Linshang Chemical
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(S)-(+)-Α-(Chloromethyl)Benzenemethanol
Linshang Chemical
|
HS Code |
710428 |
| Chemical Formula | C8H9ClO |
| Molar Mass | 156.609 g/mol |
| Appearance | Colorless to light - yellow liquid |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Boiling Point | Approximately 224 - 226 °C |
| Density | 1.195 g/cm³ |
| Flash Point | 104 °C |
| Chirality | Has a chiral center (S - configuration) |
As an accredited (S)-(+)-Α-(Chloromethyl)Benzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of (S)-(+)-α-(chloromethyl)benzenemethanol in a sealed chemical - grade bottle. |
| Storage | (s)-(+)-α-(Chloromethyl)benzenemethanol should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container to prevent exposure to air and moisture, which could potentially lead to decomposition. Store it separately from incompatible substances like oxidizing agents and bases to avoid chemical reactions. |
| Shipping | (+)-α-(Chloromethyl)benzenemethanol is shipped in specialized, well - sealed containers compliant with chemical transport regulations. Adequate cushioning and temperature - controlled conditions may be used to ensure safe transit. |
Competitive (S)-(+)-Α-(Chloromethyl)Benzenemethanol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading (S)-(+)-Α-(Chloromethyl)Benzenemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of (s )-(+)-α-( chloromethyl) benzenemethanol
(S ） - （ + ） - α - （ chloromethyl) benzyl alcohol is an important compound in organic chemistry. It has a wide range of uses and is particularly useful in the field of organic synthesis.
First, it is often used in drug synthesis. Because of its special chemical structure, it can be used as a key intermediate to prepare a variety of biologically active drug molecules. For example, through a specific chemical reaction path, it can be combined with other compounds to construct a drug structure that has curative effect on specific diseases, or in the drug modification step, this structure can be introduced to change the physical and chemical properties of the drug, such as solubility and stability, which in turn affects the bioavailability and efficacy of the drug.
Second, it also has applications in materials science. It can be used as a functional monomer to participate in the synthesis of polymer materials. By polymerizing with other monomers, the material is endowed with special properties. For example, after introducing its structure, the surface of the material may be specific hydrophobicity, biocompatibility, etc., so as to meet the special needs of material properties in different fields. For example, in the field of biomedical materials, it can be used to prepare materials that are friendly in contact with organisms.
Third, in the field of organic catalysis, (S ） - （ + ） - α - （ chloromethyl) benzyl alcohol may act as a chiral catalyst or ligand. With its chiral center, it plays an important role in asymmetric catalytic reactions, promoting the reaction to proceed in a specific chiral direction, and synthesizing compounds with high optical purity, which is of great significance for obtaining single chiral products in the fine chemical and pharmaceutical industries.
First, it is often used in drug synthesis. Because of its special chemical structure, it can be used as a key intermediate to prepare a variety of biologically active drug molecules. For example, through a specific chemical reaction path, it can be combined with other compounds to construct a drug structure that has curative effect on specific diseases, or in the drug modification step, this structure can be introduced to change the physical and chemical properties of the drug, such as solubility and stability, which in turn affects the bioavailability and efficacy of the drug.
Second, it also has applications in materials science. It can be used as a functional monomer to participate in the synthesis of polymer materials. By polymerizing with other monomers, the material is endowed with special properties. For example, after introducing its structure, the surface of the material may be specific hydrophobicity, biocompatibility, etc., so as to meet the special needs of material properties in different fields. For example, in the field of biomedical materials, it can be used to prepare materials that are friendly in contact with organisms.
Third, in the field of organic catalysis, (S ） - （ + ） - α - （ chloromethyl) benzyl alcohol may act as a chiral catalyst or ligand. With its chiral center, it plays an important role in asymmetric catalytic reactions, promoting the reaction to proceed in a specific chiral direction, and synthesizing compounds with high optical purity, which is of great significance for obtaining single chiral products in the fine chemical and pharmaceutical industries.
What are the physical properties of (s )-(+)-α-( chloromethyl) benzenemethanol
(S ） -（ + ） -α -（ chloromethyl) benzyl alcohol, this is an organic compound. Looking at its physical properties, at room temperature, it is mostly colorless to light yellow oily liquid, which has good solubility in many organic solvents, such as ethanol, ether, dichloromethane, etc. This is due to the existence of polar hydroxyl groups and benzene rings in the molecular structure.
Its boiling point is about a specific range, but the exact value is easily disturbed by impurities and external conditions, so it is difficult to accurately describe. Generally speaking, such compounds containing benzene rings and hydroxyl groups have higher boiling points, due to the intermolecular hydrogen bonds formed by the conjugated system of benzene rings and hydroxyl groups, resulting in increased intermolecular forces.
Its melting point also has a corresponding range, and it also fluctuates due to different factors. The density of this substance is slightly higher than that of water, and it can show a weak stratification phenomenon in water. Although it contains hydrophilic hydroxyl groups, the hydrophobicity of benzene rings is dominant.
In addition, its refractive index is also a specific value, which is often used as the basis for identification and purity judgment. In terms of spectral properties, in the infrared spectrum, hydroxyl groups will show absorption peaks at specific wavenumbers, which can help determine the existence of hydroxyl groups; and the characteristic peaks of benzene rings will also appear in the corresponding wavenumber interval, providing strong evidence for structural identification.
The physical properties of this compound are of great significance in many fields such as organic synthesis, medicinal chemistry, etc. Many reactions use it as a starting material or intermediate. Knowledge of its physical properties is conducive to separation and purification in experimental operations, thus promoting the development of related fields.
Its boiling point is about a specific range, but the exact value is easily disturbed by impurities and external conditions, so it is difficult to accurately describe. Generally speaking, such compounds containing benzene rings and hydroxyl groups have higher boiling points, due to the intermolecular hydrogen bonds formed by the conjugated system of benzene rings and hydroxyl groups, resulting in increased intermolecular forces.
Its melting point also has a corresponding range, and it also fluctuates due to different factors. The density of this substance is slightly higher than that of water, and it can show a weak stratification phenomenon in water. Although it contains hydrophilic hydroxyl groups, the hydrophobicity of benzene rings is dominant.
In addition, its refractive index is also a specific value, which is often used as the basis for identification and purity judgment. In terms of spectral properties, in the infrared spectrum, hydroxyl groups will show absorption peaks at specific wavenumbers, which can help determine the existence of hydroxyl groups; and the characteristic peaks of benzene rings will also appear in the corresponding wavenumber interval, providing strong evidence for structural identification.
The physical properties of this compound are of great significance in many fields such as organic synthesis, medicinal chemistry, etc. Many reactions use it as a starting material or intermediate. Knowledge of its physical properties is conducive to separation and purification in experimental operations, thus promoting the development of related fields.
What are the chemical properties of (s )-(+)-α-( chloromethyl) benzenemethanol
(S ） - （ + ） - α - （ chloromethyl) benzyl alcohol, an organic compound, has unique chemical properties and is crucial in the field of organic synthesis.
It has an alcohol hydroxyl group, so it has typical properties of alcohols. It can react with active metals, such as sodium, to form sodium alcohol and hydrogen. This reaction is like a warrior fighting a dragon. Sodium bravely captures hydrogen in the hydroxyl group and turns itself into sodium alcohol. Hydrogen escapes like the breath of a defeated dragon.
Can participate in the esterification reaction, and under acid catalysis with carboxylic acids, form esters and water. This process is like a delicate dance. The alcohol and carboxylic acid combine elegantly under the guidance of the acid, and the water quietly leaves like the petals scattered after the dance.
Because of the chlorine methyl group, the activity of chlorine atoms is high, and nucleophilic substitution reactions can occur. Nucleophilic reagents such as hydroxyl negative ions, amino negative ions, etc., will attack the chlorine methyl group like a brave knight, replacing the chlorine atoms to form new compounds.
There is also chirality, and the (s) configuration determines its extraordinary role in asymmetric synthesis. Just like a pair of dexterous hands, they can precisely guide the reaction and synthesize products with specific configurations. They are as important in drug synthesis and other fields as the needle of the sea, helping to synthesize drugs with high activity and low side effects.
This compound is rich in chemical properties and plays an indispensable role in the stage of organic synthesis, like a key role in a grand epic, promoting the development of organic chemistry.
It has an alcohol hydroxyl group, so it has typical properties of alcohols. It can react with active metals, such as sodium, to form sodium alcohol and hydrogen. This reaction is like a warrior fighting a dragon. Sodium bravely captures hydrogen in the hydroxyl group and turns itself into sodium alcohol. Hydrogen escapes like the breath of a defeated dragon.
Can participate in the esterification reaction, and under acid catalysis with carboxylic acids, form esters and water. This process is like a delicate dance. The alcohol and carboxylic acid combine elegantly under the guidance of the acid, and the water quietly leaves like the petals scattered after the dance.
Because of the chlorine methyl group, the activity of chlorine atoms is high, and nucleophilic substitution reactions can occur. Nucleophilic reagents such as hydroxyl negative ions, amino negative ions, etc., will attack the chlorine methyl group like a brave knight, replacing the chlorine atoms to form new compounds.
There is also chirality, and the (s) configuration determines its extraordinary role in asymmetric synthesis. Just like a pair of dexterous hands, they can precisely guide the reaction and synthesize products with specific configurations. They are as important in drug synthesis and other fields as the needle of the sea, helping to synthesize drugs with high activity and low side effects.
This compound is rich in chemical properties and plays an indispensable role in the stage of organic synthesis, like a key role in a grand epic, promoting the development of organic chemistry.
What are the synthesis methods of (s )-(+)-α-( chloromethyl) benzenemethanol
There are several ways to synthesize (S )-(+)-α-( chloromethyl) benzyl alcohol. First, it can be started from suitable chiral raw materials. For example, benzaldehyde derivatives with a specific chiral configuration are used as the starting point, and chloromethyl is introduced through a specific reaction. This requires the selection of reaction conditions and reagents that can accurately guide the desired chiral configuration.
Furthermore, asymmetric synthesis can be used. Chiral catalysts are used to catalyze the reaction of benzene-ring-containing substrates with chloromethylation reagents. This chiral catalyst must be highly active and selective in order to effectively guide the reaction to generate (S )-(+)-α-( chloromethyl) benzyl alcohol. During the reaction, the temperature, solvent, catalyst dosage and other conditions need to be finely regulated to achieve the best reaction effect.
Another method can be obtained by splitting the (S) - (+) -isomer from the racemic alpha - (chloromethyl) benzyl alcohol. Chiral resolution agents can be used to form diastereoisomers with racemates. Due to the differences in physical properties between the two, such as solubility and melting point, they can be separated by recrystallization, chromatographic separation, etc., and then (S )-(+)-α-( chloromethyl) benzyl alcohol can be obtained.
The above methods have their own advantages and disadvantages, and the most suitable synthesis path should be selected according to the actual situation, such as raw material availability, cost, reaction difficulty, etc.
Furthermore, asymmetric synthesis can be used. Chiral catalysts are used to catalyze the reaction of benzene-ring-containing substrates with chloromethylation reagents. This chiral catalyst must be highly active and selective in order to effectively guide the reaction to generate (S )-(+)-α-( chloromethyl) benzyl alcohol. During the reaction, the temperature, solvent, catalyst dosage and other conditions need to be finely regulated to achieve the best reaction effect.
Another method can be obtained by splitting the (S) - (+) -isomer from the racemic alpha - (chloromethyl) benzyl alcohol. Chiral resolution agents can be used to form diastereoisomers with racemates. Due to the differences in physical properties between the two, such as solubility and melting point, they can be separated by recrystallization, chromatographic separation, etc., and then (S )-(+)-α-( chloromethyl) benzyl alcohol can be obtained.
The above methods have their own advantages and disadvantages, and the most suitable synthesis path should be selected according to the actual situation, such as raw material availability, cost, reaction difficulty, etc.
Precautions for (s )-(+)-α-( chloromethyl) benzenemethanol in storage and transportation
(S ） -（+） -α -（ chloromethyl) benzyl alcohol is an organic compound. When storing and transporting, the following things must be paid attention to:
First, the storage environment is very important. This compound should be placed in a cool, dry and well ventilated place, and must not be exposed to high temperature and humid environment. High temperature can easily cause its volatilization to accelerate, and may even cause chemical reactions to cause deterioration; moisture may cause reactions such as hydrolysis of the substance, destroying its chemical structure. For example, in the hot and humid south, if stored improperly, the compound may deteriorate faster.
Second, it is necessary to strictly avoid contact with oxidants. Due to its specific chemical activity, it is easy to cause violent oxidation reactions when exposed to oxidants, or there is a risk of combustion and explosion. This situation is similar to dry firewood when exposed to fire, and it is very easy to lose control.
Third, when transporting, be sure to ensure that the packaging is intact. Appropriate packaging materials, such as sturdy glass bottles or special plastic containers, should be used, and properly fixed to prevent collisions and vibrations from causing the packaging to break. If the vehicle is bumpy during transportation, if the packaging is not strong, the compound leakage will not only cause losses, but also pose a hazard to the environment and personnel.
Fourth, in view of its possible toxicity and irritation, whether it is storage or transportation, relevant personnel should take protective measures. Wear appropriate protective gloves, masks and goggles to prevent contact with the skin, inhalation of volatile gases, and ensure your own safety.
Fifth, storage and transportation sites should be clearly marked, indicating the characteristics of the compound, warnings, etc., so that personnel can identify and respond to emergencies. There are obvious "toxic and harmful, careful operation" and other signs, so that contacts can be seen at a glance and proceed with caution.
First, the storage environment is very important. This compound should be placed in a cool, dry and well ventilated place, and must not be exposed to high temperature and humid environment. High temperature can easily cause its volatilization to accelerate, and may even cause chemical reactions to cause deterioration; moisture may cause reactions such as hydrolysis of the substance, destroying its chemical structure. For example, in the hot and humid south, if stored improperly, the compound may deteriorate faster.
Second, it is necessary to strictly avoid contact with oxidants. Due to its specific chemical activity, it is easy to cause violent oxidation reactions when exposed to oxidants, or there is a risk of combustion and explosion. This situation is similar to dry firewood when exposed to fire, and it is very easy to lose control.
Third, when transporting, be sure to ensure that the packaging is intact. Appropriate packaging materials, such as sturdy glass bottles or special plastic containers, should be used, and properly fixed to prevent collisions and vibrations from causing the packaging to break. If the vehicle is bumpy during transportation, if the packaging is not strong, the compound leakage will not only cause losses, but also pose a hazard to the environment and personnel.
Fourth, in view of its possible toxicity and irritation, whether it is storage or transportation, relevant personnel should take protective measures. Wear appropriate protective gloves, masks and goggles to prevent contact with the skin, inhalation of volatile gases, and ensure your own safety.
Fifth, storage and transportation sites should be clearly marked, indicating the characteristics of the compound, warnings, etc., so that personnel can identify and respond to emergencies. There are obvious "toxic and harmful, careful operation" and other signs, so that contacts can be seen at a glance and proceed with caution.
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