Linshang Chemical
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M-Bromochlorobenzene
Linshang Chemical
|
HS Code |
480026 |
| Chemical Formula | C6H4BrCl |
| Molar Mass | 191.45 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 201 - 203 °C |
| Melting Point | -16 °C |
| Density | 1.606 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents |
| Odor | Characteristic aromatic odor |
| Flash Point | 81 °C |
| Refractive Index | 1.579 - 1.581 |
As an accredited M-Bromochlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of M - bromochlorobenzene packaged in a sealed glass bottle. |
| Storage | M - bromochlorobenzene should be stored in a cool, dry, well - ventilated area away from sources of ignition and heat. Keep it in a tightly closed container made of compatible materials like glass or certain plastics. Avoid storing near oxidizing agents. This storage approach helps prevent potential reactions, evaporation, and ensures the chemical's stability and safety. |
| Shipping | M - bromochlorobenzene is shipped in tightly - sealed, corrosion - resistant containers. It's classified as a hazardous chemical, so transport follows strict regulations, ensuring proper handling to prevent spills and environmental or safety risks. |
Competitive M-Bromochlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading M-Bromochlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of M-bromochlorobenzene?
The chemical structure of M-bromochlorobenzene is on the benzene ring, and there are two atoms of bromine (Br) and chlorine (Cl) at the meta-position. The benzene ring is a planar hexagonal ring structure, with one carbon atom per corner, and the carbon atoms are connected by covalent bonds to form a stable system of conjugated large π bonds.
At a specific position in the benzene ring, that is, at the meta-position, the bromine atom and the chlorine atom respectively replace the hydrogen atom on the benzene ring. The difference in this substitution position makes M-bromochlorobenzene have unique physical and chemical properties. Due to the electron cloud distribution of the benzene ring, it is affected by the electronegativity and induction effect of bromine and chlorine atoms, resulting in the special activity and selectivity of the compound in chemical reactions
The arrangement of bromine and chlorine atoms in the interposition affects the polarity, boiling point, melting point and other physical properties of the molecule. And because of its location, in reactions such as electrophilic substitution and nucleophilic substitution, compared with ortho-or para-substituted isomers, it presents different reaction paths and rates. The chemical structure of M-bromochlorobenzene, due to its specific atomic substitution position and conjugation system of benzene ring, determines its wide application and research value in organic synthesis, medicinal chemistry, materials science and other fields.
At a specific position in the benzene ring, that is, at the meta-position, the bromine atom and the chlorine atom respectively replace the hydrogen atom on the benzene ring. The difference in this substitution position makes M-bromochlorobenzene have unique physical and chemical properties. Due to the electron cloud distribution of the benzene ring, it is affected by the electronegativity and induction effect of bromine and chlorine atoms, resulting in the special activity and selectivity of the compound in chemical reactions
The arrangement of bromine and chlorine atoms in the interposition affects the polarity, boiling point, melting point and other physical properties of the molecule. And because of its location, in reactions such as electrophilic substitution and nucleophilic substitution, compared with ortho-or para-substituted isomers, it presents different reaction paths and rates. The chemical structure of M-bromochlorobenzene, due to its specific atomic substitution position and conjugation system of benzene ring, determines its wide application and research value in organic synthesis, medicinal chemistry, materials science and other fields.
What are the physical properties of M-bromochlorobenzene?
M-bromochlorobenzene is one of the organic compounds. It has many physical properties. Looking at its properties, at room temperature, it is a colorless to light yellow liquid, showing a clear state. Smell it, there is a specific smell.
In terms of its boiling point, it is about 197-199 ° C. The boiling point is the temperature at which a substance changes from a liquid state to a gaseous state. At this temperature, the vapor pressure of the liquid is equal to the external pressure, and it then turns into a gas and escapes.
In terms of melting point, it is about -16 ° C. The melting point is the temperature limit at which a substance changes from a solid state to a liquid state. When the temperature reaches this, the solid M-bromochlorobenzene begins to melt into a liquid state.
Its density is about 1.71 g/cm ³, which is heavier than water. The density is the mass per unit volume of the substance. This value shows that the mass of M-bromochlorobenzene is greater than that of water in the same volume.
Solubility is also an important physical property. It is insoluble in water, but soluble in organic solvents such as ethanol, ether, and benzene. Due to the principle of "similarity and compatibility", M-bromochlorobenzene is a non-polar or weakly polar molecule with a large polar difference from water, so it is insoluble; and it is similar to the polarity of organic solvents such as ethanol, so it is soluble. The volatility of M-bromochlorobenzene is weak, and it is not easy to evaporate into gas quickly at room temperature and pressure. And it has a certain refractive index, which is the ratio of the incident angle sine to the refractive angle sine when light passes through the substance, reflecting the characteristics of the substance's refraction to light. All these physical properties are of great significance in chemical experiments, industrial production and related scientific research.
In terms of its boiling point, it is about 197-199 ° C. The boiling point is the temperature at which a substance changes from a liquid state to a gaseous state. At this temperature, the vapor pressure of the liquid is equal to the external pressure, and it then turns into a gas and escapes.
In terms of melting point, it is about -16 ° C. The melting point is the temperature limit at which a substance changes from a solid state to a liquid state. When the temperature reaches this, the solid M-bromochlorobenzene begins to melt into a liquid state.
Its density is about 1.71 g/cm ³, which is heavier than water. The density is the mass per unit volume of the substance. This value shows that the mass of M-bromochlorobenzene is greater than that of water in the same volume.
Solubility is also an important physical property. It is insoluble in water, but soluble in organic solvents such as ethanol, ether, and benzene. Due to the principle of "similarity and compatibility", M-bromochlorobenzene is a non-polar or weakly polar molecule with a large polar difference from water, so it is insoluble; and it is similar to the polarity of organic solvents such as ethanol, so it is soluble. The volatility of M-bromochlorobenzene is weak, and it is not easy to evaporate into gas quickly at room temperature and pressure. And it has a certain refractive index, which is the ratio of the incident angle sine to the refractive angle sine when light passes through the substance, reflecting the characteristics of the substance's refraction to light. All these physical properties are of great significance in chemical experiments, industrial production and related scientific research.
What are the main uses of M-bromochlorobenzene?
M-bromochlorobenzene, or m-bromochlorobenzene, has a wide range of main uses. In the field of organic synthesis, it can be called a key intermediate. Thanks to the difference in activity between bromine atoms and chlorine atoms on the benzene ring, chemists can precisely transform and modify them through various chemical reactions, thus synthesizing a series of organic compounds with unique structures and different functions. For example, when building complex drug molecular structures, m-bromochlorobenzene can be used as a starting material. Through nucleophilic substitution, bromine atoms or chlorine atoms are replaced by other groups with specific pharmacological activities, thus providing an important material basis for the development of new drugs.
In the field of materials science, m-bromochlorobenzene also plays an indispensable role. Researchers use it to prepare high-performance polymer materials. By ingeniously introducing it into the polymerization reaction system, the structure and properties of the polymer can be effectively regulated. For example, when synthesizing conjugated polymers with special photoelectric properties, m-bromochlorobenzene participates in the polymerization as a monomer, which can significantly change the conjugate length and electron cloud distribution of the polymer, thereby endowing the material with excellent photoelectric conversion efficiency and fluorescence emission characteristics. It is widely used in frontier fields such as organic Light Emitting Diodes and solar cells.
In addition, m-bromochlorobenzene is also very useful in dye chemistry. It can be used as an important raw material for the synthesis of new dyes. With the help of chemical modification, dye products with bright colors, excellent fastness and unique photochemical properties can be developed to meet the needs of high-quality dyes in textile, printing and other industries. In short, m-bromochlorobenzene has shown important application value in many fields due to its unique chemical structure, promoting the continuous development and progress of related industries.
In the field of materials science, m-bromochlorobenzene also plays an indispensable role. Researchers use it to prepare high-performance polymer materials. By ingeniously introducing it into the polymerization reaction system, the structure and properties of the polymer can be effectively regulated. For example, when synthesizing conjugated polymers with special photoelectric properties, m-bromochlorobenzene participates in the polymerization as a monomer, which can significantly change the conjugate length and electron cloud distribution of the polymer, thereby endowing the material with excellent photoelectric conversion efficiency and fluorescence emission characteristics. It is widely used in frontier fields such as organic Light Emitting Diodes and solar cells.
In addition, m-bromochlorobenzene is also very useful in dye chemistry. It can be used as an important raw material for the synthesis of new dyes. With the help of chemical modification, dye products with bright colors, excellent fastness and unique photochemical properties can be developed to meet the needs of high-quality dyes in textile, printing and other industries. In short, m-bromochlorobenzene has shown important application value in many fields due to its unique chemical structure, promoting the continuous development and progress of related industries.
What are M-bromochlorobenzene synthesis methods?
There are two common methods for making m-bromochlorobenzene. The first is to use benzene as the starting material, and first make benzene and bromine substitution reaction under the catalysis of iron bromide to obtain bromobenzene. The text says: "Mix benzene and bromine, add iron bromide into it, and the two then react to obtain bromobenzene." In this step, the hydrogen on the benzene ring is replaced by bromine. Then, make bromobenzene and chlorine in the environment of light or high temperature, and perform a free radical substitution reaction to obtain m-bromochlorobenzene. Cover light or high temperature to crack the chlorine molecules into chlorine free radicals, which take the hydrogen of the bromobenzene side chain and form a free radical intermediate, and then interact with the chlorine molecule to obtain m-bromochlorobenzene.
The second method Schilling aniline and nitrous acid at low temperature (usually 0-5 ° C), using hydrochloric acid as the medium, carry out a heavy nitriding reaction to obtain diazonium salts. The process is described as: "Take aniline, dissolve it in hydrochloric acid, cold it to 0-5 ° C, slowly drop into the sodium nitrite solution, and obtain diazonium salts." Diazonium salts are active and easy to react. Subsequently, under the catalysis of cuprous chloride, react with hydrogen chloride, and the diazonium group is replaced by chlorine to obtain chlorobenzene. Then, under the catalysis of iron, chlorobenzene and bromine undergo an electrophilic substitution reaction. Because chlorine is an ortho-para-position group, after appropriate regulation of the reaction conditions, m-bromochlorobenzene can Each of these two methods has its own length. In actual preparation, it should be selected according to various factors such as the availability of raw materials, the difficulty of reaction, and the high or low yield.
The second method Schilling aniline and nitrous acid at low temperature (usually 0-5 ° C), using hydrochloric acid as the medium, carry out a heavy nitriding reaction to obtain diazonium salts. The process is described as: "Take aniline, dissolve it in hydrochloric acid, cold it to 0-5 ° C, slowly drop into the sodium nitrite solution, and obtain diazonium salts." Diazonium salts are active and easy to react. Subsequently, under the catalysis of cuprous chloride, react with hydrogen chloride, and the diazonium group is replaced by chlorine to obtain chlorobenzene. Then, under the catalysis of iron, chlorobenzene and bromine undergo an electrophilic substitution reaction. Because chlorine is an ortho-para-position group, after appropriate regulation of the reaction conditions, m-bromochlorobenzene can Each of these two methods has its own length. In actual preparation, it should be selected according to various factors such as the availability of raw materials, the difficulty of reaction, and the high or low yield.
M-bromochlorobenzene what are the precautions in storage and transportation?
M-bromochlorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First, storage, because of its certain chemical activity, should be placed in a cool, dry and well-ventilated place. Avoid heat and fire sources to prevent the risk of fire and explosion. This compound may be sensitive to air and moisture, so it should be sealed and stored. If exposed to air, or cause deterioration, it will affect its quality and use. And it needs to be separated from oxidizing agents, reducing agents, acids, alkalis and other chemicals. Because of contact with it, it is easy to cause chemical reactions and damage the stability of the compound.
As for transportation, be sure to ensure that the packaging is intact. Packaging materials must be able to withstand a certain amount of external force to prevent them from being damaged and leaking during transportation. During transportation, temperature should be strictly controlled to avoid high temperature environments to prevent them from decomposing or volatilizing due to excessive temperature. Transportation vehicles should also be clean and dry without other chemical residues to avoid mutual contamination. At the same time, transportation personnel need to be familiar with the characteristics of the compound and emergency treatment methods. In case of emergencies such as leakage, they can be properly disposed of in time to reduce the harm.
In short, when storing and transporting M-bromochlorobenzene, we should be cautious and follow relevant regulations and operating guidelines to ensure the safety of personnel and the environment, and the properties and functions of the compound will not be affected.
First, storage, because of its certain chemical activity, should be placed in a cool, dry and well-ventilated place. Avoid heat and fire sources to prevent the risk of fire and explosion. This compound may be sensitive to air and moisture, so it should be sealed and stored. If exposed to air, or cause deterioration, it will affect its quality and use. And it needs to be separated from oxidizing agents, reducing agents, acids, alkalis and other chemicals. Because of contact with it, it is easy to cause chemical reactions and damage the stability of the compound.
As for transportation, be sure to ensure that the packaging is intact. Packaging materials must be able to withstand a certain amount of external force to prevent them from being damaged and leaking during transportation. During transportation, temperature should be strictly controlled to avoid high temperature environments to prevent them from decomposing or volatilizing due to excessive temperature. Transportation vehicles should also be clean and dry without other chemical residues to avoid mutual contamination. At the same time, transportation personnel need to be familiar with the characteristics of the compound and emergency treatment methods. In case of emergencies such as leakage, they can be properly disposed of in time to reduce the harm.
In short, when storing and transporting M-bromochlorobenzene, we should be cautious and follow relevant regulations and operating guidelines to ensure the safety of personnel and the environment, and the properties and functions of the compound will not be affected.
What are the physical properties of M-bromochlorobenzene?
M-bromochlorobenzene is one of the organic compounds. It has specific physical properties, which are described as follows:
Looking at its appearance, under room temperature and pressure, M-bromochlorobenzene is a colorless to light yellow liquid with a clear and special odor. Although this odor is not pungent or difficult to tolerate, it is also clearly identifiable, which is one of its characteristics.
When it comes to the melting point, its melting point is about -16 ° C, and its boiling point is between 219-221 ° C. This melting boiling point characteristic makes it a liquid at room temperature, and when it encounters a higher temperature, it boils into a gaseous state. Due to the intermolecular force, its molecular structure makes the intermolecular attractive force moderate, so the melting boiling point is in a specific range. The density of M-bromochlorobenzene is greater than that of water, about 1.57 g/cm ³. If it is mixed with water, it will sink to the bottom of the water, which is due to its relative density. And it is difficult to dissolve in water, because water is a polar molecule, while M-bromochlorobenzene has a weaker polarity. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in many organic solvents, such as ethanol, ether, benzene, etc., and it can form a similar intermolecular force with organic solvent molecules, so it can be miscible.
Furthermore, M-bromochlorobenzene has low volatility and is not easy to evaporate rapidly at room temperature. Due to the strong intermolecular force, molecules need more energy to escape from the liquid surface, so they evaporate slowly. This property makes it easier to store and use, and not easy to lose due to rapid volatilization.
Looking at its appearance, under room temperature and pressure, M-bromochlorobenzene is a colorless to light yellow liquid with a clear and special odor. Although this odor is not pungent or difficult to tolerate, it is also clearly identifiable, which is one of its characteristics.
When it comes to the melting point, its melting point is about -16 ° C, and its boiling point is between 219-221 ° C. This melting boiling point characteristic makes it a liquid at room temperature, and when it encounters a higher temperature, it boils into a gaseous state. Due to the intermolecular force, its molecular structure makes the intermolecular attractive force moderate, so the melting boiling point is in a specific range. The density of M-bromochlorobenzene is greater than that of water, about 1.57 g/cm ³. If it is mixed with water, it will sink to the bottom of the water, which is due to its relative density. And it is difficult to dissolve in water, because water is a polar molecule, while M-bromochlorobenzene has a weaker polarity. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in many organic solvents, such as ethanol, ether, benzene, etc., and it can form a similar intermolecular force with organic solvent molecules, so it can be miscible.
Furthermore, M-bromochlorobenzene has low volatility and is not easy to evaporate rapidly at room temperature. Due to the strong intermolecular force, molecules need more energy to escape from the liquid surface, so they evaporate slowly. This property makes it easier to store and use, and not easy to lose due to rapid volatilization.
What are the chemical properties of M-bromochlorobenzene?
M-bromochlorobenzene is an organic compound whose molecule contains two halogen atoms of bromine and chlorine, which are connected to the interposition of the benzene ring. This substance has many chemical properties, which are described as follows:
- ** Electrophilic Substitution Reaction **: The benzene ring is electron-rich and vulnerable to attack by electrophilic reagents. In M-bromochlorobenzene, although bromine and chlorine are blunt groups, they are ortho-para-sites. Taking the nitrification reaction as an example, due to the steric hindrance, the nitro group is more chlorine or the para-site of bromine. If it is co-heated with mixed acid (nitric acid mixed with sulfuric acid), products such as m-bromo p-chloro-nitrobenzene are formed.
- ** Halogen Atom Reaction * Under suitable conditions, nucleophilic substitution can occur. For example, when co-heating with a strong alkali alcohol solution, chlorine atoms or bromine atoms can be replaced by hydroxyl groups to obtain m-bromochlorophenols. And if it reacts with metal magnesium in anhydrous ether, Grignard reagent can be prepared. This reagent can react with a variety of electrophilic reagents, such as aldose and ketone, to grow carbon chains and build complex organic molecules.
- ** Oxidation reaction **: The benzene ring is relatively stable and is not easily oxidized by general oxidants. However, under specific strong oxidation conditions, the benzene ring can be destroyed. In case of extremely strong oxidants, the structure of the benzene ring disintegrates to form small molecular oxides containing bromine and chlorine.
- ** Reduction reaction **: M-bromochlorobenzene can react with hydrogen in the presence of a catalyst such as palladium carbon, and the benzene ring is hydrogenated to reduce to obtain the corresponding saturated cyclic compound. At the same time, the bromine and chlorine atoms may change, or be reduced to remove, or retained, depending on the reaction conditions.
- ** Electrophilic Substitution Reaction **: The benzene ring is electron-rich and vulnerable to attack by electrophilic reagents. In M-bromochlorobenzene, although bromine and chlorine are blunt groups, they are ortho-para-sites. Taking the nitrification reaction as an example, due to the steric hindrance, the nitro group is more chlorine or the para-site of bromine. If it is co-heated with mixed acid (nitric acid mixed with sulfuric acid), products such as m-bromo p-chloro-nitrobenzene are formed.
- ** Halogen Atom Reaction * Under suitable conditions, nucleophilic substitution can occur. For example, when co-heating with a strong alkali alcohol solution, chlorine atoms or bromine atoms can be replaced by hydroxyl groups to obtain m-bromochlorophenols. And if it reacts with metal magnesium in anhydrous ether, Grignard reagent can be prepared. This reagent can react with a variety of electrophilic reagents, such as aldose and ketone, to grow carbon chains and build complex organic molecules.
- ** Oxidation reaction **: The benzene ring is relatively stable and is not easily oxidized by general oxidants. However, under specific strong oxidation conditions, the benzene ring can be destroyed. In case of extremely strong oxidants, the structure of the benzene ring disintegrates to form small molecular oxides containing bromine and chlorine.
- ** Reduction reaction **: M-bromochlorobenzene can react with hydrogen in the presence of a catalyst such as palladium carbon, and the benzene ring is hydrogenated to reduce to obtain the corresponding saturated cyclic compound. At the same time, the bromine and chlorine atoms may change, or be reduced to remove, or retained, depending on the reaction conditions.
What are the main uses of M-bromochlorobenzene?
M-bromochlorobenzene is also an organic compound. It has a wide range of uses and is involved in all fields of chemical industry.
is the first to bear the brunt, and it is the raw material for organic synthesis. In the process of synthesizing complex organic molecules, its bromine and chlorine atoms can be used as active check points, and react with other reagents through substitution, coupling, etc., to form new carbon-carbon bonds or carbon-heteroatomic bonds, and then synthesize intermediates of various drugs, pesticides, dyes and functional materials.
In the field of pharmaceutical chemistry, compounds with specific biological activities can be created by structural modification and derivatization of M-bromochlorobenzene. For example, specific functional groups may be introduced to fit specific targets, and new therapeutic drugs may be developed, which may have potential value in anti-cancer, anti-infection, etc.
also plays an important role in the creation of pesticides. Using it as a starting material can be chemically converted to prepare high-efficiency, low-toxicity and environmentally friendly pesticides. Halogen atoms in its structure can affect the interaction between pesticide molecules and relevant receptors or enzymes in target organisms, thereby enhancing the inhibitory or killing effect of pesticides on pests and pathogens.
Furthermore, in the field of materials science, M-bromochlorobenzene can participate in the synthesis of functional polymer materials. Through its polymerization with monomers containing specific functional groups, materials can be imparted with unique electrical, optical or thermal properties, such as the preparation of conjugated polymers with special photoelectric properties, which are used in organic Light Emitting Diodes, solar cells and other optoelectronic devices.
In conclusion, although M-bromochlorobenzene is a basic organic compound, it has key uses in many fields such as organic synthesis, pharmaceuticals, pesticides and materials science, promoting the development of the chemical industry and related scientific research.
is the first to bear the brunt, and it is the raw material for organic synthesis. In the process of synthesizing complex organic molecules, its bromine and chlorine atoms can be used as active check points, and react with other reagents through substitution, coupling, etc., to form new carbon-carbon bonds or carbon-heteroatomic bonds, and then synthesize intermediates of various drugs, pesticides, dyes and functional materials.
In the field of pharmaceutical chemistry, compounds with specific biological activities can be created by structural modification and derivatization of M-bromochlorobenzene. For example, specific functional groups may be introduced to fit specific targets, and new therapeutic drugs may be developed, which may have potential value in anti-cancer, anti-infection, etc.
also plays an important role in the creation of pesticides. Using it as a starting material can be chemically converted to prepare high-efficiency, low-toxicity and environmentally friendly pesticides. Halogen atoms in its structure can affect the interaction between pesticide molecules and relevant receptors or enzymes in target organisms, thereby enhancing the inhibitory or killing effect of pesticides on pests and pathogens.
Furthermore, in the field of materials science, M-bromochlorobenzene can participate in the synthesis of functional polymer materials. Through its polymerization with monomers containing specific functional groups, materials can be imparted with unique electrical, optical or thermal properties, such as the preparation of conjugated polymers with special photoelectric properties, which are used in organic Light Emitting Diodes, solar cells and other optoelectronic devices.
In conclusion, although M-bromochlorobenzene is a basic organic compound, it has key uses in many fields such as organic synthesis, pharmaceuticals, pesticides and materials science, promoting the development of the chemical industry and related scientific research.
What are M-bromochlorobenzene synthesis methods?
For M-bromochlorobenzene, organic compounds are also synthesized by several methods.
One of them can be started with benzene. First, benzene is brominated, and iron or iron tribromide is used as a catalyst. The reaction formula is as follows: $C_ {6} H_ {6} + Br_ {2}\ xrightarrow [] {FeBr_ {3}} C_ {6} H_ {5} Br + HBr $. Next, the reaction of chlorination of bromobenzene is still using iron or iron trichloride as a catalyst to combine with chlorine to obtain m-bromochlorobenzene. However, in this process, due to the localization effect of the substituents on the benzene ring, the product or isomers with other positions need to be finely separated.
Second, m-aminobenzene sulfonic acid can also be used as a raw material. First, m-aminobenzene sulfonic acid is diazotized, and sodium nitrite and hydrochloric acid are used at low temperature to obtain diazonium salts. Then the diazonium salt interacts with cuprous bromide and hydrobromic acid to introduce bromine atoms. Then the sulfonic acid group is removed by appropriate reactions, such as hydrolysis, and then chlorination is carried out to produce m-bromochlorobenzene. This approach step is slightly more complicated, and the position of the substituent can be better controlled.
Third, m-chloroaniline is used as the starting material Make it react with sodium nitrite and hydrochloric acid at low temperature to obtain diazonium salts, and then react with potassium bromide to introduce bromine atoms to remove amino groups, and also to obtain m-bromochlorobenzene. This method also relies on the characteristics of diazotization reaction to achieve the purpose of positioning synthesis.
When synthesizing m-bromochlorobenzene, it is necessary to carefully choose the appropriate method according to many factors such as the availability of raw materials, the difficulty of reaction, and the purity of the product. During the operation, attention should be paid to the reaction conditions, safety, and the separation and purification of the product.
One of them can be started with benzene. First, benzene is brominated, and iron or iron tribromide is used as a catalyst. The reaction formula is as follows: $C_ {6} H_ {6} + Br_ {2}\ xrightarrow [] {FeBr_ {3}} C_ {6} H_ {5} Br + HBr $. Next, the reaction of chlorination of bromobenzene is still using iron or iron trichloride as a catalyst to combine with chlorine to obtain m-bromochlorobenzene. However, in this process, due to the localization effect of the substituents on the benzene ring, the product or isomers with other positions need to be finely separated.
Second, m-aminobenzene sulfonic acid can also be used as a raw material. First, m-aminobenzene sulfonic acid is diazotized, and sodium nitrite and hydrochloric acid are used at low temperature to obtain diazonium salts. Then the diazonium salt interacts with cuprous bromide and hydrobromic acid to introduce bromine atoms. Then the sulfonic acid group is removed by appropriate reactions, such as hydrolysis, and then chlorination is carried out to produce m-bromochlorobenzene. This approach step is slightly more complicated, and the position of the substituent can be better controlled.
Third, m-chloroaniline is used as the starting material Make it react with sodium nitrite and hydrochloric acid at low temperature to obtain diazonium salts, and then react with potassium bromide to introduce bromine atoms to remove amino groups, and also to obtain m-bromochlorobenzene. This method also relies on the characteristics of diazotization reaction to achieve the purpose of positioning synthesis.
When synthesizing m-bromochlorobenzene, it is necessary to carefully choose the appropriate method according to many factors such as the availability of raw materials, the difficulty of reaction, and the purity of the product. During the operation, attention should be paid to the reaction conditions, safety, and the separation and purification of the product.
M-bromochlorobenzene need to pay attention to when storing and transporting
M-bromochlorobenzene is also an organic compound. When storing and transporting, many matters need to be paid attention to.
The first thing to bear the brunt is related to storage. This substance should be placed in a cool and well-ventilated place. Because of the cool and ventilated place, it can avoid the high temperature causing its volatilization to intensify, or the chemical reaction caused by the high temperature will cause the substance to deteriorate. And it is necessary to keep away from fire and heat sources, both of which are potential sources of ignition. If it comes into contact with it, it may cause fire and endanger safety.
Furthermore, the choice of storage container is also critical. A well-sealed container must be used to prevent it from evaporating and escaping, polluting the environment, and avoiding reactions with air components. And the storage area should be equipped with suitable containment materials. In the event of leakage, it can be dealt with in time to prevent its spread.
As for transportation, relevant regulations must be strictly followed. Transportation vehicles must be equipped with corresponding fire equipment to prevent accidental ignition during transportation, and can be rescued in time. And the transportation process should be smooth, avoid violent vibration and impact, so as to avoid damage to the container and cause leakage of M-bromochlorobenzene.
At the same time, transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. In case of leakage and other emergencies, they can respond quickly and properly to reduce hazards. In short, the storage and transportation of M-bromochlorobenzene requires caution and attention to every detail to ensure that personnel safety and the environment are not damaged.
The first thing to bear the brunt is related to storage. This substance should be placed in a cool and well-ventilated place. Because of the cool and ventilated place, it can avoid the high temperature causing its volatilization to intensify, or the chemical reaction caused by the high temperature will cause the substance to deteriorate. And it is necessary to keep away from fire and heat sources, both of which are potential sources of ignition. If it comes into contact with it, it may cause fire and endanger safety.
Furthermore, the choice of storage container is also critical. A well-sealed container must be used to prevent it from evaporating and escaping, polluting the environment, and avoiding reactions with air components. And the storage area should be equipped with suitable containment materials. In the event of leakage, it can be dealt with in time to prevent its spread.
As for transportation, relevant regulations must be strictly followed. Transportation vehicles must be equipped with corresponding fire equipment to prevent accidental ignition during transportation, and can be rescued in time. And the transportation process should be smooth, avoid violent vibration and impact, so as to avoid damage to the container and cause leakage of M-bromochlorobenzene.
At the same time, transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. In case of leakage and other emergencies, they can respond quickly and properly to reduce hazards. In short, the storage and transportation of M-bromochlorobenzene requires caution and attention to every detail to ensure that personnel safety and the environment are not damaged.
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