Linshang Chemical
PRODUCTS
(Chloromethyl)Benzene
Linshang Chemical
|
HS Code |
207006 |
| Chemical Formula | C7H7Cl |
| Molar Mass | 126.58 g/mol |
| Appearance | Colorless to yellow - brown liquid |
| Odor | Pungent, irritating odor |
| Density | 1.100 g/cm³ at 20 °C |
| Boiling Point | 179 - 182 °C |
| Melting Point | -43.8 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in most organic solvents like ethanol, ether |
| Flash Point | 67 °C |
| Vapor Pressure | 0.24 kPa at 25 °C |
| Refractive Index | 1.5392 at 20 °C |
As an accredited (Chloromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - mL glass bottle with tight - fitting cap for 500 mL of (chloromethyl)benzene. |
| Storage | (Chloromethyl)benzene should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames as it is flammable. Keep it in a tightly - sealed container to prevent vapor release. Store separately from oxidizing agents and incompatible materials. Ensure the storage place has proper containment to handle spills. |
| Shipping | (Chloromethyl)benzene is shipped in tightly - sealed, corrosion - resistant containers, often made of steel or special plastics. Shipment must comply with strict hazardous chemical regulations, ensuring proper labeling and handling to prevent spills and exposure. |
Competitive (Chloromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading (Chloromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of (chloromethyl) benzene?
(Chloromethyl) benzene, commonly known as benzyl chloride, is an important raw material for organic synthesis. Its main uses are complex and it has significant power in many fields.
First, in the field of pharmaceutical synthesis, benzyl chloride plays a key role. It can be used as a variety of pharmaceutical intermediates, such as in the synthesis of certain antibiotics, sedatives, etc. Through specific chemical reactions, the chloromethyl group of benzyl chloride can participate in the construction of the key structure of drug molecules, laying the foundation for the creation of drugs with specific curative effects.
Second, benzyl chloride is also indispensable in the preparation of pesticides. It is used as a starting material for the synthesis of many pesticides. After a series of chemical transformations, pesticide products with insecticidal, bactericidal, weeding and other effects can be prepared, which is of great significance to ensure agricultural production and improve crop yield and quality.
Third, in the fragrance industry, benzyl chloride also has a place. It can be used as a raw material for synthesizing certain fragrances, giving the fragrances unique aroma and properties, and meeting people's needs for different fragrance products.
Fourth, in the field of polymer materials, benzyl chloride can participate in the synthesis of certain polymers. By polymerizing with other monomers, polymer materials with special properties can be prepared, such as used in the manufacture of special plastics, rubber, etc., to expand the application range of polymer materials.
In short, (chloromethyl) benzene, with its diverse chemical reactivity, plays an irreplaceable role in many fields such as medicine, pesticides, fragrances, and polymer materials, promoting the development and progress of various industries.
First, in the field of pharmaceutical synthesis, benzyl chloride plays a key role. It can be used as a variety of pharmaceutical intermediates, such as in the synthesis of certain antibiotics, sedatives, etc. Through specific chemical reactions, the chloromethyl group of benzyl chloride can participate in the construction of the key structure of drug molecules, laying the foundation for the creation of drugs with specific curative effects.
Second, benzyl chloride is also indispensable in the preparation of pesticides. It is used as a starting material for the synthesis of many pesticides. After a series of chemical transformations, pesticide products with insecticidal, bactericidal, weeding and other effects can be prepared, which is of great significance to ensure agricultural production and improve crop yield and quality.
Third, in the fragrance industry, benzyl chloride also has a place. It can be used as a raw material for synthesizing certain fragrances, giving the fragrances unique aroma and properties, and meeting people's needs for different fragrance products.
Fourth, in the field of polymer materials, benzyl chloride can participate in the synthesis of certain polymers. By polymerizing with other monomers, polymer materials with special properties can be prepared, such as used in the manufacture of special plastics, rubber, etc., to expand the application range of polymer materials.
In short, (chloromethyl) benzene, with its diverse chemical reactivity, plays an irreplaceable role in many fields such as medicine, pesticides, fragrances, and polymer materials, promoting the development and progress of various industries.
What are the physical properties of (chloromethyl) benzene
(Chloromethyl) benzene is an organic compound. Its physical properties are quite specific, and they are described in detail below.
Looking at its appearance, under room temperature and pressure, (chloromethyl) benzene is a colorless and transparent liquid, like crystal jade liquid, clear and pure. Its smell is pungent and aromatic, and it smells impressive. It contains both aromatic rhyme and irritation.
When it comes to density, (chloromethyl) benzene is slightly heavier than water, just like a pearl sinking to the bottom of the abyss and will settle in water. The characteristics of its density are of great significance in many chemical experiments and industrial applications, and are related to the separation and mixing of substances.
In terms of boiling point, the boiling point of (chloromethyl) benzene is suitable, neither very high nor very low. This boiling point state makes it exhibit specific physical changes during heating or cooling, and is a key factor in the control of chemical reaction conditions, the purification and refining of substances, etc.
In terms of solubility, (chloromethyl) benzene is insoluble in water, and the two seem to be distinct and incompatible with each other. However, it has good solubility in organic solvents, such as ethanol, ether and other organic solvents, which can be miscible with it, just like the joy of fish water, and can form a uniform and stable solution.
Volatility, (chloromethyl) benzene has a certain degree of volatility, in the air, like light smoke curling, slowly escaping. This volatility needs to be treated with caution during storage and use to prevent its escape from causing harm.
The many physical properties of (chloromethyl) benzene are interrelated, and play an indispensable role in chemical research, industrial production and manufacturing, etc. It is the basis and basis for many chemical processes.
Looking at its appearance, under room temperature and pressure, (chloromethyl) benzene is a colorless and transparent liquid, like crystal jade liquid, clear and pure. Its smell is pungent and aromatic, and it smells impressive. It contains both aromatic rhyme and irritation.
When it comes to density, (chloromethyl) benzene is slightly heavier than water, just like a pearl sinking to the bottom of the abyss and will settle in water. The characteristics of its density are of great significance in many chemical experiments and industrial applications, and are related to the separation and mixing of substances.
In terms of boiling point, the boiling point of (chloromethyl) benzene is suitable, neither very high nor very low. This boiling point state makes it exhibit specific physical changes during heating or cooling, and is a key factor in the control of chemical reaction conditions, the purification and refining of substances, etc.
In terms of solubility, (chloromethyl) benzene is insoluble in water, and the two seem to be distinct and incompatible with each other. However, it has good solubility in organic solvents, such as ethanol, ether and other organic solvents, which can be miscible with it, just like the joy of fish water, and can form a uniform and stable solution.
Volatility, (chloromethyl) benzene has a certain degree of volatility, in the air, like light smoke curling, slowly escaping. This volatility needs to be treated with caution during storage and use to prevent its escape from causing harm.
The many physical properties of (chloromethyl) benzene are interrelated, and play an indispensable role in chemical research, industrial production and manufacturing, etc. It is the basis and basis for many chemical processes.
What are the chemical properties of (chloromethyl) benzene
(Chloromethyl) benzene, commonly known as benzyl chloride, is one of the organic compounds. It is active and important in many organic synthesis reactions.
This substance has the typical properties of halogenated hydrocarbons. First, it is very prone to nucleophilic substitution. Due to the strong electronegativity of chlorine atoms, the carbon band connected to the benzene ring is partially positively charged, which is vulnerable to attack by nucleophiles. For example, when encountering sodium hydroxide aqueous solution, the hydroxyl nucleophilic reagent will replace the chlorine atom to generate benzyl alcohol; if it reacts with sodium cyanide, the cyanyl group will replace the chlorine to obtain phenylacetonitrile, which is an important method for growing the carbon chain.
Second, (chloromethyl) benzene can be eliminated. Under the action of strong bases such as sodium ethanol, chlorine atoms dehydrate from hydrogen on ortho-carbon to form styrene, which is a key monomer in synthetic rubber, plastics and other materials.
Third, the benzene ring part is affected by chloromethyl, the electron cloud density distribution changes, and it is more prone to electrophilic substitution on the benzene ring. Compared with the electrophilic substitution of general benzene, the reactivity is different. For example, when the nitrification reaction is carried out, the reaction conditions may be milder, and the products are mainly ortho-and para-substitution.
In addition, (chloromethyl) benzene has certain toxicity and irritation. Due to its active chemical properties, it is necessary to operate with caution and strictly follow safety procedures when storing and using to prevent accidents.
This substance has the typical properties of halogenated hydrocarbons. First, it is very prone to nucleophilic substitution. Due to the strong electronegativity of chlorine atoms, the carbon band connected to the benzene ring is partially positively charged, which is vulnerable to attack by nucleophiles. For example, when encountering sodium hydroxide aqueous solution, the hydroxyl nucleophilic reagent will replace the chlorine atom to generate benzyl alcohol; if it reacts with sodium cyanide, the cyanyl group will replace the chlorine to obtain phenylacetonitrile, which is an important method for growing the carbon chain.
Second, (chloromethyl) benzene can be eliminated. Under the action of strong bases such as sodium ethanol, chlorine atoms dehydrate from hydrogen on ortho-carbon to form styrene, which is a key monomer in synthetic rubber, plastics and other materials.
Third, the benzene ring part is affected by chloromethyl, the electron cloud density distribution changes, and it is more prone to electrophilic substitution on the benzene ring. Compared with the electrophilic substitution of general benzene, the reactivity is different. For example, when the nitrification reaction is carried out, the reaction conditions may be milder, and the products are mainly ortho-and para-substitution.
In addition, (chloromethyl) benzene has certain toxicity and irritation. Due to its active chemical properties, it is necessary to operate with caution and strictly follow safety procedures when storing and using to prevent accidents.
What are the preparation methods of (chloromethyl) benzene
(Chloromethyl) benzene, commonly known as benzyl chloride, is prepared by the following methods:
First, toluene is used as a raw material and undergoes a free radical substitution reaction with chlorine under light conditions. In this reaction, the hydrogen atom on the methyl group of toluene is attacked by chlorine free radicals and is gradually replaced by chlorine atoms to obtain benzyl chloride. Such as the conversion of various substances described in "Tiangong Kaiwu", this is also the reaction path initiated by light. When reacting, it is necessary to pay attention to the control of the reaction conditions. The light intensity and chlorine gas penetration rate are all exquisite. Too much light or chlorine gas penetration is too fast, which is easy to cause the formation of polychlorinated compounds and affects the purity of benzyl chloride. Usually between 100-130 ° C, benzyl chloride can be better obtained.
Second, benzyl alcohol and hydrogen chloride gas are reacted under the action of a catalyst. This process is similar to many catalyst-assisted reactions in "Tiangong Kaiji". Commonly used catalysts such as anhydrous zinc chloride can effectively promote the reaction. The hydroxyl group of benzyl alcohol is combined with the hydrogen of hydrogen chloride to form water to remove, and the chlorine atom replaces the hydroxyl group position to form benzyl chloride. This reaction condition is relatively mild and does not require strict equipment, but the amount and activity of the catalyst have a great impact on the reaction rate and yield, which needs to be carefully regulated.
Third, benzene is reacted with formaldehyde and hydrogen chloride under the catalysis of Lewis acid such as anhydrous zinc chloride. This reaction mechanism is slightly complicated. The benzene ring is activated by Lewis acid, formaldehyde and hydrogen chloride form chloromethyl positive ions, and then undergo electrophilic substitution reaction with the benzene ring to generate (chloromethyl) benzene. The raw materials of this method are relatively easy to obtain, but the reaction process needs to be strictly controlled in anhydrous environment and catalyst dosage, otherwise it is easy to cause side reactions and reduce the yield of benzyl chloride.
First, toluene is used as a raw material and undergoes a free radical substitution reaction with chlorine under light conditions. In this reaction, the hydrogen atom on the methyl group of toluene is attacked by chlorine free radicals and is gradually replaced by chlorine atoms to obtain benzyl chloride. Such as the conversion of various substances described in "Tiangong Kaiwu", this is also the reaction path initiated by light. When reacting, it is necessary to pay attention to the control of the reaction conditions. The light intensity and chlorine gas penetration rate are all exquisite. Too much light or chlorine gas penetration is too fast, which is easy to cause the formation of polychlorinated compounds and affects the purity of benzyl chloride. Usually between 100-130 ° C, benzyl chloride can be better obtained.
Second, benzyl alcohol and hydrogen chloride gas are reacted under the action of a catalyst. This process is similar to many catalyst-assisted reactions in "Tiangong Kaiji". Commonly used catalysts such as anhydrous zinc chloride can effectively promote the reaction. The hydroxyl group of benzyl alcohol is combined with the hydrogen of hydrogen chloride to form water to remove, and the chlorine atom replaces the hydroxyl group position to form benzyl chloride. This reaction condition is relatively mild and does not require strict equipment, but the amount and activity of the catalyst have a great impact on the reaction rate and yield, which needs to be carefully regulated.
Third, benzene is reacted with formaldehyde and hydrogen chloride under the catalysis of Lewis acid such as anhydrous zinc chloride. This reaction mechanism is slightly complicated. The benzene ring is activated by Lewis acid, formaldehyde and hydrogen chloride form chloromethyl positive ions, and then undergo electrophilic substitution reaction with the benzene ring to generate (chloromethyl) benzene. The raw materials of this method are relatively easy to obtain, but the reaction process needs to be strictly controlled in anhydrous environment and catalyst dosage, otherwise it is easy to cause side reactions and reduce the yield of benzyl chloride.
What are the precautions for (chloromethyl) benzene during use?
When using (chloromethyl) benzene, there are various things to pay attention to. Its nature is toxic and flammable, so it must be handled with caution.
When handling, it must be done in a well-ventilated place. Because of its volatilization, if it gathers in a closed place, it will enter the lungs of people, or cause poisoning and harm people's health. And it is flammable, and it will burn in case of open fire or hot topic, or even explode, so the surrounding area should be protected from fire sources and stay away from heat sources.
When using this agent, protective gear is indispensable. Wear protective gloves in front of protective clothing to prevent it from touching the skin and eating human flesh. Wear goggles to prevent it from splashing into the eyes and hurting the eyes.
(chloromethyl) benzene should also be carefully stored. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. It should not be mixed with oxidants and alkalis to prevent their interaction and unexpected changes.
Furthermore, after using this agent, the residue should not be discarded at will. It must be properly disposed of in accordance with relevant regulations to prevent pollution to the environment and harm to all parties.
When using (chloromethyl) benzene, all these must be kept in mind and done with caution, so that security is safe.
When handling, it must be done in a well-ventilated place. Because of its volatilization, if it gathers in a closed place, it will enter the lungs of people, or cause poisoning and harm people's health. And it is flammable, and it will burn in case of open fire or hot topic, or even explode, so the surrounding area should be protected from fire sources and stay away from heat sources.
When using this agent, protective gear is indispensable. Wear protective gloves in front of protective clothing to prevent it from touching the skin and eating human flesh. Wear goggles to prevent it from splashing into the eyes and hurting the eyes.
(chloromethyl) benzene should also be carefully stored. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. It should not be mixed with oxidants and alkalis to prevent their interaction and unexpected changes.
Furthermore, after using this agent, the residue should not be discarded at will. It must be properly disposed of in accordance with relevant regulations to prevent pollution to the environment and harm to all parties.
When using (chloromethyl) benzene, all these must be kept in mind and done with caution, so that security is safe.
What are the main uses of (chloromethyl) benzene?
(Chloromethyl) benzene, also known as benzyl chloride, is widely used. It is mainly used in organic synthesis. In the preparation of fragrances, it is a key raw material. It can be converted into a variety of fragrant and rich fragrances through a specific reaction path, bringing people the wonderful enjoyment of smell.
In the field of medicine, it also plays an important role. As a starting material for the synthesis of many drugs, through a series of chemical transformations, it can produce drugs with significant efficacy, which can be used to treat various diseases and protect the health of the public.
In the dye industry, (chloromethyl) benzene is also indispensable. With the help of chemical reactions, colorful dyes can be synthesized, which are widely used in textiles and other industries to make fabrics show brilliant colors.
In addition, it can also be used as a solvent to dissolve certain organic compounds, providing a suitable environment for the smooth progress of chemical reactions. At the same time, it also plays a unique role in the synthesis of polymer materials, helping to prepare polymer materials with different properties to meet the needs of different fields. In short, (chloromethyl) benzene occupies an important position in many industries due to its diverse uses, promoting the development and progress of various industries.
In the field of medicine, it also plays an important role. As a starting material for the synthesis of many drugs, through a series of chemical transformations, it can produce drugs with significant efficacy, which can be used to treat various diseases and protect the health of the public.
In the dye industry, (chloromethyl) benzene is also indispensable. With the help of chemical reactions, colorful dyes can be synthesized, which are widely used in textiles and other industries to make fabrics show brilliant colors.
In addition, it can also be used as a solvent to dissolve certain organic compounds, providing a suitable environment for the smooth progress of chemical reactions. At the same time, it also plays a unique role in the synthesis of polymer materials, helping to prepare polymer materials with different properties to meet the needs of different fields. In short, (chloromethyl) benzene occupies an important position in many industries due to its diverse uses, promoting the development and progress of various industries.
What are the physical properties of (chloromethyl) benzene
(Chloromethyl) benzene, also known as benzyl chloride, is a kind of organic compound. Its physical properties are quite specific and have applications in many fields.
Looking at its properties, (chloromethyl) benzene is a colorless to slightly yellow transparent liquid at room temperature and pressure, and emits a pungent aromatic odor. This odor is significant and easy to detect, which is also a major feature of it.
When it comes to volatility, this substance is quite volatile. Because its boiling point is about 179 ° C, it is more volatile into the air in ordinary environments. This characteristic makes it need special attention when using and storing.
In terms of solubility, (chloromethyl) benzene is insoluble in water, but it can be miscible with ethanol, ether, chloroform and many other organic solvents. This solubility characteristic makes it a good solvent in organic synthesis and other work, and helps to carry out various chemical reactions.
Above the density, (chloromethyl) benzene is slightly higher than water, and its density is about 1.100g/cm ³. This density characteristic has important reference value when separating and identifying related mixtures.
(chloromethyl) benzene's physical properties are widely used in organic synthesis, medicine, fragrance and other industries. Because of its active chemical properties, it can be used as an important organic synthesis intermediate and participate in the preparation of many organic compounds. However, because it is volatile and irritating, it is necessary to follow safety procedures when using it to prevent harm to people and the environment.
Looking at its properties, (chloromethyl) benzene is a colorless to slightly yellow transparent liquid at room temperature and pressure, and emits a pungent aromatic odor. This odor is significant and easy to detect, which is also a major feature of it.
When it comes to volatility, this substance is quite volatile. Because its boiling point is about 179 ° C, it is more volatile into the air in ordinary environments. This characteristic makes it need special attention when using and storing.
In terms of solubility, (chloromethyl) benzene is insoluble in water, but it can be miscible with ethanol, ether, chloroform and many other organic solvents. This solubility characteristic makes it a good solvent in organic synthesis and other work, and helps to carry out various chemical reactions.
Above the density, (chloromethyl) benzene is slightly higher than water, and its density is about 1.100g/cm ³. This density characteristic has important reference value when separating and identifying related mixtures.
(chloromethyl) benzene's physical properties are widely used in organic synthesis, medicine, fragrance and other industries. Because of its active chemical properties, it can be used as an important organic synthesis intermediate and participate in the preparation of many organic compounds. However, because it is volatile and irritating, it is necessary to follow safety procedures when using it to prevent harm to people and the environment.
What are the chemical properties of (chloromethyl) benzene
(Chloromethyl) benzene, also known as benzyl chloride, is an organic compound with unique chemical properties.
It is chemically active and has high functional activity of chloromethyl groups. In a nucleophilic substitution reaction, chlorine atoms are easily replaced by nucleophilic reagents. For example, when co-heated with an aqueous solution of sodium hydroxide, chlorine atoms will be replaced by hydroxyl groups to form benzyl alcohols. This reaction mechanism is that the nucleophilic reagent hydroxyl attacks the positively charged carbon atoms in the chloromethyl group, and the chlorine atoms leave with a pair of electrons.
Benzyl chloride can also undergo nucleophilic substitution with alcohols to form corresponding ether compounds. Taking ethanol as an example, under basic conditions, the alkoxy negative ion of ethanol attacks the chloromethyl group of benzyl chloride to
In addition, benzyl chloride can be eliminated. When heated in an alcohol solution of a strong base such as potassium hydroxide, a reaction to eliminate hydrogen chloride will occur, resulting in styrene. In this process, the chlorine atom and the hydrogen atom on the adjacent carbon atom are removed under the action of the base, forming a carbon-carbon double bond.
Due to the active chemical properties of benzyl chloride, caution should be taken when using it, and protective measures should be taken. Because it is corrosive and irritating, it is harmful to the human body. When storing, pay attention to avoid contact with nucleophiles, strong bases, etc., to prevent accidental reactions.
It is chemically active and has high functional activity of chloromethyl groups. In a nucleophilic substitution reaction, chlorine atoms are easily replaced by nucleophilic reagents. For example, when co-heated with an aqueous solution of sodium hydroxide, chlorine atoms will be replaced by hydroxyl groups to form benzyl alcohols. This reaction mechanism is that the nucleophilic reagent hydroxyl attacks the positively charged carbon atoms in the chloromethyl group, and the chlorine atoms leave with a pair of electrons.
Benzyl chloride can also undergo nucleophilic substitution with alcohols to form corresponding ether compounds. Taking ethanol as an example, under basic conditions, the alkoxy negative ion of ethanol attacks the chloromethyl group of benzyl chloride to
In addition, benzyl chloride can be eliminated. When heated in an alcohol solution of a strong base such as potassium hydroxide, a reaction to eliminate hydrogen chloride will occur, resulting in styrene. In this process, the chlorine atom and the hydrogen atom on the adjacent carbon atom are removed under the action of the base, forming a carbon-carbon double bond.
Due to the active chemical properties of benzyl chloride, caution should be taken when using it, and protective measures should be taken. Because it is corrosive and irritating, it is harmful to the human body. When storing, pay attention to avoid contact with nucleophiles, strong bases, etc., to prevent accidental reactions.
What are the preparation methods of (chloromethyl) benzene
(Chloromethyl) benzene, commonly known as benzyl chloride, is prepared by the following methods:
First, toluene is used as a raw material, and the radical substitution reaction occurs with chlorine gas under the action of light or initiator. This is a common method. The methyl hydrogen of toluene is affected by the benzene ring and its activity is enhanced. When illuminated, the chlorine molecules first split into chlorine radicals, which attack the hydrogen on the toluene methyl group to form benzyl radicals, which then react with chlorine molecules to generate (chloromethyl) benzene and hydrogen chloride. This process requires control of the reaction conditions. The light intensity, reaction temperature, and chlorine gas penetration rate all affect the selectivity and yield of the product. If the reaction conditions are improper, it is easy to generate polychlorinated compounds, resulting in impure products.
Second, benzyl alcohol is reacted with thionyl chloride. The reaction conditions are mild, there are few side reactions, and the product is relatively pure. The hydroxyl group of benzyl alcohol and the chlorine atom of thionyl chloride undergo nucleophilic substitution reaction to generate (chloromethyl) benzene, sulfur dioxide and hydrogen chloride. In the reaction, thionyl chloride is both a chlorination agent and a dehydrating agent, which promotes the reaction to generate products. This reaction is relatively simple to deal with after treatment, only need to remove sulfur dioxide and hydrogen chloride gas.
Third, benzaldehyde is used as a raw material and prepared by reduction and chlorination. First, benzaldehyde is reduced to benzyl alcohol, and then benzyl alcohol is reacted with chlorination reagents as described above to obtain (chloromethyl) benzene. Common methods for reducing benzaldehyde include catalytic hydrogenation, reduction with metal hydrides (such as sodium borohydride, lithium aluminum hydride), etc. The subsequent chlorination steps are similar to the preparation of benzyl alcohol. Although this path has a little more steps, it has flexibility in raw material selection and is more suitable in some cases.
First, toluene is used as a raw material, and the radical substitution reaction occurs with chlorine gas under the action of light or initiator. This is a common method. The methyl hydrogen of toluene is affected by the benzene ring and its activity is enhanced. When illuminated, the chlorine molecules first split into chlorine radicals, which attack the hydrogen on the toluene methyl group to form benzyl radicals, which then react with chlorine molecules to generate (chloromethyl) benzene and hydrogen chloride. This process requires control of the reaction conditions. The light intensity, reaction temperature, and chlorine gas penetration rate all affect the selectivity and yield of the product. If the reaction conditions are improper, it is easy to generate polychlorinated compounds, resulting in impure products.
Second, benzyl alcohol is reacted with thionyl chloride. The reaction conditions are mild, there are few side reactions, and the product is relatively pure. The hydroxyl group of benzyl alcohol and the chlorine atom of thionyl chloride undergo nucleophilic substitution reaction to generate (chloromethyl) benzene, sulfur dioxide and hydrogen chloride. In the reaction, thionyl chloride is both a chlorination agent and a dehydrating agent, which promotes the reaction to generate products. This reaction is relatively simple to deal with after treatment, only need to remove sulfur dioxide and hydrogen chloride gas.
Third, benzaldehyde is used as a raw material and prepared by reduction and chlorination. First, benzaldehyde is reduced to benzyl alcohol, and then benzyl alcohol is reacted with chlorination reagents as described above to obtain (chloromethyl) benzene. Common methods for reducing benzaldehyde include catalytic hydrogenation, reduction with metal hydrides (such as sodium borohydride, lithium aluminum hydride), etc. The subsequent chlorination steps are similar to the preparation of benzyl alcohol. Although this path has a little more steps, it has flexibility in raw material selection and is more suitable in some cases.
What are the precautions for (chloromethyl) benzene during use?
For (chloromethyl) benzene, many precautions must be kept in mind when using it.
The first thing to pay attention to is its toxicity. This substance has certain toxicity or is harmful to human health. If you accidentally touch it, whether it is through skin contact, inhalation of its volatile gas, or accidental ingestion, it can cause adverse consequences. Skin contact may cause skin irritation, redness, swelling and itching; too much inhalation may damage the respiratory tract, causing cough, asthma and other diseases; misuse is even more harmful, or damage the stomach and other organs. Therefore, when operating, you must wear appropriate protective equipment, such as gloves, masks, goggles, etc., to prevent contact with the human body.
Second, (chloromethyl) benzene is flammable. Its steam and air can form an explosive mixture, which is easy to burn and explode in case of open flame and hot topic. In storage and use, be sure to keep away from fire and heat sources, and strictly prohibit fireworks. And need to be equipped with suitable fire extinguishing equipment, just in case.
In addition, its chemical properties are active. (Chloromethyl) The chloromethyl in benzene is prone to chemical reactions, and under specific conditions, or reacts with other substances such as substitution and addition. During operation, it is extremely critical to control the reaction conditions, such as temperature, pressure, and the proportion of reactants. A little carelessness may cause the reaction to go out of control and cause danger.
Because of its volatility, it should be stored in a cool and well-ventilated place, sealed and stored to reduce its volatilization, prevent the accumulation of steam in the air, and reduce the risk of explosion. After taking it, the container must also be sealed in time to avoid its volatilization and escape.
In general, when using (chloromethyl) benzene, be careful, strictly abide by the operating procedures, and pay attention to safety protection to ensure personal safety and the smooth progress of experiments and production.
The first thing to pay attention to is its toxicity. This substance has certain toxicity or is harmful to human health. If you accidentally touch it, whether it is through skin contact, inhalation of its volatile gas, or accidental ingestion, it can cause adverse consequences. Skin contact may cause skin irritation, redness, swelling and itching; too much inhalation may damage the respiratory tract, causing cough, asthma and other diseases; misuse is even more harmful, or damage the stomach and other organs. Therefore, when operating, you must wear appropriate protective equipment, such as gloves, masks, goggles, etc., to prevent contact with the human body.
Second, (chloromethyl) benzene is flammable. Its steam and air can form an explosive mixture, which is easy to burn and explode in case of open flame and hot topic. In storage and use, be sure to keep away from fire and heat sources, and strictly prohibit fireworks. And need to be equipped with suitable fire extinguishing equipment, just in case.
In addition, its chemical properties are active. (Chloromethyl) The chloromethyl in benzene is prone to chemical reactions, and under specific conditions, or reacts with other substances such as substitution and addition. During operation, it is extremely critical to control the reaction conditions, such as temperature, pressure, and the proportion of reactants. A little carelessness may cause the reaction to go out of control and cause danger.
Because of its volatility, it should be stored in a cool and well-ventilated place, sealed and stored to reduce its volatilization, prevent the accumulation of steam in the air, and reduce the risk of explosion. After taking it, the container must also be sealed in time to avoid its volatilization and escape.
In general, when using (chloromethyl) benzene, be careful, strictly abide by the operating procedures, and pay attention to safety protection to ensure personal safety and the smooth progress of experiments and production.
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