Linshang Chemical
PRODUCTS
P-Chlorobenzenethiol
Linshang Chemical
|
HS Code |
841156 |
| Chemical Formula | C6H5ClS |
| Molar Mass | 146.62 g/mol |
| Appearance | Colorless to light yellow liquid |
| Odor | Strong, unpleasant odor |
| Density | 1.24 g/cm³ |
| Boiling Point | 205 - 207 °C |
| Melting Point | -16 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents |
| Flash Point | 86 °C |
| Pka | ca. 7.8 |
As an accredited P-Chlorobenzenethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | P - chlorobenzenethiol in 500 - gram bottles, well - sealed for chemical storage. |
| Storage | P - chlorobenzenethiol should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames as it is flammable. Keep it in a tightly sealed container to prevent vapor release. Store it separately from oxidizing agents to avoid potential reactions. The storage area should be dry to prevent hydrolysis of the thiol group. |
| Shipping | P - chlorobenzenethiol is shipped in well - sealed, corrosion - resistant containers. These are carefully packed to prevent leaks during transit, following strict hazardous chemical shipping regulations to ensure safety. |
Competitive P-Chlorobenzenethiol prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of P-chlorobenzenethiol?
For P-chlorobenzenethiol, the chemical formula is C-H-ClS, and its molecules are arranged in the para-position of the chlorine atom (Cl).
For benzene, the plane of the six-element carbon atom is aromatic. The six-element carbon atom in the benzene is related to the common π-daughter system, so that the benzene properties are determined.
The chlorine atom is related to benzene, because of its high stability, which affects the density distribution of the benzene's sub-cloud. The effect of chlorine atoms is the absorber, which reduces the density of the benzene sub-cloud, especially in the benzene and benzene regions.
-SH, also sulphur, its sulfur atom has solitary ions, which can be transformed into antibodies. The sulfur atom has a large half-oxygen atom, which makes the antibodies of the antibodies more easily soluble, and the acidity is slightly higher than that of the alcohol group.
In P-chlorobenzenethiol, the position of the chlorine atom in the antibodies of the antibodies, which not only affects the physical properties of the antibodies, such as melting boiling, solubility, etc., but also affects the antibodies of the antibodies. Due to the addition of the antibodies of the two, the density of the antibodies at a specific location of the benzene is changed, and the activity and location of the antibodies such as the substitution and the substitution of the nucleus are determined.
For benzene, the plane of the six-element carbon atom is aromatic. The six-element carbon atom in the benzene is related to the common π-daughter system, so that the benzene properties are determined.
The chlorine atom is related to benzene, because of its high stability, which affects the density distribution of the benzene's sub-cloud. The effect of chlorine atoms is the absorber, which reduces the density of the benzene sub-cloud, especially in the benzene and benzene regions.
-SH, also sulphur, its sulfur atom has solitary ions, which can be transformed into antibodies. The sulfur atom has a large half-oxygen atom, which makes the antibodies of the antibodies more easily soluble, and the acidity is slightly higher than that of the alcohol group.
In P-chlorobenzenethiol, the position of the chlorine atom in the antibodies of the antibodies, which not only affects the physical properties of the antibodies, such as melting boiling, solubility, etc., but also affects the antibodies of the antibodies. Due to the addition of the antibodies of the two, the density of the antibodies at a specific location of the benzene is changed, and the activity and location of the antibodies such as the substitution and the substitution of the nucleus are determined.
What are the physical properties of P-chlorobenzenethiol?
P-chlorothiophenol is an organic compound with unique physical properties. This substance is mostly liquid at room temperature, with a special smell, and the smell is quite pungent and unpleasant.
Looking at its color, it is often colorless to light yellow, with a clear and transparent appearance. However, it is left in the air for a long time, or due to oxidation and other effects, the color may change.
Its boiling point is about 235-237 ° C. This characteristic determines that it will change from liquid to gaseous under specific temperature conditions. In terms of melting point, it is about -16 ° C, which means that when it is lower than this temperature, P-chlorothiophenol will solidify into a solid state.
P-chlorothiophenol has a slightly higher density than water, about 1.34 g/cm ³, so if mixed with water, it will sink to the bottom. In terms of solubility, it is slightly soluble in water, but soluble in many organic solvents, such as ethanol, ether, benzene, etc. This solubility characteristic allows it to play a specific role in organic synthesis and other fields and in different solvent systems.
In addition, P-chlorothiophenol has a certain volatility, which can be slowly volatilized in air, and because of sulfur atoms, it is more active and can participate in a variety of chemical reactions. This is also related to its physical properties, which together determine its application in chemical, pharmaceutical and other fields.
Looking at its color, it is often colorless to light yellow, with a clear and transparent appearance. However, it is left in the air for a long time, or due to oxidation and other effects, the color may change.
Its boiling point is about 235-237 ° C. This characteristic determines that it will change from liquid to gaseous under specific temperature conditions. In terms of melting point, it is about -16 ° C, which means that when it is lower than this temperature, P-chlorothiophenol will solidify into a solid state.
P-chlorothiophenol has a slightly higher density than water, about 1.34 g/cm ³, so if mixed with water, it will sink to the bottom. In terms of solubility, it is slightly soluble in water, but soluble in many organic solvents, such as ethanol, ether, benzene, etc. This solubility characteristic allows it to play a specific role in organic synthesis and other fields and in different solvent systems.
In addition, P-chlorothiophenol has a certain volatility, which can be slowly volatilized in air, and because of sulfur atoms, it is more active and can participate in a variety of chemical reactions. This is also related to its physical properties, which together determine its application in chemical, pharmaceutical and other fields.
What are the main uses of P-chlorobenzenethiol?
P-chlorothiophenol is an important raw material in organic synthesis. Its main uses cover a wide range of fields.
In the way of pharmaceutical synthesis, P-chlorothiophenol can act as a key intermediate. Through a series of delicate chemical reactions, it can help build molecular structures with specific pharmacological activities. For example, in the preparation of some antibacterial drugs, the special functional groups of P-chlorothiophenol can participate in complex reaction processes, laying the foundation for the generation of drug molecules with exact therapeutic effects. Its unique chemical properties can cleverly interact with other compounds to precisely shape the chemical structure of drugs, which in turn affects the ability of drugs to bind to targets, and ultimately has a profound impact on the efficacy and safety of drugs.
In the field of pesticide creation, P-chlorothiophenol also occupies a key position. It is often used in the synthesis of pesticides with high insecticidal and bactericidal properties. Due to the characteristics of its chemical structure, after appropriate reaction modification, the synthesized pesticide can exhibit excellent activity against specific pests or pathogens. It can interfere with the physiological and metabolic process of pests, or destroy the cell wall, cell membrane and other key structures of pathogens, so as to achieve the purpose of killing pests and inhibiting the growth of pathogens. It provides strong support for agricultural pest control and ensures the healthy growth and harvest of crops.
In the field of materials science, P-chlorothiophenol also has unique uses. In the synthesis of some functional materials, it can participate in the reaction as a functional monomer. For example, when synthesizing polymer materials with special optical and electrical properties, P-chlorothiophenol is introduced into it, which can endow the material with novel properties. It can change the electron cloud distribution of polymer materials, and then affect the conductivity and fluorescence properties of the materials, opening up new paths for the development of new optoelectronic materials.
In addition, in the basic research of organic synthetic chemistry, P-chlorothiophenol is often used as a model compound. Chemists can gain a deeper understanding of the mechanisms and laws of organic reactions by in-depth investigation of the various chemical reactions it participates in, such as nucleophilic substitution and redox reactions. By studying the reactivity and selectivity of P-chlorothiophenol under different reaction conditions, it can provide key theoretical basis and practical experience for the development of organic synthesis methodology, and promote organic synthesis chemistry to a more accurate and efficient direction.
In the way of pharmaceutical synthesis, P-chlorothiophenol can act as a key intermediate. Through a series of delicate chemical reactions, it can help build molecular structures with specific pharmacological activities. For example, in the preparation of some antibacterial drugs, the special functional groups of P-chlorothiophenol can participate in complex reaction processes, laying the foundation for the generation of drug molecules with exact therapeutic effects. Its unique chemical properties can cleverly interact with other compounds to precisely shape the chemical structure of drugs, which in turn affects the ability of drugs to bind to targets, and ultimately has a profound impact on the efficacy and safety of drugs.
In the field of pesticide creation, P-chlorothiophenol also occupies a key position. It is often used in the synthesis of pesticides with high insecticidal and bactericidal properties. Due to the characteristics of its chemical structure, after appropriate reaction modification, the synthesized pesticide can exhibit excellent activity against specific pests or pathogens. It can interfere with the physiological and metabolic process of pests, or destroy the cell wall, cell membrane and other key structures of pathogens, so as to achieve the purpose of killing pests and inhibiting the growth of pathogens. It provides strong support for agricultural pest control and ensures the healthy growth and harvest of crops.
In the field of materials science, P-chlorothiophenol also has unique uses. In the synthesis of some functional materials, it can participate in the reaction as a functional monomer. For example, when synthesizing polymer materials with special optical and electrical properties, P-chlorothiophenol is introduced into it, which can endow the material with novel properties. It can change the electron cloud distribution of polymer materials, and then affect the conductivity and fluorescence properties of the materials, opening up new paths for the development of new optoelectronic materials.
In addition, in the basic research of organic synthetic chemistry, P-chlorothiophenol is often used as a model compound. Chemists can gain a deeper understanding of the mechanisms and laws of organic reactions by in-depth investigation of the various chemical reactions it participates in, such as nucleophilic substitution and redox reactions. By studying the reactivity and selectivity of P-chlorothiophenol under different reaction conditions, it can provide key theoretical basis and practical experience for the development of organic synthesis methodology, and promote organic synthesis chemistry to a more accurate and efficient direction.
What are P-chlorobenzenethiol synthesis methods?
There are several ways to prepare P-chlorothiophenol.
First, p-chlorobromobenzene and potassium hydrosulfide are used as raw materials. First, take an appropriate amount of p-chlorobromobenzene, place it in the reaction kettle, and then slowly add the solution of potassium hydrosulfide at a suitable temperature and pressure, and the two will undergo a substitution reaction. In this process, the temperature and reaction time need to be precisely controlled. Due to high or low temperature, too long or too short time, the purity and yield of the product may be affected. After the reaction is completed, the pure P-chlorothiophenol can be obtained through separation and purification methods, such as distillation, extraction, and recrystallization.
Second, p-chloroaniline is used as the starting material. First, p-chloroaniline and sodium nitrite are diazotized in an acidic environment to form diazonium salts. After that, the diazonium salt is mixed with potassium thiocyanate, and the Sandmeier reaction is carried out to obtain p-chlorobenzene thiocyanide. Finally, with a suitable reducing agent, such as zinc powder and hydrochloric acid, p-chlorobenzene thiocyanide is reduced to P-chlorothiophenol. This path step is slightly complicated, but the reaction conditions of each step are relatively mild. If the operation is proper, the product with high yield and purity can also be obtained.
Third, p-chlorobenzoyl chloride is used as the raw material. First, p-chlorobenzoyl chloride is reacted with thiourea to form an intermediate product. Then the intermediate product is hydrolyzed under alkaline conditions, and then acidified to produce P-chlorothiophenol. The raw materials used in this method are relatively common, and the reaction process is easier to control. However, it is necessary to pay attention to the post-treatment of each step to ensure the quality of the product.
First, p-chlorobromobenzene and potassium hydrosulfide are used as raw materials. First, take an appropriate amount of p-chlorobromobenzene, place it in the reaction kettle, and then slowly add the solution of potassium hydrosulfide at a suitable temperature and pressure, and the two will undergo a substitution reaction. In this process, the temperature and reaction time need to be precisely controlled. Due to high or low temperature, too long or too short time, the purity and yield of the product may be affected. After the reaction is completed, the pure P-chlorothiophenol can be obtained through separation and purification methods, such as distillation, extraction, and recrystallization.
Second, p-chloroaniline is used as the starting material. First, p-chloroaniline and sodium nitrite are diazotized in an acidic environment to form diazonium salts. After that, the diazonium salt is mixed with potassium thiocyanate, and the Sandmeier reaction is carried out to obtain p-chlorobenzene thiocyanide. Finally, with a suitable reducing agent, such as zinc powder and hydrochloric acid, p-chlorobenzene thiocyanide is reduced to P-chlorothiophenol. This path step is slightly complicated, but the reaction conditions of each step are relatively mild. If the operation is proper, the product with high yield and purity can also be obtained.
Third, p-chlorobenzoyl chloride is used as the raw material. First, p-chlorobenzoyl chloride is reacted with thiourea to form an intermediate product. Then the intermediate product is hydrolyzed under alkaline conditions, and then acidified to produce P-chlorothiophenol. The raw materials used in this method are relatively common, and the reaction process is easier to control. However, it is necessary to pay attention to the post-treatment of each step to ensure the quality of the product.
What do P-chlorobenzenethiol need to pay attention to when storing and using?
P-chlorothiophenol, when storing and using, several ends should be paid attention to.
First word storage. This substance has specific chemical properties and should be stored in a cool, dry and well-ventilated place. Cover it or be sensitive to heat and moisture. If it is in a high temperature and humid environment, it may cause deterioration and damage its chemical purity and properties. And it must be kept away from fire and heat sources. Because sulfur phenols are flammable, they are prone to burning in case of open flames and hot topics. The storage place should be equipped with suitable equipment for containing and handling leaks to prevent leakage. It can be properly disposed of in time to prevent its spread from causing greater harm.
Times and use. The user should strictly follow the safety operating procedures. When operating, it is advisable to wear appropriate protective equipment, such as protective glasses, to protect the eyes from the damage of its splashing; wear protective gloves to prevent the skin from contacting it, or irritating and corrosive to the skin. And the operation should be carried out in the fume hood, which can effectively remove the volatile vapor and prevent it from accumulating in the air, causing the operator to inhale and damage health. In addition, during use, it is necessary to accurately measure and use it according to the amount required for experiment or production. Do not waste too much, and avoid abnormal reactions due to improper dosage. After use, the remaining P-chlorothiophenol should be properly stored or disposed of as required, and must not be discarded at will to avoid polluting the environment.
First word storage. This substance has specific chemical properties and should be stored in a cool, dry and well-ventilated place. Cover it or be sensitive to heat and moisture. If it is in a high temperature and humid environment, it may cause deterioration and damage its chemical purity and properties. And it must be kept away from fire and heat sources. Because sulfur phenols are flammable, they are prone to burning in case of open flames and hot topics. The storage place should be equipped with suitable equipment for containing and handling leaks to prevent leakage. It can be properly disposed of in time to prevent its spread from causing greater harm.
Times and use. The user should strictly follow the safety operating procedures. When operating, it is advisable to wear appropriate protective equipment, such as protective glasses, to protect the eyes from the damage of its splashing; wear protective gloves to prevent the skin from contacting it, or irritating and corrosive to the skin. And the operation should be carried out in the fume hood, which can effectively remove the volatile vapor and prevent it from accumulating in the air, causing the operator to inhale and damage health. In addition, during use, it is necessary to accurately measure and use it according to the amount required for experiment or production. Do not waste too much, and avoid abnormal reactions due to improper dosage. After use, the remaining P-chlorothiophenol should be properly stored or disposed of as required, and must not be discarded at will to avoid polluting the environment.
What are the main uses of P-chlorobenzenethiol?
P-chlorothiophenol is also an organic compound. It has a wide range of uses and has important applications in many fields.
First, it plays a significant role in the synthesis of medicine. It can be used as a key intermediate to help synthesize a variety of specific drugs. Due to the special structure of thiophenol, it can endow drugs with unique biological activities and pharmacological properties. For example, some antibacterial and anti-inflammatory drugs, P-chlorothiophenol participates in the synthesis process, which plays an important role in shaping the final efficacy and characteristics of the drug.
Second, it is also indispensable in the field of materials science. In the preparation of some high-performance polymer materials, it can be used as a modifier. After adding P-chlorothiophenol, the properties of the material such as flexibility, stability and anti-aging can be improved. In the rubber industry, it can enhance the vulcanization effect of rubber and optimize the physical and mechanical properties of rubber products, such as improving their wear resistance and tensile strength.
Third, it is a commonly used reagent in the field of organic synthetic chemistry. It can participate in many organic reactions, such as nucleophilic substitution reactions, oxidation reactions, etc. Through these reactions, rich and diverse organic compound structures can be constructed, providing organic synthetic chemists with many synthetic path choices, and promoting the development and progress of organic synthetic chemistry.
Fourth, it also has potential applications in the agricultural field. It can be used as a raw material for synthetic pesticides. In the process of creating some new pesticides, the compounds derived from P-chlorothiophenol exhibit good insecticidal and herbicidal activities, and have relatively little impact on the environment, which is in line with the current needs of green agriculture development.
In summary, P-chlorothiophenol plays an important role in many fields such as medicine, materials, organic synthesis and agriculture, and plays an important role in the development of related industries.
First, it plays a significant role in the synthesis of medicine. It can be used as a key intermediate to help synthesize a variety of specific drugs. Due to the special structure of thiophenol, it can endow drugs with unique biological activities and pharmacological properties. For example, some antibacterial and anti-inflammatory drugs, P-chlorothiophenol participates in the synthesis process, which plays an important role in shaping the final efficacy and characteristics of the drug.
Second, it is also indispensable in the field of materials science. In the preparation of some high-performance polymer materials, it can be used as a modifier. After adding P-chlorothiophenol, the properties of the material such as flexibility, stability and anti-aging can be improved. In the rubber industry, it can enhance the vulcanization effect of rubber and optimize the physical and mechanical properties of rubber products, such as improving their wear resistance and tensile strength.
Third, it is a commonly used reagent in the field of organic synthetic chemistry. It can participate in many organic reactions, such as nucleophilic substitution reactions, oxidation reactions, etc. Through these reactions, rich and diverse organic compound structures can be constructed, providing organic synthetic chemists with many synthetic path choices, and promoting the development and progress of organic synthetic chemistry.
Fourth, it also has potential applications in the agricultural field. It can be used as a raw material for synthetic pesticides. In the process of creating some new pesticides, the compounds derived from P-chlorothiophenol exhibit good insecticidal and herbicidal activities, and have relatively little impact on the environment, which is in line with the current needs of green agriculture development.
In summary, P-chlorothiophenol plays an important role in many fields such as medicine, materials, organic synthesis and agriculture, and plays an important role in the development of related industries.
What are the physical properties of P-chlorobenzenethiol?
P-chlorobenzenethiol, that is, p-chlorobenzenethiol. Its physical properties are particularly important, and they are described in detail today.
Looking at its properties, it usually appears as a colorless to light yellow liquid under normal conditions. Although its color is light, it has a pungent and unique odor. This smell is strong and easy to identify.
As for its boiling point, the melting point is about -15 ° C. At this temperature, its state changes from liquid to solid. The boiling point is roughly between 234 and 235 ° C. At this temperature, p-chlorobenzenethiol turns from liquid to gas. In terms of solubility, it is extremely difficult to dissolve in water, and it is difficult to form an effective interaction with water molecules due to the characteristics of its molecular structure. However, in organic solvents such as ethanol, ether, benzene, etc., it has good solubility and can be miscible with these organic solvents in any ratio. Because the intermolecular forces between the two are similar, it conforms to the principle of similar compatibility.
Density is also one of its important physical properties. Its density is about 1.34g/cm ³, which is heavier than water. Therefore, if it is placed in one place with water, it must sink to the bottom of the water.
The vapor pressure of p-chlorothiophenol is relatively low at room temperature, which means that its volatilization rate is not very high. However, although the vapor pressure is low, its presence can still be easily detected in the air due to its strong odor. In addition, its refractive index also has a specific value, about 1.626-1.628, which is quite useful in optical related applications and analysis, and can help identify and detect purity.
Looking at its properties, it usually appears as a colorless to light yellow liquid under normal conditions. Although its color is light, it has a pungent and unique odor. This smell is strong and easy to identify.
As for its boiling point, the melting point is about -15 ° C. At this temperature, its state changes from liquid to solid. The boiling point is roughly between 234 and 235 ° C. At this temperature, p-chlorobenzenethiol turns from liquid to gas. In terms of solubility, it is extremely difficult to dissolve in water, and it is difficult to form an effective interaction with water molecules due to the characteristics of its molecular structure. However, in organic solvents such as ethanol, ether, benzene, etc., it has good solubility and can be miscible with these organic solvents in any ratio. Because the intermolecular forces between the two are similar, it conforms to the principle of similar compatibility.
Density is also one of its important physical properties. Its density is about 1.34g/cm ³, which is heavier than water. Therefore, if it is placed in one place with water, it must sink to the bottom of the water.
The vapor pressure of p-chlorothiophenol is relatively low at room temperature, which means that its volatilization rate is not very high. However, although the vapor pressure is low, its presence can still be easily detected in the air due to its strong odor. In addition, its refractive index also has a specific value, about 1.626-1.628, which is quite useful in optical related applications and analysis, and can help identify and detect purity.
What are the chemical properties of P-chlorobenzenethiol?
P-chlorothiophenol is also an organic compound. It is active and often shows unique properties in chemical reactions.
This substance has the commonality of thiophenol, and the sulfur atom of the phenolic hydroxyl group has strong nucleophilic properties. It can react with electrophilic reagents such as halogenated hydrocarbons to form new sulfur-containing organic compounds. For example, when interacting with halogenated alkanes, the sulfur atom of thiophenol can attack the carbon atom of the halogenated alkane, and the halogen atom leaves to obtain thioether products.
It is also acidic. Although slightly more acidic than phenol, it can partially ionize and release hydrogen ions in water. This acidity allows it to react with bases to form corresponding salts. When exposed to bases such as sodium hydroxide, P-chlorothiophenol sodium salt can be formed, which has many applications in organic synthesis.
The benzene ring of P-chlorothiophenol has the typical properties of aromatic compounds. Electrophilic substitution reaction can occur, and the chlorine atom is an ortho-and para-site locator, causing the electrophilic reagent to attack the ortho-and para-site of the benzene ring. If it interacts with mixed acids of nitric acid and sulfuric acid, nitro groups can be introduced into the ortho-and para-site of the benzene ring to obtain nitro-substituted P-chlorothiophenol derivatives.
And because of its sulfur-containing atoms, it has certain reductivity. It can be oxidized by appropriate oxidants, and the valence state of sulfur atoms is increased. The products may be sulfoxides and sulfones. This oxidation reaction is an important way to construct sulfur-containing oxygen compounds in organic synthesis.
P-chlorothiophenol has a wide range of uses in the field of organic synthesis. With its unique chemical properties, it can participate in a variety of reactions and is a key raw material for the preparation of complex organic sulfur compounds.
This substance has the commonality of thiophenol, and the sulfur atom of the phenolic hydroxyl group has strong nucleophilic properties. It can react with electrophilic reagents such as halogenated hydrocarbons to form new sulfur-containing organic compounds. For example, when interacting with halogenated alkanes, the sulfur atom of thiophenol can attack the carbon atom of the halogenated alkane, and the halogen atom leaves to obtain thioether products.
It is also acidic. Although slightly more acidic than phenol, it can partially ionize and release hydrogen ions in water. This acidity allows it to react with bases to form corresponding salts. When exposed to bases such as sodium hydroxide, P-chlorothiophenol sodium salt can be formed, which has many applications in organic synthesis.
The benzene ring of P-chlorothiophenol has the typical properties of aromatic compounds. Electrophilic substitution reaction can occur, and the chlorine atom is an ortho-and para-site locator, causing the electrophilic reagent to attack the ortho-and para-site of the benzene ring. If it interacts with mixed acids of nitric acid and sulfuric acid, nitro groups can be introduced into the ortho-and para-site of the benzene ring to obtain nitro-substituted P-chlorothiophenol derivatives.
And because of its sulfur-containing atoms, it has certain reductivity. It can be oxidized by appropriate oxidants, and the valence state of sulfur atoms is increased. The products may be sulfoxides and sulfones. This oxidation reaction is an important way to construct sulfur-containing oxygen compounds in organic synthesis.
P-chlorothiophenol has a wide range of uses in the field of organic synthesis. With its unique chemical properties, it can participate in a variety of reactions and is a key raw material for the preparation of complex organic sulfur compounds.
What are P-chlorobenzenethiol synthesis methods?
P-chlorothiophenol is also an organic compound. The method of its synthesis has been studied by chemists in the past.
One method, with p-chlorobrombenzene as the starting material, first reacts with magnesium chips in anhydrous ether to form Grignard's reagent. p-chlorobrombenzene and magnesium are stirred in ether, and the reaction gradually starts to generate heat, and there is Grignard's reagent. This reagent is very active, and then mixed with carbon disulfide, and then hydrolyzed to obtain P-chlorothiophenol. The reason for this reaction is that the magnesium atom in the Grignard reagent is combined with the sulfur atom of carbon disulfide, and then hydrolyzed, and the sulfur atom replaces magnesium, and then the target is obtained.
There is another method, using p-chloronitrobenzene as raw material. First reduce it to obtain p-chloroaniline. P-chloronitrobenzene is nitrified into an amino group by the action of reducing agents such as iron filings and hydrochloric acid. After that, p-chloroaniline is co-heated with ammonium thiocyanate and hydrochloric acid to produce p-chlorophenyl thiourea. p-chloroaniline and ammonium thiocyanate are heated in hydrochloric acid, and the molecules are rearranged to form this thiourea. Finally, p-chlorophenyl thiourea is hydrolyzed by alkali treatment to obtain P-chlorothiophenol.
It is also started with p-chloroanisole. After halogenation, the methyl on the benzene ring is halogenated to obtain halogenated methyl p After reacting with sodium hydrosulfide, the halogen atom is replaced by a thio-hydrogen group to obtain a derivative of P-chlorothiophenol, which is then converted into P-chlorothiophenol through appropriate reactions.
All synthesis methods have their own advantages and disadvantages. Depending on the ease of availability of raw materials, the difficulty of reaction, and the yield, chemists choose to use them to obtain this compound.
One method, with p-chlorobrombenzene as the starting material, first reacts with magnesium chips in anhydrous ether to form Grignard's reagent. p-chlorobrombenzene and magnesium are stirred in ether, and the reaction gradually starts to generate heat, and there is Grignard's reagent. This reagent is very active, and then mixed with carbon disulfide, and then hydrolyzed to obtain P-chlorothiophenol. The reason for this reaction is that the magnesium atom in the Grignard reagent is combined with the sulfur atom of carbon disulfide, and then hydrolyzed, and the sulfur atom replaces magnesium, and then the target is obtained.
There is another method, using p-chloronitrobenzene as raw material. First reduce it to obtain p-chloroaniline. P-chloronitrobenzene is nitrified into an amino group by the action of reducing agents such as iron filings and hydrochloric acid. After that, p-chloroaniline is co-heated with ammonium thiocyanate and hydrochloric acid to produce p-chlorophenyl thiourea. p-chloroaniline and ammonium thiocyanate are heated in hydrochloric acid, and the molecules are rearranged to form this thiourea. Finally, p-chlorophenyl thiourea is hydrolyzed by alkali treatment to obtain P-chlorothiophenol.
It is also started with p-chloroanisole. After halogenation, the methyl on the benzene ring is halogenated to obtain halogenated methyl p After reacting with sodium hydrosulfide, the halogen atom is replaced by a thio-hydrogen group to obtain a derivative of P-chlorothiophenol, which is then converted into P-chlorothiophenol through appropriate reactions.
All synthesis methods have their own advantages and disadvantages. Depending on the ease of availability of raw materials, the difficulty of reaction, and the yield, chemists choose to use them to obtain this compound.
P-chlorobenzenethiol what are the precautions during use
When using P-chlorothiophenol, there are many things that cannot be ignored.
First, this object has a special smell, and the smell is pungent and unpleasant. In the place of operation, make sure to ventilate it well to prevent odor accumulation, causing discomfort to the operator, or even damage to health.
Second, P-chlorothiophenol has certain toxicity. When operating, it is necessary to wear appropriate protective equipment, such as gloves, goggles, masks, etc., to protect the skin, eyes and respiratory tract from damage. If you accidentally touch it, rinse it with plenty of water quickly. If the situation is serious, seek medical attention immediately.
Third, its chemical properties are lively. When storing, it is advisable to avoid oxidizing agents, strong acids and alkalis, etc., to prevent violent reactions and cause danger. And when stored in a cool, dry and ventilated place, away from fire and heat sources, to prevent it from deteriorating due to heat or causing safety accidents.
Fourth, during use, accurate measurement and operation specifications are the key. According to experimental or production needs, accurately take an appropriate amount of P-chlorothiophenol, do not increase or decrease the dosage at will. The operation method should also be in compliance, and do not cause it to splash or cause other accidents due to improper operation.
Fifth, after use, properly dispose of the remaining materials and waste. Do not dump it at will, and treat it harmlessly in accordance with relevant regulations to avoid polluting the environment.
First, this object has a special smell, and the smell is pungent and unpleasant. In the place of operation, make sure to ventilate it well to prevent odor accumulation, causing discomfort to the operator, or even damage to health.
Second, P-chlorothiophenol has certain toxicity. When operating, it is necessary to wear appropriate protective equipment, such as gloves, goggles, masks, etc., to protect the skin, eyes and respiratory tract from damage. If you accidentally touch it, rinse it with plenty of water quickly. If the situation is serious, seek medical attention immediately.
Third, its chemical properties are lively. When storing, it is advisable to avoid oxidizing agents, strong acids and alkalis, etc., to prevent violent reactions and cause danger. And when stored in a cool, dry and ventilated place, away from fire and heat sources, to prevent it from deteriorating due to heat or causing safety accidents.
Fourth, during use, accurate measurement and operation specifications are the key. According to experimental or production needs, accurately take an appropriate amount of P-chlorothiophenol, do not increase or decrease the dosage at will. The operation method should also be in compliance, and do not cause it to splash or cause other accidents due to improper operation.
Fifth, after use, properly dispose of the remaining materials and waste. Do not dump it at will, and treat it harmlessly in accordance with relevant regulations to avoid polluting the environment.
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