Linshang Chemical
PRODUCTS
P-Ethylsulfonylchlorobenzene
Linshang Chemical
|
HS Code |
677273 |
| Chemical Formula | C8H7ClO2S |
| Molar Mass | 204.66 g/mol |
| Appearance | Typically a solid (white or off - white powder) |
| Melting Point | Data may vary, around 60 - 70 °C |
| Boiling Point | Data may vary, approximately 270 - 280 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, acetone |
| Density | Data may vary, approximate value around 1.3 - 1.4 g/cm³ |
| Odor | Pungent |
| Stability | Stable under normal conditions, but reacts with strong bases and reducing agents |
As an accredited P-Ethylsulfonylchlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of P - ethylsulfonylchlorobenzene packaged in a sealed, corrosion - resistant container. |
| Storage | P - ethylsulfonylchlorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent exposure to moisture and air, which could lead to decomposition or reaction. Store it separately from incompatible substances like oxidizing agents, bases, and reactive metals to avoid potential chemical hazards. |
| Shipping | P - ethylsulfonylchlorobenzene is a chemical. Shipping should follow strict hazardous material regulations. It must be properly packaged to prevent leakage, with clear labels indicating its nature, and transported by approved carriers. |
Competitive P-Ethylsulfonylchlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy P-Ethylsulfonylchlorobenzene in China?
As a trusted P-Ethylsulfonylchlorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading P-Ethylsulfonylchlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of P-ethylsulfonylchlorobenzene?
P-ethylsulfonylchlorobenzene, or p-ethylsulfonyl chlorobenzene, is one of the organic compounds. This substance has unique chemical properties.
Its chemical activity is quite high, because the molecule contains a sulfonyl chloride group (-SO 2O Cl), which is extremely active. In the sulfonyl chloride group, the sulfur atom is in a high oxidation state and has strong electron-absorbing properties, making the group vulnerable to attack by nucleophiles. When exposed to water, it is very easy to hydrolyze, and the sulfonyl chloride group reacts with water to form p-ethanesulfonic acid and hydrogen chloride. The hydrolysis reaction formula is roughly as follows: R-SO-Cl + H-O → R-SO-H + HCl, where R stands for p-ethylphenyl. This hydrolysis reaction is quite rapid and exothermic.
In the field of organic synthesis, p-ethylsulfonyl chlorobenzene is often used as a sulfonylation reagent. It can react with nucleophiles such as alcohols and amines to achieve the sulfonylation process. When reacting with alcohols, sulfonates can be formed. For example, when reacting with ethanol, p-ethylsulfonyl ethanol esters will be formed. The reaction mechanism is roughly as follows. The hydroxyl oxygen atom in the alcohol acts as a nucleophilic reagent to attack the sulfur atom in the sulfonyl chloride group, and then the chloride ions leave to form a sulfonate product through a series of changes. When reacting with amines, sulfonamides are formed. Nitrogen atoms in amines attack the sulfonyl chloride sulfur atom, and the chloride ions leave, Such sulfonylation reactions play a key role in the construction of sulfonyl-containing organic compounds and are widely used in drug synthesis, materials science and many other fields.
The chemical properties of p-ethylsulfonyl chlorobenzene make it play an important role in the research and practical application of organic chemistry, and provide effective pathways and key raw materials for many organic synthesis reactions.
Its chemical activity is quite high, because the molecule contains a sulfonyl chloride group (-SO 2O Cl), which is extremely active. In the sulfonyl chloride group, the sulfur atom is in a high oxidation state and has strong electron-absorbing properties, making the group vulnerable to attack by nucleophiles. When exposed to water, it is very easy to hydrolyze, and the sulfonyl chloride group reacts with water to form p-ethanesulfonic acid and hydrogen chloride. The hydrolysis reaction formula is roughly as follows: R-SO-Cl + H-O → R-SO-H + HCl, where R stands for p-ethylphenyl. This hydrolysis reaction is quite rapid and exothermic.
In the field of organic synthesis, p-ethylsulfonyl chlorobenzene is often used as a sulfonylation reagent. It can react with nucleophiles such as alcohols and amines to achieve the sulfonylation process. When reacting with alcohols, sulfonates can be formed. For example, when reacting with ethanol, p-ethylsulfonyl ethanol esters will be formed. The reaction mechanism is roughly as follows. The hydroxyl oxygen atom in the alcohol acts as a nucleophilic reagent to attack the sulfur atom in the sulfonyl chloride group, and then the chloride ions leave to form a sulfonate product through a series of changes. When reacting with amines, sulfonamides are formed. Nitrogen atoms in amines attack the sulfonyl chloride sulfur atom, and the chloride ions leave, Such sulfonylation reactions play a key role in the construction of sulfonyl-containing organic compounds and are widely used in drug synthesis, materials science and many other fields.
The chemical properties of p-ethylsulfonyl chlorobenzene make it play an important role in the research and practical application of organic chemistry, and provide effective pathways and key raw materials for many organic synthesis reactions.
What are the common uses of P-ethylsulfonylchlorobenzene?
P-ethylsulfonylchlorobenzene, that is, p-ethylsulfonyl chlorobenzene, there are several common methods for preparing this substance:
First, p-ethylbenzenesulfonic acid is used as the starting material. The p-ethylsulfonic acid is co-heated with sulfoxide chloride, and the sulfur atoms in the sulfoxide chloride are nucleophilic, which can attack the hydroxyl group in the sulfonic acid group. The hydroxyl group is replaced by the chlorine atom to obtain p-ethylsulfonyl chlorobenzene. The reaction is roughly as follows: p-ethylsulfonic acid reacts with sulfoxide chloride at a suitable temperature, and after the substitution process, sulfur dioxide and hydrogen chloride gas escape, and the final product is obtained. This reaction condition is relatively mild, and the price of sulfoxide chloride is moderate, which is easy to operate, so it is widely used.
First, p-chloroacetophenone is converted into p-chlorobenzene ethanol, which can be achieved by a reduction reaction, such as treatment with a reducing agent such as sodium borohydride. After that, p-chlorobenzene ethanol interacts with a sulfonation reagent, and a common sulfonation reagent such as chlorosulfonic acid reacts to form p-ethylsulfonyl chlorobenzene. This path step is slightly complicated, but the raw materials are relatively easy to obtain. If the reaction conditions of each step are properly controlled, a good yield can also be achieved.
Third, benzene is used as the starting material. First, through the alkylation reaction of Fu-g, benzene and chloroethane are formed under the action of catalysts such as aluminum trichloride. Next, the ethylbenzene is sulfonated and treated with sulfonating reagents such as concentrated sulfuric acid to obtain p-ethylbenzene sulfonic acid, which is then chlorinated with thionyl chloride to obtain p-ethylsulfonyl chlorobenzene. This route is inexpensive in raw materials, but it involves many steps, and each step needs to be carefully controlled to improve the total yield.
The above common production methods have their own advantages and disadvantages. In practical application, it is necessary to choose carefully according to factors such as raw material availability, cost considerations, reaction conditions and product purity requirements.
First, p-ethylbenzenesulfonic acid is used as the starting material. The p-ethylsulfonic acid is co-heated with sulfoxide chloride, and the sulfur atoms in the sulfoxide chloride are nucleophilic, which can attack the hydroxyl group in the sulfonic acid group. The hydroxyl group is replaced by the chlorine atom to obtain p-ethylsulfonyl chlorobenzene. The reaction is roughly as follows: p-ethylsulfonic acid reacts with sulfoxide chloride at a suitable temperature, and after the substitution process, sulfur dioxide and hydrogen chloride gas escape, and the final product is obtained. This reaction condition is relatively mild, and the price of sulfoxide chloride is moderate, which is easy to operate, so it is widely used.
First, p-chloroacetophenone is converted into p-chlorobenzene ethanol, which can be achieved by a reduction reaction, such as treatment with a reducing agent such as sodium borohydride. After that, p-chlorobenzene ethanol interacts with a sulfonation reagent, and a common sulfonation reagent such as chlorosulfonic acid reacts to form p-ethylsulfonyl chlorobenzene. This path step is slightly complicated, but the raw materials are relatively easy to obtain. If the reaction conditions of each step are properly controlled, a good yield can also be achieved.
Third, benzene is used as the starting material. First, through the alkylation reaction of Fu-g, benzene and chloroethane are formed under the action of catalysts such as aluminum trichloride. Next, the ethylbenzene is sulfonated and treated with sulfonating reagents such as concentrated sulfuric acid to obtain p-ethylbenzene sulfonic acid, which is then chlorinated with thionyl chloride to obtain p-ethylsulfonyl chlorobenzene. This route is inexpensive in raw materials, but it involves many steps, and each step needs to be carefully controlled to improve the total yield.
The above common production methods have their own advantages and disadvantages. In practical application, it is necessary to choose carefully according to factors such as raw material availability, cost considerations, reaction conditions and product purity requirements.
What is P-ethylsulfonylchlorobenzene synthesis method?
To prepare p-ethanesulfonyl chlorobenzene (P-ethylsulfonylchlorobenzene), the method is as follows:
First, benzene is used as the starting material, and through the Fu-gram alkylation reaction, it is co-placed with the ethylation reagent in the presence of a catalyst such as anhydrous aluminum trichloride. Benzene and haloethane (such as bromoethane) under the catalysis of anhydrous aluminum trichloride can produce ethylbenzene. The mechanism of this reaction is that the haloethane first interacts with anhydrous aluminum trichloride to form a carbon positive ion, and then undergoes electrophilic substitution of the benzene ring to obtain ethylbenzene.
Ethylbenzene is then sulfonated, and concentrated sulfuric acid or The sulfonic acid group of sulfuric acid (-SO-H) attacks the para-position of ethylbenzene, which results in p-ethylbenzene sulfonic acid due to its small steric barrier and favorable electronic effect. In this step, the sulfuric acid molecule undergoes heterocleavage to generate active electrophilic reagents, which attack the parts with high electron cloud density of the benzene ring.
The p-ethylbenzene sulfonic acid is followed by chlorinated reagents such as sulfoxide chloride (SOCl ²) or phosphorus pentachloride (PCl), which can replace the hydroxyl group of the sulfonic acid group with a chlorine atom, and finally obtain p-ethyl If thionyl chloride is used, during the reaction process, the thionyl chloride reacts with the hydroxyl group of the sulfonic acid group, and the sulfur atom in the thionyl chloride attacks the hydroxyl oxygen atom nucleophilically. After a series of intermediate transformations, sulfur dioxide and hydrogen chloride are released to complete the chlorination, and the target product p-ethanesulfonyl chlorobenzene is obtained.
First, benzene is used as the starting material, and through the Fu-gram alkylation reaction, it is co-placed with the ethylation reagent in the presence of a catalyst such as anhydrous aluminum trichloride. Benzene and haloethane (such as bromoethane) under the catalysis of anhydrous aluminum trichloride can produce ethylbenzene. The mechanism of this reaction is that the haloethane first interacts with anhydrous aluminum trichloride to form a carbon positive ion, and then undergoes electrophilic substitution of the benzene ring to obtain ethylbenzene.
Ethylbenzene is then sulfonated, and concentrated sulfuric acid or The sulfonic acid group of sulfuric acid (-SO-H) attacks the para-position of ethylbenzene, which results in p-ethylbenzene sulfonic acid due to its small steric barrier and favorable electronic effect. In this step, the sulfuric acid molecule undergoes heterocleavage to generate active electrophilic reagents, which attack the parts with high electron cloud density of the benzene ring.
The p-ethylbenzene sulfonic acid is followed by chlorinated reagents such as sulfoxide chloride (SOCl ²) or phosphorus pentachloride (PCl), which can replace the hydroxyl group of the sulfonic acid group with a chlorine atom, and finally obtain p-ethyl If thionyl chloride is used, during the reaction process, the thionyl chloride reacts with the hydroxyl group of the sulfonic acid group, and the sulfur atom in the thionyl chloride attacks the hydroxyl oxygen atom nucleophilically. After a series of intermediate transformations, sulfur dioxide and hydrogen chloride are released to complete the chlorination, and the target product p-ethanesulfonyl chlorobenzene is obtained.
What are the precautions in storage and transportation of P-ethylsulfonylchlorobenzene?
P - ethylsulfonylchlorobenzene, the things that are transformed are also. When it comes to hiding things, you can't be careless.
The place where you hide things is the first place. It should be placed in a place where things are dry and good. It can be affected by its nature or degree and degree of influence. If it is in a place where it is high and tidal, it is feared that it will be reversed, and its nature will be damaged. Therefore, it can be guaranteed.
It is also a source of fire and a source of fire. This is because P - ethylsulfonylchlorobenzene may be flammable. In case of an open fire or a high temperature, it will be dangerous, or cause a fire or an explosion. It is a place where it is hidden, and it must be prohibited from burning, and it is a fire-fighting device.
Furthermore, it is advisable to store materials such as oxidized, raw materials, and other materials.
When it comes to the environment, it is also necessary to. Equipment, clean, dry and well-sealed. Prevent its leakage, so as not to pollute the environment, and avoid harming others. On the way, people must be careful, shock absorption, collision, and prevent leakage caused by container breakage.
and, must be in accordance with the corresponding method, with urgent management material. As soon as there is a leak and other things, it can be installed immediately to damage.
In other words, P - ethylsulfonylchlorobenzene to hide and hide, and to keep everything safe and avoid accidents.
The place where you hide things is the first place. It should be placed in a place where things are dry and good. It can be affected by its nature or degree and degree of influence. If it is in a place where it is high and tidal, it is feared that it will be reversed, and its nature will be damaged. Therefore, it can be guaranteed.
It is also a source of fire and a source of fire. This is because P - ethylsulfonylchlorobenzene may be flammable. In case of an open fire or a high temperature, it will be dangerous, or cause a fire or an explosion. It is a place where it is hidden, and it must be prohibited from burning, and it is a fire-fighting device.
Furthermore, it is advisable to store materials such as oxidized, raw materials, and other materials.
When it comes to the environment, it is also necessary to. Equipment, clean, dry and well-sealed. Prevent its leakage, so as not to pollute the environment, and avoid harming others. On the way, people must be careful, shock absorption, collision, and prevent leakage caused by container breakage.
and, must be in accordance with the corresponding method, with urgent management material. As soon as there is a leak and other things, it can be installed immediately to damage.
In other words, P - ethylsulfonylchlorobenzene to hide and hide, and to keep everything safe and avoid accidents.
P-ethylsulfonylchlorobenzene impact on the environment and human health
P-ethylsulfonyl chlorobenzene is one of the organic compounds. The impact of this substance on the environment and human health is truly inconspicuous.
As far as the environment is concerned, it may be quite harmful. If released into the atmosphere, due to certain volatility, or participating in photochemical reactions, it will cause atmospheric quality to decline, damage air quality, and may form photochemical smog and other hazards, disturbing ecological balance. Entering water bodies, due to their chemical properties, or difficult to degrade, accumulate in water bodies, harming aquatic organisms. Or breaking the cell membranes of aquatic organisms, disturbing their physiological metabolism, causing aquatic organisms to grow and multiply, and reducing the population. Or passing through the food chain, enrichment, endangering higher organisms. As for the soil, or change the physical and chemical properties of the soil, affect the activity of soil microorganisms and community structure, cause soil fertility, inhibit plant growth, reduce vegetation coverage, and increase the risk of soil erosion.
When it comes to human health, ethylsulfonyl chlorobenzene is also very harmful. Entering the body through the respiratory tract irritates the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties and other diseases. Long-term exposure or damage to lung function increases the risk of respiratory diseases. Through skin contact, it can cause skin allergies, redness, swelling, itching, and even burns, break the skin barrier, and make harmful substances easy to enter the body. If ingested inadvertently, it can damage the digestive system, cause nausea, vomiting, abdominal pain, diarrhea, and may have systemic toxicity, damage important organ functions such as liver and kidney, affect the body's normal metabolism and detoxification, long-term exposure or induce gene mutation, and increase the risk of cancer.
In summary, p-ethylsulfonyl chlorobenzene poses a potential threat to the environment and human health. It should be treated with caution to prevent it from polluting the environment and protecting the ecology and human health.
As far as the environment is concerned, it may be quite harmful. If released into the atmosphere, due to certain volatility, or participating in photochemical reactions, it will cause atmospheric quality to decline, damage air quality, and may form photochemical smog and other hazards, disturbing ecological balance. Entering water bodies, due to their chemical properties, or difficult to degrade, accumulate in water bodies, harming aquatic organisms. Or breaking the cell membranes of aquatic organisms, disturbing their physiological metabolism, causing aquatic organisms to grow and multiply, and reducing the population. Or passing through the food chain, enrichment, endangering higher organisms. As for the soil, or change the physical and chemical properties of the soil, affect the activity of soil microorganisms and community structure, cause soil fertility, inhibit plant growth, reduce vegetation coverage, and increase the risk of soil erosion.
When it comes to human health, ethylsulfonyl chlorobenzene is also very harmful. Entering the body through the respiratory tract irritates the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties and other diseases. Long-term exposure or damage to lung function increases the risk of respiratory diseases. Through skin contact, it can cause skin allergies, redness, swelling, itching, and even burns, break the skin barrier, and make harmful substances easy to enter the body. If ingested inadvertently, it can damage the digestive system, cause nausea, vomiting, abdominal pain, diarrhea, and may have systemic toxicity, damage important organ functions such as liver and kidney, affect the body's normal metabolism and detoxification, long-term exposure or induce gene mutation, and increase the risk of cancer.
In summary, p-ethylsulfonyl chlorobenzene poses a potential threat to the environment and human health. It should be treated with caution to prevent it from polluting the environment and protecting the ecology and human health.
Scan to WhatsApp
