Linshang Chemical
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P-Fluorochlorobenzene
Linshang Chemical
|
HS Code |
619008 |
| Chemical Formula | C6H4ClF |
| Molar Mass | 116.546 g/mol |
| Appearance | Colorless liquid |
| Boiling Point | 131 - 132 °C |
| Melting Point | -35 °C |
| Density | 1.19 g/cm³ at 20 °C |
| Solubility In Water | Insoluble |
| Vapor Pressure | 1.33 kPa at 24.2 °C |
| Flash Point | 29 °C |
| Refractive Index | 1.4760 at 20 °C |
As an accredited P-Fluorochlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of p - fluorochlorobenzene packaged in a sealed, corrosion - resistant plastic bottle. |
| Storage | P - fluorochlorobenzene should be stored in a cool, well - ventilated area, away from heat and ignition sources. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals. Since it is flammable and may pose health risks, ensure proper labeling and restricted access in storage facilities. |
| Shipping | P - fluorochlorobenzene should be shipped in tightly - sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper labeling and segregation from incompatible substances. |
Competitive P-Fluorochlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading P-Fluorochlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of P-fluorochlorobenzene?
P-fluorochlorobenzene is p-fluorochlorobenzene. Its chemical structure is above the benzene ring, with fluorine atoms (F) and chlorine atoms (Cl) connected at the para-position (1,4-position), respectively. The benzene ring is a planar hexagonal structure, and six carbon atoms are connected to each other by conjugated large π bonds to form a stable ring system. The fluorine atom and the chlorine atom are each connected to the corresponding carbon atom on the benzene ring by covalent bonds. This structure endows p-fluorochlorobenzene with specific physical and chemical properties. Due to the different electronegativity of fluorine and chlorine atoms, the electron cloud distribution of the benzene ring will be affected, and then the reactivity and polarity of the compound will be affected. Its structure makes p-fluorochlorobenzene an important intermediate in the field of organic synthesis, participating in many chemical reactions. Through the modification and transformation of substituents on the p-benzene ring, a variety of organic compounds can be prepared.
What are the physical properties of P-fluorochlorobenzene?
P-fluorochlorobenzene is also an organic compound. Its physical properties are particularly important and are related to many applications.
Looking at its properties, under normal temperature and pressure, P-fluorochlorobenzene is in the state of a colorless liquid, with a clear and transparent texture, like autumn water. Smell it, it has a specific aromatic smell, although it is not rich and pungent, it also has its own unique taste.
When it comes to boiling point, it is between 128 and 130 degrees Celsius. At this temperature, the liquid will gradually turn into a gaseous state, such as cloud evaporation. The characteristics of boiling point are crucial in chemical operations such as separation and purification, and it can be precisely separated from the mixture according to this difference.
And the melting point is about -27 degrees Celsius. When the temperature drops, the originally flowing liquid will gradually solidify, just like time condenses, from a smart state to a solid state.
Its density is also fixed, about 1.29 grams per cubic centimeter. This value shows that under the same volume, P-fluorochlorobenzene is heavier than water. In the process of liquid mixing, the different densities will cause it to be stratified or blended with other substances.
Furthermore, P-fluorochlorobenzene is slightly soluble in water, like oil floating on the water surface, and it is difficult to integrate with water. However, in organic solvents, such as ethanol, ether, etc., it can be better dissolved, just like fish entering water and blending freely. This difference in solubility is of great significance in the fields of extraction, reaction medium selection, etc.
And the vapor pressure of P-fluorochlorobenzene has a corresponding value at a specific temperature. The level of vapor pressure affects the degree of volatilization, which is related to the safety of storage and use.
All these physical properties are related to each other, and together outline the characteristics of P-fluorochlorobenzene, which is an indispensable consideration in many industries such as chemical industry and medicine.
Looking at its properties, under normal temperature and pressure, P-fluorochlorobenzene is in the state of a colorless liquid, with a clear and transparent texture, like autumn water. Smell it, it has a specific aromatic smell, although it is not rich and pungent, it also has its own unique taste.
When it comes to boiling point, it is between 128 and 130 degrees Celsius. At this temperature, the liquid will gradually turn into a gaseous state, such as cloud evaporation. The characteristics of boiling point are crucial in chemical operations such as separation and purification, and it can be precisely separated from the mixture according to this difference.
And the melting point is about -27 degrees Celsius. When the temperature drops, the originally flowing liquid will gradually solidify, just like time condenses, from a smart state to a solid state.
Its density is also fixed, about 1.29 grams per cubic centimeter. This value shows that under the same volume, P-fluorochlorobenzene is heavier than water. In the process of liquid mixing, the different densities will cause it to be stratified or blended with other substances.
Furthermore, P-fluorochlorobenzene is slightly soluble in water, like oil floating on the water surface, and it is difficult to integrate with water. However, in organic solvents, such as ethanol, ether, etc., it can be better dissolved, just like fish entering water and blending freely. This difference in solubility is of great significance in the fields of extraction, reaction medium selection, etc.
And the vapor pressure of P-fluorochlorobenzene has a corresponding value at a specific temperature. The level of vapor pressure affects the degree of volatilization, which is related to the safety of storage and use.
All these physical properties are related to each other, and together outline the characteristics of P-fluorochlorobenzene, which is an indispensable consideration in many industries such as chemical industry and medicine.
What are the main uses of P-fluorochlorobenzene?
P-fluorochlorobenzene is also an organic compound. It has a wide range of uses and has important applications in medicine, pesticides, dyes and other fields.
In the field of medicine, this compound is often a key intermediate in the synthesis of many drugs. Due to its special chemical structure, it can endow drugs with specific pharmacological activities and properties. For example, in the preparation of some antibacterial drugs and anti-tumor drugs, P-fluorochlorobenzene can be used as a starting material or an important intermediate. After a series of chemical reactions, drug molecules with desired therapeutic effects can be constructed.
In the field of pesticides, P-fluorochlorobenzene also plays an important role. It can be used to synthesize a variety of high-efficiency pesticides, such as insecticides, fungicides, etc. Due to the structural characteristics of P-fluorochlorobenzene, these pesticides exhibit good inhibition and killing effects on pests and pathogens, and have certain selectivity. They have little impact on the environment and non-target organisms, which is conducive to the sustainable development of agriculture.
In the field of dyes, P-fluorochlorobenzene can participate in the synthesis of dyes with bright colors and excellent fastness. Its structure helps dye molecules to form a stable combination with the dye, resulting in better dyeing effect, and is widely used in textile, printing and dyeing industries.
In addition, P-fluorochlorobenzene is also a commonly used basic raw material in organic synthetic chemistry. Chemists can prepare organic compounds with diverse structures by performing various functional group conversion reactions on them, providing a foundation for the development and exploration of new substances.
In the field of medicine, this compound is often a key intermediate in the synthesis of many drugs. Due to its special chemical structure, it can endow drugs with specific pharmacological activities and properties. For example, in the preparation of some antibacterial drugs and anti-tumor drugs, P-fluorochlorobenzene can be used as a starting material or an important intermediate. After a series of chemical reactions, drug molecules with desired therapeutic effects can be constructed.
In the field of pesticides, P-fluorochlorobenzene also plays an important role. It can be used to synthesize a variety of high-efficiency pesticides, such as insecticides, fungicides, etc. Due to the structural characteristics of P-fluorochlorobenzene, these pesticides exhibit good inhibition and killing effects on pests and pathogens, and have certain selectivity. They have little impact on the environment and non-target organisms, which is conducive to the sustainable development of agriculture.
In the field of dyes, P-fluorochlorobenzene can participate in the synthesis of dyes with bright colors and excellent fastness. Its structure helps dye molecules to form a stable combination with the dye, resulting in better dyeing effect, and is widely used in textile, printing and dyeing industries.
In addition, P-fluorochlorobenzene is also a commonly used basic raw material in organic synthetic chemistry. Chemists can prepare organic compounds with diverse structures by performing various functional group conversion reactions on them, providing a foundation for the development and exploration of new substances.
What are P-fluorochlorobenzene production methods?
There are two common methods for making p-fluorobenzene. The first is to start with p-chloroaniline and react with Seaman by diazotization. Take p-chloroaniline first, so that it reacts with sodium nitrite and hydrochloric acid at low temperature, and carry out the method of diazotization to obtain p-chlorobenzene diazo salt. Then this salt interacts with fluoroboronic acid to produce p-chlorobenzene diazo fluoroborate precipitation. Then the precipitation is carefully heated and decomposed to obtain p-fluorochlorobenzene. Although this step is complicated, it has good selectivity and can obtain products with higher purity.
The second is to use chlorobenzene as a raw material and undergo direct fluoridation. Chlorobenzene reacts with fluorinated reagents, such as active potassium fluoride, in the presence of specific solvents and catalysts. In this process, the activity of fluorinated reagents, reaction temperature and time need to be precisely controlled. Due to the high activity of fluorine, the reaction is easy to get out of control, resulting in side reactions such as polyfluorinated substitution. However, this step is relatively simple, and if the conditions are suitable, p-fluorochlorobenzene can be effectively prepared. These two methods have their own advantages and disadvantages. The actual production needs to be weighed against many factors such as raw material availability, cost and product requirements.
The second is to use chlorobenzene as a raw material and undergo direct fluoridation. Chlorobenzene reacts with fluorinated reagents, such as active potassium fluoride, in the presence of specific solvents and catalysts. In this process, the activity of fluorinated reagents, reaction temperature and time need to be precisely controlled. Due to the high activity of fluorine, the reaction is easy to get out of control, resulting in side reactions such as polyfluorinated substitution. However, this step is relatively simple, and if the conditions are suitable, p-fluorochlorobenzene can be effectively prepared. These two methods have their own advantages and disadvantages. The actual production needs to be weighed against many factors such as raw material availability, cost and product requirements.
P-fluorochlorobenzene what are the precautions during use?
P-fluorochlorobenzene is an organic compound, which is widely used in industry and scientific research. When it is used, many matters must be observed.
The first thing to pay attention to is its toxicity. P-fluorochlorobenzene has certain toxicity, or is harmful to the human body. If it is accidentally touched, it can cause skin discomfort, such as redness, itching, and even burns. If it inhales its vapor, it can damage the respiratory tract, causing cough, asthma, and breathing difficulties. If eaten by mistake, it will harm the stomach, causing nausea, vomiting, and abdominal pain. Therefore, when using, protective equipment, such as gloves, masks, and goggles, must not be unprepared, and the operation should be in a well-ventilated place to avoid excessive contact with the human body.
The second time is the risk of ignition and explosion. P-fluorochlorobenzene is flammable, and in case of open flames and hot topics, there is a risk of ignition and explosion. When storing, it should be avoided from fire and heat sources, placed in a cool and ventilated place, and away from oxidants to prevent violent reactions and accidental changes.
Furthermore, its environmental impact should not be ignored. If P-fluorochlorobenzene enters the environment, it may accumulate ecology. It is difficult to degrade in soil and water, and can accumulate in living organisms, breaking the ecological balance. Therefore, waste after use should not be discarded at will, and it needs to be disposed of in accordance with regulations to reduce the harm to the environment.
Repeat, the operation specification is very important. When using P-fluorochlorobenzene, its properties should be clarified first, and the method of operation should be familiar. The experimental equipment must be clean and dry to prevent impurities from reacting with P-fluorochlorobenzene, resulting in deviations or even danger. During operation, measure accurately, control the reaction conditions, such as temperature, pressure, and time, and ensure that the reaction is stable and smooth.
In addition, the method of storage is also exquisite. It should be stored in a sealed container, protected from light, and decomposed due to light. And the material of the container should be suitable, not reacting with P-fluorochlorobenzene, to ensure its purity.
In short, when using P-fluorochlorobenzene, be careful and pay attention to all ends, in order to avoid harm and profit, and ensure safety and effectiveness.
The first thing to pay attention to is its toxicity. P-fluorochlorobenzene has certain toxicity, or is harmful to the human body. If it is accidentally touched, it can cause skin discomfort, such as redness, itching, and even burns. If it inhales its vapor, it can damage the respiratory tract, causing cough, asthma, and breathing difficulties. If eaten by mistake, it will harm the stomach, causing nausea, vomiting, and abdominal pain. Therefore, when using, protective equipment, such as gloves, masks, and goggles, must not be unprepared, and the operation should be in a well-ventilated place to avoid excessive contact with the human body.
The second time is the risk of ignition and explosion. P-fluorochlorobenzene is flammable, and in case of open flames and hot topics, there is a risk of ignition and explosion. When storing, it should be avoided from fire and heat sources, placed in a cool and ventilated place, and away from oxidants to prevent violent reactions and accidental changes.
Furthermore, its environmental impact should not be ignored. If P-fluorochlorobenzene enters the environment, it may accumulate ecology. It is difficult to degrade in soil and water, and can accumulate in living organisms, breaking the ecological balance. Therefore, waste after use should not be discarded at will, and it needs to be disposed of in accordance with regulations to reduce the harm to the environment.
Repeat, the operation specification is very important. When using P-fluorochlorobenzene, its properties should be clarified first, and the method of operation should be familiar. The experimental equipment must be clean and dry to prevent impurities from reacting with P-fluorochlorobenzene, resulting in deviations or even danger. During operation, measure accurately, control the reaction conditions, such as temperature, pressure, and time, and ensure that the reaction is stable and smooth.
In addition, the method of storage is also exquisite. It should be stored in a sealed container, protected from light, and decomposed due to light. And the material of the container should be suitable, not reacting with P-fluorochlorobenzene, to ensure its purity.
In short, when using P-fluorochlorobenzene, be careful and pay attention to all ends, in order to avoid harm and profit, and ensure safety and effectiveness.
What are the main uses of P-fluorochlorobenzene?
P-fluorochlorobenzene is also an organic compound. It has a wide range of uses and is used in various fields such as medicine, pesticides, and materials.
In the field of medicine, it is often an intermediate for drug synthesis. The characteristics of fluorine and chlorine atoms on the benzene ring can adjust the electron cloud density and spatial structure of molecules, affect the interaction between drugs and receptors, and improve the activity, selectivity and stability of drugs. For the preparation of some antibacterial and antiviral drugs, P-fluorochlorobenzene can be used as a starting material. After a series of chemical reactions, a molecular structure with specific pharmacological activities is constructed.
In the field of pesticides, P-fluorochlorobenzene also plays an important role. A variety of high-efficiency pesticides can be derived, such as pesticides and herbicides containing fluorine and chlorine. Fluorine and chlorine atoms endow pesticides with good biological activity and environmental stability, can effectively kill pests, control weed growth, and have a suitable residual period. It has little impact on the ecological environment and is commonly used in modern agricultural production.
As for the field of materials, P-fluorochlorobenzene can be used to synthesize special polymer materials. By polymerizing with other monomers, fluorine and chlorine elements are introduced into the main chain or side chain of the polymer, which can improve the properties of the material, such as improving the weather resistance, chemical corrosion resistance and thermal stability of the material. Such fluorine-containing and chlorine polymer materials are widely used in industries with strict material performance requirements such as aerospace, electronics and electrical appliances.
To sum up, P-fluorochlorobenzene, with its unique chemical structure, plays a key role in many fields such as medicine, pesticides, and materials, and is an indispensable basic raw material for the development of modern industry and science and technology.
In the field of medicine, it is often an intermediate for drug synthesis. The characteristics of fluorine and chlorine atoms on the benzene ring can adjust the electron cloud density and spatial structure of molecules, affect the interaction between drugs and receptors, and improve the activity, selectivity and stability of drugs. For the preparation of some antibacterial and antiviral drugs, P-fluorochlorobenzene can be used as a starting material. After a series of chemical reactions, a molecular structure with specific pharmacological activities is constructed.
In the field of pesticides, P-fluorochlorobenzene also plays an important role. A variety of high-efficiency pesticides can be derived, such as pesticides and herbicides containing fluorine and chlorine. Fluorine and chlorine atoms endow pesticides with good biological activity and environmental stability, can effectively kill pests, control weed growth, and have a suitable residual period. It has little impact on the ecological environment and is commonly used in modern agricultural production.
As for the field of materials, P-fluorochlorobenzene can be used to synthesize special polymer materials. By polymerizing with other monomers, fluorine and chlorine elements are introduced into the main chain or side chain of the polymer, which can improve the properties of the material, such as improving the weather resistance, chemical corrosion resistance and thermal stability of the material. Such fluorine-containing and chlorine polymer materials are widely used in industries with strict material performance requirements such as aerospace, electronics and electrical appliances.
To sum up, P-fluorochlorobenzene, with its unique chemical structure, plays a key role in many fields such as medicine, pesticides, and materials, and is an indispensable basic raw material for the development of modern industry and science and technology.
What are the physical properties of P-fluorochlorobenzene?
P-fluorochlorobenzene is also an organic compound. Its physical properties are quite interesting, let me explain them in detail for you.
First of all, its appearance, under normal circumstances, P-fluorochlorobenzene is a colorless and transparent liquid, clear and clear, like a mountain spring, which is pleasing to the eye. Its smell has a slightly aromatic charm, but this fragrance is not as rich as the orchid, nor as strong as the rose, but a unique light fragrance, slowly dispersing in the air, if not, tantalizing.
Second, its melting point is about -35 ° C. Its melting point is about -35 ° C, just like ice in winter, which melts when heated. The boiling point is about 172 ° C, and it needs to be heated moderately before it can change from liquid to gaseous state, such as phoenix nirvana, undergoing the transformation of state. This melting boiling point characteristic makes it have different physical forms in a specific temperature environment, which is of great significance in chemical production and scientific research applications.
Furthermore, the density of P-fluorochlorobenzene is heavier than that of water, about 1.29g/cm3. If it is placed in a container with water, it can be seen that it sinks in the bottom of the water, like a pearl falling in the abyss, and it is distinct.
In terms of solubility, P-fluorochlorobenzene is slightly soluble in water, just like the incompatibility of oil and water, and the two are difficult to blend. However, it is soluble in many organic solvents, such as ethanol, ether, etc., just like a wanderer meeting a bosom friend, it can be miscible with each other, and it is indistinguishable from each other. This solubility characteristic provides convenient conditions for its application in organic synthesis and other fields.
In terms of volatility, P-fluorochlorobenzene has a certain degree of volatility. In room temperature environment, its molecules are like lively spirits, constantly escaping from the liquid surface and entering the gas phase space. This volatility makes it necessary to pay attention when storing and using it, and beware of its volatilization and dissipation, which will affect the environment and use effect.
In addition, the refractive index of P-fluorochlorobenzene also has a specific value. This physical constant is like its unique identification. In the process of identification and analysis, it provides an important basis for researchers to accurately identify and study this compound.
In summary, the physical properties of P-fluorochlorobenzene are rich and diverse, and each property is related to each other, which together constitute its unique physical properties. It plays an indispensable role in many fields such as chemical industry and medicine.
First of all, its appearance, under normal circumstances, P-fluorochlorobenzene is a colorless and transparent liquid, clear and clear, like a mountain spring, which is pleasing to the eye. Its smell has a slightly aromatic charm, but this fragrance is not as rich as the orchid, nor as strong as the rose, but a unique light fragrance, slowly dispersing in the air, if not, tantalizing.
Second, its melting point is about -35 ° C. Its melting point is about -35 ° C, just like ice in winter, which melts when heated. The boiling point is about 172 ° C, and it needs to be heated moderately before it can change from liquid to gaseous state, such as phoenix nirvana, undergoing the transformation of state. This melting boiling point characteristic makes it have different physical forms in a specific temperature environment, which is of great significance in chemical production and scientific research applications.
Furthermore, the density of P-fluorochlorobenzene is heavier than that of water, about 1.29g/cm3. If it is placed in a container with water, it can be seen that it sinks in the bottom of the water, like a pearl falling in the abyss, and it is distinct.
In terms of solubility, P-fluorochlorobenzene is slightly soluble in water, just like the incompatibility of oil and water, and the two are difficult to blend. However, it is soluble in many organic solvents, such as ethanol, ether, etc., just like a wanderer meeting a bosom friend, it can be miscible with each other, and it is indistinguishable from each other. This solubility characteristic provides convenient conditions for its application in organic synthesis and other fields.
In terms of volatility, P-fluorochlorobenzene has a certain degree of volatility. In room temperature environment, its molecules are like lively spirits, constantly escaping from the liquid surface and entering the gas phase space. This volatility makes it necessary to pay attention when storing and using it, and beware of its volatilization and dissipation, which will affect the environment and use effect.
In addition, the refractive index of P-fluorochlorobenzene also has a specific value. This physical constant is like its unique identification. In the process of identification and analysis, it provides an important basis for researchers to accurately identify and study this compound.
In summary, the physical properties of P-fluorochlorobenzene are rich and diverse, and each property is related to each other, which together constitute its unique physical properties. It plays an indispensable role in many fields such as chemical industry and medicine.
Is P-fluorochlorobenzene chemically stable?
The chemical properties of P-fluorochlorobenzene are quite stable. In this material structure, fluorine and chlorine atoms are connected to the benzene ring. The structure of the benzene ring has a conjugate system, which reduces the molecular energy and increases the stability. Although fluorine and chlorine atoms have electron-absorbing induction effects, the change of electron cloud density distribution of the benzene ring does not make its chemical properties abnormal.
From the perspective of reactivity, in the electrophilic substitution reaction, the original electron cloud density distribution of the benzene ring is affected by the electron-absorbing induction effects of fluorine and chlorine, and the reactivity is slightly lower than that of benzene. However, because the conjugate system still exists, it can maintain a certain stability and does not react easily.
In the nucleophilic substitution reaction, because fluorine, chlorine and benzene ring are connected, the carbon-halogen bond has some double bond properties, which makes it difficult for the halogen atom to leave and increases its stability. Under normal conditions, without special reagents and reaction conditions, P-fluorochlorobenzene is difficult to undergo significant chemical changes, so it can be said that its chemical properties are relatively stable.
From the perspective of reactivity, in the electrophilic substitution reaction, the original electron cloud density distribution of the benzene ring is affected by the electron-absorbing induction effects of fluorine and chlorine, and the reactivity is slightly lower than that of benzene. However, because the conjugate system still exists, it can maintain a certain stability and does not react easily.
In the nucleophilic substitution reaction, because fluorine, chlorine and benzene ring are connected, the carbon-halogen bond has some double bond properties, which makes it difficult for the halogen atom to leave and increases its stability. Under normal conditions, without special reagents and reaction conditions, P-fluorochlorobenzene is difficult to undergo significant chemical changes, so it can be said that its chemical properties are relatively stable.
What are the preparation methods of P-fluorochlorobenzene?
For P-chlorofluorobenzene, organic compounds are also prepared by various methods, which are described in detail as follows:
First, p-chloroaniline is used as the beginning, and it can be obtained by diazotization and fluorination. First, p-chloroaniline is combined with sodium nitrite and hydrochloric acid at low temperature, and the reaction of diazotization is carried out to obtain diazonium salt. It should be controlled at zero to five degrees to prevent the decomposition of diazonium salt, which is the key. Next, the diazosalt obtained by fluoroboronic acid treatment is obtained by p-chlorobenzene diazofluoroborate, which is then decomposed by heating to obtain P-chlorofluorobenzene. This path step is slightly complicated, and the raw materials are easy to purchase, and the yield is acceptable.
Second, p-chlorophenol is First, p-chlorophenol is reacted with fluorinated reagents, such as potassium fluoride, in the presence of appropriate solvents and catalysts. Dimethyl sulfoxide and potassium iodide are often used as solvents, and potassium iodide is used as catalysts. Heating prompts phenolic hydroxyl fluoride to obtain the product. This method is relatively simple, but the activity and selectivity of fluorinated reagents must be carefully considered to prevent side reactions.
Third, the method is based on the nucleophilic substitution of aromatic halides. P-chlorobromophenzene and fluorinated reagents, under specific conditions, fluorine ions nucleophilic replace bromine atoms to obtain P-fluorochlorobenzene. Among them, the reaction conditions such as temperature, pressure, solvent and catalyst are very important, and the choice of reaction rate and yield is very important.
The methods for preparing P-fluorochlorobenzene have their own advantages and disadvantages. In actual operation, the choice should be made carefully according to factors such as the availability of raw materials, cost, and product purity.
First, p-chloroaniline is used as the beginning, and it can be obtained by diazotization and fluorination. First, p-chloroaniline is combined with sodium nitrite and hydrochloric acid at low temperature, and the reaction of diazotization is carried out to obtain diazonium salt. It should be controlled at zero to five degrees to prevent the decomposition of diazonium salt, which is the key. Next, the diazosalt obtained by fluoroboronic acid treatment is obtained by p-chlorobenzene diazofluoroborate, which is then decomposed by heating to obtain P-chlorofluorobenzene. This path step is slightly complicated, and the raw materials are easy to purchase, and the yield is acceptable.
Second, p-chlorophenol is First, p-chlorophenol is reacted with fluorinated reagents, such as potassium fluoride, in the presence of appropriate solvents and catalysts. Dimethyl sulfoxide and potassium iodide are often used as solvents, and potassium iodide is used as catalysts. Heating prompts phenolic hydroxyl fluoride to obtain the product. This method is relatively simple, but the activity and selectivity of fluorinated reagents must be carefully considered to prevent side reactions.
Third, the method is based on the nucleophilic substitution of aromatic halides. P-chlorobromophenzene and fluorinated reagents, under specific conditions, fluorine ions nucleophilic replace bromine atoms to obtain P-fluorochlorobenzene. Among them, the reaction conditions such as temperature, pressure, solvent and catalyst are very important, and the choice of reaction rate and yield is very important.
The methods for preparing P-fluorochlorobenzene have their own advantages and disadvantages. In actual operation, the choice should be made carefully according to factors such as the availability of raw materials, cost, and product purity.
P-fluorochlorobenzene What are the precautions during storage and transportation?
P-fluorochlorobenzene is an organic compound, and many things need to be paid attention to during storage and transportation.
First, the storage place should be cool and ventilated. This is because it is volatile to a certain extent, and high temperature can easily cause its volatilization to intensify, or even cause danger. "Tiangong Kaiwu" says: "Hide all things in a cool place to avoid the invasion of yang inflammation." If stored in a warm place, P-fluorochlorobenzene may evaporate and escape due to temperature, which not only damages its quality, but also may endanger the surrounding environment and personnel safety.
Second, be sure to keep away from fire and heat sources. This substance is flammable, and can cause combustion and explosion in case of open flame and high heat. " Fire is a taboo for things, and flammable things must not be approached. "When storing and transporting, strictly control fire and heat sources, and strictly prohibit smoking and the use of open flames to prevent accidents.
Third, it should be stored and transported separately from oxidants and edible chemicals. P-fluorochlorobenzene is mixed with oxidants, or has a violent chemical reaction, while coexisting with edible chemicals, or causing pollution. For example," Tiangong Kaiwu "also talks about the principle of avoiding things, and things of different properties should not be mixed.
Fourth, the storage container must be well sealed." The way to seal is to be tight. " If the container is not well sealed, P-chlorofluorobenzene volatilizes and leaks, which not only causes material loss, but also pollutes the environment, and may endanger human health.
Fifth, during transportation, the vehicle should have a grounding chain, and holes can be set in the groove to baffle to reduce shock and generate static electricity. Static electricity may also cause P-chlorofluorobenzene to burn and explode, which is essential for prevention.
Sixth, operators should receive professional training and act strictly in accordance with operating procedures. "If you want to do something good, you must first use your tools; if you want to perform your duties, you must first understand its rules." In this way, you can ensure the safety of storage and transportation, and avoid danger.
First, the storage place should be cool and ventilated. This is because it is volatile to a certain extent, and high temperature can easily cause its volatilization to intensify, or even cause danger. "Tiangong Kaiwu" says: "Hide all things in a cool place to avoid the invasion of yang inflammation." If stored in a warm place, P-fluorochlorobenzene may evaporate and escape due to temperature, which not only damages its quality, but also may endanger the surrounding environment and personnel safety.
Second, be sure to keep away from fire and heat sources. This substance is flammable, and can cause combustion and explosion in case of open flame and high heat. " Fire is a taboo for things, and flammable things must not be approached. "When storing and transporting, strictly control fire and heat sources, and strictly prohibit smoking and the use of open flames to prevent accidents.
Third, it should be stored and transported separately from oxidants and edible chemicals. P-fluorochlorobenzene is mixed with oxidants, or has a violent chemical reaction, while coexisting with edible chemicals, or causing pollution. For example," Tiangong Kaiwu "also talks about the principle of avoiding things, and things of different properties should not be mixed.
Fourth, the storage container must be well sealed." The way to seal is to be tight. " If the container is not well sealed, P-chlorofluorobenzene volatilizes and leaks, which not only causes material loss, but also pollutes the environment, and may endanger human health.
Fifth, during transportation, the vehicle should have a grounding chain, and holes can be set in the groove to baffle to reduce shock and generate static electricity. Static electricity may also cause P-chlorofluorobenzene to burn and explode, which is essential for prevention.
Sixth, operators should receive professional training and act strictly in accordance with operating procedures. "If you want to do something good, you must first use your tools; if you want to perform your duties, you must first understand its rules." In this way, you can ensure the safety of storage and transportation, and avoid danger.
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