Linshang Chemical
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P-Chloro Benzene Boronic Acid
Linshang Chemical
|
HS Code |
450038 |
| Chemical Formula | C6H6BClO2 |
| Molar Mass | 157.38 g/mol |
| Appearance | White to off - white solid |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, dichloromethane |
| Melting Point | 235 - 239 °C |
| Pka | Around 8.8 |
| Stability | Stable under normal conditions, but sensitive to strong oxidizing agents |
As an accredited P-Chloro Benzene Boronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of P - chloro Benzene Boronic Acid packaged in a sealed, chemical - resistant bottle. |
| Storage | P - chloro Benzene Boronic Acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption and exposure to air, which could lead to degradation. Store separately from incompatible substances like strong oxidizing agents. Ensure the storage area has good ventilation to avoid the build - up of vapors. |
| Shipping | P - chloro Benzene Boronic Acid is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical shipping regulations, ensuring proper handling to prevent spills and maintain product integrity during transit. |
Competitive P-Chloro Benzene Boronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading P-Chloro Benzene Boronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of P-chloro Benzene Boronic Acid?
The chemical structure of P-chlorophenylboronic acid is unique. The view is that it is in the para-position of the benzene ring, and the boric acid group connected to the monochlorine atom and the boron atom is opposite.
The benzene ring is a six-membered carbon ring with a conjugated system, showing a planar structure, which endows the molecule with certain stability and special electronic effects. The chlorine atom is connected to the benzene ring, because its electronegativity is higher than that of carbon, it can absorb electrons, resulting in a decrease in the electron cloud density of the benzene ring. During the electrophilic substitution reaction, the reaction activity changes, and it has the effect of ortho and
In boric acid group (-B (OH) -2), the outer electron of boron atom does not reach octet, which is electron-deficient and can be used as Lewis acid. In this structure, the boron atom is bonded with two hydroxyl oxygen atoms and the carbon atom of the benzene ring in the sp ² hybrid orbit to form a planar triangular structure. The lone pair of electrons on the oxygen atom of the hydroxyl group can be conjugated with the empty orbit of the boron atom to produce p-π, which affects the acidity of the boric acid group.
The structure of P-chlorophenylboronic acid makes it widely used in the field of organic synthesis, such as participating in the Suzuki-Miyaura coupling reaction, etc. It can use the reaction characteristics of boron atoms and halogenated aromatics to construct carbon-carbon bonds to prepare many complex organic compounds. Its unique chemical structure is a key element in opening a new path in organic synthesis.
The benzene ring is a six-membered carbon ring with a conjugated system, showing a planar structure, which endows the molecule with certain stability and special electronic effects. The chlorine atom is connected to the benzene ring, because its electronegativity is higher than that of carbon, it can absorb electrons, resulting in a decrease in the electron cloud density of the benzene ring. During the electrophilic substitution reaction, the reaction activity changes, and it has the effect of ortho and
In boric acid group (-B (OH) -2), the outer electron of boron atom does not reach octet, which is electron-deficient and can be used as Lewis acid. In this structure, the boron atom is bonded with two hydroxyl oxygen atoms and the carbon atom of the benzene ring in the sp ² hybrid orbit to form a planar triangular structure. The lone pair of electrons on the oxygen atom of the hydroxyl group can be conjugated with the empty orbit of the boron atom to produce p-π, which affects the acidity of the boric acid group.
The structure of P-chlorophenylboronic acid makes it widely used in the field of organic synthesis, such as participating in the Suzuki-Miyaura coupling reaction, etc. It can use the reaction characteristics of boron atoms and halogenated aromatics to construct carbon-carbon bonds to prepare many complex organic compounds. Its unique chemical structure is a key element in opening a new path in organic synthesis.
What are the main uses of P-chloro Benzene Boronic Acid?
P-chlorophenylboronic acid has a wide range of uses. In the field of organic synthesis, it is often a key intermediate.
First, in the reaction of building carbon-carbon bonds, p-chlorophenylboronic acid can participate in the Suzuki coupling reaction. In this reaction, it can form carbon-carbon bonds with halogenated aromatics or olefins under the action of palladium catalysts and bases, which can help to synthesize many biphenyl compounds with specific structures. Such compounds are of great significance in the fields of materials science and medicinal chemistry. For example, the synthesis of some new photoelectric materials requires the use of this reaction to precisely construct a biphenyl skeleton to give the material special optical and electrical properties.
Second, p-chlorophenylboronic acid also plays an important role in drug development. Due to its structural properties, it can be introduced into drug molecules as a key module to change the physicochemical properties of drugs, such as improving the solubility and stability of drugs, or optimizing the interaction between drugs and targets, thereby enhancing drug efficacy. For example, in the synthesis of some anti-tumor drugs, p-chlorophenylboronic acid is cleverly used to participate in the reaction, optimize the molecular structure, and improve its targeting and lethality to tumor cells.
Third, in the field of material surface modification, p-chlorophenylboronic acid can react with active groups on the surface of specific materials to achieve surface functionalization of materials. For example, by modifying the surface of a polymer material, the material is given the ability to recognize specific substances, such as sugar molecules, which can be used to build new biosensors to achieve sensitive detection of sugar substances in vivo.
First, in the reaction of building carbon-carbon bonds, p-chlorophenylboronic acid can participate in the Suzuki coupling reaction. In this reaction, it can form carbon-carbon bonds with halogenated aromatics or olefins under the action of palladium catalysts and bases, which can help to synthesize many biphenyl compounds with specific structures. Such compounds are of great significance in the fields of materials science and medicinal chemistry. For example, the synthesis of some new photoelectric materials requires the use of this reaction to precisely construct a biphenyl skeleton to give the material special optical and electrical properties.
Second, p-chlorophenylboronic acid also plays an important role in drug development. Due to its structural properties, it can be introduced into drug molecules as a key module to change the physicochemical properties of drugs, such as improving the solubility and stability of drugs, or optimizing the interaction between drugs and targets, thereby enhancing drug efficacy. For example, in the synthesis of some anti-tumor drugs, p-chlorophenylboronic acid is cleverly used to participate in the reaction, optimize the molecular structure, and improve its targeting and lethality to tumor cells.
Third, in the field of material surface modification, p-chlorophenylboronic acid can react with active groups on the surface of specific materials to achieve surface functionalization of materials. For example, by modifying the surface of a polymer material, the material is given the ability to recognize specific substances, such as sugar molecules, which can be used to build new biosensors to achieve sensitive detection of sugar substances in vivo.
What are the synthesis methods of P-chloro Benzene Boronic Acid?
There are several common methods for the synthesis of p-chlorophenylboronic acid.
One is the metallization of halogenated aromatics. First, p-chlorobrombenzene and butyllithium and other metal reagents interact to form p-chlorophenyllithium intermediates at low temperatures. This process needs to be operated at a low temperature such as -78 ° C, and in an inert atmosphere without water and oxygen to ensure a smooth reaction. Then it reacts with borate esters such as trimethyl borate, and hydrolyzes to obtain p-chlorophenylboronic acid. In this path, butyllithium has high activity, and the operation needs to be cautious. Anhydrous and anaerobic conditions are also crucial. A little carelessness can easily lead to side reactions.
The second is the palladium catalytic coupling method. Using p-chlorophenyl halide and borate as raw materials, under the catalysis of palladium catalyst such as tetra (triphenylphosphine) palladium, add appropriate bases such as potassium carbonate, sodium carbonate, etc., and heat the reaction in organic solvents such as toluene and dioxane. In this reaction, the activity and stability of palladium catalysts need to be paid attention to, and the choice of ligands will also affect the reaction effect, and the type and amount of bases have an effect on the reaction process and yield.
The third can be prepared by the Grignard reagent method. The reaction of p-chlorobrobenzene with magnesium chips in anhydrous ether or tetrahydrofuran is used to form a p-chlorophenyl Grignard reagent, which is then reacted with borate esters to obtain the In this process, the quality of magnesium chips and the drying degree of the reaction system are the key, Grignard reagent is extremely sensitive to water and oxygen, and the preparation and subsequent reactions should be isolated.
All these methods have their own advantages and disadvantages. In actual synthesis, it is necessary to weigh the choice according to the availability of raw materials, reaction conditions, cost-effectiveness and many other factors to obtain the ideal synthesis effect.
One is the metallization of halogenated aromatics. First, p-chlorobrombenzene and butyllithium and other metal reagents interact to form p-chlorophenyllithium intermediates at low temperatures. This process needs to be operated at a low temperature such as -78 ° C, and in an inert atmosphere without water and oxygen to ensure a smooth reaction. Then it reacts with borate esters such as trimethyl borate, and hydrolyzes to obtain p-chlorophenylboronic acid. In this path, butyllithium has high activity, and the operation needs to be cautious. Anhydrous and anaerobic conditions are also crucial. A little carelessness can easily lead to side reactions.
The second is the palladium catalytic coupling method. Using p-chlorophenyl halide and borate as raw materials, under the catalysis of palladium catalyst such as tetra (triphenylphosphine) palladium, add appropriate bases such as potassium carbonate, sodium carbonate, etc., and heat the reaction in organic solvents such as toluene and dioxane. In this reaction, the activity and stability of palladium catalysts need to be paid attention to, and the choice of ligands will also affect the reaction effect, and the type and amount of bases have an effect on the reaction process and yield.
The third can be prepared by the Grignard reagent method. The reaction of p-chlorobrobenzene with magnesium chips in anhydrous ether or tetrahydrofuran is used to form a p-chlorophenyl Grignard reagent, which is then reacted with borate esters to obtain the In this process, the quality of magnesium chips and the drying degree of the reaction system are the key, Grignard reagent is extremely sensitive to water and oxygen, and the preparation and subsequent reactions should be isolated.
All these methods have their own advantages and disadvantages. In actual synthesis, it is necessary to weigh the choice according to the availability of raw materials, reaction conditions, cost-effectiveness and many other factors to obtain the ideal synthesis effect.
What are the precautions for P-chloro Benzene Boronic Acid during storage and transportation?
For P-chlorophenylboronic acid, there are several things to pay attention to during storage and transportation.
Bear the brunt. When storing, it must be kept in a dry and cool place. The cover may be susceptible to moisture and high temperature due to its nature. If it is in a humid environment or causes reactions such as hydrolysis, it will damage its purity and activity. Under high temperature, it may cause decomposition and cause it to deteriorate. Therefore, it can be stored in a dry and cool place to ensure its chemical stability.
Furthermore, during transportation, it should be protected from vibration and collision. The structure of this compound may be fragile, violent vibration, collision, or damage to the package, which in turn exposes it to the external environment and causes safety problems. And the package must be strong to prevent leakage. If it accidentally leaks or pollutes the environment, it may also pose a threat to the safety of transporters.
In addition, isolation from other substances is also critical. P-chlorophenylboronic acid may chemically react with certain substances, such as strong oxidants, strong alkalis, etc. Therefore, when storing and transporting, make sure to keep it separated from such substances to avoid accidents.
It is also necessary to note that the conditions of its storage and transportation should be recorded in detail. Such as storage temperature, humidity, and the environment it passes through during transportation, etc., for future inspection, to ensure that the whole process meets the specifications, so as to ensure the quality and safety of P-chlorophenylboronic acid.
Bear the brunt. When storing, it must be kept in a dry and cool place. The cover may be susceptible to moisture and high temperature due to its nature. If it is in a humid environment or causes reactions such as hydrolysis, it will damage its purity and activity. Under high temperature, it may cause decomposition and cause it to deteriorate. Therefore, it can be stored in a dry and cool place to ensure its chemical stability.
Furthermore, during transportation, it should be protected from vibration and collision. The structure of this compound may be fragile, violent vibration, collision, or damage to the package, which in turn exposes it to the external environment and causes safety problems. And the package must be strong to prevent leakage. If it accidentally leaks or pollutes the environment, it may also pose a threat to the safety of transporters.
In addition, isolation from other substances is also critical. P-chlorophenylboronic acid may chemically react with certain substances, such as strong oxidants, strong alkalis, etc. Therefore, when storing and transporting, make sure to keep it separated from such substances to avoid accidents.
It is also necessary to note that the conditions of its storage and transportation should be recorded in detail. Such as storage temperature, humidity, and the environment it passes through during transportation, etc., for future inspection, to ensure that the whole process meets the specifications, so as to ensure the quality and safety of P-chlorophenylboronic acid.
What is the market price range for P-chloro Benzene Boronic Acid?
P-chlorophenylboronic acid, the range of the inter-market price is difficult to determine. The price of the cover is subject to many factors, and it is difficult to generalize.
First, the price of the raw material is the main factor. For the production of P-chlorophenylboronic acid, specific raw materials are required. If the supply of raw materials is less and more, the price will rise; on the contrary, if the supply is more and less, the price will drop. If the real estate situation of the raw material changes, the supply will fluctuate, and the price will also follow.
Furthermore, the method of preparation is also related to the cost. Different preparation methods have different costs. The method of high efficiency and low cost can reduce the production cost, and the market price may be low; the method of difficulty and high cost will lead to a high price.
Also, the market supply and demand situation is the key. If there is more demand for P-chlorophenylboronic acid in many fields, but the production and supply are small, and the supply is in a state of shortage, the price will rise; if there is less supply and more supply, the price will fall. For example, electronics, medicine and other industries are prosperous, and the demand for them will increase, and the price may also rise.
Moreover, the market competition situation has an impact. If there are many producers and the competition is intense, the price may be reduced in order to compete for market share; on the contrary, there are few producers and the monopoly is strong, and the price may be high.
In addition, policies and regulations, transportation costs, etc., will also be involved in the price. Tariff adjustment and environmental protection regulations can change the cost and cause the price to move; the transportation distance and high cost will also increase the total cost, and the inter-market price will be affected.
Therefore, the range of the inter-market price of P-chlorophenylboronic acid is difficult to determine. It is necessary to look at the various factors before we can get a more accurate judgment.
First, the price of the raw material is the main factor. For the production of P-chlorophenylboronic acid, specific raw materials are required. If the supply of raw materials is less and more, the price will rise; on the contrary, if the supply is more and less, the price will drop. If the real estate situation of the raw material changes, the supply will fluctuate, and the price will also follow.
Furthermore, the method of preparation is also related to the cost. Different preparation methods have different costs. The method of high efficiency and low cost can reduce the production cost, and the market price may be low; the method of difficulty and high cost will lead to a high price.
Also, the market supply and demand situation is the key. If there is more demand for P-chlorophenylboronic acid in many fields, but the production and supply are small, and the supply is in a state of shortage, the price will rise; if there is less supply and more supply, the price will fall. For example, electronics, medicine and other industries are prosperous, and the demand for them will increase, and the price may also rise.
Moreover, the market competition situation has an impact. If there are many producers and the competition is intense, the price may be reduced in order to compete for market share; on the contrary, there are few producers and the monopoly is strong, and the price may be high.
In addition, policies and regulations, transportation costs, etc., will also be involved in the price. Tariff adjustment and environmental protection regulations can change the cost and cause the price to move; the transportation distance and high cost will also increase the total cost, and the inter-market price will be affected.
Therefore, the range of the inter-market price of P-chlorophenylboronic acid is difficult to determine. It is necessary to look at the various factors before we can get a more accurate judgment.
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