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O-Chlorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
185405 |
| Chemical Formula | C6H4Cl2O2S |
| Molar Mass | 211.065 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | ~272 - 274 °C |
| Density | 1.489 g/cm³ (approximate) |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in many organic solvents like benzene, toluene |
| Hazard Class | Corrosive, causes burns to skin, eyes and respiratory tract |
As an accredited O-Chlorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1kg of O - chlorobenzenesulfonyl Chloride packaged in a sealed, corrosion - resistant container. |
| Storage | O - chlorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent moisture and air exposure, as it can react with water. Store it separately from incompatible substances like bases and reactive metals to avoid dangerous reactions. |
| Shipping | O - chlorobenzenesulfonyl chloride is a chemical. For shipping, it must be in proper, tightly - sealed containers. Shipments follow regulations for hazardous chemicals, with careful handling to prevent spills and ensure safe transportation. |
Competitive O-Chlorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of O-chlorobenzenesulfonyl Chloride?
O-chlorobenzenesulfonyl Chloride is an important reagent in organic synthesis. Its main uses are generally as follows.
First, in the field of drug synthesis, it is often used as a key intermediate. It can be introduced into the benzenesulfonyl chloride group through a specific chemical reaction, which is of great significance to the structural modification and activity adjustment of drug molecules. The construction of many drug molecules depends on its participation in the reaction to achieve the desired chemical structure and pharmacological activity. For example, in the synthesis of a certain type of antibacterial drug, the reaction of o-chlorobenzenesulfonyl chloride with a compound containing a specific functional group can be converted in multiple steps to obtain the final product with antibacterial effect.
Second, it also plays an important role in the synthesis of pesticides. By reacting with other organic compounds, the molecular structure of pesticides with specific biological activities can be constructed. For example, by combining with some nitrogen-containing heterocyclic compounds, pesticides with high-efficiency killing effect on pests can be prepared. By adjusting its chemical structure, the insecticidal spectrum and shelf life of pesticides can be optimized.
Third, for dye synthesis. O-chlorobenzenesulfonyl chloride can participate in the generation of dye intermediates containing benzenesulfonyl groups, and then synthesize dyes with rich colors and excellent fastness. Such dyes are widely used in textile printing and dyeing industries, giving fabrics a brilliant color and good color fastness.
Fourth, in the field of organic material synthesis, o-chlorobenzenesulfonyl chloride can be used as a modifier or crosslinking agent. Reaction with polymer materials can improve the physical and chemical properties of materials, such as enhancing the mechanical strength and heat resistance of materials. When preparing special engineering plastics, appropriate introduction of structural units derived from o-chlorobenzenesulfonyl chloride can significantly improve the comprehensive properties of plastics.
All these, o-chlorobenzenesulfonyl chloride plays an indispensable role in many fields of organic synthesis, promoting the development of drugs, pesticides, dyes and organic materials.
First, in the field of drug synthesis, it is often used as a key intermediate. It can be introduced into the benzenesulfonyl chloride group through a specific chemical reaction, which is of great significance to the structural modification and activity adjustment of drug molecules. The construction of many drug molecules depends on its participation in the reaction to achieve the desired chemical structure and pharmacological activity. For example, in the synthesis of a certain type of antibacterial drug, the reaction of o-chlorobenzenesulfonyl chloride with a compound containing a specific functional group can be converted in multiple steps to obtain the final product with antibacterial effect.
Second, it also plays an important role in the synthesis of pesticides. By reacting with other organic compounds, the molecular structure of pesticides with specific biological activities can be constructed. For example, by combining with some nitrogen-containing heterocyclic compounds, pesticides with high-efficiency killing effect on pests can be prepared. By adjusting its chemical structure, the insecticidal spectrum and shelf life of pesticides can be optimized.
Third, for dye synthesis. O-chlorobenzenesulfonyl chloride can participate in the generation of dye intermediates containing benzenesulfonyl groups, and then synthesize dyes with rich colors and excellent fastness. Such dyes are widely used in textile printing and dyeing industries, giving fabrics a brilliant color and good color fastness.
Fourth, in the field of organic material synthesis, o-chlorobenzenesulfonyl chloride can be used as a modifier or crosslinking agent. Reaction with polymer materials can improve the physical and chemical properties of materials, such as enhancing the mechanical strength and heat resistance of materials. When preparing special engineering plastics, appropriate introduction of structural units derived from o-chlorobenzenesulfonyl chloride can significantly improve the comprehensive properties of plastics.
All these, o-chlorobenzenesulfonyl chloride plays an indispensable role in many fields of organic synthesis, promoting the development of drugs, pesticides, dyes and organic materials.
What are the physical properties of O-chlorobenzenesulfonyl Chloride?
O-chlorobenzenesulfonyl Chloride is also an organic compound. It has unique physical properties and has attracted much attention in the fields of industry and scientific research.
Looking at its properties, o-chlorobenzenesulfonyl chloride is a colorless to light yellow liquid at room temperature, with a pungent smell. This smell is strong and irritating, and ordinary people can easily feel discomfort when they smell it. Its boiling point is quite high, about 251 ° C, which makes it begin to boil and vaporize at relatively high temperatures. The melting point is lower, around -15 ° C, which means that it is liquid at room temperature, but it is easy to solidify at lower temperatures.
Its density is heavier than that of water, about 1.49g/cm ³. When mixed with water, it will sink to the bottom of the water. It is insoluble in water, which makes it difficult to form an effective interaction with water molecules due to its molecular structure characteristics. However, it is soluble in most organic solvents, such as ether, benzene, chloroform, etc., and can be well dispersed and dissolved in organic solvents. This property is conducive to being used as a reactant or solvent in organic synthesis reactions.
O-chlorobenzenesulfonyl chloride has weak volatility, and at room temperature and pressure, the molecule escapes from the liquid phase and enters the gas phase at a low rate, which makes it relatively stable to store. However, its chemical properties are active, and substances containing active hydrogen such as water and alcohol are prone to reactions. Therefore, attention should be paid to isolating such substances during storage to prevent deterioration.
Looking at its properties, o-chlorobenzenesulfonyl chloride is a colorless to light yellow liquid at room temperature, with a pungent smell. This smell is strong and irritating, and ordinary people can easily feel discomfort when they smell it. Its boiling point is quite high, about 251 ° C, which makes it begin to boil and vaporize at relatively high temperatures. The melting point is lower, around -15 ° C, which means that it is liquid at room temperature, but it is easy to solidify at lower temperatures.
Its density is heavier than that of water, about 1.49g/cm ³. When mixed with water, it will sink to the bottom of the water. It is insoluble in water, which makes it difficult to form an effective interaction with water molecules due to its molecular structure characteristics. However, it is soluble in most organic solvents, such as ether, benzene, chloroform, etc., and can be well dispersed and dissolved in organic solvents. This property is conducive to being used as a reactant or solvent in organic synthesis reactions.
O-chlorobenzenesulfonyl chloride has weak volatility, and at room temperature and pressure, the molecule escapes from the liquid phase and enters the gas phase at a low rate, which makes it relatively stable to store. However, its chemical properties are active, and substances containing active hydrogen such as water and alcohol are prone to reactions. Therefore, attention should be paid to isolating such substances during storage to prevent deterioration.
O-chlorobenzenesulfonyl the chemistry of Chloride
O-chlorobenzenesulfonyl Chloride is a very important chemical raw material in organic synthesis. Its chemical properties are unique and highly active.
As far as its nucleophilic substitution reaction is concerned, the chlorine atom is easily replaced by many nucleophilic reagents. For example, when it encounters alcohols, nucleophilic substitution occurs to form o-chlorobenzenesulfonates. During this reaction, the oxygen atom of the alcohol acts as a nucleophilic site to attack the sulfur atom of o-chlorobenzenesulfonyl chloride, and the chloride ions are separated to achieve a reaction and generate the corresponding sulfonate product. This reaction is often used in organic synthesis to prepare specific ester compounds, which lays the foundation for the subsequent construction of complex organic molecular structures.
When reacting with amines, nucleophilic substitution also occurs to form sulfonamides. The nitrogen atom of the amine attacks the sulfur atom of o-chlorobenzenesulfonyl chloride by virtue of its unshared electron pair, and the chloride ions leave to form sulfonamide products. Sulfonamide compounds are widely used in medicine, pesticides and other fields, and this reaction has become a key step in the synthesis of such compounds.
In addition, o-chlorobenzenesulfonyl chloride also undergoes hydrolysis in contact with water. The hydroxyl groups in the water molecule attack the sulfur atoms nucleophilically, and the chloride ions are separated, thereby forming o-chlorobenzenesulfonate and hydrogen chloride. This hydrolysis reaction is prone to occur in humid environments, so it is necessary to pay attention to moisture-proof when
At the same time, because of the benzene ring structure in the molecule, o-chlorobenzenesulfonyl chloride can also participate in the aromatic electrophilic substitution reaction. However, compared with simple benzene, the electron cloud density on the benzene ring is reduced due to the electron-withdrawing effect of the sulfonyl chloride group, resulting in a slight decrease in the electrophilic substitution reaction activity. However, under suitable reaction conditions and catalysts, other substituents can still be introduced at specific positions in the benzene ring to expand the possibility of its derivatization and provide a way for the synthesis of organic compounds with diverse structures.
As far as its nucleophilic substitution reaction is concerned, the chlorine atom is easily replaced by many nucleophilic reagents. For example, when it encounters alcohols, nucleophilic substitution occurs to form o-chlorobenzenesulfonates. During this reaction, the oxygen atom of the alcohol acts as a nucleophilic site to attack the sulfur atom of o-chlorobenzenesulfonyl chloride, and the chloride ions are separated to achieve a reaction and generate the corresponding sulfonate product. This reaction is often used in organic synthesis to prepare specific ester compounds, which lays the foundation for the subsequent construction of complex organic molecular structures.
When reacting with amines, nucleophilic substitution also occurs to form sulfonamides. The nitrogen atom of the amine attacks the sulfur atom of o-chlorobenzenesulfonyl chloride by virtue of its unshared electron pair, and the chloride ions leave to form sulfonamide products. Sulfonamide compounds are widely used in medicine, pesticides and other fields, and this reaction has become a key step in the synthesis of such compounds.
In addition, o-chlorobenzenesulfonyl chloride also undergoes hydrolysis in contact with water. The hydroxyl groups in the water molecule attack the sulfur atoms nucleophilically, and the chloride ions are separated, thereby forming o-chlorobenzenesulfonate and hydrogen chloride. This hydrolysis reaction is prone to occur in humid environments, so it is necessary to pay attention to moisture-proof when
At the same time, because of the benzene ring structure in the molecule, o-chlorobenzenesulfonyl chloride can also participate in the aromatic electrophilic substitution reaction. However, compared with simple benzene, the electron cloud density on the benzene ring is reduced due to the electron-withdrawing effect of the sulfonyl chloride group, resulting in a slight decrease in the electrophilic substitution reaction activity. However, under suitable reaction conditions and catalysts, other substituents can still be introduced at specific positions in the benzene ring to expand the possibility of its derivatization and provide a way for the synthesis of organic compounds with diverse structures.
What to pay attention to when storing and transporting O-chlorobenzenesulfonyl Chloride
O-chlorobenzenesulfonyl chloride is a chemical substance, and its storage and transportation must be carefully attended to.
When storing, the first thing to do is to choose a cool, dry and well-ventilated place. This is because o-chlorobenzenesulfonyl chloride is prone to changes in moisture and heat, so it is important to avoid moisture and high temperature. The temperature of the warehouse should be controlled within a suitable range to prevent it from being unstable due to excessive temperature. In addition, it must be stored separately from oxidizing agents, alkalis and other substances. The cover of o-chlorobenzenesulfonyl chloride is active, and contact with them may cause severe chemical reactions and cause danger. And the storage place should be equipped with leakage emergency treatment equipment and suitable containment materials for emergencies.
As for transportation, there are also many precautions. Transportation vehicles must ensure that they are tight and leak-proof to prevent leakage. During transportation, avoid sun and rain, and do not expose vehicles to high temperature environments for a long time. Drivers and escorts should be familiar with their nature and emergency response methods. When loading and unloading, the operation must be gentle, and must not be wild loading and unloading, so as to avoid leakage caused by damage to the container. If a leak occurs during transportation, it should be dealt with immediately according to the predetermined emergency plan, evacuate the surrounding people, and take effective measures to collect and clean up the leakage to reduce the harm. In short, the storage and transportation of o-chlorobenzenesulfonyl chloride is related to the overall situation of safety, and everything must be done in accordance with the norms, and there should be no slack.
When storing, the first thing to do is to choose a cool, dry and well-ventilated place. This is because o-chlorobenzenesulfonyl chloride is prone to changes in moisture and heat, so it is important to avoid moisture and high temperature. The temperature of the warehouse should be controlled within a suitable range to prevent it from being unstable due to excessive temperature. In addition, it must be stored separately from oxidizing agents, alkalis and other substances. The cover of o-chlorobenzenesulfonyl chloride is active, and contact with them may cause severe chemical reactions and cause danger. And the storage place should be equipped with leakage emergency treatment equipment and suitable containment materials for emergencies.
As for transportation, there are also many precautions. Transportation vehicles must ensure that they are tight and leak-proof to prevent leakage. During transportation, avoid sun and rain, and do not expose vehicles to high temperature environments for a long time. Drivers and escorts should be familiar with their nature and emergency response methods. When loading and unloading, the operation must be gentle, and must not be wild loading and unloading, so as to avoid leakage caused by damage to the container. If a leak occurs during transportation, it should be dealt with immediately according to the predetermined emergency plan, evacuate the surrounding people, and take effective measures to collect and clean up the leakage to reduce the harm. In short, the storage and transportation of o-chlorobenzenesulfonyl chloride is related to the overall situation of safety, and everything must be done in accordance with the norms, and there should be no slack.
What are the synthesis methods of O-chlorobenzenesulfonyl Chloride?
The method of making o-chlorobenzenesulfonyl chloride has been used in ancient times, and is described in detail below.
First, take o-chlorobenzene as the starting material, and obtain it through two steps of sulfonation and chlorination. First take o-chlorobenzene, put it in the reaction kettle, use sulfuric acid as the sulfonating agent, and heat it at a controlled temperature. The temperature of sulfonation is very important. If it is too low, the reaction will be slow, and if it is too high, it will cause side reactions. To be sulfonated, get o-chlorobenzenesulfonic acid. Then, use phosphorus trichloride or phosphorus pentachloride as the chlorinating agent, and react with it. This step also requires strict control conditions, so get o-chlorobenzenesulfonyl chloride.
< b In the reactor, benzenesulfonyl chloride is added, catalyzed by an appropriate catalyst, and chlorinated by chlorine gas. There are many kinds of catalytic agents, which need to be carefully selected to promote the efficient progress of the reaction. During the reaction, pay close attention to factors such as temperature and chlorine flow rate to prevent side effects from breeding.
Third, use o-chloroaniline as raw material and prepare it through a series of steps such as diazotization and Sandmeier reaction. First, the o-chloroaniline is made into a diazo salt, and the conditions are precisely controlled. The diazo salt is unstable, and there is a slight poor pool. After the Sandmeier reaction, chlorine atoms are introduced using cuprous chloride as a medium, and then o-chlorobenzenesulfonyl chloride is obtained.
All these methods have their own advantages and disadvantages, and they need to be carefully selected according to the actual situation, such as the availability of raw materials, cost considerations, and product purity requirements, in order to achieve the purpose of preparation.
First, take o-chlorobenzene as the starting material, and obtain it through two steps of sulfonation and chlorination. First take o-chlorobenzene, put it in the reaction kettle, use sulfuric acid as the sulfonating agent, and heat it at a controlled temperature. The temperature of sulfonation is very important. If it is too low, the reaction will be slow, and if it is too high, it will cause side reactions. To be sulfonated, get o-chlorobenzenesulfonic acid. Then, use phosphorus trichloride or phosphorus pentachloride as the chlorinating agent, and react with it. This step also requires strict control conditions, so get o-chlorobenzenesulfonyl chloride.
< b In the reactor, benzenesulfonyl chloride is added, catalyzed by an appropriate catalyst, and chlorinated by chlorine gas. There are many kinds of catalytic agents, which need to be carefully selected to promote the efficient progress of the reaction. During the reaction, pay close attention to factors such as temperature and chlorine flow rate to prevent side effects from breeding.
Third, use o-chloroaniline as raw material and prepare it through a series of steps such as diazotization and Sandmeier reaction. First, the o-chloroaniline is made into a diazo salt, and the conditions are precisely controlled. The diazo salt is unstable, and there is a slight poor pool. After the Sandmeier reaction, chlorine atoms are introduced using cuprous chloride as a medium, and then o-chlorobenzenesulfonyl chloride is obtained.
All these methods have their own advantages and disadvantages, and they need to be carefully selected according to the actual situation, such as the availability of raw materials, cost considerations, and product purity requirements, in order to achieve the purpose of preparation.
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