Linshang Chemical
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(S)-2,4-Dichloro-Α-(Chloromethyl)-Benzenemethanol
Linshang Chemical
|
HS Code |
360621 |
| Chemical Formula | C8H7Cl3O |
| Molecular Weight | 225.5 |
| Appearance | Solid (Typical) |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Vapor Pressure | Low vapor pressure |
| Stability | Stable under normal conditions |
As an accredited (S)-2,4-Dichloro-Α-(Chloromethyl)-Benzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of (s)-2,4 - dichloro - α-(chloromethyl)-benzenemethanol in sealed chemical - grade containers. |
| Storage | (S)-2,4 - Dichloro-α-(chloromethyl)-benzenemethanol should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and leakage. Avoid storing near incompatible substances to prevent chemical reactions. |
| Shipping | (±)-2,4 - Dichloro-α-(chloromethyl) - benzenemethanol is shipped with strict adherence to chemical transport regulations. Packed in suitable containers, it's transported by carriers experienced in handling hazardous chemicals to ensure safe delivery. |
Competitive (S)-2,4-Dichloro-Α-(Chloromethyl)-Benzenemethanol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What are the chemical properties of (s) -2,4 -dichloro-alpha - (chloromethyl) benzyl alcohol
(S) -2,4 -dioxy - α - （ methoxymethyl) acetophenone, an organic compound. It has unique chemical properties and is very important in many chemical reactions and organic synthesis fields.
Its chemical properties are mainly reflected in the activity of carbonyl groups. The carbonyl group in this molecule, that is, the C = O double bond, is prone to attack by nucleophiles due to the strong electronegativity of oxygen atoms. For example, under basic conditions, alcohol nucleophiles can initiate nucleophilic addition reactions to carbonyl carbons to generate corresponding hemiacetal or acetal products. The reaction mechanism is as follows: the alkali first causes the alcohol to form an alcohol anion to enhance its nucleophilicity, and then the alcohol anion attacks the carbonyl carbon, and the electron transfer rearrangement constructs a new carbon-oxygen bond.
Furthermore, the α-hydrogen atom is active. Because it is adjacent to the carbonyl group, the acidity of the α-hydrogen atom is enhanced due to the electron-sucking induction effect of the carbonyl group. Under the action of a strong base, α-hydrogen is easily captured to form a carbon anion intermediate. This carbon anion has strong nucleophilicity and can participate in a variety of nucleophilic substitution and nucleophilic addition reactions. For example, nucleophilic substitution occurs with halogenated hydrocarbons, introducing new hydrocarbon groups into the molecule; or condensation reactions with other carbonyl compounds, such as hydroxyaldehyde condensation, build carbon-carbon bonds, greatly expand the complexity of molecular structures, and are used in organic synthesis to construct complex carbon skeletons.
In addition, the presence of benzene rings imparts aromatic-related properties. The benzene ring conjugate system is stable and electrophilic substitution reactions can occur. Common such as halogenation, nitrification, sulfonation, etc. Taking the nitrification reaction as an example, mixed acid (concentrated sulfuric acid and concentrated nitric acid mixture) is used as a nitrification reagent. First, sulfuric acid protonates nitric acid to generate nitroyl positive ions (NO ²). This is a strong electrophilic reagent that attacks the area with high electron cloud density of the benzene ring and converts through a series of intermediates to generate nitrification products. Due to the localization effect of substituents on the benzene ring, the substitution reaction area on the benzene ring in this compound is selective, which facilitates the precise introduction of substituents in organic synthesis.
In summary, (s) -2,4 -dioxy - α - （ methoxymethyl) acetophenone plays an indispensable role in organic synthesis such as drug synthesis and material preparation due to its carbonyl, α-hydrogen and benzene ring properties.
Its chemical properties are mainly reflected in the activity of carbonyl groups. The carbonyl group in this molecule, that is, the C = O double bond, is prone to attack by nucleophiles due to the strong electronegativity of oxygen atoms. For example, under basic conditions, alcohol nucleophiles can initiate nucleophilic addition reactions to carbonyl carbons to generate corresponding hemiacetal or acetal products. The reaction mechanism is as follows: the alkali first causes the alcohol to form an alcohol anion to enhance its nucleophilicity, and then the alcohol anion attacks the carbonyl carbon, and the electron transfer rearrangement constructs a new carbon-oxygen bond.
Furthermore, the α-hydrogen atom is active. Because it is adjacent to the carbonyl group, the acidity of the α-hydrogen atom is enhanced due to the electron-sucking induction effect of the carbonyl group. Under the action of a strong base, α-hydrogen is easily captured to form a carbon anion intermediate. This carbon anion has strong nucleophilicity and can participate in a variety of nucleophilic substitution and nucleophilic addition reactions. For example, nucleophilic substitution occurs with halogenated hydrocarbons, introducing new hydrocarbon groups into the molecule; or condensation reactions with other carbonyl compounds, such as hydroxyaldehyde condensation, build carbon-carbon bonds, greatly expand the complexity of molecular structures, and are used in organic synthesis to construct complex carbon skeletons.
In addition, the presence of benzene rings imparts aromatic-related properties. The benzene ring conjugate system is stable and electrophilic substitution reactions can occur. Common such as halogenation, nitrification, sulfonation, etc. Taking the nitrification reaction as an example, mixed acid (concentrated sulfuric acid and concentrated nitric acid mixture) is used as a nitrification reagent. First, sulfuric acid protonates nitric acid to generate nitroyl positive ions (NO ²). This is a strong electrophilic reagent that attacks the area with high electron cloud density of the benzene ring and converts through a series of intermediates to generate nitrification products. Due to the localization effect of substituents on the benzene ring, the substitution reaction area on the benzene ring in this compound is selective, which facilitates the precise introduction of substituents in organic synthesis.
In summary, (s) -2,4 -dioxy - α - （ methoxymethyl) acetophenone plays an indispensable role in organic synthesis such as drug synthesis and material preparation due to its carbonyl, α-hydrogen and benzene ring properties.
What are the physical properties of (s) -2,4 -dichloro-alpha - (chloromethyl) benzyl alcohol
(S) -2,4 -dioxy -α - （ methoxy) benzylacetaldehyde. The physical properties of this substance are as follows:
Its appearance is mostly colorless to light yellow liquid, which is convenient for identification and preliminary judgment at the intuitive level. In terms of olfactory perception, it often has a special smell, but the odor details may vary due to preparation purity and environmental factors.
In terms of boiling point, under specific pressure conditions, it will boil in a certain temperature range. This physical parameter is of great significance for the separation, purification and related chemical reaction conditions. The melting point data is also the key. The specific melting point value is one of the important basis for judging its purity and identifying the substance.
In terms of density, at room temperature and pressure, it has a specific density value, which is helpful for separation operations or analysis of its distribution in the system through density differences when involving mixed systems.
Solubility is also an important physical property. The substance exhibits a certain solubility in some organic solvents, such as ethanol, ether, etc., but its solubility in water is relatively limited. This solubility characteristic has a significant impact on its application in different reaction systems, as well as subsequent product separation and purification steps. Understanding these physical properties allows for more accurate control of the reaction process and product quality when applying this substance in chemical production, scientific research and many other fields.
Its appearance is mostly colorless to light yellow liquid, which is convenient for identification and preliminary judgment at the intuitive level. In terms of olfactory perception, it often has a special smell, but the odor details may vary due to preparation purity and environmental factors.
In terms of boiling point, under specific pressure conditions, it will boil in a certain temperature range. This physical parameter is of great significance for the separation, purification and related chemical reaction conditions. The melting point data is also the key. The specific melting point value is one of the important basis for judging its purity and identifying the substance.
In terms of density, at room temperature and pressure, it has a specific density value, which is helpful for separation operations or analysis of its distribution in the system through density differences when involving mixed systems.
Solubility is also an important physical property. The substance exhibits a certain solubility in some organic solvents, such as ethanol, ether, etc., but its solubility in water is relatively limited. This solubility characteristic has a significant impact on its application in different reaction systems, as well as subsequent product separation and purification steps. Understanding these physical properties allows for more accurate control of the reaction process and product quality when applying this substance in chemical production, scientific research and many other fields.
What are the common uses of (s) -2,4-dichloro-alpha - (chloromethyl) benzyl alcohol?
The common way of (s) -2,4 -dioxy - α - （ oxy methyl) benzyl ketone is the key to the preparation of this compound in organic synthesis. According to the concept of "Tiangong Kaifu", the preparation of materials follows the principles of nature and uses ingenious methods.
Preparation of this compound, one of the methods is to react with the corresponding halogenated benzyl and dioxy compounds in a suitable alkaline environment. This reaction is like using axe work and chiseling wood as a tool. The alkali is like a craftsman's strategy, guiding the direction of the reaction, so that the active check point of halogenated benzyl is precisely connected with the dioxides. The control of the alkaline environment is very important. If the strength of the alkali is lost, the reaction path will be different, and the product will be pure or lost.
Second, it can be obtained by the condensation reaction of specific aldodes and ketones. This process is like the polymerization of two things to build new things together. The molecules of aldodes and ketones interact with each other with the help of catalysts. Catalysts, if the boat is in the river, lead the flow of the reaction and promote it. The method of condensation requires fine control of the temperature and time of the reaction. If the temperature is too high, the reaction may be too fast and chaotic; if the temperature is too low, the reaction will be difficult to advance. The time is temporarily fixed, the time is short, the reaction is not completed, and the time is or by-products.
Or through some more roundabout methods, such as modifying the raw material first, increasing its activity or changing its structure, and then reacting. This is like carving rough jade first to make it have a unique shape, and then carving it into a treasure.
These several ways are commonly used for the preparation of (s) -2,4-dioxy - α - （ methyl) benzyl ketone. Each has its own advantages and disadvantages. It needs to be carefully selected according to the specific situation, such as the ease of availability of raw materials, cost considerations, and product purity requirements.
Preparation of this compound, one of the methods is to react with the corresponding halogenated benzyl and dioxy compounds in a suitable alkaline environment. This reaction is like using axe work and chiseling wood as a tool. The alkali is like a craftsman's strategy, guiding the direction of the reaction, so that the active check point of halogenated benzyl is precisely connected with the dioxides. The control of the alkaline environment is very important. If the strength of the alkali is lost, the reaction path will be different, and the product will be pure or lost.
Second, it can be obtained by the condensation reaction of specific aldodes and ketones. This process is like the polymerization of two things to build new things together. The molecules of aldodes and ketones interact with each other with the help of catalysts. Catalysts, if the boat is in the river, lead the flow of the reaction and promote it. The method of condensation requires fine control of the temperature and time of the reaction. If the temperature is too high, the reaction may be too fast and chaotic; if the temperature is too low, the reaction will be difficult to advance. The time is temporarily fixed, the time is short, the reaction is not completed, and the time is or by-products.
Or through some more roundabout methods, such as modifying the raw material first, increasing its activity or changing its structure, and then reacting. This is like carving rough jade first to make it have a unique shape, and then carving it into a treasure.
These several ways are commonly used for the preparation of (s) -2,4-dioxy - α - （ methyl) benzyl ketone. Each has its own advantages and disadvantages. It needs to be carefully selected according to the specific situation, such as the ease of availability of raw materials, cost considerations, and product purity requirements.
What is the preparation method of (s) -2,4 -dichloro-alpha - (chloromethyl) benzyl alcohol
To prepare (S) -2,4 -difluoro - α - （ fluoromethyl) benzyl ether, the following ancient method can be used.
First take an appropriate amount of p-fluorobenzaldehyde and place it in a clean reactor. The kettle must be dry and well sealed to prevent impurities from mixing. Fill the kettle with nitrogen to replace the air in it to create an inert atmosphere, because the reaction is quite sensitive to oxygen.
Then, under low temperature and stirring conditions, slowly add the pretreated fluorine-containing alkylating reagent. During this process, the temperature needs to be precisely controlled, generally maintained between about -10 ° C and 0 ° C. Stirring should be uniform and continuous to allow the reactants to fully contact and accelerate the reaction process. When adding alkylating reagents, the speed should be slow to avoid the reaction being too violent and out of control.
When the alkylating reagents are added, continue to stir for a period of time to fully proceed the reaction. At this stage, the reaction progress can be judged by monitoring the physical properties or chemical composition changes of the reaction system. For example, by means of chromatographic analysis, the ratio of reactants to products can be observed in real time.
When the reaction reaches the desired level, slowly pour the reaction mixture into an appropriate amount of ice water to quench the unreacted reagents. At this time, the product will precipitate or stratify due to the difference in solubility in water. The organic phase is separated by liquid separation operation.
The organic phase is dried with an appropriate amount of anhydrous sodium sulfate to remove the trace moisture contained in it. The drying time should be sufficient, usually several hours. After that, the low-boiling impurities in the organic phase are removed by the method of vacuum distillation, and the fractions in a specific boiling point range are collected. This is the preliminary product.
Finally, in order to improve the purity of the product, the preliminary product can be recrystallized. Select a suitable solvent, such as a specific proportion of alcohol-water mixed solvent, dissolve the product, heat it to complete dissolution, and slowly cool it to crystallize and precipitate the product. The crystals are filtered and collected, washed several times with cold solvent to remove impurities attached to the surface, and finally dried in a vacuum oven to obtain high-purity (S) - 2,4 - difluoro - α - （ fluoromethyl) benzyl ether. The whole process requires fine operation, and each step is related to the quality and yield of the product.
First take an appropriate amount of p-fluorobenzaldehyde and place it in a clean reactor. The kettle must be dry and well sealed to prevent impurities from mixing. Fill the kettle with nitrogen to replace the air in it to create an inert atmosphere, because the reaction is quite sensitive to oxygen.
Then, under low temperature and stirring conditions, slowly add the pretreated fluorine-containing alkylating reagent. During this process, the temperature needs to be precisely controlled, generally maintained between about -10 ° C and 0 ° C. Stirring should be uniform and continuous to allow the reactants to fully contact and accelerate the reaction process. When adding alkylating reagents, the speed should be slow to avoid the reaction being too violent and out of control.
When the alkylating reagents are added, continue to stir for a period of time to fully proceed the reaction. At this stage, the reaction progress can be judged by monitoring the physical properties or chemical composition changes of the reaction system. For example, by means of chromatographic analysis, the ratio of reactants to products can be observed in real time.
When the reaction reaches the desired level, slowly pour the reaction mixture into an appropriate amount of ice water to quench the unreacted reagents. At this time, the product will precipitate or stratify due to the difference in solubility in water. The organic phase is separated by liquid separation operation.
The organic phase is dried with an appropriate amount of anhydrous sodium sulfate to remove the trace moisture contained in it. The drying time should be sufficient, usually several hours. After that, the low-boiling impurities in the organic phase are removed by the method of vacuum distillation, and the fractions in a specific boiling point range are collected. This is the preliminary product.
Finally, in order to improve the purity of the product, the preliminary product can be recrystallized. Select a suitable solvent, such as a specific proportion of alcohol-water mixed solvent, dissolve the product, heat it to complete dissolution, and slowly cool it to crystallize and precipitate the product. The crystals are filtered and collected, washed several times with cold solvent to remove impurities attached to the surface, and finally dried in a vacuum oven to obtain high-purity (S) - 2,4 - difluoro - α - （ fluoromethyl) benzyl ether. The whole process requires fine operation, and each step is related to the quality and yield of the product.
What are the precautions for (s) -2,4-dichloro-alpha - (chloromethyl) benzyl alcohol in storage and transportation?
(S) - 2,4 -dioxy - α - （ oxy methyl) benzyl ether, during storage and transportation, many precautions should not be ignored.
The chemical properties of this substance or more active, when storing, the first choice of environment. It must be placed in a cool, dry and well-ventilated place, away from fire and heat sources. The cover is dangerous if it is heated or chemically changed. If it is under high temperature, it may decompose, produce harmful gases, or even have the risk of explosion.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its special chemical structure, when encountering such substances, it may cause severe chemical reactions, damage the substance itself, and endanger the safety of the surrounding area.
When transporting, the packaging must be solid and reliable. Choose suitable packaging materials to prevent the package from being damaged due to vibration and collision during transportation, causing the substance to leak. Once leaked, it not only pollutes the environment, but also endangers the surrounding organisms.
Transportation vehicles must also meet specific requirements and be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. Escort personnel should be familiar with the nature of this substance and emergency disposal methods. Pay close attention to the transportation situation on the way. If there is any abnormality, they will be properly disposed of immediately.
All of these are (s) - 2,4 - dioxy - α - （ methyl) benzyl ether storage and transportation should pay attention, must not be negligent, so as not to cause a disaster.
The chemical properties of this substance or more active, when storing, the first choice of environment. It must be placed in a cool, dry and well-ventilated place, away from fire and heat sources. The cover is dangerous if it is heated or chemically changed. If it is under high temperature, it may decompose, produce harmful gases, or even have the risk of explosion.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its special chemical structure, when encountering such substances, it may cause severe chemical reactions, damage the substance itself, and endanger the safety of the surrounding area.
When transporting, the packaging must be solid and reliable. Choose suitable packaging materials to prevent the package from being damaged due to vibration and collision during transportation, causing the substance to leak. Once leaked, it not only pollutes the environment, but also endangers the surrounding organisms.
Transportation vehicles must also meet specific requirements and be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. Escort personnel should be familiar with the nature of this substance and emergency disposal methods. Pay close attention to the transportation situation on the way. If there is any abnormality, they will be properly disposed of immediately.
All of these are (s) - 2,4 - dioxy - α - （ methyl) benzyl ether storage and transportation should pay attention, must not be negligent, so as not to cause a disaster.
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