Linshang Chemical
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M-Chlorobenzenethiol
Linshang Chemical
|
HS Code |
225304 |
| Chemical Formula | C6H5ClS |
| Molar Mass | 144.62 g/mol |
| Appearance | Colorless to light yellow liquid |
| Odor | Strong, unpleasant odor |
| Density | 1.254 g/cm³ (at 25°C) |
| Boiling Point | 205 - 207°C |
| Melting Point | -19°C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in most organic solvents like ethanol, ether |
| Flash Point | 81°C |
| Pka | ~7.7 |
As an accredited M-Chlorobenzenethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of M - chlorobenzenethiol packaged in a sealed, corrosion - resistant bottle. |
| Storage | M - chlorobenzenethiol should be stored in a cool, well - ventilated area away from heat and ignition sources. It should be kept in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and foodstuff to prevent reactions. Follow local safety regulations for proper storage to avoid potential hazards like fire, explosion, or release of toxic fumes. |
| Shipping | M - chlorobenzenethiol, a chemical with potential hazards, is shipped in specialized, leak - proof containers. It adheres to strict regulations for hazardous chemicals during transport, ensuring safe handling from origin to destination. |
Competitive M-Chlorobenzenethiol prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of M-chlorobenzenethiol?
M-chlorothiophenol is also an organic compound. It has special chemical properties and is quite important to chemists.
This substance has the typical properties of thiols. Mercaptans have a lot of foul odor, and M-chlorothiophenol is no exception. Its smell is pungent and unpleasant. This is due to the special structure of sulfur-hydrogen bonds in thiols, which makes it volatile and has a special odor.
In terms of chemical activity, its sulfur atom has lone pairs of electrons, so it has nucleophilicity. This nucleophilicity makes M-chlorothiophenol participate in many nucleophilic substitution reactions. For example, when meeting halogenated hydrocarbons, sulfur atoms can attack the carbon atoms of halogenated hydrocarbons, and the halogen atoms leave to form new sulfur-containing compounds. This reaction is often an important means of building carbon-sulfur bonds in organic synthesis.
Furthermore, the chlorine atoms on the benzene ring also have certain activity. Although the benzene ring is a conjugated system and is relatively stable, chlorine atoms can undergo substitution reactions under appropriate conditions. For example, in the presence of strong bases and specific catalysts, chlorine atoms can be replaced by other nucleophiles, which can introduce new functional groups to enrich the structure and properties of compounds.
In addition, M-chlorothiophenol can be oxidized. Under the action of appropriate oxidants, thiol groups can be converted into higher valence sulfur-containing functional groups such as sulfonic acid groups. This oxidation reaction is widely used in the fields of organic synthesis and fine chemistry, and can be used to prepare a variety of sulfur-containing functional materials or intermediates.
In short, M-chlorothiophenol, due to its unique structure, combines the properties of thiols and halogenated aromatics, and has shown important application value in the fields of organic synthesis and materials science. According to its characteristics, chemists can design and implement a variety of chemical reactions to meet different needs.
This substance has the typical properties of thiols. Mercaptans have a lot of foul odor, and M-chlorothiophenol is no exception. Its smell is pungent and unpleasant. This is due to the special structure of sulfur-hydrogen bonds in thiols, which makes it volatile and has a special odor.
In terms of chemical activity, its sulfur atom has lone pairs of electrons, so it has nucleophilicity. This nucleophilicity makes M-chlorothiophenol participate in many nucleophilic substitution reactions. For example, when meeting halogenated hydrocarbons, sulfur atoms can attack the carbon atoms of halogenated hydrocarbons, and the halogen atoms leave to form new sulfur-containing compounds. This reaction is often an important means of building carbon-sulfur bonds in organic synthesis.
Furthermore, the chlorine atoms on the benzene ring also have certain activity. Although the benzene ring is a conjugated system and is relatively stable, chlorine atoms can undergo substitution reactions under appropriate conditions. For example, in the presence of strong bases and specific catalysts, chlorine atoms can be replaced by other nucleophiles, which can introduce new functional groups to enrich the structure and properties of compounds.
In addition, M-chlorothiophenol can be oxidized. Under the action of appropriate oxidants, thiol groups can be converted into higher valence sulfur-containing functional groups such as sulfonic acid groups. This oxidation reaction is widely used in the fields of organic synthesis and fine chemistry, and can be used to prepare a variety of sulfur-containing functional materials or intermediates.
In short, M-chlorothiophenol, due to its unique structure, combines the properties of thiols and halogenated aromatics, and has shown important application value in the fields of organic synthesis and materials science. According to its characteristics, chemists can design and implement a variety of chemical reactions to meet different needs.
What are the physical properties of M-chlorobenzenethiol?
M-chlorothiophenol is also an organic compound. Its physical properties are quite important, let me tell them one by one.
Looking at its appearance, under room temperature and pressure, it often takes the form of a colorless to light yellow liquid, which is quite unique. This substance is left in the air for a long time, or due to oxidation, the color may become slightly darker.
When it comes to smell, M-chlorothiophenol emits a strong and pungent odor, which is extremely significant, easy to perceive, memorable to smell, and its smell can spread far.
When it comes to the boiling point, it is between 207-209 ° C. When the temperature reaches this point, the substance changes from liquid to gas. The characteristics of boiling point are crucial in chemical operations such as separation and purification.
The melting point is about -18 ° C. Under this temperature, the substance solidifies from liquid to solid. The melting point is also an important parameter for identifying and analyzing the substance.
The density is about 1.24 g/cm ³. Compared with water, its density is slightly higher. If mixed with water, M-chlorothiophenol will sink to the bottom of the water.
Solubility is also an important property. M-chlorothiophenol is slightly soluble in water, but can be soluble in a variety of organic solvents, such as ethanol, ether, benzene, etc. This solubility characteristic makes it possible to select suitable solvents for reaction, separation and other operations in the fields of organic synthesis.
In addition, the physical properties of M-chlorothiophenol, such as vapor pressure and refractive index, also have their own values, which are of important reference value in chemical production, scientific research and analysis, etc., laying a foundation for the comprehensive understanding and application of this substance.
Looking at its appearance, under room temperature and pressure, it often takes the form of a colorless to light yellow liquid, which is quite unique. This substance is left in the air for a long time, or due to oxidation, the color may become slightly darker.
When it comes to smell, M-chlorothiophenol emits a strong and pungent odor, which is extremely significant, easy to perceive, memorable to smell, and its smell can spread far.
When it comes to the boiling point, it is between 207-209 ° C. When the temperature reaches this point, the substance changes from liquid to gas. The characteristics of boiling point are crucial in chemical operations such as separation and purification.
The melting point is about -18 ° C. Under this temperature, the substance solidifies from liquid to solid. The melting point is also an important parameter for identifying and analyzing the substance.
The density is about 1.24 g/cm ³. Compared with water, its density is slightly higher. If mixed with water, M-chlorothiophenol will sink to the bottom of the water.
Solubility is also an important property. M-chlorothiophenol is slightly soluble in water, but can be soluble in a variety of organic solvents, such as ethanol, ether, benzene, etc. This solubility characteristic makes it possible to select suitable solvents for reaction, separation and other operations in the fields of organic synthesis.
In addition, the physical properties of M-chlorothiophenol, such as vapor pressure and refractive index, also have their own values, which are of important reference value in chemical production, scientific research and analysis, etc., laying a foundation for the comprehensive understanding and application of this substance.
What are the common uses of M-chlorobenzenethiol?
The common use of M-chlorothiophenol is an important raw material for organic synthesis. In the field of medicinal chemistry, it is often an indispensable intermediate for the creation of new drugs. Due to the unique chemical activity of thiophenol groups, they can react with a variety of compounds. By carefully designing synthetic routes, drug molecules with complex structures and specific biological activities can be constructed.
In the field of materials science, M-chlorothiophenol also has wonderful uses. It can be used as a modifier to interact with metal surfaces to form a self-assembled monolayer. This layer can effectively adjust the properties of the material surface, such as wettability and adhesion, thereby improving the performance of the material in specific application scenarios. For example, in the manufacturing of electronic devices, the modified metal surface can optimize the electron transport performance and improve the stability and efficiency of the device.
Furthermore, M-chlorothiophenol also plays a key role in the preparation of some fine chemicals. In the fields of fragrances, dyes, etc., using its unique chemical structure and reaction characteristics, compounds with special fragrance or color can be synthesized to meet people's needs for high-quality fine chemicals. In short, M-chlorothiophenol has shown important application value in many fields due to its unique chemical properties, promoting the continuous development and progress of related industries.
In the field of materials science, M-chlorothiophenol also has wonderful uses. It can be used as a modifier to interact with metal surfaces to form a self-assembled monolayer. This layer can effectively adjust the properties of the material surface, such as wettability and adhesion, thereby improving the performance of the material in specific application scenarios. For example, in the manufacturing of electronic devices, the modified metal surface can optimize the electron transport performance and improve the stability and efficiency of the device.
Furthermore, M-chlorothiophenol also plays a key role in the preparation of some fine chemicals. In the fields of fragrances, dyes, etc., using its unique chemical structure and reaction characteristics, compounds with special fragrance or color can be synthesized to meet people's needs for high-quality fine chemicals. In short, M-chlorothiophenol has shown important application value in many fields due to its unique chemical properties, promoting the continuous development and progress of related industries.
What are M-chlorobenzenethiol synthesis methods?
The method of preparing M-chlorothiophenol is usually obtained by the reaction of nucleophilic substitution with m-chlorobromobenzene and sodium hydrosulfide as the starting materials. The way of the reaction is to prepare a solution of m-chlorobromobenzene and sodium hydrosulfide, mix the two in an appropriate reactor, and add an appropriate amount of phase transfer catalyst, such as tetrabutylammonium bromide. The temperature is raised to an appropriate temperature, usually between 80 and 120 ° C, so that the reaction can proceed smoothly. In this reaction, the bromine atom of m-chlorobromobenzene is replaced by thiohydrogen ion to give rise to M-chlorothiophenol.
Also begins with m-chloronitrobenzene, which is first reduced to m-chloroaniline, and then through the Sandmeier reaction, the amino group is replaced by thiocyanate, and then the thiocyanate group is hydrolyzed to the mercapto group to obtain M-chlorothiophenol.
Specifically, m-chloronitrobenzene is treated with iron powder and hydrochloric acid and other reducing agents to make it into m-chloroaniline. M-chlorothiophenol is obtained by blending m-chloroaniline with sodium nitrite and hydrochloric acid, and then reacting at low temperature to obtain m-chlorodiazonium. This diazonium salt is then reacted with potassium thiocyanate to form m-chlorophenylthiocyanate. Finally, m-chlorothiophenol is obtained by hydrolyzing m-chlorothi
In addition, m-chlorobenzenesulfonic acid and sodium sulfide are sulfurized and then treated with acid, which is also one of the methods for preparing M-chlorothiophenol. First, m-chlorobenzenesulfonic acid is reacted with sodium sulfide, and the sulfonic acid group is replaced by sulfur ions to obtain the sodium salt of m-chlorothiophenol. Subsequent acid is added to convert the sodium salt into M-chlorothiophenol. These methods have their own advantages and disadvantages, and they need to be used according to the actual situation, such as the availability of raw materials, cost, and purity of the product.
Also begins with m-chloronitrobenzene, which is first reduced to m-chloroaniline, and then through the Sandmeier reaction, the amino group is replaced by thiocyanate, and then the thiocyanate group is hydrolyzed to the mercapto group to obtain M-chlorothiophenol.
Specifically, m-chloronitrobenzene is treated with iron powder and hydrochloric acid and other reducing agents to make it into m-chloroaniline. M-chlorothiophenol is obtained by blending m-chloroaniline with sodium nitrite and hydrochloric acid, and then reacting at low temperature to obtain m-chlorodiazonium. This diazonium salt is then reacted with potassium thiocyanate to form m-chlorophenylthiocyanate. Finally, m-chlorothiophenol is obtained by hydrolyzing m-chlorothi
In addition, m-chlorobenzenesulfonic acid and sodium sulfide are sulfurized and then treated with acid, which is also one of the methods for preparing M-chlorothiophenol. First, m-chlorobenzenesulfonic acid is reacted with sodium sulfide, and the sulfonic acid group is replaced by sulfur ions to obtain the sodium salt of m-chlorothiophenol. Subsequent acid is added to convert the sodium salt into M-chlorothiophenol. These methods have their own advantages and disadvantages, and they need to be used according to the actual situation, such as the availability of raw materials, cost, and purity of the product.
M-chlorobenzenethiol What are the precautions in storage and transportation?
M-chlorothiophenol is also an organic compound. During storage and transportation, many matters must be paid attention to.
First word storage. This substance is toxic and irritating, and thiophenol compounds are easily oxidized. Therefore, it should be stored in a cool and ventilated warehouse, away from fire and heat sources. The temperature of the warehouse should be controlled within an appropriate range. If it is too high, it will easily cause its volatilization to increase, or cause chemical reactions. It should be stored separately from oxidants, acids, bases, etc., and should not be mixed. It is easy to react chemically with such substances, and there is even a risk of combustion and explosion. The storage area should be equipped with suitable materials to contain leaks, in case of leakage, and can be dealt with in time to prevent its spread from causing greater harm.
As for transportation, it is necessary to ensure that the packaging is complete and the loading is safe before transportation. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. The means of transportation used should be clean and dry to avoid mixing with other impurities to react with it. During transportation, it is necessary to follow the specified route and do not stop in densely populated areas and residential areas to prevent accidental leakage from endangering the safety of the public. Transport personnel should also be familiar with its nature and emergency treatment methods. In case of leakage and other situations, they can respond quickly and correctly to reduce the damage.
First word storage. This substance is toxic and irritating, and thiophenol compounds are easily oxidized. Therefore, it should be stored in a cool and ventilated warehouse, away from fire and heat sources. The temperature of the warehouse should be controlled within an appropriate range. If it is too high, it will easily cause its volatilization to increase, or cause chemical reactions. It should be stored separately from oxidants, acids, bases, etc., and should not be mixed. It is easy to react chemically with such substances, and there is even a risk of combustion and explosion. The storage area should be equipped with suitable materials to contain leaks, in case of leakage, and can be dealt with in time to prevent its spread from causing greater harm.
As for transportation, it is necessary to ensure that the packaging is complete and the loading is safe before transportation. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. The means of transportation used should be clean and dry to avoid mixing with other impurities to react with it. During transportation, it is necessary to follow the specified route and do not stop in densely populated areas and residential areas to prevent accidental leakage from endangering the safety of the public. Transport personnel should also be familiar with its nature and emergency treatment methods. In case of leakage and other situations, they can respond quickly and correctly to reduce the damage.
What is the chemistry of M-chlorobenzenethiol?
M-chlorothiophenol, this substance has unique chemical properties. It is acidic. Due to the more active hydrogen in the sulfur-hydrogen bond, it can dissociate hydrogen ions under suitable conditions. It has stronger properties than water and alkyd. It can neutralize with bases, such as reacting with sodium hydroxide to form corresponding thiophenol salts and water.
M-chlorothiophenol has outstanding nucleophilicity. Sulfur atoms are rich in lone pair electrons, have high affinity for electrophilic reagents, and are prone to nucleophilic substitution reactions. Taking halogenated alkanes as an example, their sulfur atoms will attack the carbon atoms connected to halogens in halogenated alkanes, and the halogens will leave to form thioether compounds.
It also has reducing properties. Sulfur is in a low oxidation state. When it encounters strong oxidants such as potassium permanganate, sulfur atoms are easily oxidized and can be oxidized to sulfoxides or even sulfones.
In addition, the phenyl ring of M-chlorothiophenol is affected by chlorine atoms and sulfhydryl groups. When an electrophilic substitution reaction occurs, chlorine is an ortho-para-site group, and the sulfhydryl group also has a certain localization effect. The combined effect makes the regioselectivity of the electrophilic substitution reaction complex. For example, in halogenation and nitrification reactions, the choice of reaction check points is restricted by both electronic effects and spatial effects. In short, these properties make M-chlorothiophenol widely used in the field of organic synthesis and can be used as an intermediate for the synthesis of a variety of sulfur-containing organic compounds
M-chlorothiophenol has outstanding nucleophilicity. Sulfur atoms are rich in lone pair electrons, have high affinity for electrophilic reagents, and are prone to nucleophilic substitution reactions. Taking halogenated alkanes as an example, their sulfur atoms will attack the carbon atoms connected to halogens in halogenated alkanes, and the halogens will leave to form thioether compounds.
It also has reducing properties. Sulfur is in a low oxidation state. When it encounters strong oxidants such as potassium permanganate, sulfur atoms are easily oxidized and can be oxidized to sulfoxides or even sulfones.
In addition, the phenyl ring of M-chlorothiophenol is affected by chlorine atoms and sulfhydryl groups. When an electrophilic substitution reaction occurs, chlorine is an ortho-para-site group, and the sulfhydryl group also has a certain localization effect. The combined effect makes the regioselectivity of the electrophilic substitution reaction complex. For example, in halogenation and nitrification reactions, the choice of reaction check points is restricted by both electronic effects and spatial effects. In short, these properties make M-chlorothiophenol widely used in the field of organic synthesis and can be used as an intermediate for the synthesis of a variety of sulfur-containing organic compounds
What are the physical properties of M-chlorobenzenethiol?
M-chlorothiophenol is a kind of organic compound. Its physical properties are unique and important for chemical research and industrial applications.
Looking at its properties, it is a colorless to light yellow liquid under normal conditions. This color property makes it easy to identify and operate in specific reactions or application scenarios.
Smell it, it has a strong and special irritating odor. This odor is significant. In actual contact and use, the operator can initially judge its existence and leakage by the smell, but also warn people to operate in a well-ventilated place to prevent inhalation of harmful gases and affect health.
When it comes to the melting point, the melting point is about -18 ° C, and the boiling point is between 233-234 ° C. Such melting boiling point data is of great significance in chemical production. The lower melting point indicates that it is a liquid at room temperature and is easy to mix and participate in the reaction; the higher boiling point means that it can maintain liquid stability during the heating process, providing a relatively stable environment for the reaction, which is conducive to the progress of specific reactions and the preparation of products.
As for the density, it is about 1.24g/cm ³. This density parameter is crucial in the mixing and separation of materials in the chemical process. When mixing different liquids, according to the density difference, the mixing process and equipment can be reasonably designed to ensure uniform mixing of materials; in the separation operation, the density characteristics can also be used to achieve effective separation by means of gravity sedimentation and centrifugal separation.
Solubility, slightly soluble in water, but miscible with most organic solvents. The characteristics of slightly soluble in water limit its application in aqueous systems; and good miscibility with organic solvents greatly expands its use in the field of organic synthesis. For example, in organic reactions, suitable organic solvents can be selected to fully dissolve M-chlorothiophenol, so that the reaction can be carried out efficiently in a homogeneous system, improving the reaction rate and product purity.
Looking at its properties, it is a colorless to light yellow liquid under normal conditions. This color property makes it easy to identify and operate in specific reactions or application scenarios.
Smell it, it has a strong and special irritating odor. This odor is significant. In actual contact and use, the operator can initially judge its existence and leakage by the smell, but also warn people to operate in a well-ventilated place to prevent inhalation of harmful gases and affect health.
When it comes to the melting point, the melting point is about -18 ° C, and the boiling point is between 233-234 ° C. Such melting boiling point data is of great significance in chemical production. The lower melting point indicates that it is a liquid at room temperature and is easy to mix and participate in the reaction; the higher boiling point means that it can maintain liquid stability during the heating process, providing a relatively stable environment for the reaction, which is conducive to the progress of specific reactions and the preparation of products.
As for the density, it is about 1.24g/cm ³. This density parameter is crucial in the mixing and separation of materials in the chemical process. When mixing different liquids, according to the density difference, the mixing process and equipment can be reasonably designed to ensure uniform mixing of materials; in the separation operation, the density characteristics can also be used to achieve effective separation by means of gravity sedimentation and centrifugal separation.
Solubility, slightly soluble in water, but miscible with most organic solvents. The characteristics of slightly soluble in water limit its application in aqueous systems; and good miscibility with organic solvents greatly expands its use in the field of organic synthesis. For example, in organic reactions, suitable organic solvents can be selected to fully dissolve M-chlorothiophenol, so that the reaction can be carried out efficiently in a homogeneous system, improving the reaction rate and product purity.
What are the main uses of M-chlorobenzenethiol?
M-chlorobenzenethiol (M-chlorobenzenethiol) has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. It can involve many chemical reactions, such as participating in the construction of complex organic molecular structures.
plays an important role in medicinal chemistry. With its special chemical structure, it can be used to develop new drugs. Because of its sulfur and chlorine atoms, it gives unique chemical properties and can interact with targets in organisms, or can be used to develop drugs with antibacterial, anti-inflammatory, anti-tumor and other effects.
also has application potential in the field of materials science. It can be used as a raw material for the synthesis of functional materials, and specific functional groups are introduced through chemical reactions to impart special properties to the materials, such as improving the stability, conductivity or optical properties of the materials.
Furthermore, in the preparation of some fine chemical products, M-chlorothiophenol is indispensable. Such as for the synthesis of special fragrances, dyes or additives, etc., with its unique chemical properties, it adds unique characteristics to the product and improves product quality and performance.
To sum up, M-chlorothiophenol has important uses in many fields such as organic synthesis, medicine, materials and fine chemicals, providing key support for the development of many fields.
plays an important role in medicinal chemistry. With its special chemical structure, it can be used to develop new drugs. Because of its sulfur and chlorine atoms, it gives unique chemical properties and can interact with targets in organisms, or can be used to develop drugs with antibacterial, anti-inflammatory, anti-tumor and other effects.
also has application potential in the field of materials science. It can be used as a raw material for the synthesis of functional materials, and specific functional groups are introduced through chemical reactions to impart special properties to the materials, such as improving the stability, conductivity or optical properties of the materials.
Furthermore, in the preparation of some fine chemical products, M-chlorothiophenol is indispensable. Such as for the synthesis of special fragrances, dyes or additives, etc., with its unique chemical properties, it adds unique characteristics to the product and improves product quality and performance.
To sum up, M-chlorothiophenol has important uses in many fields such as organic synthesis, medicine, materials and fine chemicals, providing key support for the development of many fields.
What are M-chlorobenzenethiol synthesis methods?
The synthesis method of M-chlorothiophenol has been studied by chemists throughout the ages, and the following is a common method.
First, halogenated aromatics react with thiols. This compound can be obtained by heating and stirring m-chlorobromobenzene and sodium hydrosulfide in a suitable solvent, such as N, N-dimethylformamide (DMF). This reaction needs to be carried out under the protection of inert gas to avoid the oxidation of thiols. The reaction mechanism is nucleophilic substitution. The negative ion of thiohydrogen attacks the halogen atom of halogenated aromatics, and the halogen ion leaves to obtain the product.
Second, it is obtained by reduction of m-chlorobenzenesulfonyl chloride. First, the isochlorobenzenesulfonyl chloride is used as the starting material, and the reducing agent such as zinc powder and hydrochloric acid, or sodium borohydride is used to treat it. Taking zinc powder and hydrochloric acid as an example, under low temperature stirring conditions, the sulfonyl group of isochlorobenzenesulfonyl chloride is gradually reduced to thiol to obtain M-chlorothiophenol. In this process, it is crucial to control the reaction temperature and the amount of reducing agent, otherwise it is prone to excessive reduction or side reactions.
Third, through the Grignard reagent method. The Grignard reagent of isochlorobenzene bromide is first prepared from m-chlorobenzene, and then reacts with sulfur powder and then hydrolyzes with acid to obtain the target product. This method requires strict reaction conditions. The preparation of Grignard reagents requires an anhydrous and anaerobic environment, and the proportion of reactive materials is precisely controlled to improve the yield.
The above synthesis methods have their own advantages and disadvantages. In practical application, chemists need to weigh the choice according to the availability of raw materials, cost, difficulty of reaction conditions, etc., in order to achieve the best synthesis effect.
First, halogenated aromatics react with thiols. This compound can be obtained by heating and stirring m-chlorobromobenzene and sodium hydrosulfide in a suitable solvent, such as N, N-dimethylformamide (DMF). This reaction needs to be carried out under the protection of inert gas to avoid the oxidation of thiols. The reaction mechanism is nucleophilic substitution. The negative ion of thiohydrogen attacks the halogen atom of halogenated aromatics, and the halogen ion leaves to obtain the product.
Second, it is obtained by reduction of m-chlorobenzenesulfonyl chloride. First, the isochlorobenzenesulfonyl chloride is used as the starting material, and the reducing agent such as zinc powder and hydrochloric acid, or sodium borohydride is used to treat it. Taking zinc powder and hydrochloric acid as an example, under low temperature stirring conditions, the sulfonyl group of isochlorobenzenesulfonyl chloride is gradually reduced to thiol to obtain M-chlorothiophenol. In this process, it is crucial to control the reaction temperature and the amount of reducing agent, otherwise it is prone to excessive reduction or side reactions.
Third, through the Grignard reagent method. The Grignard reagent of isochlorobenzene bromide is first prepared from m-chlorobenzene, and then reacts with sulfur powder and then hydrolyzes with acid to obtain the target product. This method requires strict reaction conditions. The preparation of Grignard reagents requires an anhydrous and anaerobic environment, and the proportion of reactive materials is precisely controlled to improve the yield.
The above synthesis methods have their own advantages and disadvantages. In practical application, chemists need to weigh the choice according to the availability of raw materials, cost, difficulty of reaction conditions, etc., in order to achieve the best synthesis effect.
M-chlorobenzenethiol what are the precautions during use
M-chlorothiophenol is an organic compound. During use, many things must be paid attention to.
Bear the brunt of it, and safety protection must not be ignored. This substance is toxic and irritating, and contact can cause damage to the skin, eyes and respiratory tract. Therefore, when using, it is necessary to wear appropriate protective equipment, such as protective gloves, goggles and gas masks, to prevent direct contact with it.
Secondly, proper storage is also essential. It should be placed in a cool, ventilated and dry place, away from fire sources and oxidants, to avoid dangerous reactions. At the same time, it needs to be strictly sealed to prevent leakage.
Furthermore, the operating environment must be well ventilated. The best operation is in the fume hood, which can remove the volatile steam in time and reduce the concentration of harmful substances in the air to ensure the safety of the operator.
Also, during use, be sure to strictly abide by the operating procedures. Avoid excessive heating to prevent decomposition and generation of harmful gases. If accidentally exposed, rinse with a lot of water immediately, and seek medical treatment according to the specific situation.
Finally, the disposal of waste should not be arbitrary. Waste containing M-chlorothiophenol must be properly disposed of in accordance with relevant regulations and standards to prevent environmental pollution.
All of these are important items to pay attention to when using M-chlorothiophenol, and must not be taken lightly to ensure safe operation and worry-free environment.
Bear the brunt of it, and safety protection must not be ignored. This substance is toxic and irritating, and contact can cause damage to the skin, eyes and respiratory tract. Therefore, when using, it is necessary to wear appropriate protective equipment, such as protective gloves, goggles and gas masks, to prevent direct contact with it.
Secondly, proper storage is also essential. It should be placed in a cool, ventilated and dry place, away from fire sources and oxidants, to avoid dangerous reactions. At the same time, it needs to be strictly sealed to prevent leakage.
Furthermore, the operating environment must be well ventilated. The best operation is in the fume hood, which can remove the volatile steam in time and reduce the concentration of harmful substances in the air to ensure the safety of the operator.
Also, during use, be sure to strictly abide by the operating procedures. Avoid excessive heating to prevent decomposition and generation of harmful gases. If accidentally exposed, rinse with a lot of water immediately, and seek medical treatment according to the specific situation.
Finally, the disposal of waste should not be arbitrary. Waste containing M-chlorothiophenol must be properly disposed of in accordance with relevant regulations and standards to prevent environmental pollution.
All of these are important items to pay attention to when using M-chlorothiophenol, and must not be taken lightly to ensure safe operation and worry-free environment.
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