Linshang Chemical
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(R)-(-)-Α-(Chloromethyl)Benzenemethanol
Linshang Chemical
|
HS Code |
664479 |
| Iupac Name | (R)-(-)-α-(Chloromethyl)benzenemethanol |
| Molecular Formula | C8H9ClO |
| Molar Mass | 156.609 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 224 - 226 °C |
| Melting Point | N/A |
| Density | 1.175 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 98 °C |
| Optical Rotation | It has optical activity due to chiral center |
As an accredited (R)-(-)-Α-(Chloromethyl)Benzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | ( R )-( - )-α-(Chloromethyl)benzenemethanol, 500g, packaged in a sealed, chemical - resistant bottle. |
| Storage | (R)-( - )-α-(Chloromethyl)benzenemethanol should be stored in a cool, dry place away from direct sunlight. Keep it in a tightly - sealed container to prevent exposure to air and moisture, which could potentially lead to decomposition or hydrolysis. Store it separately from incompatible substances, such as strong oxidizing agents, to avoid dangerous reactions. |
| Shipping | (R)-( - ) - α - (Chloromethyl)benzenemethanol is a chemical. Shipping should follow strict regulations due to its potentially hazardous nature. It must be properly packaged, labeled, and transported by carriers compliant with chemical shipping guidelines. |
Competitive (R)-(-)-Α-(Chloromethyl)Benzenemethanol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy (R)-(-)-Α-(Chloromethyl)Benzenemethanol in China?
As a trusted (R)-(-)-Α-(Chloromethyl)Benzenemethanol manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading (R)-(-)-Α-(Chloromethyl)Benzenemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of (r )-(-)-α-( chloromethyl) benzenemethanol
(R) -（-) -alpha - (chloromethyl) benzyl alcohol is one of the organic compounds. It is active and rich in chemical properties.
This compound has an alcohol hydroxyl group and can react with acids by esterification. Just like the ancient craftsmen fused different materials with exquisite skills, the alcohol hydroxyl group met with the acid. Under suitable conditions, it was esterified to form esters. This process is as rigorous and orderly as the traditional process.
The chloromethyl group in its molecule also has unique activity. Nucleophilic substitution reactions can occur, just like in the ancient art of war, one side cleverly occupied an important place, and the nucleophilic reagents were like brave people, attacking the chloromethyl group, the chlorine atom left, and the new group settled in, thus realizing the transformation of the molecular structure.
Because it is a chiral compound with optical activity, it is of great significance in the field of asymmetric synthesis. Like a mysterious and unique symbol, it guides the direction to specific spatial structure products in the grand chapter of chemical synthesis, helps chemists prepare compounds with specific physiological activities, and plays a guiding role like a compass in key fields such as drug development.
In organic synthesis reactions, (R) -（-) -alpha - (chloromethyl) benzyl alcohol is often used as a key intermediate. With its chemical properties, it is like the cornerstone of building an exquisite castle. Chemists use a series of reactions to carefully construct more complex organic molecular structures, which contribute to the development of organic synthetic chemistry. Just like ancient craftsmen building magnificent palaces, every brick and tile is of great significance.
This compound has an alcohol hydroxyl group and can react with acids by esterification. Just like the ancient craftsmen fused different materials with exquisite skills, the alcohol hydroxyl group met with the acid. Under suitable conditions, it was esterified to form esters. This process is as rigorous and orderly as the traditional process.
The chloromethyl group in its molecule also has unique activity. Nucleophilic substitution reactions can occur, just like in the ancient art of war, one side cleverly occupied an important place, and the nucleophilic reagents were like brave people, attacking the chloromethyl group, the chlorine atom left, and the new group settled in, thus realizing the transformation of the molecular structure.
Because it is a chiral compound with optical activity, it is of great significance in the field of asymmetric synthesis. Like a mysterious and unique symbol, it guides the direction to specific spatial structure products in the grand chapter of chemical synthesis, helps chemists prepare compounds with specific physiological activities, and plays a guiding role like a compass in key fields such as drug development.
In organic synthesis reactions, (R) -（-) -alpha - (chloromethyl) benzyl alcohol is often used as a key intermediate. With its chemical properties, it is like the cornerstone of building an exquisite castle. Chemists use a series of reactions to carefully construct more complex organic molecular structures, which contribute to the development of organic synthetic chemistry. Just like ancient craftsmen building magnificent palaces, every brick and tile is of great significance.
What are the common uses of (r )-(-)-α-( chloromethyl) benzenemethanol
(R) -（-) -alpha - (chloromethyl) benzyl alcohol, the common preparation routes are as follows:
First, with benzaldehyde as the starting material, first with chloromethylation reagents, such as paraformaldehyde and hydrogen chloride gas under the action of suitable catalysts (such as zinc salts, etc.), the chloromethylation reaction occurs to generate alpha - (chloromethyl) benzaldehyde. In this step, the paraformaldehyde is depolymerized into formaldehyde in an acidic environment, and the alpha-position of benzaldehyde is chloromethylated together with hydrogen chloride. Afterwards, alpha - (chloromethyl) benzaldehyde is reduced to (R) -（-) -alpha - (chloromethyl) benzyl alcohol using a suitable reducing agent, such as sodium borohydride or lithium aluminum hydride. Sodium borohydride is relatively mild, and can selectively reduce aldehyde groups in appropriate solvents such as ethanol; lithium aluminum hydride has strong reductive properties, but it needs to be operated under strict anhydrous conditions such as anhydrous ether.
Second, the chiral induction synthesis strategy is adopted. Select chiral auxiliary reagents to react with benzaldehyde derivatives. For example, chiral alcohols or chiral amines and benzaldehyde form intermediates such as chiral imines or chiral acetals, and then perform chloromethylation and subsequent reduction steps. Chiral auxiliary reagents act as "chiral templates" and guide the reaction in a specific chiral direction, resulting in (R) -（-) -alpha - (chloromethyl) benzyl alcohol.
Third, biocatalysis. Using certain microorganisms or enzymes, specific precursors are used as substrates to synthesize the target product. Some microorganisms with alcohol dehydrogenase activity can catalyze the reduction of suitable chlorine-containing substrates to (R) -（-) -alpha - (chloromethyl) benzyl alcohol with the participation of coenzymes. Biocatalysis usually has high stereoselectivity, the reaction conditions are relatively mild, and it is usually carried out near neutral pH and room temperature, which is environmentally friendly.
First, with benzaldehyde as the starting material, first with chloromethylation reagents, such as paraformaldehyde and hydrogen chloride gas under the action of suitable catalysts (such as zinc salts, etc.), the chloromethylation reaction occurs to generate alpha - (chloromethyl) benzaldehyde. In this step, the paraformaldehyde is depolymerized into formaldehyde in an acidic environment, and the alpha-position of benzaldehyde is chloromethylated together with hydrogen chloride. Afterwards, alpha - (chloromethyl) benzaldehyde is reduced to (R) -（-) -alpha - (chloromethyl) benzyl alcohol using a suitable reducing agent, such as sodium borohydride or lithium aluminum hydride. Sodium borohydride is relatively mild, and can selectively reduce aldehyde groups in appropriate solvents such as ethanol; lithium aluminum hydride has strong reductive properties, but it needs to be operated under strict anhydrous conditions such as anhydrous ether.
Second, the chiral induction synthesis strategy is adopted. Select chiral auxiliary reagents to react with benzaldehyde derivatives. For example, chiral alcohols or chiral amines and benzaldehyde form intermediates such as chiral imines or chiral acetals, and then perform chloromethylation and subsequent reduction steps. Chiral auxiliary reagents act as "chiral templates" and guide the reaction in a specific chiral direction, resulting in (R) -（-) -alpha - (chloromethyl) benzyl alcohol.
Third, biocatalysis. Using certain microorganisms or enzymes, specific precursors are used as substrates to synthesize the target product. Some microorganisms with alcohol dehydrogenase activity can catalyze the reduction of suitable chlorine-containing substrates to (R) -（-) -alpha - (chloromethyl) benzyl alcohol with the participation of coenzymes. Biocatalysis usually has high stereoselectivity, the reaction conditions are relatively mild, and it is usually carried out near neutral pH and room temperature, which is environmentally friendly.
What are the synthesis methods of (r )-(-)-α-( chloromethyl) benzenemethanol
The synthesis method of (R) -（-) -alpha - (chloromethyl) benzyl alcohol has been known for a long time, and now it is detailed for you.
First, it can be started from (R) -（-) -mandelic acid. This mandelic acid can be obtained by the reduction method. (R) -（-) -alpha - (chloromethyl) benzyl alcohol. It is often reacted cautiously with strong reducing agents such as lithium aluminum hydride in suitable organic solvents. When the reaction is completed, the temperature and dosage need to be strictly checked. A little carelessness will cause errors. After the reaction is completed, the pure product can be obtained by separation and purification techniques, such as column chromatography and recrystallization.
Second, benzaldehyde is used as the starting material. First, it is co-placed in a solvent with chiral ligands such as (R) - (+) -2,2 '-dihydroxy-1,1' -binaphthalene and reducing agents such as sodium borohydride to perform asymmetric reduction reaction. In this process, the chiral ligand guides the stereochemical direction of the reaction, so that the product is biased towards the (R) configuration. The reaction is completed, and the subsequent steps are separated and purified to remove impurities and obtain the target product.
Third, the method of enzyme catalysis is used. Select suitable lipases and other enzymes, use benzaldehyde and chloromethanol derivatives as substrates, and react in a buffer solution or a mixed system of organic solvents and buffer solutions. The enzyme has a high degree of stereoselectivity and can efficiently generate (R) -（-) -alpha - (chloromethyl) benzyl alcohol. After the reaction, the product is collected by extraction, concentration and other means.
Various methods have advantages and disadvantages. It is necessary to choose the good one according to the actual situation, such as the availability of raw materials, cost considerations, and product purity requirements, in order to achieve the purpose of synthesis.
First, it can be started from (R) -（-) -mandelic acid. This mandelic acid can be obtained by the reduction method. (R) -（-) -alpha - (chloromethyl) benzyl alcohol. It is often reacted cautiously with strong reducing agents such as lithium aluminum hydride in suitable organic solvents. When the reaction is completed, the temperature and dosage need to be strictly checked. A little carelessness will cause errors. After the reaction is completed, the pure product can be obtained by separation and purification techniques, such as column chromatography and recrystallization.
Second, benzaldehyde is used as the starting material. First, it is co-placed in a solvent with chiral ligands such as (R) - (+) -2,2 '-dihydroxy-1,1' -binaphthalene and reducing agents such as sodium borohydride to perform asymmetric reduction reaction. In this process, the chiral ligand guides the stereochemical direction of the reaction, so that the product is biased towards the (R) configuration. The reaction is completed, and the subsequent steps are separated and purified to remove impurities and obtain the target product.
Third, the method of enzyme catalysis is used. Select suitable lipases and other enzymes, use benzaldehyde and chloromethanol derivatives as substrates, and react in a buffer solution or a mixed system of organic solvents and buffer solutions. The enzyme has a high degree of stereoselectivity and can efficiently generate (R) -（-) -alpha - (chloromethyl) benzyl alcohol. After the reaction, the product is collected by extraction, concentration and other means.
Various methods have advantages and disadvantages. It is necessary to choose the good one according to the actual situation, such as the availability of raw materials, cost considerations, and product purity requirements, in order to achieve the purpose of synthesis.
What is the market price of (r )-(-)-α-( chloromethyl) benzenemethanol
I don't know what the market price of " (r )-(-)-α-( chloromethyl) benzenemethanol" is. This is a rather professional chemical substance, and its market price often changes for many reasons.
First, the purity is deeply affected. If the purity is very high, it is almost flawless, the price will be high; if it contains impurities, the price will be slightly lower. Second, the yield is also the key. If the product is rare, it is a rare thing, and everyone asks for it, the price will rise; if the output is abundant, the supply will exceed the demand, and the price will decline. Third, the production method is complicated and simple. If the production requires exquisite skills, expensive raw materials, and complex processes, the cost will be high, and the price will be high; if the production is easier, the price will be close to the people. Fourth, the trend of market demand affects the price. If there is a large increase in demand in a certain field at a certain time, such as a large amount of sudden demand in the pharmaceutical, chemical and other industries, the price will rise; if the demand is low, the price may drop.
To know the exact market price, you should consult chemical material suppliers, professional chemical product trading platforms, or merchants who are skilled in chemical material trading to get a more accurate price.
First, the purity is deeply affected. If the purity is very high, it is almost flawless, the price will be high; if it contains impurities, the price will be slightly lower. Second, the yield is also the key. If the product is rare, it is a rare thing, and everyone asks for it, the price will rise; if the output is abundant, the supply will exceed the demand, and the price will decline. Third, the production method is complicated and simple. If the production requires exquisite skills, expensive raw materials, and complex processes, the cost will be high, and the price will be high; if the production is easier, the price will be close to the people. Fourth, the trend of market demand affects the price. If there is a large increase in demand in a certain field at a certain time, such as a large amount of sudden demand in the pharmaceutical, chemical and other industries, the price will rise; if the demand is low, the price may drop.
To know the exact market price, you should consult chemical material suppliers, professional chemical product trading platforms, or merchants who are skilled in chemical material trading to get a more accurate price.
(R )-(-)-α-( chloromethyl) benzenemethanol what to pay attention to when storing and transporting
(R) -（-) -alpha - (chloromethyl) benzyl alcohol should pay attention to the following aspects when storing and transporting.
First, for storage, because of its specific chemical properties, it must be placed in a cool, dry and well-ventilated place. This is because the cool environment can avoid the evaporation and decomposition of substances caused by excessive temperature; drying can prevent it from being damp, otherwise the moisture may chemically react with the substance, resulting in deterioration; good ventilation can disperse the harmful gases that may be generated in time to avoid the danger caused by its accumulation. At the same time, it should be stored separately from oxidants, acids and other substances. This is due to the chemical structure of (R) -（-) -alpha - (chloromethyl) benzyl alcohol, which may react violently with these substances, such as oxidation reaction, acid-base neutralization, etc., resulting in material loss and even safety accidents. In addition, storage containers should be made of corrosion-resistant and well-sealed materials. Corrosion resistance can prevent the container from being damaged by corrosion, good sealing can avoid material leakage, and can also prevent outside air, moisture, etc. from entering and affecting its quality.
Second, in terms of transportation, transportation vehicles must have corresponding fire and explosion-proof facilities. In view of the fact that (R) -（-) -alpha - (chloromethyl) benzyl alcohol may be flammable, and may cause combustion and explosion in case of open flame or hot topic, it is essential to prevent fire and explosion. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. If the container leaks, it will not only cause material loss, but also cause pollution to the environment. If the leakage is large and encounters fire sources, it is very likely to cause serious safety accidents. In addition, transport personnel should be professionally trained to be familiar with the characteristics of the substance and emergency treatment methods. In this way, if there is an emergency during transportation, the transport personnel can deal with it quickly and correctly, thereby minimizing losses and hazards.
First, for storage, because of its specific chemical properties, it must be placed in a cool, dry and well-ventilated place. This is because the cool environment can avoid the evaporation and decomposition of substances caused by excessive temperature; drying can prevent it from being damp, otherwise the moisture may chemically react with the substance, resulting in deterioration; good ventilation can disperse the harmful gases that may be generated in time to avoid the danger caused by its accumulation. At the same time, it should be stored separately from oxidants, acids and other substances. This is due to the chemical structure of (R) -（-) -alpha - (chloromethyl) benzyl alcohol, which may react violently with these substances, such as oxidation reaction, acid-base neutralization, etc., resulting in material loss and even safety accidents. In addition, storage containers should be made of corrosion-resistant and well-sealed materials. Corrosion resistance can prevent the container from being damaged by corrosion, good sealing can avoid material leakage, and can also prevent outside air, moisture, etc. from entering and affecting its quality.
Second, in terms of transportation, transportation vehicles must have corresponding fire and explosion-proof facilities. In view of the fact that (R) -（-) -alpha - (chloromethyl) benzyl alcohol may be flammable, and may cause combustion and explosion in case of open flame or hot topic, it is essential to prevent fire and explosion. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. If the container leaks, it will not only cause material loss, but also cause pollution to the environment. If the leakage is large and encounters fire sources, it is very likely to cause serious safety accidents. In addition, transport personnel should be professionally trained to be familiar with the characteristics of the substance and emergency treatment methods. In this way, if there is an emergency during transportation, the transport personnel can deal with it quickly and correctly, thereby minimizing losses and hazards.
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