Linshang Chemical
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N-(3-Chloro-2-Methylphenyl)-4-Methylbenzenesulfonamide
Linshang Chemical
|
HS Code |
980923 |
| Chemical Formula | C14H14ClNO2S |
| Molecular Weight | 295.785 |
| Appearance | Solid (Typical) |
As an accredited N-(3-Chloro-2-Methylphenyl)-4-Methylbenzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram pack of N-(3 - chloro - 2 - methylphenyl)-4 - methylbenzenesulfonamide in sealed pouch. |
| Storage | Store N-(3 - chloro - 2 - methylphenyl)-4 - methylbenzenesulfonamide in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly closed container to prevent moisture absorption and potential degradation. Avoid storing near incompatible substances to prevent chemical reactions. |
| Shipping | N-(3 - chloro - 2 - methylphenyl)-4 - methylbenzenesulfonamide is a chemical. Shipping requires proper packaging in accordance with chemical regulations to prevent spills and ensure safe transport, often via approved hazardous materials carriers. |
Competitive N-(3-Chloro-2-Methylphenyl)-4-Methylbenzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide?
This is the chemical structure analysis of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide. Looking at its name, its structure can be dissected step by step.
The first word "4-methylbenzenesulfonamide" indicates that there is a benzene ring, which is connected to methyl (-CH 🥰) at position 4, and the benzene ring is connected to the sulfonamide group (-SO 2O NH 2O). In the sulfonamide group, the sulfur atom (S) is connected to two oxygen atoms (O) in a double bond, and at the same time to the nitrogen atom (N).
Look again at "N- (3-chloro-2-methylphenyl) ", which means that the nitrogen atom (N) is connected to another benzene ring, which is substituted by a chlorine atom (-Cl) at position 3 and a methyl (-CH 🥰) at position 2.
In summary, the structure of this compound consists of two benzene rings connected by nitrogen atoms. One benzene ring has a methyl group at position 4 and a sulfonamide group; the other benzene ring has a chlorine atom at position 3 and a methyl group at position 2. In this way, the chemical structure of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide is outlined.
The first word "4-methylbenzenesulfonamide" indicates that there is a benzene ring, which is connected to methyl (-CH 🥰) at position 4, and the benzene ring is connected to the sulfonamide group (-SO 2O NH 2O). In the sulfonamide group, the sulfur atom (S) is connected to two oxygen atoms (O) in a double bond, and at the same time to the nitrogen atom (N).
Look again at "N- (3-chloro-2-methylphenyl) ", which means that the nitrogen atom (N) is connected to another benzene ring, which is substituted by a chlorine atom (-Cl) at position 3 and a methyl (-CH 🥰) at position 2.
In summary, the structure of this compound consists of two benzene rings connected by nitrogen atoms. One benzene ring has a methyl group at position 4 and a sulfonamide group; the other benzene ring has a chlorine atom at position 3 and a methyl group at position 2. In this way, the chemical structure of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide is outlined.
What are the main uses of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide?
N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide is one of the organic compounds. It has a wide range of uses in modern chemistry.
First, in the field of medicine, this compound may be used as an important intermediate in drug synthesis. Due to the delicacy of pharmaceutical synthesis, various intermediates with specific structures are required as bases to construct drug molecules with specific pharmacological activities. The unique molecular structure of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide can be combined with other compounds through various chemical reactions, and then derived drugs with the effect of treating specific diseases.
Second, it may also have a place in the field of materials science. Or it can participate in the synthesis process of polymer materials, through its reaction with polymer monomers, giving polymer materials different properties. Such as improving the thermal stability and mechanical properties of materials, so that materials have better application performance in many fields such as electronics and aviation.
Furthermore, in agricultural chemistry, it can be used as a raw material for pesticide synthesis. Through chemical modification and transformation, a new type of pesticide with high efficiency in killing or repelling pests, environmentally friendly and harmless to crops has been created. In this way, it can not only ensure the yield and quality of crops, but also meet the needs of current green agriculture development.
In summary, although N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide is an organic compound, it has great application potential and value in many fields such as medicine, materials, and agricultural chemistry. It is an important substance that cannot be ignored in chemical research and industrial production.
First, in the field of medicine, this compound may be used as an important intermediate in drug synthesis. Due to the delicacy of pharmaceutical synthesis, various intermediates with specific structures are required as bases to construct drug molecules with specific pharmacological activities. The unique molecular structure of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide can be combined with other compounds through various chemical reactions, and then derived drugs with the effect of treating specific diseases.
Second, it may also have a place in the field of materials science. Or it can participate in the synthesis process of polymer materials, through its reaction with polymer monomers, giving polymer materials different properties. Such as improving the thermal stability and mechanical properties of materials, so that materials have better application performance in many fields such as electronics and aviation.
Furthermore, in agricultural chemistry, it can be used as a raw material for pesticide synthesis. Through chemical modification and transformation, a new type of pesticide with high efficiency in killing or repelling pests, environmentally friendly and harmless to crops has been created. In this way, it can not only ensure the yield and quality of crops, but also meet the needs of current green agriculture development.
In summary, although N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide is an organic compound, it has great application potential and value in many fields such as medicine, materials, and agricultural chemistry. It is an important substance that cannot be ignored in chemical research and industrial production.
What are the physical properties of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide?
N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide is one of the organic compounds. Its physical properties are quite important, let me describe them in detail for you.
Looking at its properties, under normal circumstances, it is mostly white to white crystalline powder. This form is easy to identify and operate, and is easy to use and dispose of in many experimental and industrial processes.
When it comes to melting point, it is about a specific temperature range. The determination of melting point is a key indicator for identifying this compound and determining its purity. Because the melting point of pure products is relatively fixed, if it contains impurities, the melting point may be offset, and the melting range will also be widened.
Furthermore, solubility is also an important property. In organic solvents such as ethanol and acetone, it may have a certain solubility. This property makes it possible to select an appropriate solvent according to its solubility in the process of preparation, separation and purification to achieve the desired purpose. In water, its solubility is poor, which is determined by the characteristics of its molecular structure. The hydrophobic part of the molecule accounts for a large proportion, making it difficult to dissolve in the polar aqueous phase.
In addition, its density is also a specific value. Although this value may be rarely a daily concern, in some application scenarios involving accurate measurement and phase equilibrium, the accurate knowledge of density has a significant impact on process design and operation.
The physical properties of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide, such as the properties of white crystalline powder, specific melting point, solubility and density in different solvents, etc., are of critical significance in the fields of chemical research and chemical production, providing an important basis for the smooth development of related work.
Looking at its properties, under normal circumstances, it is mostly white to white crystalline powder. This form is easy to identify and operate, and is easy to use and dispose of in many experimental and industrial processes.
When it comes to melting point, it is about a specific temperature range. The determination of melting point is a key indicator for identifying this compound and determining its purity. Because the melting point of pure products is relatively fixed, if it contains impurities, the melting point may be offset, and the melting range will also be widened.
Furthermore, solubility is also an important property. In organic solvents such as ethanol and acetone, it may have a certain solubility. This property makes it possible to select an appropriate solvent according to its solubility in the process of preparation, separation and purification to achieve the desired purpose. In water, its solubility is poor, which is determined by the characteristics of its molecular structure. The hydrophobic part of the molecule accounts for a large proportion, making it difficult to dissolve in the polar aqueous phase.
In addition, its density is also a specific value. Although this value may be rarely a daily concern, in some application scenarios involving accurate measurement and phase equilibrium, the accurate knowledge of density has a significant impact on process design and operation.
The physical properties of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide, such as the properties of white crystalline powder, specific melting point, solubility and density in different solvents, etc., are of critical significance in the fields of chemical research and chemical production, providing an important basis for the smooth development of related work.
What is the synthesis method of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide?
To prepare N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide, the following method can be followed.
Take 3-chloro-2-methylaniline as the starting material, which has an amino activity check point. Mix 4-methylbenzenesulfonyl chloride with an appropriate amount of organic solvent such as dichloromethane to prepare a solution. Under low temperature and stirring, the solution of 3-chloro-2-methylaniline is slowly dropped into the solution of 4-methylbenzenesulfonyl chloride. Due to the high activity of acid chloride, nucleophilic substitution is prone to occur when encountering amine groups. This process requires a weak base such as pyridine or triethylamine as an acid binding agent, which can combine with the hydrogen chloride generated by the reaction to promote the forward reaction.
In the reaction, the amine nitrogen atom of 3-chloro-2-methylaniline launches a nucleophilic attack on the carbonyl carbon of 4-methylbenzenesulfonyl chloride, and the chlorine atom leaves to form an intermediate transition state. Then the proton is removed to obtain the target product N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide.
After the reaction is completed, the reaction solution can be poured into an appropriate amount of water, the product can be extracted with an organic solvent, the organic phase can be collected, dried with anhydrous sodium sulfate, and the solvent can be removed by reduced pressure distillation. The crude product is purified by column chromatography or recrystallization to obtain pure N- (3-chloro-2-methylphenyl) -4 -methylbenzenesulfonamide. In this way, according to the above steps and conditions, the compound can be prepared.
Take 3-chloro-2-methylaniline as the starting material, which has an amino activity check point. Mix 4-methylbenzenesulfonyl chloride with an appropriate amount of organic solvent such as dichloromethane to prepare a solution. Under low temperature and stirring, the solution of 3-chloro-2-methylaniline is slowly dropped into the solution of 4-methylbenzenesulfonyl chloride. Due to the high activity of acid chloride, nucleophilic substitution is prone to occur when encountering amine groups. This process requires a weak base such as pyridine or triethylamine as an acid binding agent, which can combine with the hydrogen chloride generated by the reaction to promote the forward reaction.
In the reaction, the amine nitrogen atom of 3-chloro-2-methylaniline launches a nucleophilic attack on the carbonyl carbon of 4-methylbenzenesulfonyl chloride, and the chlorine atom leaves to form an intermediate transition state. Then the proton is removed to obtain the target product N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide.
After the reaction is completed, the reaction solution can be poured into an appropriate amount of water, the product can be extracted with an organic solvent, the organic phase can be collected, dried with anhydrous sodium sulfate, and the solvent can be removed by reduced pressure distillation. The crude product is purified by column chromatography or recrystallization to obtain pure N- (3-chloro-2-methylphenyl) -4 -methylbenzenesulfonamide. In this way, according to the above steps and conditions, the compound can be prepared.
N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide safety precautions
N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide is a chemical substance. When using and handling, it is necessary to pay attention to many safety measures to avoid endangering yourself and the surrounding environment.
First, protective measures are essential. This substance may be harmful to the human body. When exposed, be fully armed. Eye protection is indispensable. Wearing goggles can prevent it from splashing into the eyes and avoid injury. The hands also need to be properly protected. Wear suitable gloves to prevent skin contact and avoid allergies or other adverse reactions. Respiratory protection should not be underestimated. In areas with poor ventilation, wear a gas mask to prevent inhalation of dust or steam to avoid damage to the respiratory tract.
Second, storage is also exquisite. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its nature or instability, it may be dangerous to be heated or exposed to open flames. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed to prevent chemical reactions and cause safety accidents.
Third, be careful when operating. Operating in a fume hood can effectively reduce its concentration in the air and reduce the harm to the human body. During the operation, do not eat, drink or smoke, so as not to eat or inhale by mistake and endanger health. After use, clean up the operation area in time to prevent pollution caused by residual substances.
Fourth, emergency treatment should not be ignored. If you accidentally come into contact with this substance, you should take corresponding measures immediately. If it comes into contact with the skin, quickly rinse with a large amount of flowing water for at least 15 minutes, and then seek medical treatment; if it splashes into the eyes, immediately lift the eyelids, rinse thoroughly with a large amount of flowing water or normal saline, and seek medical attention as soon as possible; if accidentally inhaled, quickly evacuate the scene to fresh air, keep the respiratory tract unobstructed, if breathing difficulties, give oxygen, if breathing stops, immediately perform artificial respiration, and seek medical attention quickly; if ingested, do not induce vomiting, seek medical attention immediately, follow the doctor's instructions for treatment.
In conclusion, the safe use of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide is of paramount importance and must not be taken lightly to avoid catastrophe.
First, protective measures are essential. This substance may be harmful to the human body. When exposed, be fully armed. Eye protection is indispensable. Wearing goggles can prevent it from splashing into the eyes and avoid injury. The hands also need to be properly protected. Wear suitable gloves to prevent skin contact and avoid allergies or other adverse reactions. Respiratory protection should not be underestimated. In areas with poor ventilation, wear a gas mask to prevent inhalation of dust or steam to avoid damage to the respiratory tract.
Second, storage is also exquisite. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its nature or instability, it may be dangerous to be heated or exposed to open flames. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed to prevent chemical reactions and cause safety accidents.
Third, be careful when operating. Operating in a fume hood can effectively reduce its concentration in the air and reduce the harm to the human body. During the operation, do not eat, drink or smoke, so as not to eat or inhale by mistake and endanger health. After use, clean up the operation area in time to prevent pollution caused by residual substances.
Fourth, emergency treatment should not be ignored. If you accidentally come into contact with this substance, you should take corresponding measures immediately. If it comes into contact with the skin, quickly rinse with a large amount of flowing water for at least 15 minutes, and then seek medical treatment; if it splashes into the eyes, immediately lift the eyelids, rinse thoroughly with a large amount of flowing water or normal saline, and seek medical attention as soon as possible; if accidentally inhaled, quickly evacuate the scene to fresh air, keep the respiratory tract unobstructed, if breathing difficulties, give oxygen, if breathing stops, immediately perform artificial respiration, and seek medical attention quickly; if ingested, do not induce vomiting, seek medical attention immediately, follow the doctor's instructions for treatment.
In conclusion, the safe use of N- (3-chloro-2-methylphenyl) -4-methylbenzenesulfonamide is of paramount importance and must not be taken lightly to avoid catastrophe.
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