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M-Chlorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
456208 |
| Chemical Formula | C6H4Cl2O2S |
| Molar Mass | 211.065 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 144 - 146 °C at 13 mmHg |
| Density | 1.48 g/cm³ |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like benzene, toluene |
| Flash Point | 110 °C |
| Vapor Pressure | Low at room temperature |
| Acidity Basicity | Acidic due to the sulfonyl chloride group |
| Odor | Pungent, irritating odor |
As an accredited M-Chlorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1kg of M - chlorobenzenesulfonyl Chloride in sealed, corrosion - resistant chemical packaging. |
| Storage | M - chlorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and sources of ignition. Store it in a tightly - sealed container to prevent contact with moisture, as it can react with water. Separate it from incompatible substances like bases, amines, and reducing agents to avoid potential hazardous reactions. |
| Shipping | M - chlorobenzenesulfonyl chloride is a hazardous chemical. It should be shipped in accordance with strict regulations, using specialized containers to prevent leakage. Shipments must follow IMDG Code guidelines for safe transportation. |
Competitive M-Chlorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading M-Chlorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of M-chlorobenzenesulfonyl Chloride?
M-chlorobenzenesulfonyl Chloride is widely used in various fields of chemical industry.
First, it is often a key raw material in the synthesis of medicine. It can be introduced into specific functional groups through a series of reactions to construct the active structure of the drug. For example, in the preparation of some antibacterial and anti-inflammatory drugs, m-chlorobenzenesulfonyl chloride participates in the reaction to help form a specific chemical structure and give the drug the required pharmacological activity, which is related to the health of all living beings.
Second, it is also indispensable in the creation of pesticides. It can be used as an intermediate to synthesize pesticides with insecticidal, herbicidal, and bactericidal effects. With its chemical properties, it reacts with other compounds to obtain highly efficient and low-toxic pesticide products, ensuring crop harvest and protecting the prosperity of agriculture.
Third, in the field of materials science, m-chlorobenzenesulfonyl chloride can be used to synthesize special polymers. By reacting with compounds containing active hydrogen or double bonds, polymer materials with special properties, such as high-performance engineering plastics, functional membrane materials, etc., are widely used in electronics, automobiles, aviation and other industries to promote the progress of high-tech.
Furthermore, in the study of organic synthesis chemistry, m-chlorobenzenesulfonyl chloride is an important reagent. Due to its active chemical properties, it provides a variety of reaction paths for organic synthesis, helping chemists explore new compounds and reaction mechanisms, and expanding the boundaries of organic chemistry. Therefore, m-chlorobenzenesulfonyl chloride has important uses in many fields, and has a profound impact on the development of the chemical industry and the progress of science and technology.
First, it is often a key raw material in the synthesis of medicine. It can be introduced into specific functional groups through a series of reactions to construct the active structure of the drug. For example, in the preparation of some antibacterial and anti-inflammatory drugs, m-chlorobenzenesulfonyl chloride participates in the reaction to help form a specific chemical structure and give the drug the required pharmacological activity, which is related to the health of all living beings.
Second, it is also indispensable in the creation of pesticides. It can be used as an intermediate to synthesize pesticides with insecticidal, herbicidal, and bactericidal effects. With its chemical properties, it reacts with other compounds to obtain highly efficient and low-toxic pesticide products, ensuring crop harvest and protecting the prosperity of agriculture.
Third, in the field of materials science, m-chlorobenzenesulfonyl chloride can be used to synthesize special polymers. By reacting with compounds containing active hydrogen or double bonds, polymer materials with special properties, such as high-performance engineering plastics, functional membrane materials, etc., are widely used in electronics, automobiles, aviation and other industries to promote the progress of high-tech.
Furthermore, in the study of organic synthesis chemistry, m-chlorobenzenesulfonyl chloride is an important reagent. Due to its active chemical properties, it provides a variety of reaction paths for organic synthesis, helping chemists explore new compounds and reaction mechanisms, and expanding the boundaries of organic chemistry. Therefore, m-chlorobenzenesulfonyl chloride has important uses in many fields, and has a profound impact on the development of the chemical industry and the progress of science and technology.
What are the physical properties of M-chlorobenzenesulfonyl Chloride?
M-chlorobenzenesulfonyl chloride is an important reagent in organic synthesis. Its physical properties are unique. In terms of its physical properties, it is a colorless to light yellow liquid. It is stable at room temperature and pressure. Smell it, it has a pungent odor. This odor is strong and needs to be treated with caution. It should be operated in a well-ventilated place.
When talking about the boiling point, it is about a certain temperature range. This property is extremely critical in the process of separation and purification. The value of its boiling point can help organic synthesizers to precisely control the reaction conditions, so that the substance can participate in the reaction at a suitable temperature or be effectively separated from the reaction system.
Melting point is also one of its important physical properties and has a specific melting point value. The melting point reflects the temperature limit of the solid-liquid conversion of the substance, which is of great significance for the setting of storage and use conditions. Knowing the melting point can ensure that the substance maintains a stable solid state during storage, and can be reasonably heated according to the melting point during use, so that it can reach the liquid state to participate in the reaction.
In terms of density, there is a corresponding value. This value determines its floating state in different media. It is an important reference when it comes to liquid-liquid reactions or separation operations.
In terms of solubility, M-chlorobenzenesulfonyl chloride is soluble in some organic solvents, such as some common aromatic hydrocarbons, halogenated hydrocarbon solvents, etc. This solubility property provides a direction for the selection of reaction solvents in organic synthesis, which can help researchers select suitable solvents to promote the smooth progress of the reaction or achieve effective separation and purification of the products.
When talking about the boiling point, it is about a certain temperature range. This property is extremely critical in the process of separation and purification. The value of its boiling point can help organic synthesizers to precisely control the reaction conditions, so that the substance can participate in the reaction at a suitable temperature or be effectively separated from the reaction system.
Melting point is also one of its important physical properties and has a specific melting point value. The melting point reflects the temperature limit of the solid-liquid conversion of the substance, which is of great significance for the setting of storage and use conditions. Knowing the melting point can ensure that the substance maintains a stable solid state during storage, and can be reasonably heated according to the melting point during use, so that it can reach the liquid state to participate in the reaction.
In terms of density, there is a corresponding value. This value determines its floating state in different media. It is an important reference when it comes to liquid-liquid reactions or separation operations.
In terms of solubility, M-chlorobenzenesulfonyl chloride is soluble in some organic solvents, such as some common aromatic hydrocarbons, halogenated hydrocarbon solvents, etc. This solubility property provides a direction for the selection of reaction solvents in organic synthesis, which can help researchers select suitable solvents to promote the smooth progress of the reaction or achieve effective separation and purification of the products.
What are the chemical properties of M-chlorobenzenesulfonyl Chloride?
M-chlorobenzenesulfonyl chloride is an important compound in organic chemistry. Its chemical properties are unique and interesting.
Looking at its nucleophilic substitution reaction, the sulfonyl chloride group is extremely active. The chlorine atom has good departure properties, and it is easily replaced when encountering nucleophilic reagents, such as alcohols and amines. When it encounters alcohols, the lone-to-electron nucleophilic of hydroxyl oxygen attacks the sulfur atom of sulfonyl chloride, and the chlorine atom leaves, and then forms a sulfonate. This sulfonate has a wide range of uses in organic synthesis and is often used as an intermediate, which can be further converted into a variety of functional groups. If it meets with amines, the nitrogen atom of amines attacks nucleophilically, forming sulfonamides. Sulfonamides are very important in the field of medicinal chemistry. Many drug molecules contain this structure because of their good biological activity and stability.
Talking about the hydrolysis reaction, M-chlorobenzenesulfonyl chloride can be hydrolyzed in water or alkaline aqueous solution. In water, water molecules attack sulfur atoms. After a series of steps, the chlorine atoms are replaced by hydroxyl groups to obtain M-chlorobenzenesulfonic acid and hydrogen chloride. Under alkaline conditions, the hydrolysis rate increases greatly, hydroxide ions have strong nucleophilicity, quickly attack sulfur atoms, and the reaction is more complete. The final product is M-chlorobenzenesulfonate.
Then talk about its reaction with metal-organic reagents, such as Grignard reagent or organolithium reagent. The carbon anion of the metal-organic reagent attacks the nucleophilic attack of the sulfur atom of the sulfonyl chloride, and the chlorine atom leaves to form a new carbon-sulfur bond. With this reaction, specific alkyl or aryl groups can be introduced into the benzene ring to expand the molecular structure, which is of great significance for the construction of complex organic molecules.
In addition, M-chlorobenzenesulfonyl chloride can also participate in the electrophilic substitution reaction under certain conditions. Although the benzene ring is a check point for the activity of electrophilic substitution, the electron-absorbing property of the sulfonyl chloride group will affect the electron cloud density distribution of the benzene ring, so that the selectivity of the electrophilic substitution reaction area is different. The density of the adjacent and para-potential electron clouds is relatively low, and the mes
Looking at its nucleophilic substitution reaction, the sulfonyl chloride group is extremely active. The chlorine atom has good departure properties, and it is easily replaced when encountering nucleophilic reagents, such as alcohols and amines. When it encounters alcohols, the lone-to-electron nucleophilic of hydroxyl oxygen attacks the sulfur atom of sulfonyl chloride, and the chlorine atom leaves, and then forms a sulfonate. This sulfonate has a wide range of uses in organic synthesis and is often used as an intermediate, which can be further converted into a variety of functional groups. If it meets with amines, the nitrogen atom of amines attacks nucleophilically, forming sulfonamides. Sulfonamides are very important in the field of medicinal chemistry. Many drug molecules contain this structure because of their good biological activity and stability.
Talking about the hydrolysis reaction, M-chlorobenzenesulfonyl chloride can be hydrolyzed in water or alkaline aqueous solution. In water, water molecules attack sulfur atoms. After a series of steps, the chlorine atoms are replaced by hydroxyl groups to obtain M-chlorobenzenesulfonic acid and hydrogen chloride. Under alkaline conditions, the hydrolysis rate increases greatly, hydroxide ions have strong nucleophilicity, quickly attack sulfur atoms, and the reaction is more complete. The final product is M-chlorobenzenesulfonate.
Then talk about its reaction with metal-organic reagents, such as Grignard reagent or organolithium reagent. The carbon anion of the metal-organic reagent attacks the nucleophilic attack of the sulfur atom of the sulfonyl chloride, and the chlorine atom leaves to form a new carbon-sulfur bond. With this reaction, specific alkyl or aryl groups can be introduced into the benzene ring to expand the molecular structure, which is of great significance for the construction of complex organic molecules.
In addition, M-chlorobenzenesulfonyl chloride can also participate in the electrophilic substitution reaction under certain conditions. Although the benzene ring is a check point for the activity of electrophilic substitution, the electron-absorbing property of the sulfonyl chloride group will affect the electron cloud density distribution of the benzene ring, so that the selectivity of the electrophilic substitution reaction area is different. The density of the adjacent and para-potential electron clouds is relatively low, and the mes
What are the precautions for M-chlorobenzenesulfonyl Chloride during storage and transportation?
M-chlorobenzenesulfonyl chloride is also a chemical substance. When storing and transporting, be sure to pay attention to many matters.
It is active, corrosive and irritating. When exposed to water or moisture, it is easy to react violently and generate acid mist. Therefore, the storage place must be kept dry to prevent it from being damp. In the warehouse, it should be well ventilated, and the temperature and humidity must be properly controlled to avoid high temperature and high humidity environment.
When transporting, it is necessary to choose suitable packaging. The container used must be resistant to corrosion and well sealed to prevent leakage. When loading and unloading, be careful not to damage the container.
Furthermore, this substance is prone to chemical reactions with alkalis, oxidants, reducing agents, etc., so it must not be mixed or mixed with such substances during storage and transportation.
And because of its toxicity, contact with the human body is harmful to health. People who work should wear appropriate protective equipment, such as protective clothing, gloves, goggles, gas masks, etc., to prevent skin, eyes from coming into contact with it, or inhaling its volatile gas.
Once there is a risk of leakage, emergency measures are also essential. Quickly isolate the scene, evacuate everyone, and strictly prohibit tinder. Small leaks can be absorbed by inert materials such as sand and vermiculite; if a large amount leaks, it is necessary to build a dike or dig a pit for containment, and then deal with it by appropriate methods. This guarantees the safety of storage and transportation.
It is active, corrosive and irritating. When exposed to water or moisture, it is easy to react violently and generate acid mist. Therefore, the storage place must be kept dry to prevent it from being damp. In the warehouse, it should be well ventilated, and the temperature and humidity must be properly controlled to avoid high temperature and high humidity environment.
When transporting, it is necessary to choose suitable packaging. The container used must be resistant to corrosion and well sealed to prevent leakage. When loading and unloading, be careful not to damage the container.
Furthermore, this substance is prone to chemical reactions with alkalis, oxidants, reducing agents, etc., so it must not be mixed or mixed with such substances during storage and transportation.
And because of its toxicity, contact with the human body is harmful to health. People who work should wear appropriate protective equipment, such as protective clothing, gloves, goggles, gas masks, etc., to prevent skin, eyes from coming into contact with it, or inhaling its volatile gas.
Once there is a risk of leakage, emergency measures are also essential. Quickly isolate the scene, evacuate everyone, and strictly prohibit tinder. Small leaks can be absorbed by inert materials such as sand and vermiculite; if a large amount leaks, it is necessary to build a dike or dig a pit for containment, and then deal with it by appropriate methods. This guarantees the safety of storage and transportation.
What are the synthesis methods of M-chlorobenzenesulfonyl Chloride?
The method of making M-chlorobenzenesulfonyl chloride has many wonderful techniques throughout the ages. One method is also to use M-chlorobenzenesulfonate as a base, through sulfonation, to obtain M-chlorobenzenesulfonate. When sulfonating, fuming sulfuric acid is often used as a sulfonating agent, and the two are stirred slowly at a suitable temperature. The first step is to control the temperature and control, so as not to clump the side effects. After obtaining M-chlorobenzenesulfonate, followed by chlorination, use phosphorus pentachloride or sulfinyl chloride and other chlorinated agents. If phosphorus pentachloride is used, it should be mixed with M-chlorobenzenesulfonate in a suitable proportion, at an appropriate temperature, when the number of static reactions, the situation should be observed and adjusted in a timely If thionyl chloride is used, this reaction is more convenient, because its by-products are all gases and easy to separate. After the reaction is completed, the impurities are removed by distillation, fractional distillation, etc., to obtain pure M-chlorobenzenesulfonyl chloride.
Another method is to use benzenesulfonyl chloride as the starting material and chlorinate it. Benzenesulfonyl chloride is stored in the catalyst and reacts with chlorine. The catalyst is usually iron filings, ferric chloride, etc. During the reaction, the temperature is controlled to a moderate extent, so that the chlorine is slowly introduced to ensure a smooth reaction. However, this method needs to be careful to avoid polychlorinated side reactions, because it is easy to produce and the product is impure. After the reaction is completed, it also needs to be purified, such as vacuum distillation, recrystallization, etc., to achieve high purity of M-chlorobenzenesulfonyl chloride.
In addition, there are also those who use m-chloroaniline as the starting material. M-chloroaniline is diazotized, and then reacted with sodium sulfite and copper sulfate to obtain M-chlorobenzenesulfonate sodium, and then acidified and chlorinated to obtain M-chlorobenzenesulfonyl chloride. Although this path is slightly complicated, the raw materials are easy to obtain, and can be flexibly adjusted according to actual needs. Each method has its own advantages and disadvantages. When it is implemented, it should be carefully selected according to the ease of raw materials, the cost, and the purity of the product.
Another method is to use benzenesulfonyl chloride as the starting material and chlorinate it. Benzenesulfonyl chloride is stored in the catalyst and reacts with chlorine. The catalyst is usually iron filings, ferric chloride, etc. During the reaction, the temperature is controlled to a moderate extent, so that the chlorine is slowly introduced to ensure a smooth reaction. However, this method needs to be careful to avoid polychlorinated side reactions, because it is easy to produce and the product is impure. After the reaction is completed, it also needs to be purified, such as vacuum distillation, recrystallization, etc., to achieve high purity of M-chlorobenzenesulfonyl chloride.
In addition, there are also those who use m-chloroaniline as the starting material. M-chloroaniline is diazotized, and then reacted with sodium sulfite and copper sulfate to obtain M-chlorobenzenesulfonate sodium, and then acidified and chlorinated to obtain M-chlorobenzenesulfonyl chloride. Although this path is slightly complicated, the raw materials are easy to obtain, and can be flexibly adjusted according to actual needs. Each method has its own advantages and disadvantages. When it is implemented, it should be carefully selected according to the ease of raw materials, the cost, and the purity of the product.
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