Linshang Chemical
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P-Chlorotrifluoromethylbenzene
Linshang Chemical
|
HS Code |
790941 |
| Chemical Formula | C7H4ClF3 |
| Molecular Weight | 180.55 |
| Appearance | Colorless to light yellow liquid |
| Odor | Pungent odor |
| Density | 1.32 g/cm³ at 20 °C |
| Boiling Point | 139 - 141 °C |
| Melting Point | -35 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in most organic solvents |
| Flash Point | 32 °C |
| Vapor Pressure | 1.6 kPa at 20 °C |
| Refractive Index | 1.4365 at 20 °C |
As an accredited P-Chlorotrifluoromethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for P - chlorotrifluoromethylbenzene chemical. |
| Storage | P - chlorotrifluoromethylbenzene should be stored in a cool, well - ventilated area away from heat and ignition sources. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, strong acids, and bases. Ensure the storage area has proper spill - containment measures to handle any potential leaks safely. |
| Shipping | P - chlorotrifluoromethylbenzene, a chemical, is shipped in sealed, corrosion - resistant containers. Adequate cushioning is used to prevent breakage. It follows strict hazardous material shipping regulations to ensure safety during transit. |
Competitive P-Chlorotrifluoromethylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading P-Chlorotrifluoromethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of P-chlorotrifluoromethylbenzene?
P-chlorotrifluoromethylbenzene is also an organic compound. Its chemical properties are unique and of great research value.
As far as the electrophilic substitution reaction is concerned, the benzene ring is electron-rich, but the trifluoromethyl group is a strong electron-absorbing group. Although chlorine is an ortho-para-localization group, the strong electron-absorbing effect of trifluoromethyl group is superior, and the electron cloud density of the benzene ring is greatly reduced, so its electrophilic substitution reaction activity is lower than that of benzene. And the reaction check point is mostly in the meso-position, because the electron-absorbing action of trifluoromethyl group decreases the electron cloud density of the ortho-para-position, especially the meso-position is relatively high, and the electrophilic re
In the nucleophilic substitution reaction, due to the low electron cloud density on the benzene ring, it is usually difficult to occur typical nucleophilic substitution. However, under specific conditions, such as strong nucleophilic reagents and high temperature, catalysts, etc., chlorine atoms can be replaced by nucleophilic reagents. This is because the presence of trifluoromethyl changes the electron cloud density distribution of the benzene ring, so that the carbon attached to the chlorine atom has a certain electrophilicity.
In terms of thermal stability, P-chlorotrifluoromethylbenzene has high thermal stability. The carbon-fluorine bond energy in trifluoromethyl is quite high and the structure is stable. Coupled with the stability of the benzene ring conjugate system, the compound can maintain structural stability within a certain temperature range
Its chemical properties are also closely related to the reaction environment. Changes in acid-base conditions will affect the reactivity and pathway. In acidic media, the electron cloud density of the benzene ring may change due to protonation; in alkaline environments, strong nucleophiles may trigger special reactions, such as the rate of chlorine atom substitution reaction or accelerated due to enhanced alkalinity.
In summary, the chemical properties of P-chlorotrifluoromethylbenzene are unique due to the synergistic effect of trifluoromethyl and chlorine atoms. It has important uses in organic synthesis, materials science and other fields. Scholars should study it in detail to clarify its characteristics and make good use of it.
As far as the electrophilic substitution reaction is concerned, the benzene ring is electron-rich, but the trifluoromethyl group is a strong electron-absorbing group. Although chlorine is an ortho-para-localization group, the strong electron-absorbing effect of trifluoromethyl group is superior, and the electron cloud density of the benzene ring is greatly reduced, so its electrophilic substitution reaction activity is lower than that of benzene. And the reaction check point is mostly in the meso-position, because the electron-absorbing action of trifluoromethyl group decreases the electron cloud density of the ortho-para-position, especially the meso-position is relatively high, and the electrophilic re
In the nucleophilic substitution reaction, due to the low electron cloud density on the benzene ring, it is usually difficult to occur typical nucleophilic substitution. However, under specific conditions, such as strong nucleophilic reagents and high temperature, catalysts, etc., chlorine atoms can be replaced by nucleophilic reagents. This is because the presence of trifluoromethyl changes the electron cloud density distribution of the benzene ring, so that the carbon attached to the chlorine atom has a certain electrophilicity.
In terms of thermal stability, P-chlorotrifluoromethylbenzene has high thermal stability. The carbon-fluorine bond energy in trifluoromethyl is quite high and the structure is stable. Coupled with the stability of the benzene ring conjugate system, the compound can maintain structural stability within a certain temperature range
Its chemical properties are also closely related to the reaction environment. Changes in acid-base conditions will affect the reactivity and pathway. In acidic media, the electron cloud density of the benzene ring may change due to protonation; in alkaline environments, strong nucleophiles may trigger special reactions, such as the rate of chlorine atom substitution reaction or accelerated due to enhanced alkalinity.
In summary, the chemical properties of P-chlorotrifluoromethylbenzene are unique due to the synergistic effect of trifluoromethyl and chlorine atoms. It has important uses in organic synthesis, materials science and other fields. Scholars should study it in detail to clarify its characteristics and make good use of it.
What are the main uses of P-chlorotrifluoromethylbenzene?
P-chlorotrifluoromethylbenzene is also an organic compound, and its use is quite extensive. In the field of medicinal chemistry, it is often a key raw material for the synthesis of special drugs. Due to its unique chemical structure, it can endow drugs with excellent physiological activity and pharmacological properties, such as some new drugs with antiviral and anti-tumor effects. It is often relied on as a starting material when synthesizing, helping drug molecules achieve the required spatial configuration and electronic effects, so as to fit the target effect and enhance the efficacy.
In the field of materials science, it also plays an important role. It can be used to prepare special polymer materials, such as fluoropolymers with excellent weather resistance and chemical corrosion resistance. Such polymers are in high demand in industries such as aerospace, automotive manufacturing, and construction, because they can resist harsh environments and prolong the service life of materials. P-chlorotrifluoromethylbenzene participates in the synthesis of fluorine-containing resins, which can be used as high-performance coatings and coated on the surface of objects to form a dense protective layer, which effectively resists wear and erosion.
It is also indispensable in the creation of pesticides. It can derive high-efficiency, low-toxicity and environmentally friendly pesticide varieties. With its fluorine-containing structure, it can enhance the affinity and selectivity of pesticides to target organisms, enhance the efficacy of insecticides, sterilization or weeding, and reduce the impact on non-target organisms, reduce environmental pollution, which is in line with the current demand of green agriculture development. All of this shows that P-chlorotrifluoromethylbenzene has critical uses in many fields, promoting the progress and development of related industries.
In the field of materials science, it also plays an important role. It can be used to prepare special polymer materials, such as fluoropolymers with excellent weather resistance and chemical corrosion resistance. Such polymers are in high demand in industries such as aerospace, automotive manufacturing, and construction, because they can resist harsh environments and prolong the service life of materials. P-chlorotrifluoromethylbenzene participates in the synthesis of fluorine-containing resins, which can be used as high-performance coatings and coated on the surface of objects to form a dense protective layer, which effectively resists wear and erosion.
It is also indispensable in the creation of pesticides. It can derive high-efficiency, low-toxicity and environmentally friendly pesticide varieties. With its fluorine-containing structure, it can enhance the affinity and selectivity of pesticides to target organisms, enhance the efficacy of insecticides, sterilization or weeding, and reduce the impact on non-target organisms, reduce environmental pollution, which is in line with the current demand of green agriculture development. All of this shows that P-chlorotrifluoromethylbenzene has critical uses in many fields, promoting the progress and development of related industries.
What is the preparation method of P-chlorotrifluoromethylbenzene?
To prepare p-chlorotrifluoromethylbenzene, the following method can be used.
First, p-chlorotoluene is used as the starting material and chlorinated by side chain to obtain p-chlorotrichlorotoluene. This step requires the presence of light or an initiator to react chlorine with p-chlorotoluene. The hydrogen of the methyl group in p-chlorotoluene has certain reactivity due to the influence of the benzene ring, and can undergo free radical substitution reaction with chlorine gas. Light or initiator can produce chlorine radicals, remove the hydrogen of the methyl group, and generate benzyl radicals, which then react with chlorine gas to gradually replace the hydrogen of the methyl group, and finally obtain p-chlorotrichlorotoluene.
Then, p-chlorotrichlorotoluene reacts with hydrogen fluoride to achieve fluorine generation. This step is usually carried out in the presence of specific catalysts, such as antimony pentachloride. Fluoride ions replace the chlorine atoms in p-chlorotrichlorotoluene to form p-chlorotrifluoromethylbenzene. In this reaction, fluoride ions have strong nucleophilicity and can attack carbon atoms, replacing chlorine atoms to obtain the target product.
Second, p-chlorobromobenzene can also be prepared by reacting with trifluoromethylation reagents. For example, with zinc trifluoromethylhalide (prepared from zinc powder and trifluoromethylhalide) as the trifluoromethylation reagent, p-chlorobromobenzene is coupled with zinc trifluoromethylhalide under the action of transition metal catalysts such as palladium or nickel. The transition metal catalyst is first oxidized with halogenated aromatic hydrocarbons to form metal-aryl intermediates, then metallized with trifluoromethylation reagents, and finally eliminated by reduction to obtain p-chlorotrifluoromethylbenzene. This method requires strict anhydrous and anaerobic conditions, and the transition metal catalyst is expensive, but the selectivity is good and the yield is also good.
Third, m-chloroaniline is used as the starting material and can be obtained by diazotization and trifluoromethylation. First, m-chloroaniline is reacted with sodium nitrite and acid to undergo diazotization to form diazonium salts. The diazonium salt has high activity, and then reacts with trifluoromethylation reagents, such as trifluoromethyl copper, etc. The diazonium group is replaced by trifluoromethyl to obtain p-chlorotrifluoromethylbenzene. There are many steps in this route, and the diazonation reaction requires strict control of temperature and other conditions to prevent the decomposition of diazonium salts, but the raw materials are relatively easy to obtain, providing another way for the preparation.
First, p-chlorotoluene is used as the starting material and chlorinated by side chain to obtain p-chlorotrichlorotoluene. This step requires the presence of light or an initiator to react chlorine with p-chlorotoluene. The hydrogen of the methyl group in p-chlorotoluene has certain reactivity due to the influence of the benzene ring, and can undergo free radical substitution reaction with chlorine gas. Light or initiator can produce chlorine radicals, remove the hydrogen of the methyl group, and generate benzyl radicals, which then react with chlorine gas to gradually replace the hydrogen of the methyl group, and finally obtain p-chlorotrichlorotoluene.
Then, p-chlorotrichlorotoluene reacts with hydrogen fluoride to achieve fluorine generation. This step is usually carried out in the presence of specific catalysts, such as antimony pentachloride. Fluoride ions replace the chlorine atoms in p-chlorotrichlorotoluene to form p-chlorotrifluoromethylbenzene. In this reaction, fluoride ions have strong nucleophilicity and can attack carbon atoms, replacing chlorine atoms to obtain the target product.
Second, p-chlorobromobenzene can also be prepared by reacting with trifluoromethylation reagents. For example, with zinc trifluoromethylhalide (prepared from zinc powder and trifluoromethylhalide) as the trifluoromethylation reagent, p-chlorobromobenzene is coupled with zinc trifluoromethylhalide under the action of transition metal catalysts such as palladium or nickel. The transition metal catalyst is first oxidized with halogenated aromatic hydrocarbons to form metal-aryl intermediates, then metallized with trifluoromethylation reagents, and finally eliminated by reduction to obtain p-chlorotrifluoromethylbenzene. This method requires strict anhydrous and anaerobic conditions, and the transition metal catalyst is expensive, but the selectivity is good and the yield is also good.
Third, m-chloroaniline is used as the starting material and can be obtained by diazotization and trifluoromethylation. First, m-chloroaniline is reacted with sodium nitrite and acid to undergo diazotization to form diazonium salts. The diazonium salt has high activity, and then reacts with trifluoromethylation reagents, such as trifluoromethyl copper, etc. The diazonium group is replaced by trifluoromethyl to obtain p-chlorotrifluoromethylbenzene. There are many steps in this route, and the diazonation reaction requires strict control of temperature and other conditions to prevent the decomposition of diazonium salts, but the raw materials are relatively easy to obtain, providing another way for the preparation.
What are the precautions in storage and transportation of P-chlorotrifluoromethylbenzene?
P-chlorotrifluoromethylbenzene is an organic compound. When storing and transporting, many matters need to be paid attention to.
First, it is related to storage. Because of its certain chemical activity, it needs to be stored in a cool and ventilated warehouse. This is due to high temperature or lack of air circulation, or chemical reactions caused by it, and even safety accidents. The temperature of the warehouse should be controlled within a suitable range, and it must not be too high. And it should be kept away from fires and heat sources. Open flames and hot topics can easily cause dangerous reactions of the substance. Furthermore, it should be stored separately from oxidants and food chemicals to avoid mixed storage. Due to the contact of different chemical substances with each other, or violent reactions, such as redox reactions, etc., it will bring potential safety hazards. The storage area should also be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to reduce harm.
Second, it involves transportation. Before transportation, make sure that the container is well sealed to prevent leakage of P-chlorotrifluoromethylbenzene. During transportation, the transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. If there is a leak during transportation, emergency treatment can be carried out in time. To follow the specified route, do not stop in densely populated areas and residential areas. Because if the substance leaks or accidents occur, it will be extremely harmful to densely populated areas and will threaten the safety and health of many people. Drivers and escorts must strictly abide by the operating procedures when transporting, and be familiar with the characteristics of the transported substances and emergency treatment methods. In the event of an emergency, they can respond properly to ensure transportation safety.
First, it is related to storage. Because of its certain chemical activity, it needs to be stored in a cool and ventilated warehouse. This is due to high temperature or lack of air circulation, or chemical reactions caused by it, and even safety accidents. The temperature of the warehouse should be controlled within a suitable range, and it must not be too high. And it should be kept away from fires and heat sources. Open flames and hot topics can easily cause dangerous reactions of the substance. Furthermore, it should be stored separately from oxidants and food chemicals to avoid mixed storage. Due to the contact of different chemical substances with each other, or violent reactions, such as redox reactions, etc., it will bring potential safety hazards. The storage area should also be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to reduce harm.
Second, it involves transportation. Before transportation, make sure that the container is well sealed to prevent leakage of P-chlorotrifluoromethylbenzene. During transportation, the transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. If there is a leak during transportation, emergency treatment can be carried out in time. To follow the specified route, do not stop in densely populated areas and residential areas. Because if the substance leaks or accidents occur, it will be extremely harmful to densely populated areas and will threaten the safety and health of many people. Drivers and escorts must strictly abide by the operating procedures when transporting, and be familiar with the characteristics of the transported substances and emergency treatment methods. In the event of an emergency, they can respond properly to ensure transportation safety.
P-chlorotrifluoromethylbenzene impact on the environment and human health
The author of "Heavenly Works and Objects" is also an ancient scientific and technological book. Today, with its example, the answer is:
The author of chlorotrifluorotoluene is also a chemical. Its impact on the environment and human health cannot be ignored.
At one end of the environment, this compound has a certain degree of characterization. If it is exposed to nature, it will decay quickly. It may be dispersed in large areas, water, etc. In the process of large areas, or dry areas, however, its cutting effect still needs to be further researched. Water, or shadow aquatic organisms. Aquatic microorganisms, water, etc., may be poisoned and cause biological damage. It may be exposed to sediment, or shadow the environment of water.
For human health, if people are exposed to this substance, they may breathe, skin contact and food contact. Breathing and entering, or irritating the respiratory tract, causing cough and asthma. Inhalation, fear of lung function. Skin contact, or sensitivity, inflammation, such as,. If the food is introduced, it may cause adverse effects on the digestive system, and may involve other organs, such as liver,, etc., affecting its normal health. However, it is also harmful due to exposure, shortness and poor health., chlorotrifluorotoluene is dangerous to the environment and human health, and it should be treated with caution, study its nature, and prevent its harm, so as to ensure the safety of people in the environment.
The author of chlorotrifluorotoluene is also a chemical. Its impact on the environment and human health cannot be ignored.
At one end of the environment, this compound has a certain degree of characterization. If it is exposed to nature, it will decay quickly. It may be dispersed in large areas, water, etc. In the process of large areas, or dry areas, however, its cutting effect still needs to be further researched. Water, or shadow aquatic organisms. Aquatic microorganisms, water, etc., may be poisoned and cause biological damage. It may be exposed to sediment, or shadow the environment of water.
For human health, if people are exposed to this substance, they may breathe, skin contact and food contact. Breathing and entering, or irritating the respiratory tract, causing cough and asthma. Inhalation, fear of lung function. Skin contact, or sensitivity, inflammation, such as,. If the food is introduced, it may cause adverse effects on the digestive system, and may involve other organs, such as liver,, etc., affecting its normal health. However, it is also harmful due to exposure, shortness and poor health., chlorotrifluorotoluene is dangerous to the environment and human health, and it should be treated with caution, study its nature, and prevent its harm, so as to ensure the safety of people in the environment.
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