Linshang Chemical
PRODUCTS
O-Chlorofluorobenzene
Linshang Chemical
|
HS Code |
428339 |
| Chemical Formula | C6H4ClF |
| Molecular Weight | 128.55 |
| Appearance | Colorless liquid |
| Odor | Characteristic aromatic odor |
| Density | 1.265 g/cm³ (at 20 °C) |
| Boiling Point | 129 - 131 °C |
| Melting Point | -45 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents |
| Flash Point | 34 °C |
| Vapor Pressure | 1.33 kPa (at 22.4 °C) |
| Refractive Index | 1.500 - 1.504 (at 20 °C) |
As an accredited O-Chlorofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | O - chlorofluorobenzene: Packed in 50 - liter drums, 10 drums per batch. |
| Storage | O - chlorofluorobenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames as it is flammable. Keep it in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents, acids, and bases to avoid potential chemical reactions. Ensure proper labeling for easy identification and safety. |
| Shipping | O - chlorofluorobenzene is shipped in tightly sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper labeling and safety measures during handling and transit. |
Competitive O-Chlorofluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy O-Chlorofluorobenzene in China?
As a trusted O-Chlorofluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading O-Chlorofluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of O-chlorofluorobenzene?
O-chlorofluorobenzene is also an organic compound. It has a wide range of uses and is used in various fields.
First, it is crucial in the synthesis of medicine. It can be used as a raw material for the synthesis of a variety of drugs. For example, in the preparation of certain antibacterial drugs, O-chlorofluorobenzene can be used as a starting material. After a series of delicate chemical reactions, it is converted into a structural unit with specific pharmacological activities, which can help the creation of antibacterial drugs to heal patients.
Second, in the field of pesticides, it is also a key component. It can be used to synthesize highly efficient and low-toxic pesticides. Through a specific chemical synthesis path, it is integrated into the molecular structure of pesticides, giving pesticides unique insecticidal, weeding or bactericidal properties, ensuring the robust growth of crops, resisting the invasion of pests and diseases, and improving agricultural output and quality.
Third, in the field of materials science, O-chlorofluorobenzene can also play a role. In the synthesis of some special polymer materials, it can participate in the reaction as a functional monomer. The resulting materials may have unique physical and chemical properties, such as excellent heat resistance, corrosion resistance, etc., and have potential applications in high-end fields such as aerospace and electronics.
In conclusion, O-chlorofluorobenzene, with its unique chemical structure, plays an indispensable role in many fields such as medicine, pesticides, and materials, promoting scientific and technological progress and industrial development in various fields.
First, it is crucial in the synthesis of medicine. It can be used as a raw material for the synthesis of a variety of drugs. For example, in the preparation of certain antibacterial drugs, O-chlorofluorobenzene can be used as a starting material. After a series of delicate chemical reactions, it is converted into a structural unit with specific pharmacological activities, which can help the creation of antibacterial drugs to heal patients.
Second, in the field of pesticides, it is also a key component. It can be used to synthesize highly efficient and low-toxic pesticides. Through a specific chemical synthesis path, it is integrated into the molecular structure of pesticides, giving pesticides unique insecticidal, weeding or bactericidal properties, ensuring the robust growth of crops, resisting the invasion of pests and diseases, and improving agricultural output and quality.
Third, in the field of materials science, O-chlorofluorobenzene can also play a role. In the synthesis of some special polymer materials, it can participate in the reaction as a functional monomer. The resulting materials may have unique physical and chemical properties, such as excellent heat resistance, corrosion resistance, etc., and have potential applications in high-end fields such as aerospace and electronics.
In conclusion, O-chlorofluorobenzene, with its unique chemical structure, plays an indispensable role in many fields such as medicine, pesticides, and materials, promoting scientific and technological progress and industrial development in various fields.
What are the physical properties of O-chlorofluorobenzene?
O-chlorofluorobenzene is also an organic compound. Its physical properties are quite unique. Looking at its form, under normal temperature and pressure, it is a colorless and transparent liquid, and its shape is clear, like a clear spring.
Smell its smell, with a special aroma. This aroma is unusual. Although it is not rich and pungent, it also has bright characteristics, which can make people distinguish its uniqueness from the breath.
As for the boiling point, it is between 129 ° C and 131 ° C. This boiling point value allows the substance to be converted from liquid to gas at a suitable temperature. When the temperature rises, the liquid boils and rolls, and the molecular movement intensifies, eventually turning into a gas to disperse.
Its melting point is about -28 ° C. At this low temperature, the substance gradually condenses from liquid to solid, and the molecular arrangement tends to be orderly and tight, showing a solid form.
In terms of density, it is about 1.309g/cm ³. This density value shows that under the same volume, the substance is heavier than water. If it is placed in one place with water, it will sink to the bottom of the water.
In terms of solubility, O-chlorofluorobenzene is insoluble in water. The polarity of water is different from the non-polar structure of the substance, so the two are difficult to dissolve, just like the difference between oil and water. However, it is soluble in organic solvents such as ethanol and ether. Because the structural properties of organic solvents are similar to O-chlorofluorobenzene, according to the principle of similar compatibility, the two can be miscibly mixed.
And because it is a liquid, it has good fluidity. In the container, it can flow smoothly, like the water of a stream, unimpeded. And it has a certain volatility. In the air, the molecules gradually dissipate, so that its odor can be perceived within a certain range.
Smell its smell, with a special aroma. This aroma is unusual. Although it is not rich and pungent, it also has bright characteristics, which can make people distinguish its uniqueness from the breath.
As for the boiling point, it is between 129 ° C and 131 ° C. This boiling point value allows the substance to be converted from liquid to gas at a suitable temperature. When the temperature rises, the liquid boils and rolls, and the molecular movement intensifies, eventually turning into a gas to disperse.
Its melting point is about -28 ° C. At this low temperature, the substance gradually condenses from liquid to solid, and the molecular arrangement tends to be orderly and tight, showing a solid form.
In terms of density, it is about 1.309g/cm ³. This density value shows that under the same volume, the substance is heavier than water. If it is placed in one place with water, it will sink to the bottom of the water.
In terms of solubility, O-chlorofluorobenzene is insoluble in water. The polarity of water is different from the non-polar structure of the substance, so the two are difficult to dissolve, just like the difference between oil and water. However, it is soluble in organic solvents such as ethanol and ether. Because the structural properties of organic solvents are similar to O-chlorofluorobenzene, according to the principle of similar compatibility, the two can be miscibly mixed.
And because it is a liquid, it has good fluidity. In the container, it can flow smoothly, like the water of a stream, unimpeded. And it has a certain volatility. In the air, the molecules gradually dissipate, so that its odor can be perceived within a certain range.
What is the chemistry of O-chlorofluorobenzene?
O-chlorofluorobenzene is also an organic compound. Its molecule contains chlorine and fluorine atoms are connected to the benzene ring. The chemical properties of this substance are specific, and it is of great value to explore.
On its chemical activity, the benzene ring is inherently stable. However, the introduction of chlorine and fluorine atoms causes the distribution of electron clouds to change, and the activity changes accordingly. Both chlorine and fluorine are electron-withdrawing groups, which reduce the electron cloud density of the benzene ring, and the activity of the electrophilic substitution reaction is inferior to that of benzene.
In the electrophilic substitution reaction, the localization effect of chlorine and fluorine atoms is also significant. They belong to adjacent and para-localized groups. Because chlorine and fluorine solitary pair electrons can be conjugated with the benzene ring, the density of the adjacent and para-electron clouds is relatively high, and the electrophilic reagents tend to However, its electron-absorbing induction effect is strong, which generally reduces the activity of benzene ring.
And it can participate in the nucleophilic substitution reaction. Chlorine and fluorine atoms can be replaced by nucleophilic reagents, because the halogen atoms have a certain degree of departure. Under specific conditions, the nucleophilic reagent attacks the benzene ring, and the halogen atoms leave to form new compounds.
O-chlorofluorobenzene has a wide range of uses in the field of organic synthesis. It can be used as an intermediate to produce complex organic molecules containing chlorine and fluorine through various reactions. It plays an indispensable role in medicine, pesticides, materials science and many other aspects. Its unique chemical properties provide rich possibilities for the research and practical application of organic chemistry.
On its chemical activity, the benzene ring is inherently stable. However, the introduction of chlorine and fluorine atoms causes the distribution of electron clouds to change, and the activity changes accordingly. Both chlorine and fluorine are electron-withdrawing groups, which reduce the electron cloud density of the benzene ring, and the activity of the electrophilic substitution reaction is inferior to that of benzene.
In the electrophilic substitution reaction, the localization effect of chlorine and fluorine atoms is also significant. They belong to adjacent and para-localized groups. Because chlorine and fluorine solitary pair electrons can be conjugated with the benzene ring, the density of the adjacent and para-electron clouds is relatively high, and the electrophilic reagents tend to However, its electron-absorbing induction effect is strong, which generally reduces the activity of benzene ring.
And it can participate in the nucleophilic substitution reaction. Chlorine and fluorine atoms can be replaced by nucleophilic reagents, because the halogen atoms have a certain degree of departure. Under specific conditions, the nucleophilic reagent attacks the benzene ring, and the halogen atoms leave to form new compounds.
O-chlorofluorobenzene has a wide range of uses in the field of organic synthesis. It can be used as an intermediate to produce complex organic molecules containing chlorine and fluorine through various reactions. It plays an indispensable role in medicine, pesticides, materials science and many other aspects. Its unique chemical properties provide rich possibilities for the research and practical application of organic chemistry.
What is O-chlorofluorobenzene production method?
The method of preparing o-chlorofluorobenzene often begins with o-chloroaniline. First, o-chloroaniline and fluoroboronic acid form a salt to obtain o-chlorobenzene diazofluoroborate, which is the process of diazotization. The reaction formula is as follows:
$C_ {6} H_ {4} ClNH_ {2} + HBF_ {4} + NaNO_ {2}\ longrightarrow C_ {6} H_ {4} ClN_ {2} BF_ {4} + NaCl + 2H_ {2} O $
Next, the o-chlorobenzene diazofluoroborate is heated and decomposed to obtain o-chlorofluorobenzene. The reaction formula for this decomposition is:
$C_ {6} H_ {4} ClN_ {2} BF_ {4}\ longrightarrow C_ {6} H_ {4} ClF + N_ {2} ↑ + BF_ {3} ↑ $
In addition, there are also those who use o-chlorophenol as a raw material. React o-chlorophenol with fluorinating agents, such as potassium fluoride, under appropriate conditions. During the reaction, a phase transfer catalyst is required to assist the reaction and promote full contact between the fluorinating agent and o-chlorophenol. The approximate reaction process is as follows:
$C_ {6} H_ {4} ClOH + KF\ stackrel {phase transfer catalyst} {\ longrightarrow} C_ {6} H_ {4} ClF + KOH $
In this process, the phase transfer catalyst can reduce the activation energy of the reaction, so that the reaction occurs under milder conditions, improving the efficiency and yield of the reaction. Both of the above are common methods for preparing o-chlorofluorobenzene.
$C_ {6} H_ {4} ClNH_ {2} + HBF_ {4} + NaNO_ {2}\ longrightarrow C_ {6} H_ {4} ClN_ {2} BF_ {4} + NaCl + 2H_ {2} O $
Next, the o-chlorobenzene diazofluoroborate is heated and decomposed to obtain o-chlorofluorobenzene. The reaction formula for this decomposition is:
$C_ {6} H_ {4} ClN_ {2} BF_ {4}\ longrightarrow C_ {6} H_ {4} ClF + N_ {2} ↑ + BF_ {3} ↑ $
In addition, there are also those who use o-chlorophenol as a raw material. React o-chlorophenol with fluorinating agents, such as potassium fluoride, under appropriate conditions. During the reaction, a phase transfer catalyst is required to assist the reaction and promote full contact between the fluorinating agent and o-chlorophenol. The approximate reaction process is as follows:
$C_ {6} H_ {4} ClOH + KF\ stackrel {phase transfer catalyst} {\ longrightarrow} C_ {6} H_ {4} ClF + KOH $
In this process, the phase transfer catalyst can reduce the activation energy of the reaction, so that the reaction occurs under milder conditions, improving the efficiency and yield of the reaction. Both of the above are common methods for preparing o-chlorofluorobenzene.
O-chlorofluorobenzene what are the precautions during use
O-chlorofluorobenzene, as well as organic compounds, is commonly used in industrial production and scientific research. When using, many matters must be paid attention to.
First safety protection. This substance has certain toxicity and irritation, and contact can cause damage to the skin, eyes and respiratory tract. Therefore, when operating, protective equipment is indispensable, such as protective clothing, gloves, protective glasses and gas masks, to prevent direct contact and inhalation.
Times and storage conditions. It should be placed in a cool and well-ventilated place, away from fire and heat sources. It must be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to prevent dangerous chemical reactions.
Furthermore, the use environment should be well ventilated. The vapor formed by the volatilization of this substance is heavier than air, and can spread at a low level to a considerable distance. In case of open flame and high heat energy, it will cause combustion and explosion. Good ventilation can reduce the risk of vapor accumulation.
Repeat, the operation should be strict and standardized. When taking it, operate according to the exact dosage to avoid waste and environmental pollution. After the experiment is completed, properly dispose of the residue and waste, follow relevant environmental regulations, and do not dump it at will.
Also, during transportation, caution must be taken. Follow the regulations on the transportation of hazardous chemicals to ensure that the packaging is complete, the label is clear, and the leakage is prevented.
All of these are to be taken into account when using O-chlorofluorobenzene, and must not be negligent, so as not to endanger personal safety and the environment.
First safety protection. This substance has certain toxicity and irritation, and contact can cause damage to the skin, eyes and respiratory tract. Therefore, when operating, protective equipment is indispensable, such as protective clothing, gloves, protective glasses and gas masks, to prevent direct contact and inhalation.
Times and storage conditions. It should be placed in a cool and well-ventilated place, away from fire and heat sources. It must be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to prevent dangerous chemical reactions.
Furthermore, the use environment should be well ventilated. The vapor formed by the volatilization of this substance is heavier than air, and can spread at a low level to a considerable distance. In case of open flame and high heat energy, it will cause combustion and explosion. Good ventilation can reduce the risk of vapor accumulation.
Repeat, the operation should be strict and standardized. When taking it, operate according to the exact dosage to avoid waste and environmental pollution. After the experiment is completed, properly dispose of the residue and waste, follow relevant environmental regulations, and do not dump it at will.
Also, during transportation, caution must be taken. Follow the regulations on the transportation of hazardous chemicals to ensure that the packaging is complete, the label is clear, and the leakage is prevented.
All of these are to be taken into account when using O-chlorofluorobenzene, and must not be negligent, so as not to endanger personal safety and the environment.
What are the main uses of O-chlorofluorobenzene?
O-chlorofluorobenzene is also an organic compound. It has a wide range of uses and is involved in various fields of chemical industry.
First, it can be used as a raw material for pharmaceutical synthesis. When creating a variety of drugs, O-chlorofluorobenzene can act as a key intermediate, participate in many complex chemical reactions, and help synthesize molecular structures with specific biological activities, which is related to the great cause of curing diseases and saving people.
Second, it also plays a crucial role in the manufacture of pesticides. It can be converted into active ingredients of pesticides through a series of reactions, and can produce pesticides, fungicides, etc., to protect crops from pests and diseases and ensure the harvest of agriculture.
Third, in the field of materials science, it can be used as a starting material for the synthesis of special polymer materials. Through ingenious chemical reactions, the material is endowed with unique properties, such as high temperature resistance, corrosion resistance, etc., which are used in high-end industries such as aerospace and electronics.
Furthermore, in the study of organic synthesis chemistry, O-chlorofluorobenzene is often used as a model compound. Chemists have expanded the methodology of organic synthesis by exploring its reaction characteristics, opening up a path for the synthesis of more novel compounds. In short, although O-chlorofluorobenzene is an organic compound, it plays a significant role in the fields of medicine, pesticides, and materials, and has far-reaching influence.
First, it can be used as a raw material for pharmaceutical synthesis. When creating a variety of drugs, O-chlorofluorobenzene can act as a key intermediate, participate in many complex chemical reactions, and help synthesize molecular structures with specific biological activities, which is related to the great cause of curing diseases and saving people.
Second, it also plays a crucial role in the manufacture of pesticides. It can be converted into active ingredients of pesticides through a series of reactions, and can produce pesticides, fungicides, etc., to protect crops from pests and diseases and ensure the harvest of agriculture.
Third, in the field of materials science, it can be used as a starting material for the synthesis of special polymer materials. Through ingenious chemical reactions, the material is endowed with unique properties, such as high temperature resistance, corrosion resistance, etc., which are used in high-end industries such as aerospace and electronics.
Furthermore, in the study of organic synthesis chemistry, O-chlorofluorobenzene is often used as a model compound. Chemists have expanded the methodology of organic synthesis by exploring its reaction characteristics, opening up a path for the synthesis of more novel compounds. In short, although O-chlorofluorobenzene is an organic compound, it plays a significant role in the fields of medicine, pesticides, and materials, and has far-reaching influence.
What are the physical properties of O-chlorofluorobenzene?
O-chlorofluorobenzene is also an organic compound. Its physical properties are particularly important, and it is now the temperature of Jun Chen.
First talk about its shape and taste. At room temperature, O-chlorofluorobenzene is a colorless and transparent liquid, and emits an aromatic odor. This odor is unique and can be used as a sign of identification.
Second and boiling point and melting point. Its boiling point is about 129-130 ° C, and its melting point is about -45 ° C. The boiling point is the temperature at which a substance changes from a liquid state to a gaseous state; the melting point is the temperature at which it solidifies from a liquid state to a liquid state. Both of these have significant guiding power in the separation, purification and storage of substances.
Furthermore, look at its density. The density of O-chlorofluorobenzene is about 1.26 g/cm ³, which is heavier than water. In liquid-liquid separation and other operations, the difference in density can be exploited for the purpose of separation.
Solubility is also a key property. It is insoluble in water, but it can be miscible with organic solvents such as ethanol and ether. This property is very useful in the field of organic synthesis. Many organic reactions need to be carried out in specific organic solvents, and the solubility of O-chlorofluorobenzene provides a suitable environment for the reaction.
In terms of volatility, O-chlorofluorobenzene has a certain volatility. In an open environment, it will gradually evaporate into the air. This property needs to be treated with caution during use and storage to prevent its escape and raise safety and environmental concerns.
Refractive index is also one of its physical properties. The refractive index can reflect the optical properties of the substance and is of great significance for identification and purity analysis. The refractive index of O-chlorofluorobenzene is about 1.520-1.522. This value can be used to analyze its purity or determine its authenticity.
First talk about its shape and taste. At room temperature, O-chlorofluorobenzene is a colorless and transparent liquid, and emits an aromatic odor. This odor is unique and can be used as a sign of identification.
Second and boiling point and melting point. Its boiling point is about 129-130 ° C, and its melting point is about -45 ° C. The boiling point is the temperature at which a substance changes from a liquid state to a gaseous state; the melting point is the temperature at which it solidifies from a liquid state to a liquid state. Both of these have significant guiding power in the separation, purification and storage of substances.
Furthermore, look at its density. The density of O-chlorofluorobenzene is about 1.26 g/cm ³, which is heavier than water. In liquid-liquid separation and other operations, the difference in density can be exploited for the purpose of separation.
Solubility is also a key property. It is insoluble in water, but it can be miscible with organic solvents such as ethanol and ether. This property is very useful in the field of organic synthesis. Many organic reactions need to be carried out in specific organic solvents, and the solubility of O-chlorofluorobenzene provides a suitable environment for the reaction.
In terms of volatility, O-chlorofluorobenzene has a certain volatility. In an open environment, it will gradually evaporate into the air. This property needs to be treated with caution during use and storage to prevent its escape and raise safety and environmental concerns.
Refractive index is also one of its physical properties. The refractive index can reflect the optical properties of the substance and is of great significance for identification and purity analysis. The refractive index of O-chlorofluorobenzene is about 1.520-1.522. This value can be used to analyze its purity or determine its authenticity.
What is the chemistry of O-chlorofluorobenzene?
O-chlorofluorobenzene is also an organic compound. It is active and has its unique properties in many chemical reactions.
On its chemical properties, the first is the electrophilic substitution reaction. Because of its electron-rich benzene ring, it is easy to be attacked by electrophilic reagents. Although both chlorine and fluorine are electron-withdrawing groups, the electron cloud density of the benzene ring still exists, so halogenation, nitrification, sulfonation and other reactions can occur. During halogenation, the electrophilic reagents approach the benzene ring and form a sigma complex, which is then left by protons to obtain halogenated products. Due to the localization effect of chlorine and fluorine, new groups are introduced into more ortho and para-sites, which are caused by the combination of induction and conjugation effects of the two.
The reaction between O-chlorofluorobenzene and metal reagents is second. O-chlorofluorobenzene can form Grignard reagents with metals such as magnesium. This reagent has a wide range of uses in organic synthesis. It can react with carbonyl compounds to increase carbon chains and form a variety of organic molecular structures.
Furthermore, its stability also has characteristics. Although the benzene ring has certain stability, the introduction of chlorine and fluorine atoms changes the distribution of molecular electron clouds and affects its chemical stability. Under certain conditions, chlorine and fluorine atoms can be replaced by nucleophiles. This process involves SNAr (addition-elimination) mechanism, which is more likely to occur when the adjacent and para-sites of the benzene ring have strong electron-absorbing groups.
In addition, O-chlorofluorobenzene can initiate free radical reactions, cause molecular structure rearrangement or react with other free radical species under high temperature or light, which is its chemical behavior in special environments. In short, O-chlorofluorobenzene has rich chemical properties and has important applications and research value in organic synthesis, medicinal chemistry and other fields.
On its chemical properties, the first is the electrophilic substitution reaction. Because of its electron-rich benzene ring, it is easy to be attacked by electrophilic reagents. Although both chlorine and fluorine are electron-withdrawing groups, the electron cloud density of the benzene ring still exists, so halogenation, nitrification, sulfonation and other reactions can occur. During halogenation, the electrophilic reagents approach the benzene ring and form a sigma complex, which is then left by protons to obtain halogenated products. Due to the localization effect of chlorine and fluorine, new groups are introduced into more ortho and para-sites, which are caused by the combination of induction and conjugation effects of the two.
The reaction between O-chlorofluorobenzene and metal reagents is second. O-chlorofluorobenzene can form Grignard reagents with metals such as magnesium. This reagent has a wide range of uses in organic synthesis. It can react with carbonyl compounds to increase carbon chains and form a variety of organic molecular structures.
Furthermore, its stability also has characteristics. Although the benzene ring has certain stability, the introduction of chlorine and fluorine atoms changes the distribution of molecular electron clouds and affects its chemical stability. Under certain conditions, chlorine and fluorine atoms can be replaced by nucleophiles. This process involves SNAr (addition-elimination) mechanism, which is more likely to occur when the adjacent and para-sites of the benzene ring have strong electron-absorbing groups.
In addition, O-chlorofluorobenzene can initiate free radical reactions, cause molecular structure rearrangement or react with other free radical species under high temperature or light, which is its chemical behavior in special environments. In short, O-chlorofluorobenzene has rich chemical properties and has important applications and research value in organic synthesis, medicinal chemistry and other fields.
What is O-chlorofluorobenzene production method?
There are various methods for preparing O-chlorofluorobenzene. One is the halogenation method, which is based on fluorobenzene, so that it interacts with chlorine under specific conditions. In the reaction vessel, put an appropriate amount of fluorobenzene, enter it with a suitable catalyst, such as ferric chloride, and heat it up to an appropriate temperature, usually tens to hundreds of degrees Celsius, and pass chlorine gas in it. Chlorine and fluorobenzene are substituted by a substitution reaction, and the chlorine atom selectively replaces the hydrogen atom on the benzene ring to form O-chlorofluorobenzene. In this reaction, the catalyst can promote the reaction, and increasing the temperature can increase the reaction rate, but too high temperature or side reactions will increase.
The second is the nitrification-halogenation-reduction method. First, fluorobenzene and mixed acid (a mixture of nitric acid and sulfuric acid) are heated together and nitrified to obtain nitrofluorobenzene. The obtained nitrofluorobenzene is chlorinated to introduce chlorine atoms into the benzene ring to form compounds containing nitro, chlorine and fluorine. At the end, a reducing agent, such as iron powder and hydrochloric acid, is used to reduce the nitro group to an amino group. After a series of reactions such as diazotization and deamination, O-chlorofluorobenzene can be obtained. Although this path is complicated, the position of the substituent can be precisely controlled and the selectivity of the product can be improved.
The third is the Grignard reagent method. The Grignard reagent is prepared from fluorobenzene, which is to react with magnesium shavings in anhydrous ethyl ether and other solvents to form phenylfluor This Grignard reagent reacts with chlorinated reagents, such as chlorinated hydrocarbons or chlorides, under appropriate conditions to obtain O-chlorofluorobenzene. The Grignard reagent method requires strict reaction conditions and requires an anhydrous and anaerobic environment to avoid the decomposition of Grignard reagents. However, it has good results in constructing carbon-halogen bonds, and can prepare halogenated aromatics with specific structures.
The second is the nitrification-halogenation-reduction method. First, fluorobenzene and mixed acid (a mixture of nitric acid and sulfuric acid) are heated together and nitrified to obtain nitrofluorobenzene. The obtained nitrofluorobenzene is chlorinated to introduce chlorine atoms into the benzene ring to form compounds containing nitro, chlorine and fluorine. At the end, a reducing agent, such as iron powder and hydrochloric acid, is used to reduce the nitro group to an amino group. After a series of reactions such as diazotization and deamination, O-chlorofluorobenzene can be obtained. Although this path is complicated, the position of the substituent can be precisely controlled and the selectivity of the product can be improved.
The third is the Grignard reagent method. The Grignard reagent is prepared from fluorobenzene, which is to react with magnesium shavings in anhydrous ethyl ether and other solvents to form phenylfluor This Grignard reagent reacts with chlorinated reagents, such as chlorinated hydrocarbons or chlorides, under appropriate conditions to obtain O-chlorofluorobenzene. The Grignard reagent method requires strict reaction conditions and requires an anhydrous and anaerobic environment to avoid the decomposition of Grignard reagents. However, it has good results in constructing carbon-halogen bonds, and can prepare halogenated aromatics with specific structures.
O-chlorofluorobenzene What are the precautions during storage and transportation?
O-chlorofluorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First storage. This substance should be stored in a cool and ventilated warehouse. Because of its volatility and flammability, high temperature may increase its volatilization, and there is a risk of fire. The temperature of the warehouse should be controlled within an appropriate range to prevent its chemical properties from changing due to excessive temperature. It must also be kept away from fires and heat sources, and fireworks are strictly prohibited. The lighting and ventilation facilities in the warehouse should be explosion-proof to avoid hazards such as static electricity and sparks. Furthermore, it should be stored separately from oxidizing agents, acids, and alkalis, and should not be stored together. Because O-chlorofluorobenzene and other such substances are prone to chemical reactions, or cause violent reactions, resulting in safety accidents.
Times and transportation. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. In summer, it is advisable to transport in the morning and evening to avoid high temperature periods. During transportation, it should be protected from exposure to the sun, rain and high temperature. Road transportation should follow the prescribed route and do not stop in residential areas and densely populated areas. It is forbidden to slip during railway transportation. If it is transported by water, it should be prevented from flowing into the water body, because it is toxic to aquatic organisms or pollutes the water environment.
Therefore, during the storage and transportation of O-chlorofluorobenzene, observe the above things to ensure safety and avoid disasters.
First storage. This substance should be stored in a cool and ventilated warehouse. Because of its volatility and flammability, high temperature may increase its volatilization, and there is a risk of fire. The temperature of the warehouse should be controlled within an appropriate range to prevent its chemical properties from changing due to excessive temperature. It must also be kept away from fires and heat sources, and fireworks are strictly prohibited. The lighting and ventilation facilities in the warehouse should be explosion-proof to avoid hazards such as static electricity and sparks. Furthermore, it should be stored separately from oxidizing agents, acids, and alkalis, and should not be stored together. Because O-chlorofluorobenzene and other such substances are prone to chemical reactions, or cause violent reactions, resulting in safety accidents.
Times and transportation. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. In summer, it is advisable to transport in the morning and evening to avoid high temperature periods. During transportation, it should be protected from exposure to the sun, rain and high temperature. Road transportation should follow the prescribed route and do not stop in residential areas and densely populated areas. It is forbidden to slip during railway transportation. If it is transported by water, it should be prevented from flowing into the water body, because it is toxic to aquatic organisms or pollutes the water environment.
Therefore, during the storage and transportation of O-chlorofluorobenzene, observe the above things to ensure safety and avoid disasters.
Scan to WhatsApp
