Linshang Chemical
PRODUCTS
S(-)-Alpha-(Chloromethyl)Benzenemethanol
Linshang Chemical
|
HS Code |
316212 |
| Chemical Formula | C8H9ClO |
| Molecular Weight | 156.609 g/mol |
| Physical State | Solid (usually) |
| Appearance | White to off - white powder |
| Boiling Point | Approx. 243 - 245 °C |
| Melting Point | 63 - 67 °C |
| Solubility In Water | Poorly soluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, dichloromethane |
| Density | Approx. 1.225 g/cm³ |
| Optical Activity | Exhibits optical activity due to chiral center |
| Flash Point | Approx. 114 °C |
As an accredited S(-)-Alpha-(Chloromethyl)Benzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle packaging for S(-)-α-(chloromethyl)benzenemethanol chemical. |
| Storage | S(-)-α-(chloromethyl)benzenemethanol should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container to prevent evaporation and exposure to air and moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Ensure proper labeling for easy identification. |
| Shipping | "S(-)-α-(chloromethyl)benzenemethanol" is likely a hazardous chemical. Shipping requires proper packaging in accordance with regulations, clearly labeled with hazard information, and transported by carriers licensed for such chemicals, ensuring safety during transit. |
Competitive S(-)-Alpha-(Chloromethyl)Benzenemethanol prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading S(-)-Alpha-(Chloromethyl)Benzenemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of S (-) -alpha- (chloromethyl) benzenemethanol?
S (-)-α-( chloromethyl) benzyl alcohol, its chemical structure is as follows: The compound molecule contains a benzene ring, which is connected to a methylene group (-CH-), and the methylene group is connected to a hydroxy group (-OH) and a chloromethyl group (-CH 2O Cl) at the same time. Because of its chiral center, there is an enantiomer, which is clearly defined here as the S configuration. The S configuration is obtained by stereochemical labeling the chiral center according to the Cahn-Ingold-Prelog rule. Under this rule, the priority of each group is determined according to the atomic number of the atom connected to the chiral center. If the order of decreasing priority is counterclockwise, it is the S configuration. The order of priority of the four groups connected to the chiral center in this compound is: -OH > -CH ² Cl > benzene ring > H, which determines its S configuration in this way. This chemical structure endows it with certain physical and chemical properties. It is often used as an important intermediate in the field of organic synthesis and participates in many chemical reactions, such as further functionalization through the reaction of hydroxyl groups, or specific substitution reactions using the activity of chloromethyl groups.
What are the main uses of S (-) -alpha- (chloromethyl) benzenemethanol?
S (-)-α-( chloromethyl) benzyl alcohol, an important organic compound, has a wide range of uses in many fields.
In the field of organic synthesis, it is often used as a key intermediate. Because its structure contains active chloromethyl and alcohol hydroxyl groups, it can participate in various chemical reactions. For example, chloromethyl can react with many nucleophiles, such as alcohols and amines, through nucleophilic substitution reactions, to form chemical bonds such as carbon-oxygen and carbon-nitrogen, and to synthesize organic compounds with diverse structures. With the reactivity of alcohol hydroxyl groups, esterification and etherification can be carried out, providing the possibility for the synthesis of complex organic molecules. In the synthesis of many drug molecules, S (-)-α-( chloromethyl) benzyl alcohol is often used as the starting material, and the molecular structure with specific pharmacological activity is precisely constructed through a series of reaction steps.
It is also of great value in materials science. By appropriate reaction, it can be introduced into the structure of polymer materials to give the material unique properties. For example, by copolymerizing with polymer monomers, it can change the solubility, crystallinity and surface properties of polymers. When preparing some functional polymer films or coatings, the introduction of S (-)-α-( chloromethyl) benzyl alcohol can make the material have better biocompatibility, antibacterial or optical properties, etc., and expand the application of the material in biomedicine, optical devices and other fields.
In the field of asymmetric synthesis, S (-)-α-( chloromethyl) benzyl alcohol can be used as a chiral adjuvant or a chiral induction reagent because of its own chiral structure. In some asymmetric reactions, it can induce the reaction to selectively generate products of specific configurations and improve the optical purity of the target product. This chiral induction plays a key role in the synthesis of physiologically active chiral compounds, such as total synthesis of natural products, which helps to obtain products with a single chiral configuration and meet the needs of high-purity chiral compounds in the pharmaceutical, pesticide and other industries.
In summary, S (-)-α-( chloromethyl) benzyl alcohol is an indispensable and important substance in the fields of organic synthesis, materials science and asymmetric synthesis, and has made great contributions to the development of related fields.
In the field of organic synthesis, it is often used as a key intermediate. Because its structure contains active chloromethyl and alcohol hydroxyl groups, it can participate in various chemical reactions. For example, chloromethyl can react with many nucleophiles, such as alcohols and amines, through nucleophilic substitution reactions, to form chemical bonds such as carbon-oxygen and carbon-nitrogen, and to synthesize organic compounds with diverse structures. With the reactivity of alcohol hydroxyl groups, esterification and etherification can be carried out, providing the possibility for the synthesis of complex organic molecules. In the synthesis of many drug molecules, S (-)-α-( chloromethyl) benzyl alcohol is often used as the starting material, and the molecular structure with specific pharmacological activity is precisely constructed through a series of reaction steps.
It is also of great value in materials science. By appropriate reaction, it can be introduced into the structure of polymer materials to give the material unique properties. For example, by copolymerizing with polymer monomers, it can change the solubility, crystallinity and surface properties of polymers. When preparing some functional polymer films or coatings, the introduction of S (-)-α-( chloromethyl) benzyl alcohol can make the material have better biocompatibility, antibacterial or optical properties, etc., and expand the application of the material in biomedicine, optical devices and other fields.
In the field of asymmetric synthesis, S (-)-α-( chloromethyl) benzyl alcohol can be used as a chiral adjuvant or a chiral induction reagent because of its own chiral structure. In some asymmetric reactions, it can induce the reaction to selectively generate products of specific configurations and improve the optical purity of the target product. This chiral induction plays a key role in the synthesis of physiologically active chiral compounds, such as total synthesis of natural products, which helps to obtain products with a single chiral configuration and meet the needs of high-purity chiral compounds in the pharmaceutical, pesticide and other industries.
In summary, S (-)-α-( chloromethyl) benzyl alcohol is an indispensable and important substance in the fields of organic synthesis, materials science and asymmetric synthesis, and has made great contributions to the development of related fields.
What are the synthesis methods of S (-) -alpha- (chloromethyl) benzenemethanol?
To prepare S (-)-α-( chloromethyl) benzyl alcohol, there are many methods, each with its own advantages.
First, asymmetric reduction can be used. Transition metal catalysts containing specific chiral ligands are used to catalyze the reduction reaction of alpha - (chloromethyl) benzaldehyde. The coordination between the chiral ligand and the metal center can create an asymmetric microenvironment, guide the reducer to selectively attack the aldehyde group from a specific direction, and then obtain high enantioselectivity S (-)-α-( chloromethyl) benzyl alcohol. This method has mild conditions and good selectivity, but the chiral ligand transition metal catalysts are often expensive and cumbersome to prepare, and the cost consideration in large-scale production is quite heavy.
Second, biocatalysis is also possible. Some specific enzymes, such as alcohol dehydrogenase, can catalyze the asymmetric reduction of alpha - (chloromethyl) benzaldehyde. Enzymes are highly specific and stereoselective, and can efficiently catalyze the reaction under mild reaction conditions, such as aqueous environment, near neutral pH and moderate temperature. And the enzyme reaction is green and environmentally friendly, with few side reactions. However, the stability of the enzyme is limited, it is sensitive to reaction conditions, and separation and recovery are also difficult.
Third, chiral adjuvant induction method. First, alpha - (chloromethyl) benzaldehyde reacts with chiral adjuvants to form chiral intermediates. The steric resistance and electronic effects of chiral adjuvants can guide the stereochemical results of the subsequent reaction. After the reaction is completed, the chiral adjuvant is removed to obtain the target product. In this process, the chiral adjuvant can be recycled and reused, but the reaction steps increase, and the overall yield may be affected. The selection of chiral adjuvants and the optimization of reaction conditions need to be carefully considered.
First, asymmetric reduction can be used. Transition metal catalysts containing specific chiral ligands are used to catalyze the reduction reaction of alpha - (chloromethyl) benzaldehyde. The coordination between the chiral ligand and the metal center can create an asymmetric microenvironment, guide the reducer to selectively attack the aldehyde group from a specific direction, and then obtain high enantioselectivity S (-)-α-( chloromethyl) benzyl alcohol. This method has mild conditions and good selectivity, but the chiral ligand transition metal catalysts are often expensive and cumbersome to prepare, and the cost consideration in large-scale production is quite heavy.
Second, biocatalysis is also possible. Some specific enzymes, such as alcohol dehydrogenase, can catalyze the asymmetric reduction of alpha - (chloromethyl) benzaldehyde. Enzymes are highly specific and stereoselective, and can efficiently catalyze the reaction under mild reaction conditions, such as aqueous environment, near neutral pH and moderate temperature. And the enzyme reaction is green and environmentally friendly, with few side reactions. However, the stability of the enzyme is limited, it is sensitive to reaction conditions, and separation and recovery are also difficult.
Third, chiral adjuvant induction method. First, alpha - (chloromethyl) benzaldehyde reacts with chiral adjuvants to form chiral intermediates. The steric resistance and electronic effects of chiral adjuvants can guide the stereochemical results of the subsequent reaction. After the reaction is completed, the chiral adjuvant is removed to obtain the target product. In this process, the chiral adjuvant can be recycled and reused, but the reaction steps increase, and the overall yield may be affected. The selection of chiral adjuvants and the optimization of reaction conditions need to be carefully considered.
What are the physical properties of S (-) -alpha- (chloromethyl) benzenemethanol?
S (-)-α-( chloromethyl) benzyl alcohol is an important member of the field of organic compounds. Its physical properties are quite unique, let me tell you one by one.
Looking at its properties, under room temperature and pressure, it mostly appears as a colorless to light yellow liquid form. This substance has a certain volatility and can evaporate slowly in the air. Its smell is special, but the specific smell is difficult to describe exactly, and it needs to be sensed by smelling it.
When it comes to melting point and boiling point, there are also considerable points. The melting point value is generally in a specific low temperature range due to different or slightly different measurement conditions; the boiling point is at a certain temperature, the substance will be converted from liquid to gaseous state. This temperature is one of its important physical constants, which can be used as an important basis for identifying and purifying the substance.
In terms of solubility, S (-)-α-( chloromethyl) benzyl alcohol exhibits good solubility in organic solvents, such as common ethanol, ether and other organic solvents, can be miscible with it; however, its solubility in water is poor, because of its molecular structure characteristics, it interacts weakly with water molecules, so it is difficult to dissolve in water.
In addition, density is also a key factor in the physical properties of the substance. Its density is higher or lower than that of water, which is particularly important when it comes to the separation and mixing of the substance. Knowing its density can help the experimenter to carry out the relevant operations more accurately and ensure the smooth development of the experiment.
In summary, the physical properties of S (-)-α-( chloromethyl) benzyl alcohol are rich and diverse, covering many aspects such as properties, melting point, boiling point, solubility and density. These properties have laid a solid foundation for its application in many fields such as organic synthesis and chemical research.
Looking at its properties, under room temperature and pressure, it mostly appears as a colorless to light yellow liquid form. This substance has a certain volatility and can evaporate slowly in the air. Its smell is special, but the specific smell is difficult to describe exactly, and it needs to be sensed by smelling it.
When it comes to melting point and boiling point, there are also considerable points. The melting point value is generally in a specific low temperature range due to different or slightly different measurement conditions; the boiling point is at a certain temperature, the substance will be converted from liquid to gaseous state. This temperature is one of its important physical constants, which can be used as an important basis for identifying and purifying the substance.
In terms of solubility, S (-)-α-( chloromethyl) benzyl alcohol exhibits good solubility in organic solvents, such as common ethanol, ether and other organic solvents, can be miscible with it; however, its solubility in water is poor, because of its molecular structure characteristics, it interacts weakly with water molecules, so it is difficult to dissolve in water.
In addition, density is also a key factor in the physical properties of the substance. Its density is higher or lower than that of water, which is particularly important when it comes to the separation and mixing of the substance. Knowing its density can help the experimenter to carry out the relevant operations more accurately and ensure the smooth development of the experiment.
In summary, the physical properties of S (-)-α-( chloromethyl) benzyl alcohol are rich and diverse, covering many aspects such as properties, melting point, boiling point, solubility and density. These properties have laid a solid foundation for its application in many fields such as organic synthesis and chemical research.
What are the precautions for S (-) -alpha- (chloromethyl) benzenemethanol during storage and transportation?
S (-)-α-( chloromethyl) benzyl alcohol, there are many things to pay attention to during storage and transportation. This is a substance with specific chemical properties and should be treated with care.
When storing, the temperature and humidity of the environment are the first priority. It should be placed in a cool and dry place. If the temperature and humidity are too high, it may cause chemical reactions and cause quality damage. For example, high temperature or cause its volatilization to intensify, and the humidity can cause deliquescence.
Avoidance of light is also the key. This substance may be sensitive to light, under light, or cause luminescent chemical reactions, changing its chemical structure and losing its original characteristics. Therefore, it should be stored in a container or warehouse that is shaded from light.
Furthermore, it needs to be isolated from other chemicals. Because it has specific functional groups or reacts with certain substances, such as strong oxidizing agents, strong acids and alkalis, etc., mixing may cause dangerous accidents and damage its own quality.
When transporting, the packaging must be stable. Suitable packaging materials need to be used to ensure that there is no leakage during bumps and vibrations. Leakage not only causes material loss, but also poses a hazard to the environment and transportation personnel.
The transportation environment should also be controlled. If the temperature, it needs to be maintained in a suitable range to avoid extreme temperatures. At the same time, the transportation vehicle should be clean and free of foreign matter to prevent impurities from mixing in. In short, S (-)-α-( chloromethyl) benzyl alcohol needs to be carefully considered during storage and transportation, from environmental conditions to packaging protection, to ensure its quality and transportation safety.
When storing, the temperature and humidity of the environment are the first priority. It should be placed in a cool and dry place. If the temperature and humidity are too high, it may cause chemical reactions and cause quality damage. For example, high temperature or cause its volatilization to intensify, and the humidity can cause deliquescence.
Avoidance of light is also the key. This substance may be sensitive to light, under light, or cause luminescent chemical reactions, changing its chemical structure and losing its original characteristics. Therefore, it should be stored in a container or warehouse that is shaded from light.
Furthermore, it needs to be isolated from other chemicals. Because it has specific functional groups or reacts with certain substances, such as strong oxidizing agents, strong acids and alkalis, etc., mixing may cause dangerous accidents and damage its own quality.
When transporting, the packaging must be stable. Suitable packaging materials need to be used to ensure that there is no leakage during bumps and vibrations. Leakage not only causes material loss, but also poses a hazard to the environment and transportation personnel.
The transportation environment should also be controlled. If the temperature, it needs to be maintained in a suitable range to avoid extreme temperatures. At the same time, the transportation vehicle should be clean and free of foreign matter to prevent impurities from mixing in. In short, S (-)-α-( chloromethyl) benzyl alcohol needs to be carefully considered during storage and transportation, from environmental conditions to packaging protection, to ensure its quality and transportation safety.
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