Linshang Chemical
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P-Chloroiodobenzene
Linshang Chemical
|
HS Code |
542610 |
| Chemical Formula | C6H4ClI |
| Molar Mass | 238.45 g/mol |
| Appearance | Pale yellow solid |
| Density | 1.98 g/cm³ |
| Melting Point | 34 - 37 °C |
| Boiling Point | 228 - 230 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 107.2 °C |
| Refractive Index | 1.634 (predicted) |
As an accredited P-Chloroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | P - chloroiodobenzene packaged in 500 - gram bottles for secure storage and transport. |
| Storage | P - chloroiodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly closed container to prevent vapor leakage. Since it is a chemical, it should be in a location separate from food and beverages, and clearly labeled for easy identification and to ensure proper handling. |
| Shipping | P - chloroiodobenzene is shipped in tightly - sealed, corrosion - resistant containers. It is transported under controlled conditions, away from heat, flames, and incompatible substances to ensure safe transit. |
Competitive P-Chloroiodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a trusted P-Chloroiodobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading P-Chloroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the Chinese name of P-chloroiodobenzene?
The Chinese name of P-chloroiodobenzene is chloroiodobenzene. This name is derived from its transformation. "Benzene" is the aromatic mother of hexacarbon, which is the basic framework of this compound. "Chlorine" and "iodine" are the substituents on benzene. With benzene, according to the position of the substituent, we use the phase position nomenclature, where P stands for para -, which means the position, indicating that the chlorine atoms and iodine atoms are separated from the carbon atoms on the benzene. Therefore, this substance is chloroiodobenzene, so named that it can clearly show the characteristics of its molecule, so that the chemist can use this name to know the location of the atom in the molecule, which is important in many aspects such as chemical research, engineering and communication, etc., to avoid confusion caused by unclear names and to protect information.
What are the main uses of P-chloroiodobenzene?
P-chloroiodobenzene, or p-chloroiodobenzene, is an important chemical substance in the field of organic synthesis, with many main uses.
First, in the field of medicinal chemistry, this substance plays a key role. The synthesis path of many drugs often uses p-chloroiodobenzene as the starting material. Because the chlorine atoms and iodine atoms in the structure have high reactivity, various functional groups can be introduced by means of nucleophilic substitution reactions, coupling reactions, etc., and then complex drug molecular structures can be constructed. For example, when developing small molecule drugs with specific biological activities, a series of reactions with p-chloroiodobenzene can be carried out to precisely design and synthesize the required drugs to achieve effective treatment of diseases.
Second, in the field of materials science, p-chloroiodobenzene is also indispensable. When preparing organic optoelectronic materials, its reactivity can be used to integrate them into the main chain or side chain of polymer materials through chemical synthesis. In this way, the material can be endowed with unique optoelectronic properties, such as adjusting the energy band structure of the material and improving the charge transfer efficiency, which can be applied to organic Light Emitting Diode (OLED), organic solar cells and other fields to help improve material properties and device efficiency.
Third, p-chloroiodobenzene is an important intermediate in the field of organic synthesis chemistry. With its help, various types of reactions can be carried out, such as Ullman reaction, Suzuki reaction, etc. Through these reactions, carbon-carbon bonds, carbon-heteroatomic bonds, etc. can be formed, providing an effective way for the synthesis of complex organic compounds, enabling organic chemists to synthesize organic molecules with diverse structures and unique functions, and promoting the continuous development of organic synthetic chemistry.
First, in the field of medicinal chemistry, this substance plays a key role. The synthesis path of many drugs often uses p-chloroiodobenzene as the starting material. Because the chlorine atoms and iodine atoms in the structure have high reactivity, various functional groups can be introduced by means of nucleophilic substitution reactions, coupling reactions, etc., and then complex drug molecular structures can be constructed. For example, when developing small molecule drugs with specific biological activities, a series of reactions with p-chloroiodobenzene can be carried out to precisely design and synthesize the required drugs to achieve effective treatment of diseases.
Second, in the field of materials science, p-chloroiodobenzene is also indispensable. When preparing organic optoelectronic materials, its reactivity can be used to integrate them into the main chain or side chain of polymer materials through chemical synthesis. In this way, the material can be endowed with unique optoelectronic properties, such as adjusting the energy band structure of the material and improving the charge transfer efficiency, which can be applied to organic Light Emitting Diode (OLED), organic solar cells and other fields to help improve material properties and device efficiency.
Third, p-chloroiodobenzene is an important intermediate in the field of organic synthesis chemistry. With its help, various types of reactions can be carried out, such as Ullman reaction, Suzuki reaction, etc. Through these reactions, carbon-carbon bonds, carbon-heteroatomic bonds, etc. can be formed, providing an effective way for the synthesis of complex organic compounds, enabling organic chemists to synthesize organic molecules with diverse structures and unique functions, and promoting the continuous development of organic synthetic chemistry.
What are the physical properties of P-chloroiodobenzene?
P-chloroiodobenzene, that is, p-chloroiodobenzene, is an organic compound with specific physical properties. It is mostly colorless to light yellow liquid at room temperature and pressure. This form makes it more convenient to participate in many organic synthesis reactions. Its fluidity can improve the contact and mixing between reactants.
p-chloroiodobenzene is volatile and will evaporate slowly in the air. In the chemical production environment, it is necessary to pay attention to the safety risk caused by the increase of its volatile concentration. Its boiling point is about 205-207 ° C. This boiling point characteristic allows it to be separated from the mixture by controlling the temperature during separation operations such as distillation.
p-chloroiodobenzene is insoluble in water. This property is related to its molecular structure. Because it is a non-polar organic molecule, the force between it and water molecules is weak. However, it is soluble in common organic solvents, such as ether, chloroform, benzene, etc. In organic synthesis experiments, suitable solvents are often selected to dissolve it according to this solubility, so as to achieve reaction or separation with other substances.
The density of p-chloroiodobenzene is greater than that of water, about 1.80 g/cm ³. In operations involving liquid-liquid stratification, the organic phase containing p-chloroiodobenzene is often in the lower layer, which helps to achieve its separation from the aqueous phase by means of liquid separation. In addition, although the chemical properties of p-chloroiodobenzene are relatively stable, under suitable conditions, such as the presence of specific catalysts, temperatures, and reactants, its chlorine atoms and iodine atoms can participate in substitution reactions, etc., and are widely used in the field of organic synthesis. It can be used to prepare a variety of organic compounds such as drugs, pesticides, and functional materials.
p-chloroiodobenzene is volatile and will evaporate slowly in the air. In the chemical production environment, it is necessary to pay attention to the safety risk caused by the increase of its volatile concentration. Its boiling point is about 205-207 ° C. This boiling point characteristic allows it to be separated from the mixture by controlling the temperature during separation operations such as distillation.
p-chloroiodobenzene is insoluble in water. This property is related to its molecular structure. Because it is a non-polar organic molecule, the force between it and water molecules is weak. However, it is soluble in common organic solvents, such as ether, chloroform, benzene, etc. In organic synthesis experiments, suitable solvents are often selected to dissolve it according to this solubility, so as to achieve reaction or separation with other substances.
The density of p-chloroiodobenzene is greater than that of water, about 1.80 g/cm ³. In operations involving liquid-liquid stratification, the organic phase containing p-chloroiodobenzene is often in the lower layer, which helps to achieve its separation from the aqueous phase by means of liquid separation. In addition, although the chemical properties of p-chloroiodobenzene are relatively stable, under suitable conditions, such as the presence of specific catalysts, temperatures, and reactants, its chlorine atoms and iodine atoms can participate in substitution reactions, etc., and are widely used in the field of organic synthesis. It can be used to prepare a variety of organic compounds such as drugs, pesticides, and functional materials.
What are the chemical properties of P-chloroiodobenzene?
P-chloroiodobenzene is an organic compound with unique chemical properties. First, the halogen atom substituent changes the electron cloud density of the benzene ring, which affects its reactivity. Chlorine and iodine have different electronegativity, resulting in uneven distribution of the electron cloud of the benzene ring. The electron cloud density of the adjacent and para-position decreases slightly, and the meta-position is relatively high. The electrophilic substitution reactivity is different from that of benzene.
Second, during the electrophilic substitution reaction, due to the electron-absorbing induction effect of chlorine and iodine, the reaction check point is mostly in the meta-position, and the reaction activity is lower than that of benzene. More severe
Third, the halogen atom is self-reactive. Chlorine and iodine can participate in the nucleophilic substitution reaction. Under appropriate nucleophilic reagents, solvents and conditions, halogen atoms can be replaced to form new compounds.
Fourth, P-chloroiodobenzene has different stability from benzene due to halogen atoms. At high temperature and in the presence of strong oxidants or reducing agents, halogen atoms or participate in the reaction to cause molecular structure changes.
In short, P-chloroiodobenzene has rich chemical properties due to the presence of chlorine and iodine substituents. It has a wide range of uses in the field of organic synthesis and can prepare a variety of organic compounds through reactions such as electrophilic and nucleophilic substitution.
Second, during the electrophilic substitution reaction, due to the electron-absorbing induction effect of chlorine and iodine, the reaction check point is mostly in the meta-position, and the reaction activity is lower than that of benzene. More severe
Third, the halogen atom is self-reactive. Chlorine and iodine can participate in the nucleophilic substitution reaction. Under appropriate nucleophilic reagents, solvents and conditions, halogen atoms can be replaced to form new compounds.
Fourth, P-chloroiodobenzene has different stability from benzene due to halogen atoms. At high temperature and in the presence of strong oxidants or reducing agents, halogen atoms or participate in the reaction to cause molecular structure changes.
In short, P-chloroiodobenzene has rich chemical properties due to the presence of chlorine and iodine substituents. It has a wide range of uses in the field of organic synthesis and can prepare a variety of organic compounds through reactions such as electrophilic and nucleophilic substitution.
What are the synthesis methods of P-chloroiodobenzene?
The common methods for preparing P-chloroiodobenzene are as follows.
One is the electrophilic substitution method. Starting with benzene, chlorobenzene is obtained by chlorination. The chlorine of chlorobenzene is an ortho-para-site group, which can then undergo electrophilic substitution reaction with iodine. Under suitable reaction conditions, such as in the presence of a catalyst, chlorobenzene reacts with iodine at a certain temperature and pressure, and iodine attacks the para-position of chlorine on the benzene ring to generate P-chloroiodobenzene. However, this reaction requires the selection of a high-efficiency catalyst to improve the reaction efficiency and selectivity, and the activity of iodine is different from that of other halogens, and the reaction conditions need to be finely regulated.
< br The diazonium salt was prepared by diazotization of aniline, and then reacted with reagents such as cuprous chloride and potassium iodide. Aniline and nitrous acid formed diazonium salts under low temperature and acidic conditions, and the diazonium groups of diazonium salts could be replaced by chlorine atoms and iodine atoms. By controlling the reaction sequence and conditions, chlorine was introduced first, and then iodine was introduced in the para-position to obtain P-chloroiodobenzene. The diazotization reaction in this process needs to be carried out at low temperature to prevent the decomposition of diazonium salts, and the subsequent substitution reaction also needs to precisely control the conditions.
The third is the metal-catalyzed cross-coupling method. Cross-coupling of halogenated arom For example, using p-chlorobromobenzene as raw material, in the presence of palladium and other metal catalysts and suitable ligands, the coupling reaction occurs with the iodizing reagent. This method requires the selection of suitable metal catalysts and ligands, and the optimization of the solvent, base and other conditions of the reaction system to promote the efficient and high selectivity of the cross-coupling reaction, so as to successfully prepare P-chlorobromobenzene. Each method has its own advantages and disadvantages. In the actual synthesis, it is necessary to comprehensively consider the availability of raw materials, cost, reaction conditions and other factors to choose the best method.
One is the electrophilic substitution method. Starting with benzene, chlorobenzene is obtained by chlorination. The chlorine of chlorobenzene is an ortho-para-site group, which can then undergo electrophilic substitution reaction with iodine. Under suitable reaction conditions, such as in the presence of a catalyst, chlorobenzene reacts with iodine at a certain temperature and pressure, and iodine attacks the para-position of chlorine on the benzene ring to generate P-chloroiodobenzene. However, this reaction requires the selection of a high-efficiency catalyst to improve the reaction efficiency and selectivity, and the activity of iodine is different from that of other halogens, and the reaction conditions need to be finely regulated.
< br The diazonium salt was prepared by diazotization of aniline, and then reacted with reagents such as cuprous chloride and potassium iodide. Aniline and nitrous acid formed diazonium salts under low temperature and acidic conditions, and the diazonium groups of diazonium salts could be replaced by chlorine atoms and iodine atoms. By controlling the reaction sequence and conditions, chlorine was introduced first, and then iodine was introduced in the para-position to obtain P-chloroiodobenzene. The diazotization reaction in this process needs to be carried out at low temperature to prevent the decomposition of diazonium salts, and the subsequent substitution reaction also needs to precisely control the conditions.
The third is the metal-catalyzed cross-coupling method. Cross-coupling of halogenated arom For example, using p-chlorobromobenzene as raw material, in the presence of palladium and other metal catalysts and suitable ligands, the coupling reaction occurs with the iodizing reagent. This method requires the selection of suitable metal catalysts and ligands, and the optimization of the solvent, base and other conditions of the reaction system to promote the efficient and high selectivity of the cross-coupling reaction, so as to successfully prepare P-chlorobromobenzene. Each method has its own advantages and disadvantages. In the actual synthesis, it is necessary to comprehensively consider the availability of raw materials, cost, reaction conditions and other factors to choose the best method.
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