organic chemistry.
First, it can be used as an important intermediate in the process of drug synthesis. In terms of creating a drug molecule with a specific structure, it can introduce a sulfonyl chloride group, which can react with many nitrogenous, oxygen-containing and other nucleophiles to build a complex drug skeleton. For example, when synthesizing a certain type of antibacterial drug, chloro-3-methylbenzenesulfonyl chloride reacts with a specific amine compound. After carefully regulating the reaction conditions, key drug precursors can be obtained, which can be subsequently transformed into antibacterial drugs.
Second, in the field of materials science, it also has important functions. It can be used to prepare special polymer materials. Reacting it with polymer monomers containing active hydrogen, such as some polymers containing hydroxyl groups, can make sulfonyl chloride groups react with hydroxyl groups and react with hydroxyl groups, and then modify the polymer. The modified polymer may have significant improvement in heat resistance, mechanical properties, etc., and can be used in aerospace, automobile manufacturing and other fields that require strict material properties.
Third, it also has a place in the field of dye synthesis. It can be used to react with specific aromatic amines and other compounds to construct chromophore groups to synthesize dyes with specific colors and properties. By ingeniously designing the reaction route, dyes with bright colors and good light fastness can be prepared, which can be used in textile printing and dyeing and other industries to impart brilliant colors to fabrics.
All of these demonstrate the important uses of chlorine-3-methylbenzenesulfonyl chloride in many fields of organic synthesis, and are indeed indispensable compounds in the field of organic chemistry.
What are the physical properties of Chloro-3-methylbenzenesulfonyl Chloride?
Chloro-3 -methylbenzenesulfonyl chloride, this substance is colorless to slightly yellow liquid with a pungent and foul odor. Its boiling point is quite high, about 250-260 ° C, at which temperature the substance can be converted from liquid to gaseous. The melting point is around -15 ° C. When the temperature drops below the melting point, the substance solidifies from liquid to solid.
Its density is greater than that of water, about 1.38-1.42g/cm ³, so it will sink to the bottom when placed in water. It is insoluble in water, but easily soluble in organic solvents such as ether, benzene, and chloroform, and can be uniformly dispersed in these solvents.
This substance is chemically active. As an acyl chloride compound, it easily reacts with substances containing active hydrogen. In contact with water, it will hydrolyze rapidly to form 3-methylbenzenesulfonic acid and hydrogen chloride gas, and this process is accompanied by heat release. When it encounters alcohols, an alcoholysis reaction will occur to form corresponding sulfonates; when it comes into contact with amines, an aminolysis reaction will occur to form sulfonamides. Due to its active chemical properties, it is widely used in the field of organic synthesis and can be used to prepare a variety of sulfur-containing organic compounds. However, due to its corrosive and irritating properties, it is necessary to take extra care and take protective measures when using it.
Its density is greater than that of water, about 1.38-1.42g/cm ³, so it will sink to the bottom when placed in water. It is insoluble in water, but easily soluble in organic solvents such as ether, benzene, and chloroform, and can be uniformly dispersed in these solvents.
This substance is chemically active. As an acyl chloride compound, it easily reacts with substances containing active hydrogen. In contact with water, it will hydrolyze rapidly to form 3-methylbenzenesulfonic acid and hydrogen chloride gas, and this process is accompanied by heat release. When it encounters alcohols, an alcoholysis reaction will occur to form corresponding sulfonates; when it comes into contact with amines, an aminolysis reaction will occur to form sulfonamides. Due to its active chemical properties, it is widely used in the field of organic synthesis and can be used to prepare a variety of sulfur-containing organic compounds. However, due to its corrosive and irritating properties, it is necessary to take extra care and take protective measures when using it.
What are the chemical properties of Chloro-3-methylbenzenesulfonyl Chloride?
Chloro-3-methylbenzenesulfonyl chloride is an important reagent in organic synthesis. It has active chemical properties and shows unique performance in many organic reactions.
This compound contains chlorine atoms and sulfonyl chloride groups, so it has very high reactivity. Sulfonyl chloride groups are prone to nucleophilic substitution reactions. In case of nucleophilic reagents, such as alcohols and amines, the chlorine in the sulfonyl chloride group is easily replaced by nucleophilic groups. React with alcohols to obtain sulfonate compounds. This reaction condition is usually milder and can be carried out in the presence of a suitable catalyst or base. When reacted with amines, sulfonamides are formed. This reaction is widely used in the field of drug synthesis and materials science, and can construct a variety of nitrogen-containing functional structures.
Furthermore, the methyl group on the benzene ring also affects its chemical properties. Methyl group is the power supply group, which can increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution. For example, under suitable conditions, it can be substituted with electrophilic reagents such as halogenating agents and nitrifiers, and other functional groups can be introduced at specific positions of the benzene ring, thereby expanding the derivation path of the compound and laying the foundation for the synthesis of complex organic molecules.
And because of its chlorine-containing atoms, under certain conditions, it can participate in some reactions involving the breaking of carbon-chlorine bonds, such as coupling reactions with metal-organic reagents, etc., which can realize the construction of carbon-carbon bonds and further enrich its application in organic synthesis. In short, chlorine-3-methylbenzenesulfonyl chloride has a wide range of active chemical properties due to its unique structure, and is widely used in the field of organic synthesis.
This compound contains chlorine atoms and sulfonyl chloride groups, so it has very high reactivity. Sulfonyl chloride groups are prone to nucleophilic substitution reactions. In case of nucleophilic reagents, such as alcohols and amines, the chlorine in the sulfonyl chloride group is easily replaced by nucleophilic groups. React with alcohols to obtain sulfonate compounds. This reaction condition is usually milder and can be carried out in the presence of a suitable catalyst or base. When reacted with amines, sulfonamides are formed. This reaction is widely used in the field of drug synthesis and materials science, and can construct a variety of nitrogen-containing functional structures.
Furthermore, the methyl group on the benzene ring also affects its chemical properties. Methyl group is the power supply group, which can increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution. For example, under suitable conditions, it can be substituted with electrophilic reagents such as halogenating agents and nitrifiers, and other functional groups can be introduced at specific positions of the benzene ring, thereby expanding the derivation path of the compound and laying the foundation for the synthesis of complex organic molecules.
And because of its chlorine-containing atoms, under certain conditions, it can participate in some reactions involving the breaking of carbon-chlorine bonds, such as coupling reactions with metal-organic reagents, etc., which can realize the construction of carbon-carbon bonds and further enrich its application in organic synthesis. In short, chlorine-3-methylbenzenesulfonyl chloride has a wide range of active chemical properties due to its unique structure, and is widely used in the field of organic synthesis.
What are the synthesis methods of Chloro-3-methylbenzenesulfonyl Chloride?
There are many ways to synthesize chloro-3-methylbenzenesulfonyl chloride, and each has its own advantages and disadvantages, which are suitable for different situations.
First, 3-methylbenzenesulfonic acid is used as the starting material. 3-methylbenzenesulfonic acid is reacted with chlorinating agents such as phosphorus pentachloride ($PCl_ {5} $) or dichlorosulfoxide ($SOCl_ {2} $). In the case of phosphorus pentachloride, the reaction is violent and requires careful operation, and the byproducts are phosphorus oxychloride ($POCl_ {3} $) and hydrogen chloride ($HCl $) gas. The reaction formula is: $C_ {7} H_ {8} O_ {3} S + PCl_ {5}\ longrightarrow C_ {7} H_ {6} ClO_ {2} S + POCl_ {3} + HCl $. If sulfoxide is used, the reaction is relatively mild, and the by-products are sulfur dioxide ($SO_ {2} $) and hydrogen chloride gas, and the post-treatment is relatively simple. The reaction formula is: $C_ {7} H_ {8} O_ {3} S + SOCl_ {2}\ longrightarrow C_ {7} H_ {6} ClO_ {2} S + SO_ {2} + HCl $.
Second, starting from 3-methylchlorobenzene. First, through a sulfonation reaction, concentrated sulfuric acid or fuming sulfuric acid is used as a sulfonating agent to generate 3-methylbenzenesulfonic acid. This step of the reaction needs to control the temperature and reaction time to prevent excessive sulfonation. Then chlorination is carried out with the above chlorinating agent to convert it to chloro-3-methylbenzenesulfonyl chloride.
Third, toluene is used as the starting material. First, sulfonation is carried out to obtain a mixture of p-toluenesulfonic acid and o-toluenesulfonic acid, which is separated to obtain 3-methylbenzenesulfonic acid, and then chlorinated by the same method. However, the separation process
When synthesizing chloro-3-methylbenzenesulfonyl chloride, it is necessary to comprehensively consider factors such as raw material cost, reaction conditions, yield, and difficulty of post-treatment, and choose an appropriate method to achieve the purpose of high efficiency, economy and environmental protection.
First, 3-methylbenzenesulfonic acid is used as the starting material. 3-methylbenzenesulfonic acid is reacted with chlorinating agents such as phosphorus pentachloride ($PCl_ {5} $) or dichlorosulfoxide ($SOCl_ {2} $). In the case of phosphorus pentachloride, the reaction is violent and requires careful operation, and the byproducts are phosphorus oxychloride ($POCl_ {3} $) and hydrogen chloride ($HCl $) gas. The reaction formula is: $C_ {7} H_ {8} O_ {3} S + PCl_ {5}\ longrightarrow C_ {7} H_ {6} ClO_ {2} S + POCl_ {3} + HCl $. If sulfoxide is used, the reaction is relatively mild, and the by-products are sulfur dioxide ($SO_ {2} $) and hydrogen chloride gas, and the post-treatment is relatively simple. The reaction formula is: $C_ {7} H_ {8} O_ {3} S + SOCl_ {2}\ longrightarrow C_ {7} H_ {6} ClO_ {2} S + SO_ {2} + HCl $.
Second, starting from 3-methylchlorobenzene. First, through a sulfonation reaction, concentrated sulfuric acid or fuming sulfuric acid is used as a sulfonating agent to generate 3-methylbenzenesulfonic acid. This step of the reaction needs to control the temperature and reaction time to prevent excessive sulfonation. Then chlorination is carried out with the above chlorinating agent to convert it to chloro-3-methylbenzenesulfonyl chloride.
Third, toluene is used as the starting material. First, sulfonation is carried out to obtain a mixture of p-toluenesulfonic acid and o-toluenesulfonic acid, which is separated to obtain 3-methylbenzenesulfonic acid, and then chlorinated by the same method. However, the separation process
When synthesizing chloro-3-methylbenzenesulfonyl chloride, it is necessary to comprehensively consider factors such as raw material cost, reaction conditions, yield, and difficulty of post-treatment, and choose an appropriate method to achieve the purpose of high efficiency, economy and environmental protection.
What to pay attention to when storing and transporting Chloro-3-methylbenzenesulfonyl Chloride
Chloro-3-methylbenzenesulfonyl chloride is a chemical substance, and it should be stored and transported with caution to ensure safety.
First, when storing, it should be placed in a cool, dry and well-ventilated place. This is because the substance is susceptible to moisture and deterioration, and it is afraid of high temperature. Under high temperature or its properties may be unstable, which may cause danger. Therefore, it is necessary to choose a cool and dry place and place it properly to prevent it from being damaged by the external environment.
Second, the substance is corrosive, and the container used for storage should be corrosion-resistant. Special chemical containers should be used, the material must be able to resist the corrosion of chlorine-3-methylbenzenesulfonyl chloride, and the seal must be good. If the lid is not well sealed, this material may evaporate and pollute the environment. What's more, contact with people will cause harm.
Third, when transporting, we must also strictly abide by the specifications. Transportation vehicles should be equipped with perfect protection and emergency facilities, just in case. And transport personnel must be professionally trained, familiar with the characteristics of this material and emergency treatment methods. During loading and unloading, the action should be gentle to avoid collision and dumping, otherwise once the container is damaged, the consequences will be unimaginable.
Fourth, whether stored or transported, they should be kept away from fire sources, heat sources, flammable and combustible materials. Chloro-3-methylbenzenesulfonyl chloride is exposed to fire or hot topic, or reacts violently, causing combustion or even explosion, so the surrounding environment must prevent such dangerous factors.
Fifth, the place of storage and transportation should be equipped with obvious warning signs. Let everyone know at a glance that there are dangerous chemicals here, so as to be vigilant and act cautiously, so as not to accidentally touch and cause a disaster.
First, when storing, it should be placed in a cool, dry and well-ventilated place. This is because the substance is susceptible to moisture and deterioration, and it is afraid of high temperature. Under high temperature or its properties may be unstable, which may cause danger. Therefore, it is necessary to choose a cool and dry place and place it properly to prevent it from being damaged by the external environment.
Second, the substance is corrosive, and the container used for storage should be corrosion-resistant. Special chemical containers should be used, the material must be able to resist the corrosion of chlorine-3-methylbenzenesulfonyl chloride, and the seal must be good. If the lid is not well sealed, this material may evaporate and pollute the environment. What's more, contact with people will cause harm.
Third, when transporting, we must also strictly abide by the specifications. Transportation vehicles should be equipped with perfect protection and emergency facilities, just in case. And transport personnel must be professionally trained, familiar with the characteristics of this material and emergency treatment methods. During loading and unloading, the action should be gentle to avoid collision and dumping, otherwise once the container is damaged, the consequences will be unimaginable.
Fourth, whether stored or transported, they should be kept away from fire sources, heat sources, flammable and combustible materials. Chloro-3-methylbenzenesulfonyl chloride is exposed to fire or hot topic, or reacts violently, causing combustion or even explosion, so the surrounding environment must prevent such dangerous factors.
Fifth, the place of storage and transportation should be equipped with obvious warning signs. Let everyone know at a glance that there are dangerous chemicals here, so as to be vigilant and act cautiously, so as not to accidentally touch and cause a disaster.
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