Linshang Chemical
PRODUCTS
(R)-N-(1-(5-Chloro-2-Hydroxyphenyl)Ethyl)-4-Methylbenzenesulfonamide
Linshang Chemical
|
HS Code |
640811 |
| Chemical Formula | C15H16ClNO3S |
| Molecular Weight | 325.81 |
As an accredited (R)-N-(1-(5-Chloro-2-Hydroxyphenyl)Ethyl)-4-Methylbenzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of (r)-n-(1-(5 - chloro - 2 - hydroxyphenyl)ethyl)-4 - methylbenzenesulfonamide in sealed container. |
| Storage | Store (r)-n-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide in a cool, dry place away from direct sunlight. Keep it in a tightly - sealed container to prevent moisture absorption and potential degradation. Avoid storing near incompatible substances, like strong oxidizing agents or acids, which could react and compromise its integrity. |
| Shipping | The chemical (r)-n-(1-(5 - chloro - 2 - hydroxyphenyl)ethyl)-4 - methylbenzenesulfonamide should be shipped in sealed, corrosion - resistant containers. Ensure proper labeling and compliance with hazardous chemical shipping regulations for safe transport. |
Competitive (R)-N-(1-(5-Chloro-2-Hydroxyphenyl)Ethyl)-4-Methylbenzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy (R)-N-(1-(5-Chloro-2-Hydroxyphenyl)Ethyl)-4-Methylbenzenesulfonamide in China?
As a trusted (R)-N-(1-(5-Chloro-2-Hydroxyphenyl)Ethyl)-4-Methylbenzenesulfonamide manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading (R)-N-(1-(5-Chloro-2-Hydroxyphenyl)Ethyl)-4-Methylbenzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of (r) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide?
(R) -N- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide is a key substance. In the field of medicine, it is often an important raw material for drug research and development. Due to its specific chemical structure, it can be combined with specific targets in organisms, or it has the effect of regulating physiological functions and treating diseases.
The drug synthesis path is often obtained through multiple delicate reactions. The control of reaction conditions at each step and the precise ratio of raw materials are all related to the purity and activity of the final product. When developing new anti-inflammatory drugs, researchers modify their chemical structures to enhance the affinity and selectivity of drugs to inflammation-related targets, thereby enhancing anti-inflammatory effects and reducing adverse reactions.
In the chemical industry, it may also be used as a special additive. Due to its unique chemical properties, it may optimize the performance of chemical products. For example, in the synthesis of some polymer materials, adding an appropriate amount of this substance may improve the stability, solubility and other characteristics of the material, making the material more suitable for specific industrial production needs, improving product quality and market competitiveness.
In addition, it is also used in materials science research, or as a key component in the preparation of functional materials. After ingenious design and synthesis, it can be integrated into a specific material system, which can endow materials with special properties such as light response and electrical response, paving the way for the development of new smart materials, and showing broad application prospects in cutting-edge fields such as electronic devices and sensors.
The drug synthesis path is often obtained through multiple delicate reactions. The control of reaction conditions at each step and the precise ratio of raw materials are all related to the purity and activity of the final product. When developing new anti-inflammatory drugs, researchers modify their chemical structures to enhance the affinity and selectivity of drugs to inflammation-related targets, thereby enhancing anti-inflammatory effects and reducing adverse reactions.
In the chemical industry, it may also be used as a special additive. Due to its unique chemical properties, it may optimize the performance of chemical products. For example, in the synthesis of some polymer materials, adding an appropriate amount of this substance may improve the stability, solubility and other characteristics of the material, making the material more suitable for specific industrial production needs, improving product quality and market competitiveness.
In addition, it is also used in materials science research, or as a key component in the preparation of functional materials. After ingenious design and synthesis, it can be integrated into a specific material system, which can endow materials with special properties such as light response and electrical response, paving the way for the development of new smart materials, and showing broad application prospects in cutting-edge fields such as electronic devices and sensors.
What are the chemical properties of (r) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide
(R) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide is one of the organic compounds. Its chemical properties are particularly important and are related to many chemical and biological processes.
This compound has specific physical and chemical properties. From the perspective of chemical structure, its molecular structure, 5-chloro-2-hydroxyphenyl is connected to ethyl group and 4-methylbenzenesulfonamide group. This structure gives it unique chemical activity.
In terms of acid-base properties, the hydroxyl groups in the molecule can exhibit weak acidity. Under appropriate conditions, protons can be dissociated and react with bases to form corresponding salts.
Its solubility is also an important property. In view of the fact that there are both hydrophilic hydroxyl groups and hydrophobic benzene rings and sulfonamide groups in the molecule, it may have a certain solubility in organic solvents such as dichloromethane and chloroform; in water, due to the influence of hydrophobic groups, its solubility may be limited.
Furthermore, the chlorine atoms on the benzene ring in this compound give it some properties of halogenated aromatics, which can participate in nucleophilic substitution reactions. Under suitable nucleophilic reagents and reaction conditions, chlorine atoms can be replaced by other groups to realize the modification and derivatization of molecular structures.
And its sulfonamide group also endows the molecule with certain chemical activity, which can participate in the related reactions of amides, such as hydrolysis reactions. Under acidic or basic conditions, sulfonamide bonds can be broken to generate corresponding sulfonic acids and amines.
In addition, the chiral carbon atoms connected to the benzene ring in this compound make it exist in enantiomers. Different configurations may have differences in biological activity, physical and chemical properties, which is of great significance in the fields of asymmetric synthesis and medicinal chemistry.
This compound has specific physical and chemical properties. From the perspective of chemical structure, its molecular structure, 5-chloro-2-hydroxyphenyl is connected to ethyl group and 4-methylbenzenesulfonamide group. This structure gives it unique chemical activity.
In terms of acid-base properties, the hydroxyl groups in the molecule can exhibit weak acidity. Under appropriate conditions, protons can be dissociated and react with bases to form corresponding salts.
Its solubility is also an important property. In view of the fact that there are both hydrophilic hydroxyl groups and hydrophobic benzene rings and sulfonamide groups in the molecule, it may have a certain solubility in organic solvents such as dichloromethane and chloroform; in water, due to the influence of hydrophobic groups, its solubility may be limited.
Furthermore, the chlorine atoms on the benzene ring in this compound give it some properties of halogenated aromatics, which can participate in nucleophilic substitution reactions. Under suitable nucleophilic reagents and reaction conditions, chlorine atoms can be replaced by other groups to realize the modification and derivatization of molecular structures.
And its sulfonamide group also endows the molecule with certain chemical activity, which can participate in the related reactions of amides, such as hydrolysis reactions. Under acidic or basic conditions, sulfonamide bonds can be broken to generate corresponding sulfonic acids and amines.
In addition, the chiral carbon atoms connected to the benzene ring in this compound make it exist in enantiomers. Different configurations may have differences in biological activity, physical and chemical properties, which is of great significance in the fields of asymmetric synthesis and medicinal chemistry.
What is the synthesis method of (r) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide
To prepare (r) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide, the synthesis method is as follows:
At the beginning, select suitable raw materials. 5-chloro-2-hydroxyacetophenone is a key raw material, because its structure contains 5-chloro-2-hydroxyphenyl, which is in line with the structure of the target product. 4-methylbenzenesulfonyl chloride is also required, which is an essential reagent for the introduction of 4-methylbenzenesulfonyl.
First, 5-chloro-2-hydroxyacetophenone is reacted with a reducing agent, such as sodium borohydride, in a suitable solvent, such as methanol, at low temperature and under stirring conditions. Sodium borohydride can reduce the carbonyl group of 5-chloro-2-hydroxyacetophenone to a hydroxyl group, resulting in (1 - (5-chloro-2-hydroxyphenyl) ethanol. This process requires attention to the reaction temperature. If the temperature is too high, side reactions may occur and affect the purity of the product.
Then, mix (1- (5-chloro-2-hydroxyphenyl) ethanol with p-methylbenzenesulfonyl chloride. In an alkaline environment, such as the presence of pyridine, the substitution reaction can occur between the two. Pyridine can neutralize the hydrogen chloride generated by the reaction and promote the forward progress of the reaction. In this step, the sulfonyl group of p-methylbenzenesulfonyl chloride replaces the hydrogen of the alcohol hydroxyl group to obtain (1- (5-chloro-2-hydroxyphenyl) ethyl) - 4-methylbenzenesulfonate.
Subsequently, this sulfonate is reacted with an ammonia source, such as an ammonia alcohol solution, under the condition of heating and reflux. The nitrogen atom of ammonia nucleophilically attacks the carbon atom of the sulfonate, and the sulfonate group leaves, thereby introducing the amino group to give (r) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide. However, this process requires control of the reaction time and temperature. If the reaction time is too short, or the reaction is incomplete; if the time is too long, or too many impurities are produced. After the reaction is completed, a pure target product can be obtained by separation and purification methods, such as column chromatography, recrystallization, etc.
At the beginning, select suitable raw materials. 5-chloro-2-hydroxyacetophenone is a key raw material, because its structure contains 5-chloro-2-hydroxyphenyl, which is in line with the structure of the target product. 4-methylbenzenesulfonyl chloride is also required, which is an essential reagent for the introduction of 4-methylbenzenesulfonyl.
First, 5-chloro-2-hydroxyacetophenone is reacted with a reducing agent, such as sodium borohydride, in a suitable solvent, such as methanol, at low temperature and under stirring conditions. Sodium borohydride can reduce the carbonyl group of 5-chloro-2-hydroxyacetophenone to a hydroxyl group, resulting in (1 - (5-chloro-2-hydroxyphenyl) ethanol. This process requires attention to the reaction temperature. If the temperature is too high, side reactions may occur and affect the purity of the product.
Then, mix (1- (5-chloro-2-hydroxyphenyl) ethanol with p-methylbenzenesulfonyl chloride. In an alkaline environment, such as the presence of pyridine, the substitution reaction can occur between the two. Pyridine can neutralize the hydrogen chloride generated by the reaction and promote the forward progress of the reaction. In this step, the sulfonyl group of p-methylbenzenesulfonyl chloride replaces the hydrogen of the alcohol hydroxyl group to obtain (1- (5-chloro-2-hydroxyphenyl) ethyl) - 4-methylbenzenesulfonate.
Subsequently, this sulfonate is reacted with an ammonia source, such as an ammonia alcohol solution, under the condition of heating and reflux. The nitrogen atom of ammonia nucleophilically attacks the carbon atom of the sulfonate, and the sulfonate group leaves, thereby introducing the amino group to give (r) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide. However, this process requires control of the reaction time and temperature. If the reaction time is too short, or the reaction is incomplete; if the time is too long, or too many impurities are produced. After the reaction is completed, a pure target product can be obtained by separation and purification methods, such as column chromatography, recrystallization, etc.
What are the side effects of (r) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide
(This drug) is called (r) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide, and its side effects are as follows:
First of all, it may affect the digestive system. After taking this drug, some people may feel nausea, something in the abdomen seems to be stirring, and they want to vomit, which is quite uncomfortable. Some people may also feel stomach pain, such as needles, dull pain, appetite will also decrease, see food but no appetite. What's more, there may be diarrhea, several times a day, the intestines are like a runaway car, and the operation is disordered.
Secondly, it also interferes with the nervous system. Some people will feel dizzy after taking it, as if they are in a cloud, stand unsteady, and feel their footsteps are vain when walking. And it is easy to cause headaches, or pain, like the head is tightened; or tingling, an instant attack, people are caught off guard. Some people also experience drowsiness, listlessness all day, sleepiness, and difficulty concentrating on things.
Furthermore, the skin also reacts. It may cause a rash, and many red rashes appear on the skin like sesame seeds, itching is intolerable, scratching, or skin damage, causing infection. Severe cases, or skin allergies, skin redness, swelling and fever, and even affect normal life.
In addition, long-term or excessive use of this drug may cause damage to liver and kidney function. The liver is originally a place for storing blood and detoxifying, and after damage, it may cause toxins in the body to be difficult to excrete, causing other diseases. The kidneys are the main water metabolism. If damaged, the water metabolism is abnormal, or edema is seen, especially in the lower limbs.
First of all, it may affect the digestive system. After taking this drug, some people may feel nausea, something in the abdomen seems to be stirring, and they want to vomit, which is quite uncomfortable. Some people may also feel stomach pain, such as needles, dull pain, appetite will also decrease, see food but no appetite. What's more, there may be diarrhea, several times a day, the intestines are like a runaway car, and the operation is disordered.
Secondly, it also interferes with the nervous system. Some people will feel dizzy after taking it, as if they are in a cloud, stand unsteady, and feel their footsteps are vain when walking. And it is easy to cause headaches, or pain, like the head is tightened; or tingling, an instant attack, people are caught off guard. Some people also experience drowsiness, listlessness all day, sleepiness, and difficulty concentrating on things.
Furthermore, the skin also reacts. It may cause a rash, and many red rashes appear on the skin like sesame seeds, itching is intolerable, scratching, or skin damage, causing infection. Severe cases, or skin allergies, skin redness, swelling and fever, and even affect normal life.
In addition, long-term or excessive use of this drug may cause damage to liver and kidney function. The liver is originally a place for storing blood and detoxifying, and after damage, it may cause toxins in the body to be difficult to excrete, causing other diseases. The kidneys are the main water metabolism. If damaged, the water metabolism is abnormal, or edema is seen, especially in the lower limbs.
What is the market price of (r) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide?
The price of (r) -n- (1- (5-chloro-2-hydroxyphenyl) ethyl) -4-methylbenzenesulfonamide in the market is difficult to break. The price often changes due to many factors, such as the abundance of raw materials, the difficulty of production methods, the amount of demand, and the stability of the current situation.
If the raw materials are easily available, the production area is smooth and the supply is abundant, the price may be leveled. However, if the production area is damaged and the raw materials are scarce, the price will rise. If the production method is simple and mature, the cost is controllable, and the price can be close to the people; if the steps are complicated, the technical barriers are high, and the cost is greatly increased, the price will be high.
Market demand is also the key. If there is strong demand in the fields of medicine, chemical industry, etc., and the demand exceeds the supply, the price will go up; if the demand is sluggish, the supply exceeds the demand, and the price may decline. Furthermore, the current situation is stable, the trade is smooth, and the price may be stable; in case of war, epidemic and other extraordinary changes, the logistics will be blocked, the production will be stagnant, and the price will fluctuate unpredictably.
Therefore, if you want to know the exact inter-market price of this product, you need to consider the current situation in detail, and explore it in detail on various trading platforms and industry information offices to obtain a more accurate number, which is difficult to hide.
If the raw materials are easily available, the production area is smooth and the supply is abundant, the price may be leveled. However, if the production area is damaged and the raw materials are scarce, the price will rise. If the production method is simple and mature, the cost is controllable, and the price can be close to the people; if the steps are complicated, the technical barriers are high, and the cost is greatly increased, the price will be high.
Market demand is also the key. If there is strong demand in the fields of medicine, chemical industry, etc., and the demand exceeds the supply, the price will go up; if the demand is sluggish, the supply exceeds the demand, and the price may decline. Furthermore, the current situation is stable, the trade is smooth, and the price may be stable; in case of war, epidemic and other extraordinary changes, the logistics will be blocked, the production will be stagnant, and the price will fluctuate unpredictably.
Therefore, if you want to know the exact inter-market price of this product, you need to consider the current situation in detail, and explore it in detail on various trading platforms and industry information offices to obtain a more accurate number, which is difficult to hide.
Scan to WhatsApp
