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N-(5-Chloro-3-Pyrazine)-4-Aminobenzenesulfonamino
Linshang Chemical
|
HS Code |
529902 |
As an accredited N-(5-Chloro-3-Pyrazine)-4-Aminobenzenesulfonamino factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of "N-(5 - chloro - 3 - pyrazine)-4 - aminobenzenesulfonamino" in sealed chemical - grade packaging. |
| Storage | Store “N-(5 - chloro - 3 - pyrazine)-4 - aminobenzenesulfonamino” in a cool, dry place, away from heat sources and direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and contamination. It should be stored separately from incompatible substances, such as strong oxidizers or acids, in a dedicated chemical storage area with proper ventilation. |
| Shipping | The chemical "N-(5 - chloro - 3 - pyrazine)-4 - aminobenzenesulfonamino" will be shipped in well - sealed, corrosion - resistant containers. Shipment will follow strict hazardous chemical transport regulations to ensure safety during transit. |
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What is the chemical structure of N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamino?
"N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamide", its structure can be seen from the self-name.
First look at the "4-aminobenzenesulfonamide" part, which is based on the benzene ring, and the counterposition of the benzene ring. One is an amino group (-NH2O) and the other is a sulfonamide group (-SO2O NH2O). In the sulfonamide group, the sulfur atom is connected to two oxygen atoms by a double bond, and it is also connected to the nitrogen atom. This nitrogen atom is connected to the carbon atom of the benzene ring, forming the basic structure of benzenesulfonamide.
Look at "5-chloro-3-pyrazine" again. Pyrazine is a six-membered heterocycle containing two nitrogen atoms, and the two nitrogen atoms are in the opposite position. At position 3 of the pyrazine ring, there are other groups connected, while position 5 is replaced by a chlorine atom (-Cl).
In the name of this compound, "N- (5-chloro-3-pyrazine) " means that the pyrazine ring is connected to the nitrogen atom of the benzenesulfonamide part through a certain bond. It is probably connected by a covalent bond between a carbon atom and a nitrogen atom on the pyrazine ring, so the chemical structure of this "N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamide" is obtained. Although the description is brief, it has tried its best to describe the structure of this complex compound in ancient words.
What are the physical properties of N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamino?
The physical properties of N- (5-chloro-3-pyrazinyl) -4 -aminobenzenesulfonamide are crucial and are related to many uses.
Its appearance is often in the shape of white to off-white crystalline powder, which is easy to identify and distinguish. Looking at it, the color is pure and the texture is delicate, just like the snow that falls at the beginning of winter, delicate and regular.
When it comes to solubility, in water, its solubility is very small, just like a boat is difficult to walk in a shoal, and it is difficult to spread freely. However, in some organic solvents, such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), it can exhibit good solubility, just like fish getting water, and can be dispersed more uniformly. This difference in solubility has far-reaching implications in drug development and chemical synthesis, and is related to the process of the reaction and the purity of the product.
Melting point is also one of its important physical properties. Its melting point is relatively high, and within a specific temperature range, it will change from solid to liquid. The precise control of this temperature limit is crucial in production and quality control. If there is a slight deviation in temperature, it may cause changes in product quality.
Furthermore, its density also has a specific value. Although it is not as heavy as gold and silver, it plays an important role in the relationship between the quantity and volume of the substance. The stability of density can ensure that the product has similar physical characteristics between different batches and maintain the uniformity of product quality.
In addition, the stability of this substance cannot be ignored. It can exist relatively stably in a dry and clean environment at room temperature and pressure. However, if it encounters high temperature, high humidity, or comes into contact with specific chemical substances, or undergoes chemical changes, its structure and properties will change. The physical properties of N- (5-chloro-3-pyrazinyl) -4-aminobenzenesulfonamide, from appearance to solubility, melting point, density and stability, are interrelated and play a unique and critical role in various applications.
Its appearance is often in the shape of white to off-white crystalline powder, which is easy to identify and distinguish. Looking at it, the color is pure and the texture is delicate, just like the snow that falls at the beginning of winter, delicate and regular.
When it comes to solubility, in water, its solubility is very small, just like a boat is difficult to walk in a shoal, and it is difficult to spread freely. However, in some organic solvents, such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), it can exhibit good solubility, just like fish getting water, and can be dispersed more uniformly. This difference in solubility has far-reaching implications in drug development and chemical synthesis, and is related to the process of the reaction and the purity of the product.
Melting point is also one of its important physical properties. Its melting point is relatively high, and within a specific temperature range, it will change from solid to liquid. The precise control of this temperature limit is crucial in production and quality control. If there is a slight deviation in temperature, it may cause changes in product quality.
Furthermore, its density also has a specific value. Although it is not as heavy as gold and silver, it plays an important role in the relationship between the quantity and volume of the substance. The stability of density can ensure that the product has similar physical characteristics between different batches and maintain the uniformity of product quality.
In addition, the stability of this substance cannot be ignored. It can exist relatively stably in a dry and clean environment at room temperature and pressure. However, if it encounters high temperature, high humidity, or comes into contact with specific chemical substances, or undergoes chemical changes, its structure and properties will change. The physical properties of N- (5-chloro-3-pyrazinyl) -4-aminobenzenesulfonamide, from appearance to solubility, melting point, density and stability, are interrelated and play a unique and critical role in various applications.
What are the main uses of N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamino?
N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamide, which is widely used. In the field of medicine, it is often the key raw material for the creation of new antibacterial drugs. Because of its unique chemical structure, it has a significant inhibitory effect on the growth and reproduction of specific bacteria. Based on it, doctors have carefully developed a series of antibacterial drugs to help patients resist the invasion of bacteria and restore health.
In agriculture, N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamide also plays an important role. Can be made into pesticides to help protect crops. It can effectively kill many pests and pathogens that harm crops, ensure the strong growth of crops, improve food production, and contribute to the food and clothing of the people all over the world.
In addition, in the field of chemical research, it is also an important research object. Scientists use it as a starting material, and through various experiments and explorations, try to develop more new materials and new substances with excellent performance, promote the continuous development of chemical technology, and bring more novel and useful things to the world. In short, N- (5-chloro-3-pyrazine) - 4-aminobenzenesulfonamide occupies a key position in many fields such as medicine, agriculture, and chemical research, and has a profound impact on the lives of the world and the progress of science and technology.
In agriculture, N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamide also plays an important role. Can be made into pesticides to help protect crops. It can effectively kill many pests and pathogens that harm crops, ensure the strong growth of crops, improve food production, and contribute to the food and clothing of the people all over the world.
In addition, in the field of chemical research, it is also an important research object. Scientists use it as a starting material, and through various experiments and explorations, try to develop more new materials and new substances with excellent performance, promote the continuous development of chemical technology, and bring more novel and useful things to the world. In short, N- (5-chloro-3-pyrazine) - 4-aminobenzenesulfonamide occupies a key position in many fields such as medicine, agriculture, and chemical research, and has a profound impact on the lives of the world and the progress of science and technology.
What are the synthesis methods of N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamino?
To prepare N- (5-chloro-3-pyrazinyl) -4-aminobenzenesulfonamide, the following ancient method can be used.
The first 4-aminobenzenesulfonamide is taken as the base material, which is used in the field of organic synthesis and is often used as the basis for constructing sulfonamide structures. An appropriate amount of 4-aminobenzenesulfonamide is placed in a clean reactor to dissolve in a suitable organic solvent. The organic solvent should have good solubility and no side reactions with the reactants and products, such as N, N-dimethylformamide (DMF), which can provide a stable homogeneous environment for subsequent reactions.
5-chloro-3-halopyrazine is prepared for the second time. The halogen atom of halopyrazine is quite active, which is conducive to the occurrence of nucleophilic substitution reactions. Add 5-chloro-3-halopyrazine slowly to the solution containing 4-aminobenzenesulfonamide, and add an appropriate amount of base. The base can promote the formation of nucleophilic reagents (4-aminobenzenesulfonamide amino group) and speed up the reaction process. Weak bases such as potassium carbonate and sodium carbonate are commonly used to precisely regulate the reaction rate and selectivity.
When reacting, the temperature needs to be strictly controlled. If the temperature is too low, the reaction rate is slow and time-consuming; if the temperature is too high, side reactions will easily occur, resulting in poor product purity. Generally, the temperature is controlled in a moderate range, such as between 60 and 80 ° C. At this temperature range, the reaction can be carried out efficiently while ensuring the purity and yield of the product. At the same time, continue to stir with a magnetic stirrer to make the reactants fully contact and the reaction is uniform.
After the reaction is completed, pour the reaction solution into an appropriate amount of ice water, and the product may precipitate due to changes in solubility. The crude product is obtained by filtration. The crude product contains impurities and needs to be further purified. Recrystallization is often used to select a suitable solvent, such as ethanol-water mixed solvent. According to the difference in solubility between the product and impurities in different solvents, multiple recrystallization is used to obtain high purity N- (5-chloro-3-pyrazinyl) -4 -aminobenzenesulfonamide.
This is an ancient method for preparing N- (5-chloro-3-pyrazinyl) -4 -aminobenzenesulfonamide. Although the steps are complicated, fine operation can lead to good products.
The first 4-aminobenzenesulfonamide is taken as the base material, which is used in the field of organic synthesis and is often used as the basis for constructing sulfonamide structures. An appropriate amount of 4-aminobenzenesulfonamide is placed in a clean reactor to dissolve in a suitable organic solvent. The organic solvent should have good solubility and no side reactions with the reactants and products, such as N, N-dimethylformamide (DMF), which can provide a stable homogeneous environment for subsequent reactions.
5-chloro-3-halopyrazine is prepared for the second time. The halogen atom of halopyrazine is quite active, which is conducive to the occurrence of nucleophilic substitution reactions. Add 5-chloro-3-halopyrazine slowly to the solution containing 4-aminobenzenesulfonamide, and add an appropriate amount of base. The base can promote the formation of nucleophilic reagents (4-aminobenzenesulfonamide amino group) and speed up the reaction process. Weak bases such as potassium carbonate and sodium carbonate are commonly used to precisely regulate the reaction rate and selectivity.
When reacting, the temperature needs to be strictly controlled. If the temperature is too low, the reaction rate is slow and time-consuming; if the temperature is too high, side reactions will easily occur, resulting in poor product purity. Generally, the temperature is controlled in a moderate range, such as between 60 and 80 ° C. At this temperature range, the reaction can be carried out efficiently while ensuring the purity and yield of the product. At the same time, continue to stir with a magnetic stirrer to make the reactants fully contact and the reaction is uniform.
After the reaction is completed, pour the reaction solution into an appropriate amount of ice water, and the product may precipitate due to changes in solubility. The crude product is obtained by filtration. The crude product contains impurities and needs to be further purified. Recrystallization is often used to select a suitable solvent, such as ethanol-water mixed solvent. According to the difference in solubility between the product and impurities in different solvents, multiple recrystallization is used to obtain high purity N- (5-chloro-3-pyrazinyl) -4 -aminobenzenesulfonamide.
This is an ancient method for preparing N- (5-chloro-3-pyrazinyl) -4 -aminobenzenesulfonamide. Although the steps are complicated, fine operation can lead to good products.
What are the safety precautions for N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamino?
N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamide, this is a chemical substance. Regarding its safety precautions, it needs to be detailed.
Bear the brunt, this substance is chemically active, or reacts with other chemical reagents, causing accidental accidents. During operation, be sure to understand its chemical properties and avoid mixing with incompatible substances. If you encounter unknown chemicals, do not mix them rashly. Check the reaction characteristics first to prevent violent reactions, fires or even explosions.
Furthermore, exposure to this substance may pose a health risk. It may be absorbed through the skin, inhaled through the mouth and nose, or taken by mistake. Therefore, when operating, protective gear is indispensable. Protective clothing is required to protect the skin of the whole body; protective gloves are worn to avoid direct contact with the skin; protective masks and masks are equipped to prevent the inhalation of small particles or gases. If you accidentally touch it, rinse it with plenty of water as soon as possible; if it enters the eye, rinse it immediately and seek medical attention as soon as possible.
When storing, you should also be cautious. It should be placed in a dry, cool and well-ventilated place, away from fire and heat sources, to prevent environmental factors such as temperature and humidity from causing it to deteriorate or cause danger. Labels must be clearly marked, indicating key information such as chemical names, characteristics, and hazard warnings for easy access and management.
In the place of use, emergency equipment should be readily available. Such as eye washers, spray devices, etc., in case of emergencies. Operators should also be familiar with emergency handling procedures. In case of emergencies, they can respond quickly and properly to minimize harm. In short, the operation of N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamide must strictly follow safety procedures and must not be negligent.
Bear the brunt, this substance is chemically active, or reacts with other chemical reagents, causing accidental accidents. During operation, be sure to understand its chemical properties and avoid mixing with incompatible substances. If you encounter unknown chemicals, do not mix them rashly. Check the reaction characteristics first to prevent violent reactions, fires or even explosions.
Furthermore, exposure to this substance may pose a health risk. It may be absorbed through the skin, inhaled through the mouth and nose, or taken by mistake. Therefore, when operating, protective gear is indispensable. Protective clothing is required to protect the skin of the whole body; protective gloves are worn to avoid direct contact with the skin; protective masks and masks are equipped to prevent the inhalation of small particles or gases. If you accidentally touch it, rinse it with plenty of water as soon as possible; if it enters the eye, rinse it immediately and seek medical attention as soon as possible.
When storing, you should also be cautious. It should be placed in a dry, cool and well-ventilated place, away from fire and heat sources, to prevent environmental factors such as temperature and humidity from causing it to deteriorate or cause danger. Labels must be clearly marked, indicating key information such as chemical names, characteristics, and hazard warnings for easy access and management.
In the place of use, emergency equipment should be readily available. Such as eye washers, spray devices, etc., in case of emergencies. Operators should also be familiar with emergency handling procedures. In case of emergencies, they can respond quickly and properly to minimize harm. In short, the operation of N- (5-chloro-3-pyrazine) -4-aminobenzenesulfonamide must strictly follow safety procedures and must not be negligent.
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