Linshang Chemical
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O-Iodochlorobenzene
Linshang Chemical
|
HS Code |
395890 |
| Chemical Formula | C6H4ClI |
| Molar Mass | 238.45 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Density | 1.94 g/cm³ |
| Boiling Point | 217 - 218 °C |
| Melting Point | −1 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ether, benzene |
| Flash Point | 88 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
| Odor | Characteristic aromatic odor |
As an accredited O-Iodochlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of O - iodochlorobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | O - iodochlorobenzene should be stored in a cool, dry, well - ventilated area away from sources of heat and ignition. Keep it in a tightly - sealed container to prevent vapor release. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. This storage approach helps maintain its stability and ensures safety. |
| Shipping | O - iodochlorobenzene is shipped in well - sealed, corrosion - resistant containers. It must be labeled clearly indicating its chemical nature. Shipments follow strict regulations to prevent spills and ensure safety during transport. |
Competitive O-Iodochlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading O-Iodochlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of O-iodochlorobenzene?
O-iodochlorobenzene is also an organic halogenated aromatic compound. It has a halogen atom, so its chemical properties are active.
Its halogen atoms can be involved in nucleophilic substitution reactions. The electron cloud density of the capsulated benzene ring decreases due to the electron-absorbing effect of halogen atoms, making the adjacent and para-electron cloud densities of the benzene ring relatively high. Nucleophilic reagents can attack the carbon sites attached to the halogen atoms, and the halogen atoms leave to form new compounds. If reacted with sodium alcohol, iodine or chlorine atoms can be substituted with alkoxy groups to obtain corresponding ethers.
can also participate in metal-catalyzed cross-coupling reactions. Under the action of metal catalysts such as palladium and nickel, it is coupled with carbon-containing nucleophiles (such as organoboronic acid and organozinc reagents) to expand the carbon chain and build a complex aromatic structure, which is quite useful in the fields of drug synthesis and material chemistry.
Its chemical properties are also affected by the benzene ring. The conjugated system of the benzene ring makes the molecule have certain stability, but it can also undergo electrophilic substitution reactions. Although the halogen atom is an ortho-and para-site locator, the subsequent electrophilic substitution reactions mainly occur in the ortho-and para-sites, and the reaction activity is slightly lower than that of benzene because the halogen atom absorbs electr O-iodochlorobenzene is an important starting material for the construction of complex organic molecules because of the interaction between halogen atom and benzene ring conjugated system, which exhibits various chemical properties.
Its halogen atoms can be involved in nucleophilic substitution reactions. The electron cloud density of the capsulated benzene ring decreases due to the electron-absorbing effect of halogen atoms, making the adjacent and para-electron cloud densities of the benzene ring relatively high. Nucleophilic reagents can attack the carbon sites attached to the halogen atoms, and the halogen atoms leave to form new compounds. If reacted with sodium alcohol, iodine or chlorine atoms can be substituted with alkoxy groups to obtain corresponding ethers.
can also participate in metal-catalyzed cross-coupling reactions. Under the action of metal catalysts such as palladium and nickel, it is coupled with carbon-containing nucleophiles (such as organoboronic acid and organozinc reagents) to expand the carbon chain and build a complex aromatic structure, which is quite useful in the fields of drug synthesis and material chemistry.
Its chemical properties are also affected by the benzene ring. The conjugated system of the benzene ring makes the molecule have certain stability, but it can also undergo electrophilic substitution reactions. Although the halogen atom is an ortho-and para-site locator, the subsequent electrophilic substitution reactions mainly occur in the ortho-and para-sites, and the reaction activity is slightly lower than that of benzene because the halogen atom absorbs electr O-iodochlorobenzene is an important starting material for the construction of complex organic molecules because of the interaction between halogen atom and benzene ring conjugated system, which exhibits various chemical properties.
What are the common uses of O-iodochlorobenzene?
O-iodochlorobenzene is o-iodochlorobenzene, and its common uses are as follows.
In the field of organic synthesis, o-iodochlorobenzene has a wide range of uses. Because it contains both iodine and chlorine halogen atoms in its molecule, it has unique properties. Iodine atoms are highly active and can act as leaving groups in many reactions, participating in Suzuki coupling reactions, Stille coupling reactions, etc. In Suzuki coupling reactions, o-iodochlorobenzene can be coupled with boron-containing compounds under the action of palladium catalysts to form a series of biphenyl derivatives with specific structures. These derivatives are of great value in pharmaceutical chemistry, materials science, etc. For example, they can be used to synthesize new organic optoelectronic materials to improve the optical and electrical properties of materials.
Furthermore, although chlorine atoms are slightly less active than iodine atoms, they can also participate in specific reactions. Under suitable reaction conditions, chlorine atoms can be replaced by nucleophiles, thereby introducing various functional groups into the molecule and expanding the structural diversity of compounds. This is an important strategy for constructing complex organic molecular structures, which can be used to prepare pharmaceutical intermediates with special biological activities.
In the field of medicine, o-iodine chlorobenzene can become a key structural fragment of some drug molecules after being transformed by a series of chemical reactions. Due to its unique chemical structure, it can affect the activity, solubility, stability and many other properties of drug molecules. In the development of some drugs with antibacterial and antiviral activities, the intermediates derived from o-iodochlorobenzene play an important role, providing the possibility for the creation of new and efficient drugs.
In the field of materials, using o-iodochlorobenzene as the starting material, polymerization or other reactions can prepare polymer materials with special properties. For example, when synthesizing polymers with specific photoelectric properties, o-iodochlorobenzene is introduced as a monomer or structural unit, which can regulate the conjugate structure of the polymer, thereby affecting its electrical and optical properties. It is expected to be used in organic Light Emitting Diode (OLED), solar cells and other devices.
In the field of organic synthesis, o-iodochlorobenzene has a wide range of uses. Because it contains both iodine and chlorine halogen atoms in its molecule, it has unique properties. Iodine atoms are highly active and can act as leaving groups in many reactions, participating in Suzuki coupling reactions, Stille coupling reactions, etc. In Suzuki coupling reactions, o-iodochlorobenzene can be coupled with boron-containing compounds under the action of palladium catalysts to form a series of biphenyl derivatives with specific structures. These derivatives are of great value in pharmaceutical chemistry, materials science, etc. For example, they can be used to synthesize new organic optoelectronic materials to improve the optical and electrical properties of materials.
Furthermore, although chlorine atoms are slightly less active than iodine atoms, they can also participate in specific reactions. Under suitable reaction conditions, chlorine atoms can be replaced by nucleophiles, thereby introducing various functional groups into the molecule and expanding the structural diversity of compounds. This is an important strategy for constructing complex organic molecular structures, which can be used to prepare pharmaceutical intermediates with special biological activities.
In the field of medicine, o-iodine chlorobenzene can become a key structural fragment of some drug molecules after being transformed by a series of chemical reactions. Due to its unique chemical structure, it can affect the activity, solubility, stability and many other properties of drug molecules. In the development of some drugs with antibacterial and antiviral activities, the intermediates derived from o-iodochlorobenzene play an important role, providing the possibility for the creation of new and efficient drugs.
In the field of materials, using o-iodochlorobenzene as the starting material, polymerization or other reactions can prepare polymer materials with special properties. For example, when synthesizing polymers with specific photoelectric properties, o-iodochlorobenzene is introduced as a monomer or structural unit, which can regulate the conjugate structure of the polymer, thereby affecting its electrical and optical properties. It is expected to be used in organic Light Emitting Diode (OLED), solar cells and other devices.
What are the synthesis methods of O-iodochlorobenzene?
O-iodochlorobenzene is o-iodochlorobenzene. The common synthesis methods are as follows:
First, o-chloroaniline is used as the starting material. First, o-chloroaniline is reacted with sodium nitrite in a hydrochloric acid solution to form diazonium salts. This process needs to be controlled at low temperature to prevent the decomposition of diazonium salts, such as maintaining the temperature between 0-5 ° C. Subsequently, potassium iodide solution is added to the diazonium salt solution, and the diazonium group will be replaced by iodine atoms to produce o-iodochlorobenzene. This method is relatively simple. The diazotization reaction is a common means to introduce specific functional groups in organic synthesis. By carefully controlling the reaction conditions, a higher yield can be obtained.
Second, o-chlorobenzoic acid is used as the starting material. First, o-chlorobenzoic acid is reacted with phosphorus pentachloride to convert the carboxyl group into an acyl chloride. Then, in the presence of a palladium catalyst and appropriate ligands, a halogen exchange reaction occurs with iodizing reagents such as cuprous iodide. The palladium catalyst can effectively promote the exchange process of halogen atoms and improve the reaction efficiency. The reaction system needs to be carried out under the protection of inert gas to avoid catalyst poisoning and side reactions, and finally generate o-iodochlorobenzene.
Third, it is constructed by the electrophilic substitution reaction of benzene. Using benzene as the raw material, the chlorination reaction is carried out first. Under the action of a suitable catalyst such as ferric chloride, chlorine gas re After that, the chlorobenzene is then iodized, and a suitable iodide reagent such as a mixed system of iodine and sulfuric acid is used. Under specific conditions, the iodine atom can replace the hydrogen atom at the neighboring position on the benzene ring, and then the o-iodine chlorobenzene is obtained. This method is based on the electrophilic substitution characteristics of the benzene ring, and different halogen atoms are introduced step by step to achieve the synthesis of the target product, but the control of the reaction conditions is very critical, and it needs to be precisely regulated according to the characteristics of each step of the reaction.
First, o-chloroaniline is used as the starting material. First, o-chloroaniline is reacted with sodium nitrite in a hydrochloric acid solution to form diazonium salts. This process needs to be controlled at low temperature to prevent the decomposition of diazonium salts, such as maintaining the temperature between 0-5 ° C. Subsequently, potassium iodide solution is added to the diazonium salt solution, and the diazonium group will be replaced by iodine atoms to produce o-iodochlorobenzene. This method is relatively simple. The diazotization reaction is a common means to introduce specific functional groups in organic synthesis. By carefully controlling the reaction conditions, a higher yield can be obtained.
Second, o-chlorobenzoic acid is used as the starting material. First, o-chlorobenzoic acid is reacted with phosphorus pentachloride to convert the carboxyl group into an acyl chloride. Then, in the presence of a palladium catalyst and appropriate ligands, a halogen exchange reaction occurs with iodizing reagents such as cuprous iodide. The palladium catalyst can effectively promote the exchange process of halogen atoms and improve the reaction efficiency. The reaction system needs to be carried out under the protection of inert gas to avoid catalyst poisoning and side reactions, and finally generate o-iodochlorobenzene.
Third, it is constructed by the electrophilic substitution reaction of benzene. Using benzene as the raw material, the chlorination reaction is carried out first. Under the action of a suitable catalyst such as ferric chloride, chlorine gas re After that, the chlorobenzene is then iodized, and a suitable iodide reagent such as a mixed system of iodine and sulfuric acid is used. Under specific conditions, the iodine atom can replace the hydrogen atom at the neighboring position on the benzene ring, and then the o-iodine chlorobenzene is obtained. This method is based on the electrophilic substitution characteristics of the benzene ring, and different halogen atoms are introduced step by step to achieve the synthesis of the target product, but the control of the reaction conditions is very critical, and it needs to be precisely regulated according to the characteristics of each step of the reaction.
What are the precautions for O-iodochlorobenzene during storage and transportation?
O-iodine chlorobenzene is also an organic compound. During storage and transportation, all precautions are essential and should not be ignored.
First word storage. This substance should be placed in a cool and ventilated warehouse. Because of the cool and ventilated place, it can avoid high temperature and humidity to prevent its properties from changing. And it must be kept away from fire and heat sources to avoid the risk of explosion. Explosion-proof type should be used for lighting and ventilation facilities in the warehouse, and electrical equipment should also meet the explosion-proof requirements to prevent danger caused by electric sparks. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed. Because O-iodine chlorobenzene and various substances can react chemically, causing accidents.
Second talk about transportation. When transporting, the packaging must be complete and the loading should be safe. During transportation, ensure that the container does not leak, collapse, fall or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Driving routes should avoid densely populated areas and residential areas, and should be protected from exposure to the sun, rain and high temperature during transportation. In case of emergency, drivers and passengers should be familiar with emergency treatment methods to ensure safety.
In short, in the storage and transportation of O-iodine chlorobenzene, every step must be carefully carried out, and relevant rules and standards should be followed to avoid disasters and ensure the safety of people and property.
First word storage. This substance should be placed in a cool and ventilated warehouse. Because of the cool and ventilated place, it can avoid high temperature and humidity to prevent its properties from changing. And it must be kept away from fire and heat sources to avoid the risk of explosion. Explosion-proof type should be used for lighting and ventilation facilities in the warehouse, and electrical equipment should also meet the explosion-proof requirements to prevent danger caused by electric sparks. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed. Because O-iodine chlorobenzene and various substances can react chemically, causing accidents.
Second talk about transportation. When transporting, the packaging must be complete and the loading should be safe. During transportation, ensure that the container does not leak, collapse, fall or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Driving routes should avoid densely populated areas and residential areas, and should be protected from exposure to the sun, rain and high temperature during transportation. In case of emergency, drivers and passengers should be familiar with emergency treatment methods to ensure safety.
In short, in the storage and transportation of O-iodine chlorobenzene, every step must be carefully carried out, and relevant rules and standards should be followed to avoid disasters and ensure the safety of people and property.
What are the effects of O-iodochlorobenzene on the environment and human health?
O-iodochlorobenzene, or o-iodochlorobenzene, has an impact on the environment and human health.
First talk about its impact on the environment. O-iodochlorobenzene has a certain stability, is difficult to degrade in the natural environment, and can be retained for a long time. If it is released into the water body, it will be adsorbed by soil particles, hindering the absorption of nutrients and water by plant roots, inhibiting crop growth, and may also be transmitted and enriched through the food chain. For example, o-iodochlorobenzene in the soil is absorbed by plants, eaten by herbivores, and then in carnivores, the concentration gradually rises, disturbing the balance of the ecosystem.
The following describes the effects on human health. O-Iodine chlorobenzene can be ingested into the human body through the respiratory tract, skin contact and digestive tract. Inhalation through the respiratory tract can irritate the respiratory mucosa, causing symptoms such as cough, asthma, breathing difficulties, long-term exposure or damage to lung function, and increase the risk of respiratory diseases. Skin contact can cause skin allergies, itching, redness and swelling, and even penetrate the skin into the blood circulation, damaging other organs. If eaten by mistake, it can irritate the gastrointestinal tract, causing nausea, vomiting, abdominal pain, diarrhea, etc., and may also damage important organs such as the liver and kidneys. Due to its toxicity, it interferes with the normal metabolism and function of cells, and affects the normal operation of organs. Long-term or high-dose exposure may increase the risk of cancer. Because of the halogen atoms in its structure or mutagenicity, it causes changes in cellular genetic material and causes carcinogenesis.
In summary, o-iodine chlorobenzene has many adverse effects on the environment and human health. When producing, using and handling, proper protection and disposal measures must be taken to reduce its harm.
First talk about its impact on the environment. O-iodochlorobenzene has a certain stability, is difficult to degrade in the natural environment, and can be retained for a long time. If it is released into the water body, it will be adsorbed by soil particles, hindering the absorption of nutrients and water by plant roots, inhibiting crop growth, and may also be transmitted and enriched through the food chain. For example, o-iodochlorobenzene in the soil is absorbed by plants, eaten by herbivores, and then in carnivores, the concentration gradually rises, disturbing the balance of the ecosystem.
The following describes the effects on human health. O-Iodine chlorobenzene can be ingested into the human body through the respiratory tract, skin contact and digestive tract. Inhalation through the respiratory tract can irritate the respiratory mucosa, causing symptoms such as cough, asthma, breathing difficulties, long-term exposure or damage to lung function, and increase the risk of respiratory diseases. Skin contact can cause skin allergies, itching, redness and swelling, and even penetrate the skin into the blood circulation, damaging other organs. If eaten by mistake, it can irritate the gastrointestinal tract, causing nausea, vomiting, abdominal pain, diarrhea, etc., and may also damage important organs such as the liver and kidneys. Due to its toxicity, it interferes with the normal metabolism and function of cells, and affects the normal operation of organs. Long-term or high-dose exposure may increase the risk of cancer. Because of the halogen atoms in its structure or mutagenicity, it causes changes in cellular genetic material and causes carcinogenesis.
In summary, o-iodine chlorobenzene has many adverse effects on the environment and human health. When producing, using and handling, proper protection and disposal measures must be taken to reduce its harm.
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