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Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate
Linshang Chemical
|
HS Code |
309909 |
| Chemical Formula | C10H8BrClO2 |
| Molecular Weight | 263.526 g/mol |
| Appearance | Typically a solid (appearance can vary) |
| Boiling Point | Data may vary depending on purity and conditions |
| Melting Point | Data may vary depending on purity and conditions |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in many organic solvents like dichloromethane, chloroform |
| Density | Data may vary depending on purity and conditions |
| Flash Point | Data may vary depending on purity and conditions |
| Hazard Class | Can be a hazardous chemical, potentially corrosive and toxic |
As an accredited Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of Methyl Alpha - bromo - 2 - chlorobenzeneacetic Acetate in a sealed chemical - grade bottle. |
| Storage | Methyl Alpha - bromo - 2 - chlorobenzeneacetic Acetate should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to decomposition or reaction. Label the storage clearly for easy identification and safety. |
| Shipping | Methyl Alpha - bromo - 2 - chlorobenzeneacetic Acetate, a chemical, is shipped in specialized, leak - proof containers. These are carefully labeled and handled following strict safety regulations to ensure secure transportation. |
Competitive Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate prices that fit your budget—flexible terms and customized quotes for every order.
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Where to Buy Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate in China?
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As a leading Methyl Alpha-Bromo-2-Chlorobenzeneacetic Acetate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of Methyl Alpha-bromo-2-chlorobenzeneacetic Acetate?
Methyl-α-bromo-2-chlorophenylacetate ethyl ester is an important raw material for organic synthesis and has a wide range of uses.
First, it is very useful in the field of pharmaceutical synthesis. It can be used as a key intermediate in the preparation of many drugs. Taking the synthesis of some compounds with specific pharmacological activities as an example, methyl-α-bromo-2-chlorophenylacetate ethyl ester can participate in multi-step reactions due to its unique chemical structure. After ingenious transformation, complex drug molecular structures are constructed, which in turn lay the foundation for the development of new drugs.
Second, it also plays an important role in the creation of pesticides. The development of pesticides pursues high efficiency, low toxicity and environmental friendliness. This compound can be used as a starting material to derive pesticide active ingredients with insecticidal, bactericidal or weeding effects through a series of chemical reactions. Because of its structural characteristics, it endows the synthesized pesticide with a unique mechanism of action and biological activity, which helps to improve the performance of pesticides.
Furthermore, it is also indispensable for the synthesis of fine chemicals. Fine chemicals cover many fields such as fragrances and coating additives. Methyl-α-bromo-2-chlorophenylacetate ethyl ester can be used as an important building block for the synthesis of fine chemicals with special structures. By reacting with other reagents, specific functional groups are introduced to obtain fine chemicals that meet different needs and meet market requirements for high-quality and high-performance products. In conclusion, methyl-α-bromo-2-chlorophenylacetate ethyl ester plays an important role in many branches of organic synthesis, promoting the development and progress of the pharmaceutical, pesticide, and fine chemicals industries.
First, it is very useful in the field of pharmaceutical synthesis. It can be used as a key intermediate in the preparation of many drugs. Taking the synthesis of some compounds with specific pharmacological activities as an example, methyl-α-bromo-2-chlorophenylacetate ethyl ester can participate in multi-step reactions due to its unique chemical structure. After ingenious transformation, complex drug molecular structures are constructed, which in turn lay the foundation for the development of new drugs.
Second, it also plays an important role in the creation of pesticides. The development of pesticides pursues high efficiency, low toxicity and environmental friendliness. This compound can be used as a starting material to derive pesticide active ingredients with insecticidal, bactericidal or weeding effects through a series of chemical reactions. Because of its structural characteristics, it endows the synthesized pesticide with a unique mechanism of action and biological activity, which helps to improve the performance of pesticides.
Furthermore, it is also indispensable for the synthesis of fine chemicals. Fine chemicals cover many fields such as fragrances and coating additives. Methyl-α-bromo-2-chlorophenylacetate ethyl ester can be used as an important building block for the synthesis of fine chemicals with special structures. By reacting with other reagents, specific functional groups are introduced to obtain fine chemicals that meet different needs and meet market requirements for high-quality and high-performance products. In conclusion, methyl-α-bromo-2-chlorophenylacetate ethyl ester plays an important role in many branches of organic synthesis, promoting the development and progress of the pharmaceutical, pesticide, and fine chemicals industries.
What are the physical properties of Methyl Alpha-bromo-2-chlorobenzeneacetic Acetate?
Methyl-α-bromo-2-chlorophenylacetate ethyl ester is one of the organic compounds. Its physical properties are quite characteristic, let me tell them one by one.
Looking at its properties, under room temperature and pressure, it is mostly a colorless to pale yellow transparent liquid, with a relatively uniform texture and no obvious impurities and suspended solids. This compound has a certain volatility, but its volatility is not extremely strong, and it can be stored more stably in containers in ordinary environments.
When it comes to odor, it often emits a special aromatic smell, but this smell is not rich and pungent, but relatively mild, not too long in a closed space, or feel uncomfortable.
Its density is greater than that of water. If it is mixed with water, it will sink underwater, and the two are significantly stratified. Its melting point and boiling point are also important physical properties. The melting point is usually in a lower temperature range, and the specific value varies slightly according to factors such as preparation purity; the boiling point is relatively high, and a certain amount of heat is required to convert it from liquid to gaseous.
In terms of solubility, it exhibits good solubility in common organic solvents such as ethanol, ether, chloroform, etc., and can be miscible with these solvents in a certain proportion. This property is widely used in many fields such as organic synthesis. In water, its solubility is very small and almost insoluble. Due to the structural characteristics of the compound molecule, it is difficult to form an effective interaction with water molecules.
In summary, methyl-α-bromo-2-chlorophenylacetate ethyl ester has unique physical properties, which lays the foundation for its application in chemical, pharmaceutical and other fields.
Looking at its properties, under room temperature and pressure, it is mostly a colorless to pale yellow transparent liquid, with a relatively uniform texture and no obvious impurities and suspended solids. This compound has a certain volatility, but its volatility is not extremely strong, and it can be stored more stably in containers in ordinary environments.
When it comes to odor, it often emits a special aromatic smell, but this smell is not rich and pungent, but relatively mild, not too long in a closed space, or feel uncomfortable.
Its density is greater than that of water. If it is mixed with water, it will sink underwater, and the two are significantly stratified. Its melting point and boiling point are also important physical properties. The melting point is usually in a lower temperature range, and the specific value varies slightly according to factors such as preparation purity; the boiling point is relatively high, and a certain amount of heat is required to convert it from liquid to gaseous.
In terms of solubility, it exhibits good solubility in common organic solvents such as ethanol, ether, chloroform, etc., and can be miscible with these solvents in a certain proportion. This property is widely used in many fields such as organic synthesis. In water, its solubility is very small and almost insoluble. Due to the structural characteristics of the compound molecule, it is difficult to form an effective interaction with water molecules.
In summary, methyl-α-bromo-2-chlorophenylacetate ethyl ester has unique physical properties, which lays the foundation for its application in chemical, pharmaceutical and other fields.
What is the synthesis method of Methyl Alpha-bromo-2-chlorobenzeneacetic Acetate?
To prepare methyl-α-bromo-2-chlorophenylacetate ethyl ester, the method is as follows:
Take 2-chlorophenylacetic acid first, place it in a reaction kettle, and dissolve it with an appropriate amount of organic solvent, such as dichloromethane, which can make the reactants evenly dispersed and facilitate the reaction. The reaction system is cooled to a specific low temperature, such as 0-5 ° C, which can reduce the occurrence of side reactions. Slow dropwise addition of brominating agents, such as bromine, requires strict control of the speed during dropwise addition. Due to the violent bromination reaction, too fast dropwise addition is easy to cause the reaction to go out of control. After the dropwise addition, maintain a low temperature and continue the reaction for a period of time. The reaction progress is monitored by thin-layer chromatography. When the raw material point is basically eliminated, it indicates that the bromination reaction of 2-chlorophenylacetic acid is basically completed, and α-bromo-2-chlorophenylacetic acid is obtained.
Then, α-bromo-2-chlorophenylacetic acid is mixed with ethanol and concentrated sulfuric acid in a certain proportion. Concentrated sulfuric acid is used as a catalyst to accelerate the esterification reaction. Heat up to a suitable temperature, such as 60-80 ° C, and carry out a reflux reaction. During the reaction process, the water generated by the reaction is continuously evaporated, so that the reaction equilibrium moves in the direction of ester formation. After several hours of reaction, no more water is
Next, the cooled reaction solution is poured into a separation funnel and washed with a saturated sodium bicarbonate solution to remove unreacted acid and residual concentrated sulfuric acid. At this time, a stratification phenomenon can be seen. The organic layer is on the top and the water layer is on the bottom, and the organic layer is separated. Then the organic layer is dried with anhydrous magnesium sulfate to remove the residual water. Finally, the organic solvent is removed by reduced pressure distillation, and the fraction with a specific boiling point range is collected to obtain methyl-α-bromo-2-chlorophenylacetate ethyl ester. The whole preparation process requires strict control of the reaction conditions and steps to ensure the purity and yield of the product.
Take 2-chlorophenylacetic acid first, place it in a reaction kettle, and dissolve it with an appropriate amount of organic solvent, such as dichloromethane, which can make the reactants evenly dispersed and facilitate the reaction. The reaction system is cooled to a specific low temperature, such as 0-5 ° C, which can reduce the occurrence of side reactions. Slow dropwise addition of brominating agents, such as bromine, requires strict control of the speed during dropwise addition. Due to the violent bromination reaction, too fast dropwise addition is easy to cause the reaction to go out of control. After the dropwise addition, maintain a low temperature and continue the reaction for a period of time. The reaction progress is monitored by thin-layer chromatography. When the raw material point is basically eliminated, it indicates that the bromination reaction of 2-chlorophenylacetic acid is basically completed, and α-bromo-2-chlorophenylacetic acid is obtained.
Then, α-bromo-2-chlorophenylacetic acid is mixed with ethanol and concentrated sulfuric acid in a certain proportion. Concentrated sulfuric acid is used as a catalyst to accelerate the esterification reaction. Heat up to a suitable temperature, such as 60-80 ° C, and carry out a reflux reaction. During the reaction process, the water generated by the reaction is continuously evaporated, so that the reaction equilibrium moves in the direction of ester formation. After several hours of reaction, no more water is
Next, the cooled reaction solution is poured into a separation funnel and washed with a saturated sodium bicarbonate solution to remove unreacted acid and residual concentrated sulfuric acid. At this time, a stratification phenomenon can be seen. The organic layer is on the top and the water layer is on the bottom, and the organic layer is separated. Then the organic layer is dried with anhydrous magnesium sulfate to remove the residual water. Finally, the organic solvent is removed by reduced pressure distillation, and the fraction with a specific boiling point range is collected to obtain methyl-α-bromo-2-chlorophenylacetate ethyl ester. The whole preparation process requires strict control of the reaction conditions and steps to ensure the purity and yield of the product.
Methyl Alpha-bromo-2-chlorobenzeneacetic Acetate in storage and transportation
Methyl-alpha-bromo-2-chlorophenylacetate ethyl ester, this is an organic compound. When storing and transporting, there are many things to pay attention to.
The first priority is safety, because it has certain chemical activity or potential danger. Storage must be in a cool, dry and well-ventilated place, away from fire and heat sources to prevent fire or chemical reactions. It should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. It may react violently with these substances and cause accidents.
Packaging is also crucial, and it must be ensured that it is tightly sealed to avoid leakage. During transportation, it should be properly fixed to prevent damage to the container. The means of transportation used must be clean, dry, and comply with relevant dangerous goods transportation regulations. The escort personnel should also be familiar with its characteristics and emergency treatment methods.
Storage temperature also needs to be strictly controlled, too high temperature may cause it to decompose and deteriorate. The storage status should also be checked regularly to see if there are any leaks, packaging damage and other abnormalities. If there is a leak, emergency measures should be taken quickly, such as evacuating people, cutting off the fire source, and using suitable materials to absorb or neutralize the leak. When transporting, follow the established route and do not stop in densely populated areas or traffic arteries. In this way, the safety of methyl-α-bromo-2-chlorophenylacetate can be ensured during storage and transportation.
The first priority is safety, because it has certain chemical activity or potential danger. Storage must be in a cool, dry and well-ventilated place, away from fire and heat sources to prevent fire or chemical reactions. It should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. It may react violently with these substances and cause accidents.
Packaging is also crucial, and it must be ensured that it is tightly sealed to avoid leakage. During transportation, it should be properly fixed to prevent damage to the container. The means of transportation used must be clean, dry, and comply with relevant dangerous goods transportation regulations. The escort personnel should also be familiar with its characteristics and emergency treatment methods.
Storage temperature also needs to be strictly controlled, too high temperature may cause it to decompose and deteriorate. The storage status should also be checked regularly to see if there are any leaks, packaging damage and other abnormalities. If there is a leak, emergency measures should be taken quickly, such as evacuating people, cutting off the fire source, and using suitable materials to absorb or neutralize the leak. When transporting, follow the established route and do not stop in densely populated areas or traffic arteries. In this way, the safety of methyl-α-bromo-2-chlorophenylacetate can be ensured during storage and transportation.
Effects of Methyl Alpha-bromo-2-chlorobenzeneacetic Acetate on the Environment and Human Health
Methyl-α-bromo-2-chlorophenylacetate ethyl ester is related to the environment and human health, and the impact is particularly complex.
At the environmental end, it may be persistent. If released in nature, due to its chemical structure, it is difficult to be rapidly decomposed by natural degradation mechanisms, and it is easy to persist in soil and water bodies for a long time. In this way, it may cause damage to soil fertility, affect the absorption of nutrients by plant roots, and hinder plant growth. In water bodies, it will interfere with aquatic ecosystems and affect the survival and reproduction of aquatic organisms. It may have toxic effects on plankton, fish, etc., destroy the balance of the food chain, and trigger a chain reaction in the ecosystem.
As for human health, it may cause harm through various channels. If ingested orally, the substance may irritate the digestive system, causing nausea, vomiting, abdominal pain and other diseases. And because it contains bromine, chlorine and other halogen elements, or is enriched in the body, it damages important organs such as the liver and kidneys. If skin contact, or cause contact dermatitis, symptoms such as redness, swelling, itching, and blisters appear. Long-term exposure may increase the risk of cancer. Because of its structure or mutagenicity, it interferes with the normal gene expression and regulation of human cells, causing abnormal cell proliferation and eventually carcinogenesis.
In summary, methyl-α-bromo-2-chlorophenylacetate ethyl ester poses a potential threat to both the environment and human health, and needs to be treated with caution and its use and emission should be reasonably controlled.
At the environmental end, it may be persistent. If released in nature, due to its chemical structure, it is difficult to be rapidly decomposed by natural degradation mechanisms, and it is easy to persist in soil and water bodies for a long time. In this way, it may cause damage to soil fertility, affect the absorption of nutrients by plant roots, and hinder plant growth. In water bodies, it will interfere with aquatic ecosystems and affect the survival and reproduction of aquatic organisms. It may have toxic effects on plankton, fish, etc., destroy the balance of the food chain, and trigger a chain reaction in the ecosystem.
As for human health, it may cause harm through various channels. If ingested orally, the substance may irritate the digestive system, causing nausea, vomiting, abdominal pain and other diseases. And because it contains bromine, chlorine and other halogen elements, or is enriched in the body, it damages important organs such as the liver and kidneys. If skin contact, or cause contact dermatitis, symptoms such as redness, swelling, itching, and blisters appear. Long-term exposure may increase the risk of cancer. Because of its structure or mutagenicity, it interferes with the normal gene expression and regulation of human cells, causing abnormal cell proliferation and eventually carcinogenesis.
In summary, methyl-α-bromo-2-chlorophenylacetate ethyl ester poses a potential threat to both the environment and human health, and needs to be treated with caution and its use and emission should be reasonably controlled.
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