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N,N-Bis(2-Chloroethyl)Benzenemethanaminehydrochloride
Linshang Chemical
|
HS Code |
834203 |
| Chemical Formula | C11H16Cl3N |
| Molar Mass | 266.61 g/mol |
| Appearance | Solid |
| Solubility In Water | Soluble |
| Melting Point | 119 - 121 °C |
| Vapor Pressure | Very low (solid compound) |
| Odor | Typically has an odor associated with organic chloro - amine compounds |
As an accredited N,N-Bis(2-Chloroethyl)Benzenemethanaminehydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of N,n - bis(2 - chloroethyl)benzenemethanamine hydrochloride in sealed chemical - grade pouch. |
| Storage | N,n - bis(2 - chloroethyl)benzenemethanamine hydrochloride should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, flames, and incompatible substances. Store in a tightly - sealed container to prevent moisture absorption and potential decomposition. Due to its hazardous nature, store it in accordance with local safety regulations, preferably in a dedicated chemical storage facility. |
| Shipping | N,n - bis(2 - chloroethyl)benzenemethanamine hydrochloride, a chemical, must be shipped in accordance with strict hazardous materials regulations. Use appropriate, sealed containers to prevent leakage during transit to ensure safety. |
Competitive N,N-Bis(2-Chloroethyl)Benzenemethanaminehydrochloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading N,N-Bis(2-Chloroethyl)Benzenemethanaminehydrochloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of N, n - bis (2 - chloroethyl) benzenemethanamine hydrochloride?
The chemical structure of N, N-bis (2-chloroethyl) aniline hydrochloride is one of the organic compounds. In the structure of this compound, the core is the structure of aniline. For aniline, the benzene ring is connected to a methylene group, and the methylene group is connected to an amine group. On this basis, the nitrogen atom of the amine group is connected to two 2-chloroethyl groups. The 2-chloroethyl group, that is, the hydrogen atom at one end of the ethane molecule, is replaced by the chlorine atom, and the other end of the ethane is connected to the nitrogen atom. As for the hydrochloric form, the organic base reacts with hydrochloric acid to form a salt. In the structure, the hydrogen ion of hydrochloric acid combines with the nitrogen atom of the amine group to form a positively charged ammonium ion, and the chloride ion pairs with it to balance the charge. This chemical structure endows the compound with specific physical and chemical properties, and has important research value and application potential in many fields such as organic synthesis and medicinal chemistry.
What are the main uses of N, n - bis (2 - chloroethyl) benzenemethanamine hydrochloride?
N, n -bis (2-chloroethyl) aniline hydrochloride, this is an organic compound. It has a wide range of uses and is often used as a raw material for anti-tumor drugs in the field of medicine. Because it has certain cytotoxicity, it can interfere with the normal metabolism and proliferation of tumor cells, thereby inhibiting tumor growth.
In the chemical industry, it is also an important intermediate. It can participate in a variety of organic synthesis reactions, and through chemical transformation, it can prepare compounds with specific structures and properties, such as polymers used to synthesize certain special functions, giving materials unique properties.
In addition, it is a commonly used chemical reagent in scientific research and exploration. Scientists use their research on organic reaction mechanisms, drug action mechanisms, etc., to help gain in-depth insight into the mysteries of chemical and biological processes, and provide key support for theoretical development and technological innovation in related fields. In fact, it plays an indispensable role in many fields.
In the chemical industry, it is also an important intermediate. It can participate in a variety of organic synthesis reactions, and through chemical transformation, it can prepare compounds with specific structures and properties, such as polymers used to synthesize certain special functions, giving materials unique properties.
In addition, it is a commonly used chemical reagent in scientific research and exploration. Scientists use their research on organic reaction mechanisms, drug action mechanisms, etc., to help gain in-depth insight into the mysteries of chemical and biological processes, and provide key support for theoretical development and technological innovation in related fields. In fact, it plays an indispensable role in many fields.
What are the precautions for the use of N, n - bis (2 - chloroethyl) benzenemethanamine hydrochloride?
N, N-bis (2-chloroethyl) aniline hydrochloride is a special chemical substance, and many things need to be paid attention to during use.
First, it is related to safety protection. This substance is potentially toxic and irritating, and it is necessary to wear appropriate protective equipment during operation, such as laboratory clothes, gloves and protective glasses, to avoid contact with skin and eyes. If you come into contact accidentally, rinse with plenty of water immediately and seek medical attention according to the specific situation. Operate in a well-ventilated environment, preferably in a fume hood to prevent inhalation of its volatile gases and damage to the respiratory tract.
Second, storage conditions are also critical. Store in a cool, dry and ventilated place, away from fire and heat sources. Due to its chemical properties, improper storage or deterioration will affect the use effect. Therefore, it is necessary to ensure that the storage container is well sealed to prevent moisture and pollution.
Third, the use specifications cannot be ignored. Strictly control the dosage according to the experimental procedures or production requirements, and avoid random increase or decrease. Be sure to fully understand its chemical properties and reaction principles before use, and know the possible chemical reactions and latent risks. Carefully record the experimental process, including the dosage, reaction conditions and experimental phenomena, for subsequent analysis and summary.
Fourth, waste treatment is also exquisite. After use, the remaining substances and waste cannot be discarded at will, and should be properly disposed of in accordance with relevant environmental protection regulations. Usually, it needs to be collected centrally and disposed of by professional institutions to prevent pollution to the environment. Only by treating the above points with caution can we ensure the safety of personnel and the smooth progress of experiments and production when using N, N-bis (2-chloroethyl) aniline hydrochloride.
First, it is related to safety protection. This substance is potentially toxic and irritating, and it is necessary to wear appropriate protective equipment during operation, such as laboratory clothes, gloves and protective glasses, to avoid contact with skin and eyes. If you come into contact accidentally, rinse with plenty of water immediately and seek medical attention according to the specific situation. Operate in a well-ventilated environment, preferably in a fume hood to prevent inhalation of its volatile gases and damage to the respiratory tract.
Second, storage conditions are also critical. Store in a cool, dry and ventilated place, away from fire and heat sources. Due to its chemical properties, improper storage or deterioration will affect the use effect. Therefore, it is necessary to ensure that the storage container is well sealed to prevent moisture and pollution.
Third, the use specifications cannot be ignored. Strictly control the dosage according to the experimental procedures or production requirements, and avoid random increase or decrease. Be sure to fully understand its chemical properties and reaction principles before use, and know the possible chemical reactions and latent risks. Carefully record the experimental process, including the dosage, reaction conditions and experimental phenomena, for subsequent analysis and summary.
Fourth, waste treatment is also exquisite. After use, the remaining substances and waste cannot be discarded at will, and should be properly disposed of in accordance with relevant environmental protection regulations. Usually, it needs to be collected centrally and disposed of by professional institutions to prevent pollution to the environment. Only by treating the above points with caution can we ensure the safety of personnel and the smooth progress of experiments and production when using N, N-bis (2-chloroethyl) aniline hydrochloride.
What are the physical properties of N, n - bis (2 - chloroethyl) benzenemethanamine hydrochloride?
N, n-bis (2-chloroethyl) aniline hydrochloride is one of the organic compounds. Its physical properties are particularly important, related to its use and reaction characteristics.
Looking at its morphology, it usually shows the shape of white crystalline powder under normal conditions, which is easy to identify and deal with. Its solubility is quite critical, it has good solubility in water and can be evenly dispersed. This property makes it convenient for reactions or applications in many aqueous systems. And it also has a certain solubility in some organic solvents, such as ethanol, etc., to broaden its scope of application.
When it comes to the melting point, a specific value can be obtained after measurement. This value is one of its physical identifiers and is of great significance in identification and purity testing. When heated to the melting point, the state of the substance changes from solid to liquid, reflecting the characteristics of its intermolecular forces.
As for the boiling point, although the relevant information may be lacking due to different emphases, it can be inferred from its molecular structure and the properties of similar compounds that a gas-liquid phase transition will occur within a certain temperature range.
Density is also an important physical property, which is related to the relationship between the volume and mass it occupies in actual operation. Through experimental determination, its exact value can be obtained, which provides a basis for process design and material ratio.
The physical properties of this compound are the basis for research and application. Only by in-depth understanding of it can we make good use of it and exert its effectiveness in chemical, pharmaceutical and other fields.
Looking at its morphology, it usually shows the shape of white crystalline powder under normal conditions, which is easy to identify and deal with. Its solubility is quite critical, it has good solubility in water and can be evenly dispersed. This property makes it convenient for reactions or applications in many aqueous systems. And it also has a certain solubility in some organic solvents, such as ethanol, etc., to broaden its scope of application.
When it comes to the melting point, a specific value can be obtained after measurement. This value is one of its physical identifiers and is of great significance in identification and purity testing. When heated to the melting point, the state of the substance changes from solid to liquid, reflecting the characteristics of its intermolecular forces.
As for the boiling point, although the relevant information may be lacking due to different emphases, it can be inferred from its molecular structure and the properties of similar compounds that a gas-liquid phase transition will occur within a certain temperature range.
Density is also an important physical property, which is related to the relationship between the volume and mass it occupies in actual operation. Through experimental determination, its exact value can be obtained, which provides a basis for process design and material ratio.
The physical properties of this compound are the basis for research and application. Only by in-depth understanding of it can we make good use of it and exert its effectiveness in chemical, pharmaceutical and other fields.
What are the synthesis methods of N, n - bis (2 - chloroethyl) benzenemethanamine hydrochloride?
The synthesis method of N, N-bis (2-chloroethyl) aniline hydrochloride has a long history, and there are various methods, each with its own advantages.
In the past, benzaldehyde was used as the starting material. First, benzaldehyde was reacted with dimethylamine to obtain an imine intermediate. This step requires temperature control and time control to make the reaction proceed smoothly. The imine is obtained in the shape of a slight yellow oil. Then the imine is reduced with sodium borohydride. The amount of sodium borohydride and the pH of the reaction environment are all key. After reduction, N-methyl-N-benzylamine is obtained, and then it is reacted with 2-chloroethanol under alkaline conditions. The type and amount of base have a great impact on the reaction process. Finally, after acidification, the target product N, N -bis (2-chloroethyl) aniline hydrochloride can be obtained.
There is also a method of using benzylamine as the starting material. Benzylamine is first added to acrylonitrile. Whether the addition reaction conditions are mild or not depends on the purity of the product. The addition product is hydrolyzed and reduced to obtain N-benzyl-3-aminopropanol. Then chlorinated with thionyl chloride. When chlorinated, the temperature and the drip acceleration of thionyl chloride need to be carefully controlled to obtain a high-purity product. Finally, it is acidified with hydrochloric acid to obtain N, N -bis (2-chloroethyl) aniline hydrochloride.
Another method is to react with aniline and 2-chloroethyl chloride in the presence of a base. The choice of base, such as potassium carbonate, sodium carbonate, etc., has advantages and disadvantages. During the reaction process, the choice of solvent is also important. A suitable solvent can make the reaction sufficient and increase the yield. After the reaction is completed, it is post-treated, acidified, and the final product is obtained.
All kinds of synthesis methods have their own advantages and disadvantages. According to the actual situation, such as the availability of raw materials, cost, product purity requirements, etc., choose the best one and use it.
In the past, benzaldehyde was used as the starting material. First, benzaldehyde was reacted with dimethylamine to obtain an imine intermediate. This step requires temperature control and time control to make the reaction proceed smoothly. The imine is obtained in the shape of a slight yellow oil. Then the imine is reduced with sodium borohydride. The amount of sodium borohydride and the pH of the reaction environment are all key. After reduction, N-methyl-N-benzylamine is obtained, and then it is reacted with 2-chloroethanol under alkaline conditions. The type and amount of base have a great impact on the reaction process. Finally, after acidification, the target product N, N -bis (2-chloroethyl) aniline hydrochloride can be obtained.
There is also a method of using benzylamine as the starting material. Benzylamine is first added to acrylonitrile. Whether the addition reaction conditions are mild or not depends on the purity of the product. The addition product is hydrolyzed and reduced to obtain N-benzyl-3-aminopropanol. Then chlorinated with thionyl chloride. When chlorinated, the temperature and the drip acceleration of thionyl chloride need to be carefully controlled to obtain a high-purity product. Finally, it is acidified with hydrochloric acid to obtain N, N -bis (2-chloroethyl) aniline hydrochloride.
Another method is to react with aniline and 2-chloroethyl chloride in the presence of a base. The choice of base, such as potassium carbonate, sodium carbonate, etc., has advantages and disadvantages. During the reaction process, the choice of solvent is also important. A suitable solvent can make the reaction sufficient and increase the yield. After the reaction is completed, it is post-treated, acidified, and the final product is obtained.
All kinds of synthesis methods have their own advantages and disadvantages. According to the actual situation, such as the availability of raw materials, cost, product purity requirements, etc., choose the best one and use it.
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