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P-Chlorobenzenesulfonyl Bromide
Linshang Chemical
|
HS Code |
410114 |
| Chemical Formula | C6H4BrClO2S |
| Molar Mass | 269.52 g/mol |
| Appearance | White to off - white solid |
| Melting Point | 38 - 42 °C |
| Boiling Point | 152 - 154 °C (1.5 mmHg) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | N/A (solid, density data may be less common) |
| Odor | Pungent odor |
| Reactivity | Reactive towards nucleophiles |
| Hazard Class | Corrosive, can cause burns to skin and eyes |
As an accredited P-Chlorobenzenesulfonyl Bromide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of P - chlorobenzenesulfonyl Bromide packaged in a sealed, corrosion - resistant bottle. |
| Storage | P - chlorobenzenesulfonyl bromide should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and incompatible substances such as strong bases and reducing agents. Store it in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air or moisture which could cause decomposition or unwanted reactions. |
| Shipping | P - chlorobenzenesulfonyl Bromide is a chemical. For shipping, it must be in a well - sealed, corrosion - resistant container. Label it clearly as a hazardous chemical. Follow all relevant regulations for safe transportation. |
Competitive P-Chlorobenzenesulfonyl Bromide prices that fit your budget—flexible terms and customized quotes for every order.
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P-chlorobenzenesulfonyl the chemistry of Bromide
P-chlorobenzenesulfonyl bromide, this material is strong and active. Its appearance is often colorless to light yellow liquid, and the smell has a pungent smell, just like the ancient books say "pungent smell, uncomfortable".
In terms of chemical activity, the sulfonyl bromide group (-SO ² Br) is extremely active, and is often used as an electrophilic reagent to participate in various chemical reactions. In contact with water, it is like a dragon getting rain, and it quickly hydrolyzes and turns into P-chlorobenzenesulfonic acid and hydrobromic acid. This process is like water and fire, and it is very violent. "It changes when it encounters water, and it generates acid and is strong."
In the field of organic synthesis, its status is respected. If it can meet alcohols, it will be like friends. It will be replaced by nucleophiles and turn into sulfonates. This reaction is in the "battle" of organic synthesis. It is a good way to construct sulfonate compounds, "and the alcohol phase, and the structure of ester formation". When it meets amines, it is also unwilling to be lonely and can produce sulfonamides. This is a common way to prepare sulfonamides. "When it encounters amines, it will combine and form sulfonamides."
Furthermore, P-chlorobenzenesulfonyl bromide contains chlorine atoms and sulfonyl bromide groups, and the electron cloud distribution is unique, which disturbs the electron cloud density of the benzene ring. In the aromatic electrophilic substitution reaction, it exhibits different activities, which affects the check point and rate of the reaction.
Because of its active chemical properties, corrosive and toxic, when operating, it must be cautious, follow strict procedures, and protect it well, so as not to hurt itself. "The nature is strong and toxic, and the operation must be careful, and the protection is comprehensive, so as to keep it safe."
In terms of chemical activity, the sulfonyl bromide group (-SO ² Br) is extremely active, and is often used as an electrophilic reagent to participate in various chemical reactions. In contact with water, it is like a dragon getting rain, and it quickly hydrolyzes and turns into P-chlorobenzenesulfonic acid and hydrobromic acid. This process is like water and fire, and it is very violent. "It changes when it encounters water, and it generates acid and is strong."
In the field of organic synthesis, its status is respected. If it can meet alcohols, it will be like friends. It will be replaced by nucleophiles and turn into sulfonates. This reaction is in the "battle" of organic synthesis. It is a good way to construct sulfonate compounds, "and the alcohol phase, and the structure of ester formation". When it meets amines, it is also unwilling to be lonely and can produce sulfonamides. This is a common way to prepare sulfonamides. "When it encounters amines, it will combine and form sulfonamides."
Furthermore, P-chlorobenzenesulfonyl bromide contains chlorine atoms and sulfonyl bromide groups, and the electron cloud distribution is unique, which disturbs the electron cloud density of the benzene ring. In the aromatic electrophilic substitution reaction, it exhibits different activities, which affects the check point and rate of the reaction.
Because of its active chemical properties, corrosive and toxic, when operating, it must be cautious, follow strict procedures, and protect it well, so as not to hurt itself. "The nature is strong and toxic, and the operation must be careful, and the protection is comprehensive, so as to keep it safe."
What are the main uses of P-chlorobenzenesulfonyl Bromide?
P-chlorobenzenesulfonyl bromide is an important compound in the field of organic synthesis and has a wide range of uses.
First, it is used to prepare sulfonamide compounds. It can react with various amines to form sulfonamides. This reaction is of great significance in the field of medicinal chemistry. Many drugs contain sulfonamide groups in their molecular structures. P-chlorobenzenesulfonyl bromide provides a key starting material for the synthesis of such drugs. For example, in the synthesis of some antibacterial drugs and diuretic drugs, by reacting with specific amines, p-chlorobenzenesulfonyl bromide can build a key sulfonamide structure, which in turn endows the drug with specific physiological activities.
Second, it is used to synthesize sul p-Chlorobenzenesulfonyl bromide can react with compounds containing carbon negative ions, such as Grignard reagents, to form sulfone compounds. Sulfone compounds have certain applications in the field of materials science, such as the synthesis of some high-performance engineering plastics. Sulfone structures can improve the thermal stability and mechanical properties of materials.
Third, it is used as a sulfonylating agent in organic synthesis. p-Chlorobenzenesulfonyl bromide can sulfonate hydroxyl compounds such as alcohols and phenols, introducing sulfonyl groups into the molecules of these compounds. The generated sulfonyl esters are often used as good leaving groups in organic synthesis, participating in subsequent substitution reactions, elimination reactions, etc., providing convenience for the construction of complex organic molecular structures.
Fourth, it is also used in the field of dye synthesis. Through the reaction of p-chlorobenzenesulfonyl bromide, specific functional groups can be introduced into dye molecules to improve the solubility, stability and dyeing properties of dyes.
In summary, p-chlorobenzenesulfonyl bromide plays an indispensable role in many fields due to its unique chemical properties, and is of great significance in the development of organic synthesis chemistry.
First, it is used to prepare sulfonamide compounds. It can react with various amines to form sulfonamides. This reaction is of great significance in the field of medicinal chemistry. Many drugs contain sulfonamide groups in their molecular structures. P-chlorobenzenesulfonyl bromide provides a key starting material for the synthesis of such drugs. For example, in the synthesis of some antibacterial drugs and diuretic drugs, by reacting with specific amines, p-chlorobenzenesulfonyl bromide can build a key sulfonamide structure, which in turn endows the drug with specific physiological activities.
Second, it is used to synthesize sul p-Chlorobenzenesulfonyl bromide can react with compounds containing carbon negative ions, such as Grignard reagents, to form sulfone compounds. Sulfone compounds have certain applications in the field of materials science, such as the synthesis of some high-performance engineering plastics. Sulfone structures can improve the thermal stability and mechanical properties of materials.
Third, it is used as a sulfonylating agent in organic synthesis. p-Chlorobenzenesulfonyl bromide can sulfonate hydroxyl compounds such as alcohols and phenols, introducing sulfonyl groups into the molecules of these compounds. The generated sulfonyl esters are often used as good leaving groups in organic synthesis, participating in subsequent substitution reactions, elimination reactions, etc., providing convenience for the construction of complex organic molecular structures.
Fourth, it is also used in the field of dye synthesis. Through the reaction of p-chlorobenzenesulfonyl bromide, specific functional groups can be introduced into dye molecules to improve the solubility, stability and dyeing properties of dyes.
In summary, p-chlorobenzenesulfonyl bromide plays an indispensable role in many fields due to its unique chemical properties, and is of great significance in the development of organic synthesis chemistry.
P-chlorobenzenesulfonyl Bromide's method of synthesis
To prepare p-chlorobenzenesulfonyl bromide, the method is as follows:
Take p-chlorobenzenesulfonic acid first, which is the key starting material. Place it in a suitable reaction vessel and add an appropriate amount of solvent to ensure that the p-chlorobenzenesulfonic acid is evenly dispersed. The choice of this solvent should be taken into account that it does not interfere with the reaction and can effectively dissolve the reactants.
Then, slowly add the brominating agent. Commonly used brominating agents, such as phosphorus tribromide or phosphorus pentabromide, should be added in an appropriate proportion. When adding, the speed must be carefully controlled to prevent the reaction from being too dramatic. Due to the high activity of the brominating agent, it is easy to cause the reaction to go out of control if it is added Generally speaking, the temperature needs to be determined according to the selected brominating agent and reaction characteristics, and it is usually controlled within a certain range to make the reaction progress steadily. Pressure cannot be ignored, and atmospheric pressure or slightly pressurized depends on the specific reaction.
During the reaction, it is advisable to stir to allow the reactants to fully contact, speed up the reaction process, and make the reaction more complete. When the reaction reaches a certain extent, monitor the reaction progress with suitable analytical means, such as thin-layer chromatography.
When the reaction reaches the expected level, stop the reaction. After the conventional post-treatment methods, such as extraction, washing, drying, etc. Extraction can be used with a suitable organic solvent to separate the target product from the reaction system; washing removes impurities; drying removes residual moisture.
Finally, pure p-chlorobenzenesulfonyl bromide can be obtained by distillation, recrystallization and other purification methods. This whole process requires fine operation and attention to the conditions of each link to obtain the product with ideal yield and purity.
Take p-chlorobenzenesulfonic acid first, which is the key starting material. Place it in a suitable reaction vessel and add an appropriate amount of solvent to ensure that the p-chlorobenzenesulfonic acid is evenly dispersed. The choice of this solvent should be taken into account that it does not interfere with the reaction and can effectively dissolve the reactants.
Then, slowly add the brominating agent. Commonly used brominating agents, such as phosphorus tribromide or phosphorus pentabromide, should be added in an appropriate proportion. When adding, the speed must be carefully controlled to prevent the reaction from being too dramatic. Due to the high activity of the brominating agent, it is easy to cause the reaction to go out of control if it is added Generally speaking, the temperature needs to be determined according to the selected brominating agent and reaction characteristics, and it is usually controlled within a certain range to make the reaction progress steadily. Pressure cannot be ignored, and atmospheric pressure or slightly pressurized depends on the specific reaction.
During the reaction, it is advisable to stir to allow the reactants to fully contact, speed up the reaction process, and make the reaction more complete. When the reaction reaches a certain extent, monitor the reaction progress with suitable analytical means, such as thin-layer chromatography.
When the reaction reaches the expected level, stop the reaction. After the conventional post-treatment methods, such as extraction, washing, drying, etc. Extraction can be used with a suitable organic solvent to separate the target product from the reaction system; washing removes impurities; drying removes residual moisture.
Finally, pure p-chlorobenzenesulfonyl bromide can be obtained by distillation, recrystallization and other purification methods. This whole process requires fine operation and attention to the conditions of each link to obtain the product with ideal yield and purity.
P-chlorobenzenesulfonyl Bromide what to pay attention to when storing and shipping
For P-chlorobenzenesulfonyl bromide, many matters need to be paid attention to during storage and transportation.
The first to bear the brunt is related to the storage environment. This material is delicate and should be placed in a cool and dry place. If it is placed in a warm and humid place, it may cause chemical reactions and cause it to deteriorate. Warm cover can greatly increase its molecular activity, and humid gas is easy to cause hydrolysis and other changes. Therefore, cool and dry is essential to ensure the stability of its chemical properties.
Second, about packaging. When it is placed in a tightly sealed container. The sealing effect is to prevent it from contacting with outside air and prevent it from being oxidized; the second is to avoid the intrusion of water vapor and prevent the risk of hydrolysis. The material of the container used should also be carefully selected, and it should not chemically react with P-chlorobenzenesulfonyl bromide. Glass or specific plastic materials should be used after consideration.
Furthermore, during transportation, vibration and collision must be avoided. Due to its chemical structure, excessive vibration and collision may cause internal chemical bonds to break, causing accidental reactions. Transportation vehicles should be driven smoothly, and if the road conditions are not good, they should be cautious.
In addition, this substance is toxic and corrosive. Those who store and transport must wear professional protective equipment, such as protective clothing, gloves, goggles, etc., to prevent accidental contact and injury to the body. If there is a leak, do not panic, and deal with it according to the established emergency law. In the case of small leaks, cover the adsorption with inert materials such as sand immediately; in the case of large leaks, evacuate the surrounding population, seal the scene, and wait for professionals to properly handle it.
All of these are important points that should not be ignored when storing and transporting P-chlorobenzenesulfonyl bromide. It is necessary to always keep in mind and follow the rules to ensure safety.
The first to bear the brunt is related to the storage environment. This material is delicate and should be placed in a cool and dry place. If it is placed in a warm and humid place, it may cause chemical reactions and cause it to deteriorate. Warm cover can greatly increase its molecular activity, and humid gas is easy to cause hydrolysis and other changes. Therefore, cool and dry is essential to ensure the stability of its chemical properties.
Second, about packaging. When it is placed in a tightly sealed container. The sealing effect is to prevent it from contacting with outside air and prevent it from being oxidized; the second is to avoid the intrusion of water vapor and prevent the risk of hydrolysis. The material of the container used should also be carefully selected, and it should not chemically react with P-chlorobenzenesulfonyl bromide. Glass or specific plastic materials should be used after consideration.
Furthermore, during transportation, vibration and collision must be avoided. Due to its chemical structure, excessive vibration and collision may cause internal chemical bonds to break, causing accidental reactions. Transportation vehicles should be driven smoothly, and if the road conditions are not good, they should be cautious.
In addition, this substance is toxic and corrosive. Those who store and transport must wear professional protective equipment, such as protective clothing, gloves, goggles, etc., to prevent accidental contact and injury to the body. If there is a leak, do not panic, and deal with it according to the established emergency law. In the case of small leaks, cover the adsorption with inert materials such as sand immediately; in the case of large leaks, evacuate the surrounding population, seal the scene, and wait for professionals to properly handle it.
All of these are important points that should not be ignored when storing and transporting P-chlorobenzenesulfonyl bromide. It is necessary to always keep in mind and follow the rules to ensure safety.
P-chlorobenzenesulfonyl Bromide's impact on the environment and human health
The author of "Tiangong Kaiwu" is also a strange book of ancient times. It is famous all over the world for containing the skills and products of all kinds of workers. Today, I have asked about "the impact of P-chlorobenzenesulfonyl Bromide on the environment and human body". Let me tell you one by one.
The impact of p-chlorobenzenesulfonyl bromide on the environment should not be underestimated. If it accidentally flows into natural water bodies, it may cause water pollution. Aquatic organisms, such as fish and shrimp, may suffer from it. Because of its chemical activity, it may interfere with the physiological metabolism of aquatic organisms, causing their growth to be blocked and reproduction to be implicated. What's more, it may cause disorder in the ecological chain, causing the entire aquatic ecosystem to lose its balance.
As for soil, if it is contaminated with p-chlorobenzenesulfonyl bromide, it is also a serious problem. It may change the chemical properties of the soil and affect the survival and reproduction of soil microorganisms. Microorganisms are essential for the maintenance of soil fertility and the growth of plants. Once the microbial community is destroyed, the soil nutrient cycle is not smooth, plant growth is also adversely affected, and the land may gradually lose its fertility.
When it comes to the impact on the human body, it is even more vigilant. If this substance enters the human body through breathing, or irritates the respiratory tract, it can make people cough, asthma, and even cause respiratory inflammation to worsen. If you accidentally come into contact with the skin, because of its corrosive nature, it can burn the skin, make the skin red, swollen, painful, if not handled properly, or leave scars, affecting the health and appearance of the skin. If eaten by mistake, it is particularly harmful to the digestive system, or corrodes the mucosa of the digestive tract, causing abdominal pain, vomiting and other diseases. In severe cases, it may endanger life.
To sum up, p-chlorobenzenesulfonyl bromide has potential harm to the environment and human body. The world should be cautious. Its production, use, transportation and other aspects should be strictly regulated to reduce its adverse effects on the environment and human body, which is a long-term solution.
The impact of p-chlorobenzenesulfonyl bromide on the environment should not be underestimated. If it accidentally flows into natural water bodies, it may cause water pollution. Aquatic organisms, such as fish and shrimp, may suffer from it. Because of its chemical activity, it may interfere with the physiological metabolism of aquatic organisms, causing their growth to be blocked and reproduction to be implicated. What's more, it may cause disorder in the ecological chain, causing the entire aquatic ecosystem to lose its balance.
As for soil, if it is contaminated with p-chlorobenzenesulfonyl bromide, it is also a serious problem. It may change the chemical properties of the soil and affect the survival and reproduction of soil microorganisms. Microorganisms are essential for the maintenance of soil fertility and the growth of plants. Once the microbial community is destroyed, the soil nutrient cycle is not smooth, plant growth is also adversely affected, and the land may gradually lose its fertility.
When it comes to the impact on the human body, it is even more vigilant. If this substance enters the human body through breathing, or irritates the respiratory tract, it can make people cough, asthma, and even cause respiratory inflammation to worsen. If you accidentally come into contact with the skin, because of its corrosive nature, it can burn the skin, make the skin red, swollen, painful, if not handled properly, or leave scars, affecting the health and appearance of the skin. If eaten by mistake, it is particularly harmful to the digestive system, or corrodes the mucosa of the digestive tract, causing abdominal pain, vomiting and other diseases. In severe cases, it may endanger life.
To sum up, p-chlorobenzenesulfonyl bromide has potential harm to the environment and human body. The world should be cautious. Its production, use, transportation and other aspects should be strictly regulated to reduce its adverse effects on the environment and human body, which is a long-term solution.
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