Linshang Chemical
PRODUCTS
(S)-2,4-Dichloro-Alpha-(Chloromethyl)-Benzenemethanol
Linshang Chemical
|
HS Code |
405677 |
| Chemical Formula | C8H7Cl3O |
| Molecular Weight | 225.5 |
| Appearance | Solid |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents |
| Vapor Pressure | Low |
| Stability | Stable under normal conditions |
As an accredited (S)-2,4-Dichloro-Alpha-(Chloromethyl)-Benzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram pack of (s)-2,4 - dichloro - α-(chloromethyl) - benzenemethanol in sealed container. |
| Storage | (s)-2,4 - Dichloro-α-(chloromethyl) - benzenemethanol should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly closed container to prevent moisture absorption and evaporation. Label the container clearly to avoid misidentification. |
| Shipping | (±)-2,4 - dichloro - α-(chloromethyl) - benzenemethanol is likely shipped in sealed, corrosion - resistant containers. Special handling is required due to its chemical nature, following strict regulations to ensure safe transportation. |
Competitive (S)-2,4-Dichloro-Alpha-(Chloromethyl)-Benzenemethanol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy (S)-2,4-Dichloro-Alpha-(Chloromethyl)-Benzenemethanol in China?
As a trusted (S)-2,4-Dichloro-Alpha-(Chloromethyl)-Benzenemethanol manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading (S)-2,4-Dichloro-Alpha-(Chloromethyl)-Benzenemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of (s) -2,4-dichloro-alpha - (chloromethyl) benzyl alcohol?
(S) -2,4 -dioxy - α - （ oxy methyl) benzyl ketone, the chemical properties of this substance are as follows:
Its appearance is often white to light yellow crystalline powder, with certain physical properties. In terms of solubility, it is slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, etc. This characteristic is due to the interaction of polar and non-polar parts in its molecular structure.
In terms of chemical activity, the intra-molecular carbonyl (C = O) is the activity check point, and many typical carbonyl reactions can occur. For example, it can react with nucleophilic reagents, like Grignard reagents, and nucleophilic hydrocarbons will attack carbonyl carbons, forming new carbon-carbon bonds, and then constructing more complex organic structures.
At the same time, the α-hydrogen of the compound is affected by carbonyl, which has a certain acidity and can be taken away under appropriate alkaline conditions, causing reactions such as condensation. For example, with another molecule containing carbonyl compounds under alkali catalysis, after α-hydrogen leaves, the negative carbon ion can attack another carbonyl group, and a hydroxyaldehyde condensation reaction occurs to generate a β-hydroxycarbonyl compound. If the reaction conditions are appropriate, it can be further dehydrated to form α, β-unsaturated carbonyl compounds.
In addition, the benzene ring part also has certain reactivity, and electrophilic substitution reactions can occur. Because the substituents on the benzene ring have an impact on the electron cloud density distribution of the benzene ring, the specific position of the benzene ring is more susceptible to attack by electrophilic reagents, such as halogenation, nitrification, sulfonation, etc. In organic synthesis, different functional groups can be introduced to expand the derivation path of the compound and realize the construction of more organic molecules with specific functions.
Its appearance is often white to light yellow crystalline powder, with certain physical properties. In terms of solubility, it is slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, etc. This characteristic is due to the interaction of polar and non-polar parts in its molecular structure.
In terms of chemical activity, the intra-molecular carbonyl (C = O) is the activity check point, and many typical carbonyl reactions can occur. For example, it can react with nucleophilic reagents, like Grignard reagents, and nucleophilic hydrocarbons will attack carbonyl carbons, forming new carbon-carbon bonds, and then constructing more complex organic structures.
At the same time, the α-hydrogen of the compound is affected by carbonyl, which has a certain acidity and can be taken away under appropriate alkaline conditions, causing reactions such as condensation. For example, with another molecule containing carbonyl compounds under alkali catalysis, after α-hydrogen leaves, the negative carbon ion can attack another carbonyl group, and a hydroxyaldehyde condensation reaction occurs to generate a β-hydroxycarbonyl compound. If the reaction conditions are appropriate, it can be further dehydrated to form α, β-unsaturated carbonyl compounds.
In addition, the benzene ring part also has certain reactivity, and electrophilic substitution reactions can occur. Because the substituents on the benzene ring have an impact on the electron cloud density distribution of the benzene ring, the specific position of the benzene ring is more susceptible to attack by electrophilic reagents, such as halogenation, nitrification, sulfonation, etc. In organic synthesis, different functional groups can be introduced to expand the derivation path of the compound and realize the construction of more organic molecules with specific functions.
What are the physical properties of (s) -2,4-dichloro-alpha - (chloromethyl) benzyl alcohol?
(S) - 2,4 -dioxy - α - （ methoxy methyl) acetophenone, the physical properties are as follows:
It is an organic compound, at room temperature and pressure, generally colorless to light yellow liquid or crystalline. It has a certain volatility and can evaporate slowly in the air.
Looking at its properties, it has a regular crystal form when crystallized, and the texture is relatively fine. Its melting point is usually in a specific range. This melting point value is crucial for its identification and purity determination. With accurate measurement of melting point, its purity and authenticity can be preliminarily inferred.
In terms of solubility, it shows good solubility in organic solvents, such as common ethanol, ether, chloroform, etc., which can be miscible with it. This property makes it widely used as a reactant or solvent in the field of organic synthesis. However, the solubility in water is poor, because the proportion of hydrophilic groups in the molecular structure is limited, the interaction between it and water is weak.
The density is slightly larger than that of water, and it will sink to the bottom when placed in water. Its density value is also an important physical constant, which is related to the separation and purification in the mixture.
In addition, the substance has a certain odor. Although it is not stinky and pungent, it also has a unique odor. During operation and use, the odor can be used as a preliminary identification and warning basis. Knowing these physical properties is of great significance for their storage, transportation, and use. During storage, a dry, ventilated, and away from fire and water should be selected according to their volatility and solubility to ensure their stability and safety.
It is an organic compound, at room temperature and pressure, generally colorless to light yellow liquid or crystalline. It has a certain volatility and can evaporate slowly in the air.
Looking at its properties, it has a regular crystal form when crystallized, and the texture is relatively fine. Its melting point is usually in a specific range. This melting point value is crucial for its identification and purity determination. With accurate measurement of melting point, its purity and authenticity can be preliminarily inferred.
In terms of solubility, it shows good solubility in organic solvents, such as common ethanol, ether, chloroform, etc., which can be miscible with it. This property makes it widely used as a reactant or solvent in the field of organic synthesis. However, the solubility in water is poor, because the proportion of hydrophilic groups in the molecular structure is limited, the interaction between it and water is weak.
The density is slightly larger than that of water, and it will sink to the bottom when placed in water. Its density value is also an important physical constant, which is related to the separation and purification in the mixture.
In addition, the substance has a certain odor. Although it is not stinky and pungent, it also has a unique odor. During operation and use, the odor can be used as a preliminary identification and warning basis. Knowing these physical properties is of great significance for their storage, transportation, and use. During storage, a dry, ventilated, and away from fire and water should be selected according to their volatility and solubility to ensure their stability and safety.
What are the common uses of (s) -2,4-dichloro-alpha - (chloromethyl) benzyl alcohol?
(S) -2,4 -dioxy - α - （ oxy methyl) benzyl ketone, which is commonly used in the field of organic synthesis.
In the process of organic synthesis, it can serve as a key intermediate. By means of nucleophilic substitution, it interacts with many nucleophilic reagents, such as alcohols and amines, and can derive compounds with different structures. With alcohols as nucleophiles, ether products can be formed under suitable conditions. The reaction mechanism lies in the attack of the nucleophilic tester on the carbonyl group, followed by the separation of the leaving group, and finally the corresponding ethers are obtained. In this process, the carbonyl and leaving group characteristics of (s) -2,4-dioxy - α - （ methyl) benzyl ketones have a great influence on the reaction direction and yield.
It also plays an important role in the field of medicinal chemistry. Due to its unique chemical structure, it can be used as a starting point for modification of lead compounds. By precisely modifying its structure, such as introducing specific functional groups, the pharmacological activity and pharmacokinetic properties of compounds can be optimized. By adjusting its interaction with biological targets, or improving the solubility and stability of compounds, it can pave the way for the development of new drugs. Many studies have shown that the derivatives obtained from the structural modification of this compound have potential activities in anti-tumor, antibacterial and other pharmacological studies.
In the field of materials science, (s) -2,4 -dioxy - α - （ oxy methyl) benzyl ketone can be used to prepare polymer materials with special properties after specific reaction conversion. For example, by copolymerization with compounds containing double bonds, polymers with specific functional groups can be prepared, thereby imparting special optical, electrical or mechanical properties to the materials.
In the process of organic synthesis, it can serve as a key intermediate. By means of nucleophilic substitution, it interacts with many nucleophilic reagents, such as alcohols and amines, and can derive compounds with different structures. With alcohols as nucleophiles, ether products can be formed under suitable conditions. The reaction mechanism lies in the attack of the nucleophilic tester on the carbonyl group, followed by the separation of the leaving group, and finally the corresponding ethers are obtained. In this process, the carbonyl and leaving group characteristics of (s) -2,4-dioxy - α - （ methyl) benzyl ketones have a great influence on the reaction direction and yield.
It also plays an important role in the field of medicinal chemistry. Due to its unique chemical structure, it can be used as a starting point for modification of lead compounds. By precisely modifying its structure, such as introducing specific functional groups, the pharmacological activity and pharmacokinetic properties of compounds can be optimized. By adjusting its interaction with biological targets, or improving the solubility and stability of compounds, it can pave the way for the development of new drugs. Many studies have shown that the derivatives obtained from the structural modification of this compound have potential activities in anti-tumor, antibacterial and other pharmacological studies.
In the field of materials science, (s) -2,4 -dioxy - α - （ oxy methyl) benzyl ketone can be used to prepare polymer materials with special properties after specific reaction conversion. For example, by copolymerization with compounds containing double bonds, polymers with specific functional groups can be prepared, thereby imparting special optical, electrical or mechanical properties to the materials.
What are the synthesis methods of (s) -2,4-dichloro-alpha - (chloromethyl) benzyl alcohol?
To prepare (s) -2,4 -difluoro -α - ( fluoromethyl) benzyl ketone, there are various methods.
First, you can start from a suitable benzyl halide. First, take benzyl halogen, and fluorine-containing nucleophilic reagents, such as potassium fluoride, in a suitable organic solvent, such as dimethylformamide (DMF), heated to carry out nucleophilic substitution reaction. In this process, the halogen atom is replaced by a fluorine atom to obtain a fluorine-containing benzyl intermediate. Then, this intermediate is reacted with an acylating agent, such as acetyl chloride, under the catalyst of Lewis acid catalyst, such as aluminum trichloride, at low temperature to room temperature, acetyl groups can be introduced, and after subsequent treatment, the target (s) -2,4 -difluoro -α - ( fluoromethyl) benzyl ketones can be obtained.
Second, fluorine-containing aromatics can also be started. Using a specific fluorobenzene as a raw material, fluoromethyl is first introduced by Fu-g alkylation reaction. Select suitable halogenated fluoromethane and Lewis acid catalysts, such as anhydrous aluminum trichloride, and react in inert solvents such as dichloromethane. After generating a fluoromethyl substituted aromatic hydrocarbon, a Fu-gram acylation reaction is carried out. Acetyl chloride is used as an acylating agent, and the target product can be obtained under the catalysis of Lewis acid. After the reaction is completed, the product is purified through separation and purification steps.
Third, a chiral adjuvant strategy can be considered. First, a chiral adjuvant is combined with a suitable benzyl derivative and introduced into a chiral environment. After the above-mentioned similar nucleophilic substitution and acylation steps, the structure of the target molecule is gradually constructed while maintaining chirality. After the reaction is completed, the chiral additives are carefully removed. After careful separation and purification, high-purity (s) -2,4 -difluoro -α - ( fluoromethyl) benzyl ketone can be obtained. Each method has advantages and disadvantages, and it is necessary to choose the appropriate one according to the actual situation, such as the availability of raw materials, cost, and purity requirements of the product.
First, you can start from a suitable benzyl halide. First, take benzyl halogen, and fluorine-containing nucleophilic reagents, such as potassium fluoride, in a suitable organic solvent, such as dimethylformamide (DMF), heated to carry out nucleophilic substitution reaction. In this process, the halogen atom is replaced by a fluorine atom to obtain a fluorine-containing benzyl intermediate. Then, this intermediate is reacted with an acylating agent, such as acetyl chloride, under the catalyst of Lewis acid catalyst, such as aluminum trichloride, at low temperature to room temperature, acetyl groups can be introduced, and after subsequent treatment, the target (s) -2,4 -difluoro -α - ( fluoromethyl) benzyl ketones can be obtained.
Second, fluorine-containing aromatics can also be started. Using a specific fluorobenzene as a raw material, fluoromethyl is first introduced by Fu-g alkylation reaction. Select suitable halogenated fluoromethane and Lewis acid catalysts, such as anhydrous aluminum trichloride, and react in inert solvents such as dichloromethane. After generating a fluoromethyl substituted aromatic hydrocarbon, a Fu-gram acylation reaction is carried out. Acetyl chloride is used as an acylating agent, and the target product can be obtained under the catalysis of Lewis acid. After the reaction is completed, the product is purified through separation and purification steps.
Third, a chiral adjuvant strategy can be considered. First, a chiral adjuvant is combined with a suitable benzyl derivative and introduced into a chiral environment. After the above-mentioned similar nucleophilic substitution and acylation steps, the structure of the target molecule is gradually constructed while maintaining chirality. After the reaction is completed, the chiral additives are carefully removed. After careful separation and purification, high-purity (s) -2,4 -difluoro -α - ( fluoromethyl) benzyl ketone can be obtained. Each method has advantages and disadvantages, and it is necessary to choose the appropriate one according to the actual situation, such as the availability of raw materials, cost, and purity requirements of the product.
(S) What are the precautions for storing and transporting 2,4-dichloro-alpha - (chloromethyl) benzyl alcohol?
(S) -2,4-dioxy-alpha- (methoxy) benzyl ketone needs to pay attention to many matters during storage and transportation.
This substance has a certain chemical activity. When stored, the first environment is dry. Because it is quite sensitive to humidity, humid environment can easily cause chemical reactions such as hydrolysis, damage the structure, and reduce the quality and efficiency. Therefore, it should be placed in a dry and ventilated place, and desiccant can be used to assist in maintaining the dry environment.
Temperature is also critical. Store in a cool place to avoid high temperature. High temperature will speed up the movement of molecules, improve the reactivity, and cause them to decompose or deteriorate. It is generally recommended that the storage temperature be maintained in a specific low temperature range, depending on the characteristics of the substance, generally 2-8 ° C.
In addition, sealing measures need to be taken. The substance may react with oxygen, carbon dioxide and other components in the air, and sealing can prevent it from contacting with the air and prolong the shelf life.
During transportation, shock resistance is essential. This substance may be damaged due to severe vibration, and then leak. Packaging should be filled with strong and shock-resistant materials, such as foam, sponge, etc., to reduce the impact of transportation vibration on it.
It is also necessary to pay attention to the temperature and humidity of the transportation environment. Appropriate temperature control and moisture-proof equipment should be used to ensure stable conditions throughout transportation and meet storage requirements.
At the same time, strictly abide by relevant transportation regulations and safety standards. Because it may belong to the category of hazardous chemicals, transportation requires professional qualifications and procedures, and operates according to the specified procedures to ensure transportation safety and prevent accidents.
This substance has a certain chemical activity. When stored, the first environment is dry. Because it is quite sensitive to humidity, humid environment can easily cause chemical reactions such as hydrolysis, damage the structure, and reduce the quality and efficiency. Therefore, it should be placed in a dry and ventilated place, and desiccant can be used to assist in maintaining the dry environment.
Temperature is also critical. Store in a cool place to avoid high temperature. High temperature will speed up the movement of molecules, improve the reactivity, and cause them to decompose or deteriorate. It is generally recommended that the storage temperature be maintained in a specific low temperature range, depending on the characteristics of the substance, generally 2-8 ° C.
In addition, sealing measures need to be taken. The substance may react with oxygen, carbon dioxide and other components in the air, and sealing can prevent it from contacting with the air and prolong the shelf life.
During transportation, shock resistance is essential. This substance may be damaged due to severe vibration, and then leak. Packaging should be filled with strong and shock-resistant materials, such as foam, sponge, etc., to reduce the impact of transportation vibration on it.
It is also necessary to pay attention to the temperature and humidity of the transportation environment. Appropriate temperature control and moisture-proof equipment should be used to ensure stable conditions throughout transportation and meet storage requirements.
At the same time, strictly abide by relevant transportation regulations and safety standards. Because it may belong to the category of hazardous chemicals, transportation requires professional qualifications and procedures, and operates according to the specified procedures to ensure transportation safety and prevent accidents.
Scan to WhatsApp
