Linshang Chemical
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M-Chloroiodobenzene
Linshang Chemical
|
HS Code |
563276 |
| Chemical Formula | C6H4ClI |
| Molar Mass | 238.45 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 217 - 219 °C |
| Melting Point | −27 °C |
| Density | 1.88 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 93 °C |
| Refractive Index | 1.6365 |
| Odor | Characteristic aromatic odor |
As an accredited M-Chloroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of M - chloroiodobenzene packaged in a sealed glass bottle. |
| Storage | M - chloroiodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. Ensure proper labeling for easy identification and safety. |
| Shipping | M - chloroiodobenzene is shipped in sealed, corrosion - resistant containers. Adequate cushioning is used to prevent breakage. It follows strict hazardous chemical shipping regulations, with proper labeling for safe transport. |
Competitive M-Chloroiodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a trusted M-Chloroiodobenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading M-Chloroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of M-chloroiodobenzene?
M-chloroiodobenzene is also an organic compound. Its molecules contain chlorine atoms and iodine atoms attached to the benzene ring interposition. The chemical properties of this substance are determined by the functional groups and benzene ring structure they contain.
In terms of reactivity, although both chlorine and iodine are halogen atoms, the two have different activities. Iodine atoms are relatively small in the C-I bond energy due to their large atomic radius, so in the nucleophilic substitution reaction, iodine is easier to leave and exhibits higher activity. For example, when reacting with nucleophiles, nucleophiles are more likely to attack the carbon site of iodine and replace it to form new organic compounds.
And chlorine atoms, although less active than iodine, can also participate in specific reactions. The electron cloud distribution of the benzene ring changes due to the presence of chlorine and iodine. The halogen atom is an electron-withdrawing group, which reduces the electron cloud density of the benzene ring, especially in the ortho and para-positions, resulting in a decrease in the electrophilic substitution activity of the benzene ring.
In the redox reaction, M-chloroiodobenzene can have different behaviors depending on the reaction conditions. Under the action of a specific oxidant, it may cause the oxidation state of the halogen atom to change, or cause the oxidation reaction of the benzene ring.
In addition, its physical properties also affect the chemical behavior. The substance has certain solubility, and its solubility in organic solvents may be better than that of water. This property is related to the choice of reaction medium in organic synthesis reactions, and has an important impact on the reaction rate and product In the field of organic synthesis, M-chloroiodobenzene is often used as an intermediate to build complex organic molecular structures through the reactivity of its halogen atoms, which is commonly used in organic chemistry research and related industrial production.
In terms of reactivity, although both chlorine and iodine are halogen atoms, the two have different activities. Iodine atoms are relatively small in the C-I bond energy due to their large atomic radius, so in the nucleophilic substitution reaction, iodine is easier to leave and exhibits higher activity. For example, when reacting with nucleophiles, nucleophiles are more likely to attack the carbon site of iodine and replace it to form new organic compounds.
And chlorine atoms, although less active than iodine, can also participate in specific reactions. The electron cloud distribution of the benzene ring changes due to the presence of chlorine and iodine. The halogen atom is an electron-withdrawing group, which reduces the electron cloud density of the benzene ring, especially in the ortho and para-positions, resulting in a decrease in the electrophilic substitution activity of the benzene ring.
In the redox reaction, M-chloroiodobenzene can have different behaviors depending on the reaction conditions. Under the action of a specific oxidant, it may cause the oxidation state of the halogen atom to change, or cause the oxidation reaction of the benzene ring.
In addition, its physical properties also affect the chemical behavior. The substance has certain solubility, and its solubility in organic solvents may be better than that of water. This property is related to the choice of reaction medium in organic synthesis reactions, and has an important impact on the reaction rate and product In the field of organic synthesis, M-chloroiodobenzene is often used as an intermediate to build complex organic molecular structures through the reactivity of its halogen atoms, which is commonly used in organic chemistry research and related industrial production.
What are the main uses of M-chloroiodobenzene?
M-chloroiodobenzene is also an organic compound. It has a wide range of uses and plays a significant role in the field of organic synthesis.
First, it can be used as a key intermediate to prepare a variety of complex organic compounds. For example, when synthesizing drug molecules with specific biological activities, M-chloroiodobenzene can introduce the required functional groups through nucleophilic substitution and coupling reactions due to the reaction characteristics of halogenated aromatics to build the basic structure of drug molecules. Taking the Suzuki coupling reaction as an example, M-chloroiodobenzene and suitable boric acid reagents can efficiently form carbon-carbon bonds and construct more complex aromatic compounds under the action of palladium catalysts. This is a common strategy for creating novel chemical entities in the process of drug development.
Second, in the field of materials science, M-chloroiodobenzene is also useful. When preparing some functional polymer materials, it can participate in the polymerization reaction as a monomer. Due to the presence of chlorine and iodine atoms, the material is endowed with unique electronic properties and reactivity, so that the obtained polymer material has special photoelectric properties, which can be applied to organic Light Emitting Diode (OLED), solar cells and other optoelectronic devices to improve the material's charge transport and luminous efficiency.
Third, in the synthesis of dyes, M-chloroiodobenzene can introduce specific structural units into dye molecules to adjust the color, solubility and stability of dyes. By chemical modification, it can be converted into dyes with specific absorption and emission spectra, which can be used in textile, printing and other industries to meet different color requirements and application scenarios.
First, it can be used as a key intermediate to prepare a variety of complex organic compounds. For example, when synthesizing drug molecules with specific biological activities, M-chloroiodobenzene can introduce the required functional groups through nucleophilic substitution and coupling reactions due to the reaction characteristics of halogenated aromatics to build the basic structure of drug molecules. Taking the Suzuki coupling reaction as an example, M-chloroiodobenzene and suitable boric acid reagents can efficiently form carbon-carbon bonds and construct more complex aromatic compounds under the action of palladium catalysts. This is a common strategy for creating novel chemical entities in the process of drug development.
Second, in the field of materials science, M-chloroiodobenzene is also useful. When preparing some functional polymer materials, it can participate in the polymerization reaction as a monomer. Due to the presence of chlorine and iodine atoms, the material is endowed with unique electronic properties and reactivity, so that the obtained polymer material has special photoelectric properties, which can be applied to organic Light Emitting Diode (OLED), solar cells and other optoelectronic devices to improve the material's charge transport and luminous efficiency.
Third, in the synthesis of dyes, M-chloroiodobenzene can introduce specific structural units into dye molecules to adjust the color, solubility and stability of dyes. By chemical modification, it can be converted into dyes with specific absorption and emission spectra, which can be used in textile, printing and other industries to meet different color requirements and application scenarios.
What are the synthesis methods of M-chloroiodobenzene?
The synthesis method of M-chloroiodobenzene often involves several routes. One is to start with m-chloroaniline, which is obtained by the reaction of diazotization and iodine substitution. First, m-chloroaniline and sodium nitrite are reacted at low temperature in an acidic medium to obtain diazonium salts. This step needs to be controlled at 0-5 ° C to prevent the decomposition of diazonium salts. The reaction formula is: m-chloroaniline + NaNO 2 + HCl → m-chlorobenzene diazonium salt + NaCl + H 2O O. Subsequently, the diazonium salt is mixed with potassium iodide solution and heated to react. The diazonium group is replaced by an iodine atom to generate M-chloroiodobenzene. The reaction formula is: m-chlorobenzene diazonium salt + KI → M-chloroiodobenzene + N ³ ↑ + KCl.
Second, it can be started from m-chlorobenzoic acid. First, the m-chlorobenzoic acid is converted to m-chlorobenzoyl chloride, which is often reacted with sulfoxide chloride or phosphorus trichloride. The reaction formula is: m-chlorobenzoic acid + SOCl ³ → m-chlorobenzoyl chloride + SO ³ ↑ + HCl ↑. Then m-chlorobenzoyl chloride is reacted with sodium iodide in a suitable solvent (such as acetone), and M-chloroiodobenzene is obtained through the process of reductive decarbonylation and iodization of acyl groups. In this reaction, the iodine anion of sodium iodide attacks the carbonyl carbon, and then carbon monoxide and chloride ions are removed to form the product.
Or it is synthesized by the reaction of m-chlorophenylboronic acid with iodine substitution reagent. M-chloroiodobenzene is synthesized by the reaction of m-chlorobenzoic acid and iodine elemental substance in a solvent (such as a mixture of dioxane and water) in the presence of a suitable catalyst (such as copper salt) and a base (such as potassium carbonate). The reaction goes through the transfer and rearrangement of In this process, the catalyst promotes the reaction, and the alkali adjusts the pH of the reaction system, which is conducive to the movement of the reaction balance to the direction of product formation.
The above methods have their own advantages and disadvantages, and should be selected reasonably according to actual needs, such as raw material availability, cost, product purity and other factors.
Second, it can be started from m-chlorobenzoic acid. First, the m-chlorobenzoic acid is converted to m-chlorobenzoyl chloride, which is often reacted with sulfoxide chloride or phosphorus trichloride. The reaction formula is: m-chlorobenzoic acid + SOCl ³ → m-chlorobenzoyl chloride + SO ³ ↑ + HCl ↑. Then m-chlorobenzoyl chloride is reacted with sodium iodide in a suitable solvent (such as acetone), and M-chloroiodobenzene is obtained through the process of reductive decarbonylation and iodization of acyl groups. In this reaction, the iodine anion of sodium iodide attacks the carbonyl carbon, and then carbon monoxide and chloride ions are removed to form the product.
Or it is synthesized by the reaction of m-chlorophenylboronic acid with iodine substitution reagent. M-chloroiodobenzene is synthesized by the reaction of m-chlorobenzoic acid and iodine elemental substance in a solvent (such as a mixture of dioxane and water) in the presence of a suitable catalyst (such as copper salt) and a base (such as potassium carbonate). The reaction goes through the transfer and rearrangement of In this process, the catalyst promotes the reaction, and the alkali adjusts the pH of the reaction system, which is conducive to the movement of the reaction balance to the direction of product formation.
The above methods have their own advantages and disadvantages, and should be selected reasonably according to actual needs, such as raw material availability, cost, product purity and other factors.
What are the precautions for M-chloroiodobenzene during storage and transportation?
M-chloroiodobenzene is an organic compound, and many things should be paid attention to when storing and transporting.
When storing, choose the first environment. It should be placed in a cool and well-ventilated place. Because of its certain chemical activity, high temperature can easily cause its reactivity to change, or cause decomposition and other adverse conditions. And it must be kept away from fire and heat sources, both of which may trigger chemical reactions and cause dangerous accidents.
Furthermore, it should be stored separately from oxidants, acids, bases and other substances. Due to the chemical properties of M-chloroiodobenzene, it is easy to react chemically, or generate harmful gases, or cause dangerous situations such as combustion and explosion.
Storage containers should also be selected with caution. Containers with good sealing performance should be used to prevent their volatilization and escape, pollute the environment, and avoid reactions with components in the air to ensure their chemical stability.
During transportation, it should not be ignored. Transportation vehicles must be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. If there is an accident such as leakage on the way, it can be dealt with in time to reduce the damage.
When handling, it should be handled lightly, and it should not be collided or under heavy pressure. It is damaged due to its chemical structure or due to severe impact or heavy pressure, which will cause chemical reactions and threaten transportation safety.
During transportation, it should also ensure that the container does not leak, collapse, fall, or damage. Strictly follow the prescribed route and do not stop in densely populated areas and residential areas. In this way, the safety of M-chloroiodobenzene during storage and transportation can be guaranteed to avoid dangerous accidents.
When storing, choose the first environment. It should be placed in a cool and well-ventilated place. Because of its certain chemical activity, high temperature can easily cause its reactivity to change, or cause decomposition and other adverse conditions. And it must be kept away from fire and heat sources, both of which may trigger chemical reactions and cause dangerous accidents.
Furthermore, it should be stored separately from oxidants, acids, bases and other substances. Due to the chemical properties of M-chloroiodobenzene, it is easy to react chemically, or generate harmful gases, or cause dangerous situations such as combustion and explosion.
Storage containers should also be selected with caution. Containers with good sealing performance should be used to prevent their volatilization and escape, pollute the environment, and avoid reactions with components in the air to ensure their chemical stability.
During transportation, it should not be ignored. Transportation vehicles must be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. If there is an accident such as leakage on the way, it can be dealt with in time to reduce the damage.
When handling, it should be handled lightly, and it should not be collided or under heavy pressure. It is damaged due to its chemical structure or due to severe impact or heavy pressure, which will cause chemical reactions and threaten transportation safety.
During transportation, it should also ensure that the container does not leak, collapse, fall, or damage. Strictly follow the prescribed route and do not stop in densely populated areas and residential areas. In this way, the safety of M-chloroiodobenzene during storage and transportation can be guaranteed to avoid dangerous accidents.
What are the effects of M-chloroiodobenzene on the environment and human health?
M-chloroiodobenzene is also an organic compound. Its impact on the environment and human health cannot be ignored.
At the environmental end, if M-chloroiodobenzene is released in nature, it is difficult to degrade in the environment due to its certain chemical stability. Or it exists in soil and water bodies, and is transmitted and enriched through the food chain. It can affect the community structure and activity of soil microorganisms, disturb the material cycle and energy conversion of soil ecosystems, and cause soil fertility to decline. In water bodies, it may harm aquatic organisms and interfere with their normal physiological functions, such as affecting the respiration and reproduction of fish, and reducing the population.
As for human health, M-chloroiodobenzene is ingested into the human body through respiration, skin contact or diet. It is fat-soluble and easily accumulates in human adipose tissue. It may damage the human nervous system, causing headaches, dizziness, fatigue, etc. Long-term exposure or neurological decline. It may also affect the human endocrine system, interfere with the normal secretion and regulation of hormones, and have adverse effects on reproduction and development, such as reduced reproductive capacity and abnormal fetal development. And studies have shown that it may be potentially carcinogenic, and long-term exposure can increase the risk of cancer. Therefore, in the production, use and disposal of M-chloroiodobenzene, due care should be taken, and proper protection and treatment measures should be taken to reduce its harm to the environment and human health.
At the environmental end, if M-chloroiodobenzene is released in nature, it is difficult to degrade in the environment due to its certain chemical stability. Or it exists in soil and water bodies, and is transmitted and enriched through the food chain. It can affect the community structure and activity of soil microorganisms, disturb the material cycle and energy conversion of soil ecosystems, and cause soil fertility to decline. In water bodies, it may harm aquatic organisms and interfere with their normal physiological functions, such as affecting the respiration and reproduction of fish, and reducing the population.
As for human health, M-chloroiodobenzene is ingested into the human body through respiration, skin contact or diet. It is fat-soluble and easily accumulates in human adipose tissue. It may damage the human nervous system, causing headaches, dizziness, fatigue, etc. Long-term exposure or neurological decline. It may also affect the human endocrine system, interfere with the normal secretion and regulation of hormones, and have adverse effects on reproduction and development, such as reduced reproductive capacity and abnormal fetal development. And studies have shown that it may be potentially carcinogenic, and long-term exposure can increase the risk of cancer. Therefore, in the production, use and disposal of M-chloroiodobenzene, due care should be taken, and proper protection and treatment measures should be taken to reduce its harm to the environment and human health.
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